SitesBLAST
Comparing WP_058860023.1 NCBI__GCF_001482365.1:WP_058860023.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6aa8E Crystal structure of (s)-3-hydroxybutyryl-coenzymea dehydrogenase from clostridium acetobutylicum complexed with NAD+ (see paper)
41% identity, 96% coverage: 11:292/293 of query aligns to 1:280/281 of 6aa8E
- active site: S116 (= S127), H137 (= H148), E149 (= E160), N187 (= N199)
- binding nicotinamide-adenine-dinucleotide: I6 (≠ V16), G9 (= G19), T10 (≠ A20), M11 (= M21), R29 (≠ S39), D30 (= D40), I31 (≠ L41), A86 (= A97), A87 (= A98), E89 (= E100), K94 (= K105), N114 (= N125), S116 (= S127)
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Homo sapiens (Human) (see 7 papers)
40% identity, 96% coverage: 10:291/293 of query aligns to 27:313/314 of Q16836
- GGGLMG 34:39 (≠ GSGAMG 17:22) binding NAD(+)
- A40 (≠ T23) to T: in HADH deficiency; dbSNP:rs137853101
- D57 (= D40) binding NAD(+); to E: in HADH deficiency; dbSNP:rs137853102; to G: found in a patient with Reye-like syndrome; does not affect 3-hydroxyacyl-CoA dehydrogenase activity; increases KM value for NADH; does not affect dimerization
- S73 (≠ R56) binding CoA
- K80 (= K63) binding CoA
- L86 (vs. gap) to P: in dbSNP:rs4956145
- E122 (= E100) binding NAD(+)
- K127 (= K105) binding NAD(+); modified: N6-(2-hydroxyisobutyryl)lysine
- S149 (= S127) binding CoA; binding NAD(+)
- Q152 (≠ P130) to H: in dbSNP:rs1051519
- N173 (= N151) binding NAD(+)
- Y226 (≠ L205) to H: found in a patient with Reye-like syndrome; loss of 3-hydroxyacyl-CoA dehydrogenase activity. Does not affect dimerization; dbSNP:rs146036912
- P258 (= P237) to L: in HHF4; loss of 3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137853103
- K305 (= K283) binding NAD(+)
1f0yA L-3-hydroxyacyl-coa dehydrogenase complexed with acetoacetyl-coa and NAD+ (see paper)
40% identity, 96% coverage: 10:291/293 of query aligns to 4:290/291 of 1f0yA
- active site: S126 (= S127), H147 (= H148), E159 (= E160), N197 (= N199)
- binding acetoacetyl-coenzyme a: S50 (≠ R56), K57 (= K63), S126 (= S127), H147 (= H148), F149 (= F150), N150 (= N151), P151 (= P152), P153 (≠ L154), V154 (= V155), N197 (= N199), P232 (= P234), M233 (= M235), L238 (= L240)
- binding nicotinamide-adenine-dinucleotide: G13 (= G19), L14 (≠ A20), M15 (= M21), D34 (= D40), Q35 (≠ L41), A96 (= A97), I97 (≠ A98), E99 (= E100), K104 (= K105), N124 (= N125), S126 (= S127), H147 (= H148), N150 (= N151), V242 (= V244), T246 (≠ V248), K282 (= K283)
1f17A L-3-hydroxyacyl-coa dehydrogenase complexed with nadh (see paper)
40% identity, 96% coverage: 10:291/293 of query aligns to 4:290/293 of 1f17A
- active site: S126 (= S127), H147 (= H148), E159 (= E160), N197 (= N199)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G13 (= G19), L14 (≠ A20), M15 (= M21), D34 (= D40), Q35 (≠ L41), A96 (= A97), I97 (≠ A98), E99 (= E100), K104 (= K105), N124 (= N125), S126 (= S127), H147 (= H148)
1f12A L-3-hydroxyacyl-coa dehydrogenase complexed with 3-hydroxybutyryl-coa (see paper)
40% identity, 96% coverage: 10:291/293 of query aligns to 4:290/293 of 1f12A
- active site: S126 (= S127), H147 (= H148), E159 (= E160), N197 (= N199)
- binding 3-hydroxybutanoyl-coenzyme a: K57 (= K63), S126 (= S127), H147 (= H148), F149 (= F150), N150 (= N151), M155 (= M156), N197 (= N199), L200 (= L202), P232 (= P234), M233 (= M235), L238 (= L240)
P00348 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; L-3-hydroxyacyl CoA dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Sus scrofa (Pig) (see paper)
40% identity, 96% coverage: 10:291/293 of query aligns to 27:313/314 of P00348
- GGGLMG 34:39 (≠ GSGAMG 17:22) binding NAD(+)
- D57 (= D40) binding NAD(+)
- E122 (= E100) binding NAD(+)
- K127 (= K105) binding NAD(+)
- S149 (= S127) binding NAD(+)
4kugA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with NAD from clostridium butyricum
38% identity, 97% coverage: 10:292/293 of query aligns to 1:281/282 of 4kugA
- active site: S117 (= S127), H138 (= H148), E150 (= E160), N188 (= N199)
- binding nicotinamide-adenine-dinucleotide: G10 (= G19), T11 (≠ A20), M12 (= M21), R30 (≠ S39), D31 (= D40), A87 (= A97), A88 (= A98), E90 (= E100), N115 (= N125), S117 (= S127), H138 (= H148)
4kuhA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with acetoacetyl-coa from clostridium butyricum
38% identity, 96% coverage: 10:291/293 of query aligns to 1:280/280 of 4kuhA
4pzeA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with acetoacetyl-coa (see paper)
36% identity, 97% coverage: 9:292/293 of query aligns to 1:282/283 of 4pzeA
4pzdA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with NAD+ (see paper)
36% identity, 97% coverage: 9:292/293 of query aligns to 1:282/283 of 4pzdA
- active site: S118 (= S127), H139 (= H148), E151 (= E160), N189 (= N199)
- binding nicotinamide-adenine-dinucleotide: G11 (= G19), T12 (≠ A20), M13 (= M21), D32 (= D40), A88 (= A97), A89 (= A98), T90 (≠ V99), E91 (= E100), I99 (≠ L108), N116 (= N125), S118 (= S127), N142 (= N151)
P9WNP7 3-hydroxybutyryl-CoA dehydrogenase; Beta-hydroxybutyryl-CoA dehydrogenase; BHBD; EC 1.1.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
39% identity, 97% coverage: 8:291/293 of query aligns to 3:286/286 of P9WNP7
- S122 (= S127) mutation to A: Loss of fatty acyl dehydrogenase activity.
4dydA Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase (see paper)
36% identity, 96% coverage: 10:291/293 of query aligns to 4:283/283 of 4dydA
- active site: S122 (= S127), H143 (= H148), E155 (= E160), N194 (= N199)
- binding nicotinamide-adenine-dinucleotide: G11 (= G17), T12 (≠ S18), G13 (= G19), V14 (≠ A20), L15 (≠ M21), D34 (= D40), I35 (≠ L41), V93 (≠ A98), P94 (≠ V99), E95 (= E100), L99 (≠ I104), K100 (= K105), N120 (= N125), S122 (= S127), H143 (= H148)
6iunB Crystal structure of enoyl-coa hydratase (ech) from ralstonia eutropha h16 in complex with NAD
34% identity, 96% coverage: 10:291/293 of query aligns to 291:566/692 of 6iunB
- active site: S407 (= S127), H428 (= H148), E440 (= E160), N478 (= N199)
- binding nicotinamide-adenine-dinucleotide: G300 (= G19), T301 (≠ A20), M302 (= M21), E321 (≠ D40), T322 (≠ L41), Y365 (≠ L85), A377 (= A97), V378 (≠ A98), E380 (= E100), V384 (≠ I104), V388 (≠ L108), N405 (= N125), S407 (= S127)
Sites not aligning to the query:
9jheA 3-hydroxybutyryl-coa dehydrogenase with NAD (see paper)
33% identity, 95% coverage: 15:291/293 of query aligns to 5:278/289 of 9jheA
- binding nicotinamide-adenine-dinucleotide: I6 (≠ V16), G7 (= G17), G9 (= G19), T10 (≠ A20), M11 (= M21), D31 (= D40), I32 (≠ L41), K74 (≠ E86), A87 (= A97), A88 (= A98), F89 (≠ V99), E90 (= E100), N115 (= N125), S117 (= S127), H136 (= H148)
9jhyB 3-hydroxybutyryl-coa dehydrogenase mutant (s117a) with acetoacetyl coa (see paper)
33% identity, 95% coverage: 15:291/293 of query aligns to 5:274/285 of 9jhyB
- binding acetoacetyl-coenzyme a: L51 (= L60), K54 (= K63), K56 (≠ A65), I57 (≠ R66), H132 (= H148), F134 (= F150), N135 (= N151), R139 (≠ V155), N182 (= N199), L185 (= L202), M218 (= M235), I227 (≠ V244)
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80 (see paper)
31% identity, 97% coverage: 10:292/293 of query aligns to 334:617/728 of 8oqrA