SitesBLAST
Comparing WP_058930994.1 NCBI__GCF_001484605.1:WP_058930994.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7egvA Acetolactate synthase from trichoderma harzianum with inhibitor harzianic acid (see paper)
30% identity, 92% coverage: 44:581/584 of query aligns to 7:552/590 of 7egvA
- active site: Y28 (≠ V65), G30 (= G67), G31 (≠ E68), A32 (≠ S69), I33 (≠ F70), E54 (= E90), T77 (= T113), F116 (= F152), Q117 (= Q153), K166 (≠ E202), E220 (≠ D257), M256 (≠ Y293), V283 (≠ I320), V400 (≠ A426), L425 (vs. gap), G426 (= G451), M428 (= M453), Q483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514), L511 (≠ M536), G516 (= G544), I517 (= I545)
- binding flavin-adenine dinucleotide: R156 (= R192), G209 (= G247), Q210 (vs. gap), G211 (= G248), T236 (≠ E273), L237 (≠ W274), H238 (≠ R275), G276 (= G313), S277 (≠ T314), R278 (≠ V315), D280 (≠ G317), R282 (≠ V319), V283 (≠ I320), E309 (≠ Q353), I310 (= I354), D328 (= D364), V329 (= V366), M405 (≠ N431), G423 (≠ R449), G424 (≠ N450)
- binding (2S)-3-methyl-2-[[(2S,4R)-1-methyl-4-[(2E,4E)-octa-2,4-dienoyl]-3,5-bis(oxidanylidene)pyrrolidin-2-yl]methyl]-2-oxidanyl-butanoic acid: F493 (≠ H518), Y494 (= Y519)
- binding magnesium ion: D453 (= D478), N480 (= N505), E482 (= E507)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: P29 (= P66), E54 (= E90), Q117 (= Q153), V400 (≠ A426), G401 (= G427), Q402 (≠ E428), H403 (= H429), G426 (= G451), M428 (= M453), D453 (= D478), A454 (≠ G479), S455 (≠ E480), E482 (= E507), Q483 (≠ Y508), G484 (= G509), M485 (≠ T510), V486 (≠ I511)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
28% identity, 89% coverage: 38:557/584 of query aligns to 1:524/582 of 1t9dB
- active site: Y28 (≠ V65), G30 (= G67), G31 (≠ E68), A32 (≠ S69), I33 (≠ F70), E54 (= E90), T77 (= T113), F116 (= F152), Q117 (= Q153), E118 (= E154), K166 (≠ E202), R213 (≠ Q258), M249 (≠ Y293), V276 (≠ I320), V392 (≠ A426), L417 (vs. gap), G418 (= G451), M420 (= M453), D445 (= D478), N472 (= N505), E474 (= E507), Q475 (≠ Y508), M477 (≠ T510), V478 (≠ I511), W481 (≠ H514), L503 (≠ M536), G508 (= G541), L509 (≠ G542)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (≠ E68), A32 (≠ S69), V106 (≠ I142), P107 (= P143), F116 (= F152), K166 (≠ E202), M249 (≠ Y293), D274 (= D318), R275 (≠ V319), W481 (≠ H514)
- binding flavin-adenine dinucleotide: R156 (= R192), G202 (= G247), A203 (≠ G248), G204 (≠ N249), N207 (≠ T252), T229 (≠ E273), L230 (≠ W274), Q231 (≠ R275), L247 (≠ I291), M249 (≠ Y293), H250 (≠ G294), G269 (= G313), A270 (≠ T314), R271 (≠ V315), D273 (≠ G317), R275 (≠ V319), V276 (≠ I320), E302 (≠ D340), V303 (≠ P341), N307 (≠ G345), G320 (≠ P358), D321 (≠ E359), A322 (= A360), Q396 (≠ T430), M397 (≠ N431), G415 (≠ R449), G416 (≠ N450)
- binding magnesium ion: D445 (= D478), N472 (= N505), E474 (= E507)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E90), P80 (= P116), G418 (= G451), M420 (= M453), M450 (= M483)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
28% identity, 89% coverage: 38:557/584 of query aligns to 2:525/583 of 1t9bA
- active site: Y29 (≠ V65), G31 (= G67), G32 (≠ E68), A33 (≠ S69), I34 (≠ F70), E55 (= E90), T78 (= T113), F117 (= F152), Q118 (= Q153), E119 (= E154), K167 (≠ E202), R214 (≠ Q258), M250 (≠ Y293), V277 (≠ I320), V393 (≠ A426), L418 (vs. gap), G419 (= G451), M421 (= M453), D446 (= D478), N473 (= N505), E475 (= E507), Q476 (≠ Y508), M478 (≠ T510), V479 (≠ I511), W482 (≠ H514), L504 (≠ M536), G509 (= G541), L510 (≠ G542)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ I142), P108 (= P143), F117 (= F152), D275 (= D318), R276 (≠ V319), M478 (≠ T510), W482 (≠ H514)
- binding flavin-adenine dinucleotide: R157 (= R192), G203 (= G247), A204 (≠ G248), G205 (≠ N249), N208 (≠ T252), T230 (≠ E273), L231 (≠ W274), Q232 (≠ R275), M247 (≠ P290), L248 (≠ I291), M250 (≠ Y293), H251 (≠ G294), G270 (= G313), A271 (≠ T314), R272 (≠ V315), D274 (≠ G317), R276 (≠ V319), V277 (≠ I320), E303 (≠ D340), V304 (≠ P341), N308 (≠ G345), D322 (≠ E359), A323 (= A360), Q397 (≠ T430), M398 (≠ N431), G416 (≠ R449), G417 (≠ N450)
- binding magnesium ion: D446 (= D478), N473 (= N505), E475 (= E507)
Sites not aligning to the query:
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
28% identity, 90% coverage: 35:557/584 of query aligns to 1:541/599 of 1n0hA
- active site: Y31 (≠ V65), G33 (= G67), G34 (≠ E68), A35 (≠ S69), I36 (≠ F70), E57 (= E90), T80 (= T113), F119 (= F152), Q120 (= Q153), E121 (= E154), K169 (≠ E202), R230 (≠ Q258), M266 (≠ Y293), V293 (≠ I320), V409 (≠ A426), L434 (vs. gap), G435 (= G451), M437 (= M453), D462 (= D478), N489 (= N505), E491 (= E507), Q492 (≠ Y508), M494 (≠ T510), V495 (≠ I511), W498 (≠ H514), L520 (≠ M536), G525 (= G541), L526 (≠ G542)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ A426), G410 (= G427), Q411 (≠ E428), H412 (= H429), G435 (= G451), M437 (= M453), G461 (= G477), D462 (= D478), A463 (≠ G479), S464 (≠ E480), M467 (= M483), N489 (= N505), E491 (= E507), Q492 (≠ Y508), G493 (= G509), V495 (≠ I511)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ E68), A35 (≠ S69), V109 (≠ I142), P110 (= P143), F119 (= F152), K169 (≠ E202), M266 (≠ Y293), D291 (= D318), R292 (≠ V319), V495 (≠ I511), W498 (≠ H514)
- binding flavin-adenine dinucleotide: R159 (= R192), G219 (= G247), A220 (≠ G248), G221 (≠ N249), N224 (≠ T252), T246 (≠ E273), L247 (≠ W274), Q248 (≠ R275), L264 (≠ I291), G265 (= G292), M266 (≠ Y293), H267 (≠ G294), G286 (= G313), A287 (≠ T314), R288 (≠ V315), D290 (≠ G317), R292 (≠ V319), V293 (≠ I320), E319 (≠ D340), V320 (≠ P341), N324 (≠ G345), G337 (≠ P358), D338 (≠ E359), A339 (= A360), M414 (≠ N431), G432 (≠ R449), G433 (≠ N450)
- binding magnesium ion: D462 (= D478), N489 (= N505), E491 (= E507)
- binding thiamine diphosphate: Y31 (≠ V65), E57 (= E90), P83 (= P116)
Sites not aligning to the query:
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
28% identity, 89% coverage: 38:557/584 of query aligns to 2:533/591 of 5wkcA
- active site: Y29 (≠ V65), G31 (= G67), G32 (≠ E68), A33 (≠ S69), I34 (≠ F70), E55 (= E90), T78 (= T113), F117 (= F152), Q118 (= Q153), E119 (= E154), K167 (≠ E202), R222 (≠ Q258), M258 (≠ Y293), V285 (≠ I320), V401 (≠ A426), L426 (vs. gap), G427 (= G451), M429 (= M453), D454 (= D478), N481 (= N505), E483 (= E507), Q484 (≠ Y508), M486 (≠ T510), V487 (≠ I511), W490 (≠ H514), L512 (≠ M536), G517 (= G541), L518 (≠ G542)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ A426), G402 (= G427), Q403 (≠ E428), H404 (= H429), G427 (= G451), M429 (= M453), G453 (= G477), D454 (= D478), A455 (≠ G479), S456 (≠ E480), M459 (= M483), N481 (= N505), E483 (= E507), Q484 (≠ Y508), G485 (= G509), M486 (≠ T510), V487 (≠ I511)
- binding ethaneperoxoic acid: G32 (≠ E68), Q118 (= Q153)
- binding flavin-adenine dinucleotide: R157 (= R192), G211 (= G247), A212 (≠ G248), G213 (≠ N249), N216 (≠ T252), T238 (≠ E273), L239 (≠ W274), Q240 (≠ R275), L256 (≠ I291), M258 (≠ Y293), G278 (= G313), A279 (≠ T314), R280 (≠ V315), R284 (≠ V319), V285 (≠ I320), E311 (≠ D340), V312 (≠ P341), N316 (≠ G345), D330 (≠ E359), A331 (= A360), M406 (≠ N431), G424 (≠ R449)
- binding magnesium ion: D454 (= D478), N481 (= N505), E483 (= E507)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ E68), A33 (≠ S69), V107 (≠ I142), F117 (= F152), K167 (≠ E202), M258 (≠ Y293), R284 (≠ V319), M486 (≠ T510), W490 (≠ H514)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P66), E55 (= E90)
Sites not aligning to the query:
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
26% identity, 90% coverage: 35:557/584 of query aligns to 3:549/607 of 6u9dB
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), I38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M274 (≠ Y293), V301 (≠ I320), V417 (≠ A426), G443 (= G451), M445 (= M453), D470 (= D478), N497 (= N505), E499 (= E507), Q500 (≠ Y508), M502 (≠ T510), V503 (≠ I511), W506 (≠ H514)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ E68), V111 (≠ I142), P112 (= P143), F121 (= F152), K171 (≠ E202), D299 (= D318), R300 (≠ V319), M502 (≠ T510), W506 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), A228 (≠ G248), G229 (≠ N249), N232 (≠ T252), T254 (≠ E273), L255 (≠ W274), Q256 (≠ R275), L272 (≠ I291), M274 (≠ Y293), G294 (= G313), R296 (≠ V315), D298 (≠ G317), R300 (≠ V319), V301 (≠ I320), E327 (≠ D340), V328 (≠ P341), N332 (≠ G345), D346 (≠ E359), A347 (= A360), M422 (≠ N431), G440 (≠ R449), G441 (≠ N450)
- binding magnesium ion: D470 (= D478), N497 (= N505)
- binding thiamine diphosphate: E59 (= E90), P85 (= P116), V417 (≠ A426), G418 (= G427), Q419 (≠ E428), H420 (= H429), G443 (= G451), M445 (= M453), A471 (≠ G479), S472 (≠ E480), N497 (= N505), E499 (= E507), Q500 (≠ Y508), G501 (= G509), M502 (≠ T510), V503 (≠ I511)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
28% identity, 89% coverage: 38:557/584 of query aligns to 2:537/595 of 1t9bB
- active site: Y29 (≠ V65), G31 (= G67), G32 (≠ E68), A33 (≠ S69), I34 (≠ F70), E55 (= E90), T78 (= T113), F117 (= F152), Q118 (= Q153), E119 (= E154), K167 (≠ E202), R226 (≠ Q258), M262 (≠ Y293), V289 (≠ I320), V405 (≠ A426), L430 (vs. gap), G431 (= G451), M433 (= M453), D458 (= D478), N485 (= N505), E487 (= E507), Q488 (≠ Y508), M490 (≠ T510), V491 (≠ I511), W494 (≠ H514), L516 (≠ M536), G521 (= G541), L522 (≠ G542)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ I142), P108 (= P143), D287 (= D318), R288 (≠ V319), M490 (≠ T510), W494 (≠ H514)
- binding flavin-adenine dinucleotide: R157 (= R192), G215 (= G247), A216 (≠ G248), G217 (≠ N249), N220 (≠ T252), T242 (≠ E273), L243 (≠ W274), Q244 (≠ R275), M259 (≠ P290), L260 (≠ I291), M262 (≠ Y293), H263 (≠ G294), G282 (= G313), A283 (≠ T314), R284 (≠ V315), D286 (≠ G317), R288 (≠ V319), V289 (≠ I320), E315 (≠ D340), V316 (≠ P341), N320 (≠ G345), G333 (≠ P358), D334 (≠ E359), A335 (= A360), Q409 (≠ T430), M410 (≠ N431), G428 (≠ R449), G429 (≠ N450)
- binding magnesium ion: D458 (= D478), N485 (= N505), E487 (= E507)
Sites not aligning to the query:
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
26% identity, 90% coverage: 35:557/584 of query aligns to 83:629/687 of P07342
- R241 (= R192) binding
- 355:376 (vs. 294:315, 18% identical) binding
- 407:426 (vs. 340:359, 20% identical) binding
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
28% identity, 89% coverage: 38:557/584 of query aligns to 3:539/597 of 1t9aA
- active site: Y30 (≠ V65), G32 (= G67), G33 (≠ E68), A34 (≠ S69), I35 (≠ F70), E56 (= E90), T79 (= T113), F118 (= F152), Q119 (= Q153), E120 (= E154), K168 (≠ E202), R228 (≠ Q258), M264 (≠ Y293), V291 (≠ I320), V407 (≠ A426), L432 (vs. gap), G433 (= G451), M435 (= M453), D460 (= D478), N487 (= N505), E489 (= E507), Q490 (≠ Y508), M492 (≠ T510), V493 (≠ I511), W496 (≠ H514), L518 (≠ M536), G523 (= G541), L524 (≠ G542)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ E68), V108 (≠ I142), P109 (= P143), F118 (= F152), K168 (≠ E202), M264 (≠ Y293), D289 (= D318), R290 (≠ V319), M492 (≠ T510), V493 (≠ I511), W496 (≠ H514)
- binding flavin-adenine dinucleotide: R158 (= R192), G217 (= G247), A218 (≠ G248), G219 (≠ N249), N222 (≠ T252), T244 (≠ E273), L245 (≠ W274), Q246 (≠ R275), L262 (≠ I291), M264 (≠ Y293), H265 (≠ G294), G284 (= G313), A285 (≠ T314), R286 (≠ V315), D288 (≠ G317), R290 (≠ V319), V291 (≠ I320), E317 (≠ D340), V318 (≠ P341), N322 (≠ G345), G335 (≠ P358), D336 (≠ E359), A337 (= A360), Q411 (≠ T430), M412 (≠ N431), G430 (≠ R449), G431 (≠ N450)
- binding magnesium ion: D460 (= D478), N487 (= N505), E489 (= E507)
- binding propyl trihydrogen diphosphate: V407 (≠ A426), G408 (= G427), Q409 (≠ E428), H410 (= H429), M435 (= M453), G459 (= G477), D460 (= D478), A461 (≠ G479), S462 (≠ E480), N487 (= N505), E489 (= E507), Q490 (≠ Y508), G491 (= G509), M492 (≠ T510)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G451), M435 (= M453), M465 (= M483)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
28% identity, 89% coverage: 38:557/584 of query aligns to 2:538/596 of 1t9dA
- active site: Y29 (≠ V65), G31 (= G67), G32 (≠ E68), A33 (≠ S69), I34 (≠ F70), E55 (= E90), T78 (= T113), F117 (= F152), Q118 (= Q153), E119 (= E154), K167 (≠ E202), R227 (≠ Q258), M263 (≠ Y293), V290 (≠ I320), V406 (≠ A426), L431 (vs. gap), G432 (= G451), M434 (= M453), D459 (= D478), N486 (= N505), E488 (= E507), Q489 (≠ Y508), M491 (≠ T510), V492 (≠ I511), W495 (≠ H514), L517 (≠ M536), G522 (= G541), L523 (≠ G542)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ E68), A33 (≠ S69), V107 (≠ I142), P108 (= P143), F117 (= F152), K167 (≠ E202), M263 (≠ Y293), D288 (= D318), R289 (≠ V319), W495 (≠ H514)
- binding flavin-adenine dinucleotide: R157 (= R192), G216 (= G247), A217 (≠ G248), G218 (≠ N249), N221 (≠ T252), T243 (≠ E273), L244 (≠ W274), Q245 (≠ R275), M260 (≠ P290), L261 (≠ I291), H264 (≠ G294), G283 (= G313), A284 (≠ T314), R285 (≠ V315), D287 (≠ G317), R289 (≠ V319), V290 (≠ I320), E316 (≠ D340), V317 (≠ P341), N321 (≠ G345), G334 (≠ P358), D335 (≠ E359), A336 (= A360), Q410 (≠ T430), M411 (≠ N431), G429 (≠ R449), G430 (≠ N450)
- binding magnesium ion: D459 (= D478), N486 (= N505), E488 (= E507)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E90), P81 (= P116), Q118 (= Q153), G432 (= G451), M434 (= M453), M464 (= M483)
Sites not aligning to the query:
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
28% identity, 89% coverage: 38:557/584 of query aligns to 2:538/596 of 1t9cA
- active site: Y29 (≠ V65), G31 (= G67), G32 (≠ E68), A33 (≠ S69), I34 (≠ F70), E55 (= E90), T78 (= T113), F117 (= F152), Q118 (= Q153), E119 (= E154), K167 (≠ E202), R227 (≠ Q258), M263 (≠ Y293), V290 (≠ I320), V406 (≠ A426), L431 (vs. gap), G432 (= G451), M434 (= M453), D459 (= D478), N486 (= N505), E488 (= E507), Q489 (≠ Y508), M491 (≠ T510), V492 (≠ I511), W495 (≠ H514), L517 (≠ M536), G522 (= G541), L523 (≠ G542)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ E68), V107 (≠ I142), P108 (= P143), F117 (= F152), K167 (≠ E202), D288 (= D318), R289 (≠ V319), W495 (≠ H514)
- binding flavin-adenine dinucleotide: R157 (= R192), G216 (= G247), A217 (≠ G248), G218 (≠ N249), N221 (≠ T252), T243 (≠ E273), L244 (≠ W274), Q245 (≠ R275), L261 (≠ I291), M263 (≠ Y293), H264 (≠ G294), G283 (= G313), A284 (≠ T314), R285 (≠ V315), D287 (≠ G317), R289 (≠ V319), V290 (≠ I320), E316 (≠ D340), V317 (≠ P341), N321 (≠ G345), G334 (≠ P358), D335 (≠ E359), A336 (= A360), M411 (≠ N431), G429 (≠ R449), G430 (≠ N450)
- binding magnesium ion: D459 (= D478), N486 (= N505), E488 (= E507)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A426), G401 (= G427), Q402 (≠ E428), H403 (= H429), G426 (= G451), M428 (= M453), G452 (= G477), D453 (= D478), G454 (= G479), S455 (≠ E480), M458 (= M483), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), G484 (= G509), M485 (≠ T510), V486 (≠ I511)
- binding flavin-adenine dinucleotide: R161 (= R192), G222 (= G247), G223 (= G248), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), L264 (≠ I291), M266 (vs. gap), H267 (≠ Y293), G286 (= G313), V287 (≠ T314), R288 (≠ V315), D290 (≠ G317), R292 (≠ V319), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), D329 (≠ K357), V330 (≠ P358), M405 (≠ N431), G423 (≠ R449)
- binding magnesium ion: F370 (≠ A397), D453 (= D478), M458 (= M483), Q461 (= Q486), N480 (= N505), H482 (≠ E507), K533 (≠ D550)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (vs. gap), R292 (≠ V319), M485 (≠ T510), W489 (≠ H514)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 5wj1A
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), S38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M266 (vs. gap), V293 (≠ I320), V400 (≠ A426), G426 (= G451), M428 (= M453), D453 (= D478), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), G222 (= G247), G223 (= G248), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), M263 (≠ P290), L264 (≠ I291), G286 (= G313), R288 (≠ V315), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), D329 (≠ K357), V330 (≠ P358), M405 (≠ N431), G423 (≠ R449), G424 (≠ N450)
- binding magnesium ion: D453 (= D478), N480 (= N505), H482 (≠ E507)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (vs. gap), D291 (= D318), R292 (≠ V319), M485 (≠ T510), W489 (≠ H514)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A426), G401 (= G427), Q402 (≠ E428), H403 (= H429), M428 (= M453), D453 (= D478), G454 (= G479), S455 (≠ E480), M458 (= M483), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), G484 (= G509), M485 (≠ T510), V486 (≠ I511)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 5k6tA
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), S38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M266 (vs. gap), V293 (≠ I320), V400 (≠ A426), G426 (= G451), M428 (= M453), D453 (= D478), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ Y293), R292 (≠ V319), M485 (≠ T510), W489 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), G222 (= G247), G223 (= G248), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), L264 (≠ I291), G286 (= G313), R288 (≠ V315), D290 (≠ G317), R292 (≠ V319), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), D329 (≠ K357), V330 (≠ P358), Q404 (≠ T430), M405 (≠ N431), G423 (≠ R449)
- binding magnesium ion: D453 (= D478), N480 (= N505), H482 (≠ E507)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A426), G401 (= G427), Q402 (≠ E428), H403 (= H429), G426 (= G451), M428 (= M453), G452 (= G477), G454 (= G479), S455 (≠ E480), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), G484 (= G509)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 5k6rA
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), S38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M266 (vs. gap), V293 (≠ I320), V400 (≠ A426), G426 (= G451), M428 (= M453), D453 (= D478), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (≠ V319), W489 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), G222 (= G247), G223 (= G248), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), L264 (≠ I291), M266 (vs. gap), G286 (= G313), R288 (≠ V315), R292 (≠ V319), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), G328 (≠ A356), D329 (≠ K357), V330 (≠ P358), M405 (≠ N431), G423 (≠ R449)
- binding magnesium ion: D453 (= D478), N480 (= N505), H482 (≠ E507)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A426), G401 (= G427), Q402 (≠ E428), H403 (= H429), G426 (= G451), M428 (= M453), D453 (= D478), G454 (= G479), S455 (≠ E480), M458 (= M483), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), G484 (= G509), M485 (≠ T510), V486 (≠ I511)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 1z8nA
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), S38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M266 (vs. gap), V293 (≠ I320), V400 (≠ A426), G426 (= G451), M428 (= M453), D453 (= D478), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K166), R161 (= R192), Y191 (≠ G223), R194 (vs. gap), D291 (= D318), R292 (≠ V319), D312 (= D340), W489 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), G222 (= G247), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), L264 (≠ I291), G265 (= G292), M266 (vs. gap), H267 (≠ Y293), G286 (= G313), V287 (≠ T314), R288 (≠ V315), D290 (≠ G317), R292 (≠ V319), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), D329 (≠ K357), V330 (≠ P358), M405 (≠ N431), G423 (≠ R449), G424 (≠ N450)
- binding magnesium ion: D453 (= D478), N480 (= N505)
- binding thiamine diphosphate: V400 (≠ A426), G401 (= G427), Q402 (≠ E428), H403 (= H429), G426 (= G451), M428 (= M453), G452 (= G477), G454 (= G479), S455 (≠ E480), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), G484 (= G509), M485 (≠ T510), V486 (≠ I511)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 1yi1A
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), S38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M266 (vs. gap), V293 (≠ I320), V400 (≠ A426), G426 (= G451), M428 (= M453), D453 (= D478), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D318), R292 (≠ V319), W489 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), G223 (= G248), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), M263 (≠ P290), L264 (≠ I291), G265 (= G292), M266 (vs. gap), H267 (≠ Y293), G286 (= G313), V287 (≠ T314), R288 (≠ V315), D290 (≠ G317), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), D329 (≠ K357), V330 (≠ P358), M405 (≠ N431), G423 (≠ R449), G424 (≠ N450)
- binding magnesium ion: D453 (= D478), N480 (= N505), H482 (≠ E507)
Sites not aligning to the query:
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 1yi0A
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), S38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M266 (vs. gap), V293 (≠ I320), V400 (≠ A426), G426 (= G451), M428 (= M453), D453 (= D478), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D318), R292 (≠ V319), W489 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), G222 (= G247), G223 (= G248), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), L264 (≠ I291), G265 (= G292), M266 (vs. gap), H267 (≠ Y293), G286 (= G313), V287 (≠ T314), R288 (≠ V315), D290 (≠ G317), R292 (≠ V319), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), G328 (≠ A356), D329 (≠ K357), V330 (≠ P358), M405 (≠ N431), G423 (≠ R449), G424 (≠ N450)
- binding magnesium ion: D453 (= D478), N480 (= N505), H482 (≠ E507)
Sites not aligning to the query:
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 1yhzA
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), S38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M266 (vs. gap), V293 (≠ I320), V400 (≠ A426), G426 (= G451), M428 (= M453), D453 (= D478), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D318), R292 (≠ V319), M485 (≠ T510), W489 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), G223 (= G248), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), L264 (≠ I291), M266 (vs. gap), H267 (≠ Y293), G286 (= G313), V287 (≠ T314), R288 (≠ V315), D290 (≠ G317), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), D329 (≠ K357), V330 (≠ P358), Q404 (≠ T430), M405 (≠ N431), G423 (≠ R449), G424 (≠ N450)
- binding magnesium ion: D453 (= D478), N480 (= N505), H482 (≠ E507)
Sites not aligning to the query:
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
27% identity, 89% coverage: 44:561/584 of query aligns to 12:544/582 of 1yhyA
- active site: Y33 (≠ V65), G35 (= G67), G36 (≠ E68), A37 (≠ S69), S38 (≠ F70), E59 (= E90), T82 (= T113), F121 (= F152), Q122 (= Q153), E123 (= E154), K171 (≠ E202), M266 (vs. gap), V293 (≠ I320), V400 (≠ A426), G426 (= G451), M428 (= M453), D453 (= D478), N480 (= N505), H482 (≠ E507), L483 (≠ Y508), M485 (≠ T510), V486 (≠ I511), W489 (≠ H514)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D318), R292 (≠ V319), V486 (≠ I511), W489 (≠ H514)
- binding flavin-adenine dinucleotide: R161 (= R192), G222 (= G247), G223 (= G248), G224 (≠ N249), T246 (≠ E273), L247 (≠ W274), M248 (≠ R275), L264 (≠ I291), G265 (= G292), M266 (vs. gap), H267 (≠ Y293), G286 (= G313), V287 (≠ T314), R288 (≠ V315), D290 (≠ G317), V293 (≠ I320), D310 (≠ T338), I311 (≠ A339), D329 (≠ K357), V330 (≠ P358), Q404 (≠ T430), M405 (≠ N431), G423 (≠ R449), G424 (≠ N450)
- binding magnesium ion: D453 (= D478), N480 (= N505), H482 (≠ E507)
Sites not aligning to the query:
Query Sequence
>WP_058930994.1 NCBI__GCF_001484605.1:WP_058930994.1
MTTETEATLTASHTLPAAVGNSEQVSREAHHPEVPHADTGQALKSAGHVIVDSLVAHGVE
RTYVVPGESFLDVLDGLHNSDIETIVCRHEGGAAYMAEADGKMHQRPGIAMVTRGPGAAN
AHVGLHTAWQDSTPMLLFVGLIPFAHRDREAFQEFDIKAWFDTGAKRVMVLDHAERASEI
VAEAMFAAMSGRPGPVVVGLPEDIIRQQIDPALHPAIPVAAGGMSTSDAAALEAALAESS
KPLFVTGGNDWTQGAADQLTEWLERHHIPAAAEWRTQGTVSFDSPSYVGPIGYGRPRPTY
DLFEETDLLVFVGTVPGDVITDGFVCRQDWNKKNFLVTADPSLRGRSGPVSRQILAKPEA
FVRDLVGIDLPAKEEWKAWTDRMRGEQERFAALPPAAPAAGQARMDTLMANLVPRLPEDS
LVTFGAGEHTNWAHRYFPTRRYASMISARNGSMGYSVPSAIAASLAEPRRRVVTIAGDGE
FLMNGQELATAAQYGATPLVIVMDNQEYGTIRTHQERHYPSRVSGTQLKNPDFGLMARAF
GGFGITVTEDCDVPAALDAALAAIDEDGVFALIHLIVEQRVKAY
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory