SitesBLAST
Comparing WP_057507603.1 NCBI__GCF_001431535.1:WP_057507603.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 8 hits to proteins with known functional sites (download)
3ukaA Crystal structure of udp-galactopyranose mutase from aspergillus fumigatus (see paper)
27% identity, 38% coverage: 773:1258/1270 of query aligns to 7:468/506 of 3ukaA
- binding flavin-adenine dinucleotide: G13 (= G779), G15 (= G781), P16 (= P782), T17 (= T783), D37 (≠ E799), S38 (≠ K800), G44 (= G806), L45 (≠ W807), V59 (≠ H820), G60 (≠ A821), G61 (= G822), H62 (= H823), V238 (= V1053), M265 (≠ L1080), R443 (= R1235), G452 (vs. gap), N453 (= N1243), Q454 (≠ S1244), S457 (≠ A1247)
3ukfA Crystal structure of udp-galactopyranose mutase from aspergillus fumigatus in complex with udpgalp (reduced) (see paper)
27% identity, 38% coverage: 773:1258/1270 of query aligns to 7:471/509 of 3ukfA
- binding dihydroflavine-adenine dinucleotide: G13 (= G779), G15 (= G781), P16 (= P782), T17 (= T783), D37 (≠ E799), S38 (≠ K800), L45 (≠ W807), V59 (≠ H820), H62 (= H823), V63 (≠ I824), V241 (= V1053), G445 (= G1234), R446 (= R1235), G455 (vs. gap), N456 (= N1243), Q457 (≠ S1244), S460 (≠ A1247)
- binding galactose-uridine-5'-diphosphate: Y103 (= Y862), P104 (= P863), F105 (= F864), Q106 (= Q865), F157 (= F973), M158 (≠ A974), N162 (= N978), R181 (= R997), Y316 (= Y1128), R326 (= R1137), Y452 (= Y1241)
3ukkA Crystal structure of r182k-udp-galactopuranose mutase from aspergillus fumigatus in complex with udpgalp (see paper)
27% identity, 38% coverage: 773:1258/1270 of query aligns to 7:471/517 of 3ukkA
- binding dihydroflavine-adenine dinucleotide: P16 (= P782), T17 (= T783), D37 (≠ E799), S38 (≠ K800), V59 (≠ H820), H62 (= H823), V63 (≠ I824), V241 (= V1053), M268 (≠ L1080), G445 (= G1234), R446 (= R1235), N456 (= N1243), Q457 (≠ S1244), S460 (≠ A1247)
- binding uridine-5'-diphosphate: Y103 (= Y862), F105 (= F864), Q106 (= Q865), F157 (= F973), M158 (≠ A974), N162 (= N978), V182 (= V998), Y316 (= Y1128), R326 (= R1137), Y452 (= Y1241)
5hhfA Crystal structure of aspergillus fumigatus udp-galactopyranose mutase mutant h63a with covalent fad-galactopyranose and bound udp (see paper)
27% identity, 38% coverage: 773:1258/1270 of query aligns to 6:470/505 of 5hhfA
- binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{S})-5-[5-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]-7,8-dimethyl-2,4-bis(oxidanyl)benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: G12 (= G779), G14 (= G781), P15 (= P782), T16 (= T783), D36 (≠ E799), S37 (≠ K800), G43 (= G806), L44 (≠ W807), G59 (≠ A821), G60 (= G822), A61 (≠ H823), V62 (≠ I824), F64 (= F826), R180 (= R997), N205 (= N1021), V240 (= V1053), M267 (≠ L1080), W313 (= W1126), R325 (= R1137), E371 (= E1159), Y417 (= Y1207), G444 (= G1234), R445 (= R1235), G454 (vs. gap), N455 (= N1243), Q456 (≠ S1244), S459 (≠ A1247)
- binding meso-erythritol: Q436 (≠ L1226), N469 (= N1257)
- binding uridine-5'-diphosphate: Y102 (= Y862), F104 (= F864), Q105 (= Q865), F156 (= F973), M157 (≠ A974), Y160 (= Y977), N161 (= N978), W165 (= W982), R180 (= R997), V181 (= V998), Y315 (= Y1128), R325 (= R1137), Y417 (= Y1207), Y451 (= Y1241)
Sites not aligning to the query:
5vwuA Crystal structure of oxidized aspergillus fumigatus udp- galactopyranose mutase complexed with nadh (see paper)
26% identity, 38% coverage: 773:1258/1270 of query aligns to 6:460/494 of 5vwuA
- binding flavin-adenine dinucleotide: G12 (= G779), G14 (= G781), P15 (= P782), T16 (= T783), D36 (≠ E799), S37 (≠ K800), G43 (= G806), L44 (≠ W807), G59 (≠ A821), V232 (= V1053), M259 (≠ L1080), T285 (≠ V1109), R315 (= R1137), E361 (= E1159), R435 (= R1235), G444 (vs. gap), N445 (= N1243), Q446 (≠ S1244), S449 (≠ A1247)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I63 (≠ M825), H66 (≠ N828), R89 (= R849), S91 (≠ A851), Y102 (= Y862), Y407 (= Y1207), R435 (= R1235), Y441 (= Y1241), N445 (= N1243)
5vwtA Crystal structure of oxidized aspergillus fumigatus udp- galactopyranose mutase complexed with NADPH (see paper)
26% identity, 38% coverage: 773:1258/1270 of query aligns to 6:462/495 of 5vwtA
- binding flavin-adenine dinucleotide: G12 (= G779), G14 (= G781), P15 (= P782), T16 (= T783), D36 (≠ E799), S37 (≠ K800), G43 (= G806), L44 (≠ W807), G59 (≠ A821), G60 (= G822), H61 (= H823), V232 (= V1053), M259 (≠ L1080), R317 (= R1137), E363 (= E1159), G436 (= G1234), R437 (= R1235), G446 (vs. gap), N447 (= N1243), Q448 (≠ S1244), S451 (≠ A1247)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: F64 (= F826), H66 (≠ N828), R89 (= R849), Y102 (= Y862), Y409 (= Y1207), R437 (= R1235), Y443 (= Y1241), N447 (= N1243)
4dshA Crystal structure of reduced udp-galactopyranose mutase (see paper)
27% identity, 39% coverage: 776:1270/1270 of query aligns to 7:457/473 of 4dshA
- binding dihydroflavine-adenine dinucleotide: I9 (≠ L778), G10 (= G779), G12 (= G781), P13 (= P782), T14 (= T783), E34 (= E799), C35 (≠ K800), N36 (≠ E801), G41 (= G806), L42 (≠ W807), S43 (≠ C808), L56 (≠ H820), G58 (= G822), H59 (= H823), V60 (≠ I824), Q232 (≠ R1052), A233 (≠ V1053), V260 (≠ L1080), G419 (= G1234), R420 (= R1235), G429 (vs. gap), N430 (= N1243), Q431 (≠ S1244), S434 (≠ A1247)
- binding uridine-5'-diphosphate: Y97 (= Y862), P98 (= P863), F99 (= F864), Q100 (= Q865), F149 (≠ M948), N154 (= N956), R173 (= R997), Y314 (= Y1128), R324 (= R1137), Y392 (= Y1207), Y426 (= Y1241)
4dsgA Crystal structure of oxidized udp-galactopyranose mutase (see paper)
27% identity, 39% coverage: 776:1270/1270 of query aligns to 7:457/473 of 4dsgA
- binding flavin-adenine dinucleotide: G12 (= G781), P13 (= P782), T14 (= T783), E34 (= E799), C35 (≠ K800), G41 (= G806), L42 (≠ W807), S43 (≠ C808), L56 (≠ H820), H59 (= H823), V60 (≠ I824), Q232 (≠ R1052), A233 (≠ V1053), V260 (≠ L1080), G419 (= G1234), R420 (= R1235), G429 (vs. gap), N430 (= N1243), Q431 (≠ S1244), S434 (≠ A1247)
- binding uridine-5'-diphosphate: Y97 (= Y862), P98 (= P863), F99 (= F864), Q100 (= Q865), F149 (≠ M948), N154 (= N956), R173 (= R997), Y314 (= Y1128), R324 (= R1137), Y392 (= Y1207), Y426 (= Y1241)
Query Sequence
>WP_057507603.1 NCBI__GCF_001431535.1:WP_057507603.1
MKWIGGFEGADHVNGSGRALSMAVDSGHLARLDTDYRRLRRMGFSAVRESLGWRTCEQGD
GFNFQSLHARMQAAERAGLEIRWTLMHYGVPADLDLLDGNKTAFVERFAAFCQATATALA
DYASPSPRLINPINEISFLSWAATHTGLIHPHAGDRPAEAGRLKSLLIRAALAGCSAFRR
VDPTARMLWVEPLIHVVAPLASPALRQQAERLHAGQFEVLDALMGRVQPSLGGAPGYVDL
IGVNYYHGNQWEAGSQRPLDWHRADPQRVPFSRLLVKLQQRYGVPLTLSETSHVGCGRGA
WLSDIAQQVRYAADAGARLEGICLYPVVDRPDWESPLHWHQSGLWDVQPNLALKPLSLVR
DYALAYLQARTSLAHHIPLQPGRNGMQQLLVFSHLRWDFVYQRPQHVLSRLGQRWPIVFF
EEPVHDPDREAWLEVLQPCIGVTVLRPHSPLADPGFADAQFPVLDALLHAWLAEHGEPEM
AVWLYTPMALPLLQSLQPVAIIYDCMDQLGAFKDAPERLMDRERTLLDIAGVVFTGGPSL
YDAKHPHNPNVVCFPSSVDVAHFAQARRERDPAARAAAPRLGFFGVLDERLDLPLLDALA
TAHPGWEIDLVGPVVKIDPQSLPRAANLHYLGQRGYDELPALIAGWDVCLLPFALNASTA
YISPTKTLEYMAARKPVVSTAVRDVIRLYADGVQVAVSSEDFIAACDAALGERETTRRNR
IADQDRLTSATSWDQTADAMAECIFDTVKAGLSPRAALYLAGGQVVRIEEAPVACLILGA
GPTGLSAAYHYGAGSVLVEKEQTVGGWCRSLDDQGFRFDHAGHIMFSNDATVLRLYQTLL
GDNLHWQNREAWVYSKGVHTRYPFQGALYGLPPAVLKECLVGAIEARFGPITATGTPAGL
PAANAAARAEPVPKRAAPADCCADGTVMADITEGDPKDAASGVNVASMARSGPPANFEEF
IYQVWGAGVAKHFAVPYNTKLWTVPLHEMETSWLGGRVPLPDLQEMIEGALEPVAAPVGP
NARFGYPLKGGFQALMDGFLPLLEGKLSLGRRVSAVSVRRREVSFADGQRMRWQHLVSTL
PLPEFIALMGDEAPERVRLAAGGLRHVSVRCVNLGVGRADLTDKHWIYYPEDTIFHRIFV
QGNASPHNNPPGGFGLTCEITYSPTKPLPLDGDALIARCIRECVEVGMLRAEDPILTTSI
VDMPYAYVLYDHARAANVDTIRSWLLTHDIELAGRYSEWEYYNSDHAFLAGRRAAGNVQA
SLTKRRAGAT
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory