Comparing WP_057509319.1 NCBI__GCF_001431535.1:WP_057509319.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6vpbB A novel membrane-bound 6-phosphogluconate dehydrogenase from the acetic acid bacteria gluconacetobacter diazotrophicus (gd6pgd) (see paper)
46% identity, 97% coverage: 1:293/301 of query aligns to 1:324/324 of 6vpbB
2w90B Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase with bound 6- phosphogluconate (see paper)
37% identity, 91% coverage: 3:275/301 of query aligns to 8:292/471 of 2w90B
Sites not aligning to the query:
7cb2A The 6-phosphogluconate dehydrogenase (NADP-bound) from staphylococcus aureus
37% identity, 91% coverage: 3:275/301 of query aligns to 5:289/466 of 7cb2A
7cb5B The 6-phosphogluconate dehydrogenase from staphylococcus aureus (6- phosphogluconate bound) (see paper)
37% identity, 91% coverage: 3:275/301 of query aligns to 5:289/467 of 7cb5B
Sites not aligning to the query:
P96789 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
33% identity, 96% coverage: 2:290/301 of query aligns to 5:303/472 of P96789
Sites not aligning to the query:
2iyoA Structural characterization of a bacterial 6pdh reveals aspects of specificity, mechanism and mode of inhibition (see paper)
33% identity, 96% coverage: 2:290/301 of query aligns to 5:303/470 of 2iyoA
Sites not aligning to the query:
2iypB Product rup (see paper)
33% identity, 96% coverage: 2:290/301 of query aligns to 6:304/470 of 2iypB
Sites not aligning to the query:
2iypA Product rup (see paper)
33% identity, 96% coverage: 2:290/301 of query aligns to 5:303/469 of 2iypA
2iz1B 6pdh complexed with pex inhibitor synchrotron data (see paper)
33% identity, 96% coverage: 2:290/301 of query aligns to 7:305/471 of 2iz1B
Sites not aligning to the query:
6fqzA Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate (see paper)
32% identity, 95% coverage: 2:286/301 of query aligns to 3:309/468 of 6fqzA
Sites not aligning to the query:
6fqyA Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate (see paper)
32% identity, 95% coverage: 2:286/301 of query aligns to 3:309/468 of 6fqyA
P00350 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Escherichia coli (strain K12) (see paper)
33% identity, 96% coverage: 3:290/301 of query aligns to 6:301/468 of P00350
3fwnB Dimeric 6-phosphogluconate dehydrogenase complexed with 6- phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate (see paper)
33% identity, 96% coverage: 3:290/301 of query aligns to 5:300/467 of 3fwnB
Sites not aligning to the query:
3fwnA Dimeric 6-phosphogluconate dehydrogenase complexed with 6- phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate (see paper)
33% identity, 96% coverage: 3:290/301 of query aligns to 5:300/467 of 3fwnA
Sites not aligning to the query:
2zydA Dimeric 6-phosphogluconate dehydrogenase complexed with glucose (see paper)
33% identity, 96% coverage: 3:290/301 of query aligns to 4:299/464 of 2zydA
Sites not aligning to the query:
8i4qA Crystal structure of 6-phosphogluconate dehydrogenase from corynebacterium glutamicum (see paper)
34% identity, 91% coverage: 3:275/301 of query aligns to 5:290/479 of 8i4qA
5uq9E Crystal structure of 6-phosphogluconate dehydrogenase with ((4r,5r)-5- (hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate (see paper)
36% identity, 98% coverage: 2:295/301 of query aligns to 4:313/468 of 5uq9E
2jkvA Structure of human phosphogluconate dehydrogenase in complex with NADPH at 2.53a
36% identity, 98% coverage: 2:295/301 of query aligns to 4:313/482 of 2jkvA
Sites not aligning to the query:
P52209 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Homo sapiens (Human)
36% identity, 98% coverage: 2:295/301 of query aligns to 5:314/483 of P52209
Sites not aligning to the query:
P78812 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
38% identity, 91% coverage: 2:275/301 of query aligns to 8:294/492 of P78812
>WP_057509319.1 NCBI__GCF_001431535.1:WP_057509319.1
MDIAMIGLGRMGANMAQRLQRGGHRVVGHDPMEAARARAAESGLEVFATLAEAVAALPVP
RVVWLMVPAGDTVDQTLAQLVPHLAEGDVVIDGGNSNYQDSVRRARSLADDDIFYLDCGT
SGGVWGLQEGYSLMIGGDAAAVEQLATVFQALAPAADRGWARVGPSGAGHYTKMIHNGIE
YGMMQAYAEGFALMERKEEMELDLGQVAEVWRHGSVVRSWLLDLSAQALQRNPALDGIAP
YVEDSGEGRWTVAEAIALDVPAPVITLALLERLRSRQSNSFSDRLLAAMRNEFGGHAIKK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory