SitesBLAST
Comparing WP_057507768.1 NCBI__GCF_001431535.1:WP_057507768.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8qmrA Succinic semialdehyde dehydrogenase from e. Coli with bound NAD+ and succinic semialdehyde (see paper)
50% identity, 98% coverage: 6:452/454 of query aligns to 10:456/460 of 8qmrA
- binding nicotinamide-adenine-dinucleotide: I131 (≠ V127), M132 (= M128), P133 (= P129), W134 (= W130), K158 (= K154), N191 (= N187), V194 (≠ A190), G210 (= G206), S211 (= S207), R213 (= R209), A214 (= A210), I218 (= I214), G234 (= G230), C266 (= C262), R310 (= R306), E363 (= E359), F365 (= F361)
- binding 4-oxobutanoic acid: F136 (= F132), W139 (= W135), Q140 (= Q136), R143 (= R139), C266 (= C262), S423 (= S419)
8qmqA Succinic semialdehyde dehydrogenase from e. Coli with bound NAD+ (see paper)
50% identity, 98% coverage: 6:452/454 of query aligns to 10:456/460 of 8qmqA
- binding nicotinamide-adenine-dinucleotide: I131 (≠ V127), M132 (= M128), P133 (= P129), W134 (= W130), N135 (= N131), Q140 (= Q136), R143 (= R139), K158 (= K154), N191 (= N187), V194 (≠ A190), T209 (= T205), G210 (= G206), S211 (= S207), A214 (= A210), E232 (= E228), L233 (= L229), G234 (= G230), C266 (= C262), E363 (= E359), F365 (= F361)
3efvA Crystal structure of a putative succinate-semialdehyde dehydrogenase from salmonella typhimurium lt2 with bound NAD (see paper)
50% identity, 98% coverage: 6:452/454 of query aligns to 9:455/459 of 3efvA
- active site: N134 (= N131), E231 (= E228), C265 (= C262), E439 (= E436)
- binding nicotinamide-adenine-dinucleotide: I130 (≠ V127), M131 (= M128), P132 (= P129), W133 (= W130), N134 (= N131), Q139 (= Q136), R142 (= R139), K157 (= K154), A159 (= A156), N190 (= N187), V193 (≠ A190), T208 (= T205), G209 (= G206), S210 (= S207), A213 (= A210), E231 (= E228), L232 (= L229), G233 (= G230), C265 (= C262), E362 (= E359), F364 (= F361), F428 (= F425)
4itbA Structure of bacterial enzyme in complex with cofactor and substrate (see paper)
48% identity, 99% coverage: 3:453/454 of query aligns to 2:452/453 of 4itbA
- active site: N130 (= N131), K153 (= K154), E227 (= E228), C261 (= C262), E358 (= E359), E435 (= E436)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: V126 (= V127), M127 (= M128), P128 (= P129), W129 (= W130), N130 (= N131), K153 (= K154), A155 (= A156), S156 (= S157), A186 (≠ N187), V189 (≠ A190), G205 (= G206), S206 (= S207), A209 (= A210), S212 (= S213), L228 (= L229), C261 (= C262), E358 (= E359), F360 (= F361)
- binding 4-oxobutanoic acid: E227 (= E228), C261 (= C262), S418 (= S419)
3vz3A Structural insights into substrate and cofactor selection by sp2771 (see paper)
47% identity, 99% coverage: 3:453/454 of query aligns to 2:452/453 of 3vz3A
- active site: N130 (= N131), K153 (= K154), E227 (= E228), A261 (≠ C262), E358 (= E359), E435 (= E436)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: V126 (= V127), M127 (= M128), W129 (= W130), N130 (= N131), Q135 (= Q136), R138 (= R139), K153 (= K154), A155 (= A156), S156 (= S157), A186 (≠ N187), V189 (≠ A190), T204 (= T205), G205 (= G206), S206 (= S207), A209 (= A210), E227 (= E228), L228 (= L229), G229 (= G230), A261 (≠ C262), F360 (= F361)
- binding 4-oxobutanoic acid: F131 (= F132), W134 (= W135), S260 (≠ T261), A261 (≠ C262), I262 (= I263), S418 (= S419)
4ywuA Structural insight into the substrate inhibition mechanism of NADP+- dependent succinic semialdehyde dehydrogenase from streptococcus pyogenes (see paper)
39% identity, 99% coverage: 4:453/454 of query aligns to 3:453/455 of 4ywuA
- active site: N131 (= N131), K154 (= K154), E228 (= E228), C262 (= C262), E359 (= E359), E436 (= E436)
- binding 4-oxobutanoic acid: N131 (= N131), Q136 (= Q136), R139 (= R139), E228 (= E228), V261 (≠ T261), C262 (= C262), F425 (= F425)
4ohtA Crystal structure of succinic semialdehyde dehydrogenase from streptococcus pyogenes in complex with NADP+ as the cofactor (see paper)
39% identity, 99% coverage: 4:453/454 of query aligns to 3:453/455 of 4ohtA
- active site: N131 (= N131), K154 (= K154), E228 (= E228), C262 (= C262), E359 (= E359), E436 (= E436)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: V127 (= V127), E128 (≠ M128), P129 (= P129), W130 (= W130), K154 (= K154), H155 (= H155), A156 (= A156), S157 (= S157), Y187 (≠ N187), S207 (= S207), I214 (= I214)
8of1A Structure of aldh5f1 from moss physcomitrium patens in complex with NAD+ in the contracted conformation
33% identity, 99% coverage: 2:451/454 of query aligns to 44:495/505 of 8of1A
- binding nicotinamide-adenine-dinucleotide: I170 (≠ V127), A171 (≠ M128), P172 (= P129), W173 (= W130), K197 (= K154), A230 (≠ N187), F248 (≠ L204), G250 (= G206), S251 (= S207), V254 (≠ A210), M257 (≠ S213), L273 (= L229), C306 (= C262), K356 (≠ E312), E403 (= E359), F405 (= F361)
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
34% identity, 99% coverage: 3:453/454 of query aligns to 28:480/482 of P25526
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
34% identity, 99% coverage: 3:453/454 of query aligns to 27:479/481 of 3jz4A