SitesBLAST
Comparing WP_058932300.1 NCBI__GCF_001484605.1:WP_058932300.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P19920 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
40% identity, 98% coverage: 2:286/292 of query aligns to 1:286/288 of P19920
1n5wC Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
40% identity, 98% coverage: 2:286/292 of query aligns to 1:286/287 of 1n5wC
1ffuC Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
40% identity, 98% coverage: 3:287/292 of query aligns to 2:287/287 of 1ffuC
- binding flavin-adenine dinucleotide: K29 (≠ R30), L30 (≠ V31), A32 (= A33), G33 (= G34), G34 (= G35), H35 (= H36), S36 (= S37), L37 (= L38), I54 (= I55), I101 (= I102), A102 (= A103), G110 (= G111), T111 (= T112), G114 (= G115), D115 (≠ S116), A117 (≠ C118), N123 (≠ E124), D124 (= D125), L161 (≠ V162), V166 (≠ L167), M167 (≠ L168), W193 (= W193)
7dqxE Crystal structure of xanthine dehydrogenase family protein
36% identity, 99% coverage: 4:291/292 of query aligns to 3:292/293 of 7dqxE
- binding flavin-adenine dinucleotide: K29 (≠ R30), I30 (≠ V31), I31 (= I32), G33 (= G34), G34 (= G35), Q35 (≠ H36), S36 (= S37), L37 (= L38), H78 (= H79), I101 (= I102), A102 (= A103), I106 (≠ V107), G110 (= G111), T111 (= T112), G113 (= G114), G114 (= G115), S115 (= S116), A117 (≠ C118), A123 (≠ E124), E124 (≠ D125), I167 (≠ L168), Y193 (≠ W193)
4zohB Crystal structure of glyceraldehyde oxidoreductase (see paper)
34% identity, 95% coverage: 4:279/292 of query aligns to 3:269/274 of 4zohB
- active site: Y256 (= Y266)
- binding flavin-adenine dinucleotide: R28 (= R30), P29 (≠ V31), A31 (= A33), G32 (= G34), G33 (= G35), H34 (= H36), S35 (= S37), L36 (= L38), H77 (= H79), I95 (= I102), G96 (≠ A103), V100 (= V107), T105 (= T112), G108 (= G115), S109 (= S116), S111 (≠ C118), A117 (≠ E124), D118 (= D125), L160 (= L167), V161 (≠ L168), D185 (= D192), F186 (≠ W193)
1t3qC Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
34% identity, 96% coverage: 1:279/292 of query aligns to 1:276/285 of 1t3qC
- binding flavin-adenine dinucleotide: I29 (≠ V31), A31 (= A33), G32 (= G34), G33 (= G35), Q34 (≠ H36), S35 (= S37), L36 (= L38), V100 (≠ I102), A101 (= A103), V105 (= V107), T110 (= T112), G113 (= G115), S114 (= S116), A116 (≠ C118), A122 (≠ E124), E123 (≠ D125), L166 (= L168), Y190 (≠ W193)
3hrdG Crystal structure of nicotinate dehydrogenase (see paper)
29% identity, 72% coverage: 7:215/292 of query aligns to 4:212/292 of 3hrdG
- binding flavin-adenine dinucleotide: I29 (≠ V31), A31 (= A33), G32 (= G34), G33 (= G35), T34 (≠ H36), D35 (≠ S37), F77 (≠ H79), V100 (≠ I102), G101 (≠ A103), I105 (≠ V107), T110 (= T112), G113 (= G115), N114 (≠ S116), S116 (≠ C118), T117 (≠ Q119), G122 (≠ E124), D123 (= D125), I168 (≠ L167), M169 (≠ L168)
Q0QLF4 Nicotinate dehydrogenase FAD-subunit; NDH; Nicotinic acid hydroxylase FAD-subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
29% identity, 72% coverage: 7:215/292 of query aligns to 4:212/296 of Q0QLF4
- 29:36 (vs. 31:38, 63% identical) binding FAD
- G101 (≠ A103) binding FAD
- TIGGN 110:114 (≠ TIGGS 112:116) binding FAD
- D123 (= D125) binding FAD
- R160 (≠ E159) binding FAD
- M169 (≠ L168) binding FAD
- K187 (= K185) binding FAD
P77324 Aldehyde oxidoreductase FAD-binding subunit PaoB; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
27% identity, 70% coverage: 7:209/292 of query aligns to 4:253/318 of P77324
- 26:34 (vs. 30:38, 56% identical) binding FAD
- T108 (= T112) binding FAD
- C119 (vs. gap) binding [4Fe-4S] cluster
- C129 (vs. gap) binding [4Fe-4S] cluster
- C138 (vs. gap) binding [4Fe-4S] cluster
- C157 (= C118) binding [4Fe-4S] cluster
- D164 (= D125) binding FAD
- I213 (≠ L168) binding FAD
- K230 (= K185) binding FAD
5g5gB Escherichia coli periplasmic aldehyde oxidase (see paper)
27% identity, 70% coverage: 7:209/292 of query aligns to 4:253/316 of 5g5gB
- binding flavin-adenine dinucleotide: K26 (≠ R30), F27 (≠ V31), A29 (= A33), G30 (= G34), G31 (= G35), T32 (≠ H36), N33 (≠ S37), L34 (= L38), G98 (≠ I102), A99 (= A103), L103 (≠ V107), A107 (≠ G111), T108 (= T112), A110 (≠ G114), G111 (= G115), N112 (≠ S116), L114 (vs. gap), Q115 (vs. gap), S163 (≠ E124), D164 (= D125), L212 (= L167), I213 (≠ L168), F239 (≠ V195)
- binding iron/sulfur cluster: C119 (vs. gap), C129 (vs. gap), N130 (vs. gap), K131 (vs. gap), C138 (vs. gap), H148 (vs. gap), C157 (= C118), I158 (≠ Q119), A159 (= A120)
5y6qB Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
32% identity, 39% coverage: 6:119/292 of query aligns to 3:114/330 of 5y6qB
- binding flavin-adenine dinucleotide: I26 (≠ V31), A28 (= A33), G29 (= G34), G30 (= G35), T31 (≠ H36), T32 (≠ S37), Q33 (≠ L38), A97 (≠ I102), A98 (= A103), I102 (≠ V107), A106 (≠ G111), T107 (= T112), G110 (= G115), N111 (≠ S116), R113 (≠ C118), Q114 (= Q119)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 164, 165, 213, 214, 232, 241
- binding iron/sulfur cluster: 118, 121, 130, 131, 139, 141, 158, 159, 160
2e3tA Crystal structure of rat xanthine oxidoreductase mutant (w335a and f336l) (see paper)
26% identity, 75% coverage: 9:227/292 of query aligns to 208:437/1291 of 2e3tA
- binding flavin-adenine dinucleotide: K228 (≠ R30), L229 (≠ V31), V230 (≠ I32), V231 (≠ A33), G232 (= G34), N233 (≠ G35), T234 (≠ H36), E235 (≠ S37), I236 (≠ L38), L309 (≠ I102), A318 (≠ G111), S319 (≠ T112), G322 (= G115), N323 (≠ S116), I325 (≠ C118), T326 (≠ Q119), S331 (≠ E124), D332 (= D125), I375 (≠ L167), L376 (= L168)
Sites not aligning to the query:
- active site: 740, 775, 853, 857, 885, 1233, 1234
- binding bicarbonate ion: 812, 813, 850, 882, 883, 887, 888, 891
- binding calcium ion: 713, 714, 716, 809, 810, 840, 843, 844, 847, 880, 881
- binding flavin-adenine dinucleotide: 44
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 71, 109, 110, 113, 145, 147, 717
- binding uric acid: 775, 853, 887, 982, 983, 1051, 1052, 1234
6a7xA Rat xanthine oxidoreductase, d428a variant, NAD bound form
26% identity, 75% coverage: 9:227/292 of query aligns to 208:437/1295 of 6a7xA
- binding flavin-adenine dinucleotide: K228 (≠ R30), L229 (≠ V31), V230 (≠ I32), V231 (≠ A33), G232 (= G34), N233 (≠ G35), T234 (≠ H36), E235 (≠ S37), I236 (≠ L38), F309 (≠ I102), V314 (= V107), S319 (≠ T112), G322 (= G115), N323 (≠ S116), I325 (≠ C118), T326 (≠ Q119), D332 (= D125), L376 (= L168)
- binding nicotinamide-adenine-dinucleotide: P329 (= P122), Y365 (≠ P157), R366 (≠ Y158), A432 (vs. gap), D433 (= D223)
Sites not aligning to the query:
- active site: 740, 775, 853, 857, 885, 1233, 1234
- binding bicarbonate ion: 812, 813, 850, 883, 884, 887, 888, 891
- binding flavin-adenine dinucleotide: 44
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 71, 109, 110, 111, 113, 145, 147
- binding nicotinamide-adenine-dinucleotide: 473, 480
- binding uric acid: 775, 853, 887, 982, 983, 1052, 1234
6a7xB Rat xanthine oxidoreductase, d428a variant, NAD bound form
26% identity, 75% coverage: 9:227/292 of query aligns to 206:435/1291 of 6a7xB
- binding flavin-adenine dinucleotide: L227 (≠ V31), V228 (≠ I32), V229 (≠ A33), G230 (= G34), N231 (≠ G35), T232 (≠ H36), E233 (≠ S37), I234 (≠ L38), F307 (≠ I102), V312 (= V107), S317 (≠ T112), G320 (= G115), N321 (≠ S116), I323 (≠ C118), T324 (≠ Q119), D330 (= D125), I373 (≠ L167), L374 (= L168)
- binding nicotinamide-adenine-dinucleotide: P327 (= P122), Y363 (≠ P157), R364 (≠ Y158), G428 (= G221), A430 (vs. gap), D431 (= D223)
Sites not aligning to the query:
- active site: 738, 773, 851, 855, 883, 1231, 1232
- binding bicarbonate ion: 810, 811, 880, 881, 885, 886, 889
- binding flavin-adenine dinucleotide: 44
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 71, 109, 110, 111, 113, 145, 147, 715
- binding nicotinamide-adenine-dinucleotide: 471, 478
- binding uric acid: 773, 851, 885, 980, 981, 1049, 1050, 1232
Q8GUQ8 Xanthine dehydrogenase 1; AtXDH1; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 71% coverage: 9:216/292 of query aligns to 264:485/1361 of Q8GUQ8
- W364 (≠ S100) mutation to A: Decreases activity 8-fold.
- Y421 (≠ P157) mutation to A: Decreases activity 4-fold.
Sites not aligning to the query:
- 831 E→A: Loss of activity.
- 909 R→A: Decreases activity 12-fold.
- 1297 E→A: Decreases activity 40-fold.
P22985 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Rattus norvegicus (Rat) (see 2 papers)
26% identity, 75% coverage: 9:227/292 of query aligns to 235:464/1331 of P22985
- 256:263 (vs. 31:38, 13% identical) binding FAD
- WF 335:336 (≠ VI 101:102) mutation to AL: Converts the enzyme to the oxidase form that utilizes molecular oxygen as electron acceptor. Interferes with normal conversion to the dehydrogenase form by reducing agents.
- SIGGN 346:350 (≠ TIGGS 112:116) binding FAD
- D359 (= D125) binding FAD
- L403 (= L168) binding FAD
Sites not aligning to the query:
- 43 binding [2Fe-2S] cluster
- 48 binding [2Fe-2S] cluster
- 51 binding [2Fe-2S] cluster
- 73 binding [2Fe-2S] cluster
- 112 binding [2Fe-2S] cluster
- 115 binding [2Fe-2S] cluster
- 147 binding [2Fe-2S] cluster
- 149 binding [2Fe-2S] cluster
- 535 C→A: Slows the conversion from the dehydrogenase form to the oxidase form; when associated with R-992. Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with R-992 and S-1316.
- 992 C→R: Slows the conversion from the dehydrogenase form to the oxidase form; when associated with A-535. Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with A-535 and S-1316.
- 1316 C→S: Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with A-535 and R-992.
P47989 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Homo sapiens (Human) (see 4 papers)
25% identity, 89% coverage: 9:267/292 of query aligns to 236:508/1333 of P47989
- 257:264 (vs. 31:38, 13% identical) binding FAD
- F337 (≠ I102) binding FAD
- SVGGN 347:351 (≠ TIGGS 112:116) binding FAD
- D360 (= D125) binding FAD
- K395 (≠ E159) to M: in dbSNP:rs34929837
- K422 (≠ E184) binding FAD
Sites not aligning to the query:
- 133 E → K: in dbSNP:rs45447191
- 172 G → R: in dbSNP:rs45523133
- 235 T → M: in dbSNP:rs45469499
- 509 modified: Disulfide link with 1318, In oxidase form
- 536 modified: Disulfide link with 993, In oxidase form
- 555 P → S: in dbSNP:rs45577338
- 584 D → A: in dbSNP:rs45491693
- 607 R → Q: in dbSNP:rs45442092
- 617 K → N: in dbSNP:rs45442398
- 623 T → I: in dbSNP:rs45448694
- 646 I → V: in dbSNP:rs17323225
- 703 I → V: in dbSNP:rs17011368
- 763 L → F: in a breast cancer sample; somatic mutation
- 791 R → G: in a breast cancer sample; somatic mutation; dbSNP:rs775646772
- 910 T → M: in dbSNP:rs669884
- 993 modified: Disulfide link with 536, In oxidase form
- 1091 V → L: in dbSNP:rs45619033
- 1109 N → T: in dbSNP:rs45547640
- 1150 P → R: in dbSNP:rs1042036
- 1176 R → C: in dbSNP:rs45624433
- 1296 R → W: in dbSNP:rs45564939
- 1318 modified: Disulfide link with 509, In oxidase form
2e1qA Crystal structure of human xanthine oxidoreductase mutant, glu803val (see paper)
25% identity, 89% coverage: 9:267/292 of query aligns to 210:482/1307 of 2e1qA
- binding flavin-adenine dinucleotide: K230 (≠ R30), L231 (≠ V31), V232 (≠ I32), V233 (≠ A33), G234 (= G34), N235 (≠ G35), T236 (≠ H36), E237 (≠ S37), I238 (≠ L38), F311 (≠ I102), A312 (= A103), V316 (= V107), A320 (≠ G111), S321 (≠ T112), G324 (= G115), N325 (≠ S116), I327 (≠ C118), T328 (≠ Q119), S333 (≠ E124), D334 (= D125), I377 (≠ L167), L378 (= L168)
Sites not aligning to the query:
- active site: 742, 777, 855, 859, 887, 1235, 1236
- binding bicarbonate ion: 814, 815, 852, 886, 889, 890, 893
- binding calcium ion: 715, 716, 718, 741, 747, 780, 781, 784, 811, 812
- binding flavin-adenine dinucleotide: 43, 44
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 71, 110, 111, 112, 114, 146, 148, 719
- binding hydroxy(dioxo)molybdenum: 773, 774, 887, 1053, 1054, 1236
4yswA Structure of rat xanthine oxidoreductase, c-terminal deletion protein variant, nadh bound form (see paper)
26% identity, 75% coverage: 9:227/292 of query aligns to 206:435/1286 of 4yswA
- binding flavin-adenine dinucleotide: K226 (≠ R30), L227 (≠ V31), V228 (≠ I32), V229 (≠ A33), G230 (= G34), N231 (≠ G35), T232 (≠ H36), E233 (≠ S37), I234 (≠ L38), F307 (≠ I102), A308 (= A103), V312 (= V107), A316 (≠ G111), S317 (≠ T112), G320 (= G115), N321 (≠ S116), I323 (≠ C118), T324 (≠ Q119), S329 (≠ E124), D330 (= D125), I373 (≠ L167), L374 (= L168), D399 (≠ G191)
- binding 1,4-dihydronicotinamide adenine dinucleotide: E233 (≠ S37), S326 (≠ D121), P327 (= P122), I328 (≠ A123), Y363 (≠ P157), R364 (≠ Y158), D400 (= D192), I401 (≠ W193), G428 (= G221), A430 (vs. gap), D431 (= D223)
Sites not aligning to the query:
- active site: 738, 773, 851, 855, 883, 1231, 1232
- binding bicarbonate ion: 810, 811, 848, 880, 881, 882, 885, 886, 889
- binding calcium ion: 838, 841, 842, 845, 878, 879
- binding flavin-adenine dinucleotide: 44
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 71, 110, 111, 113, 145, 147, 715
- binding 1,4-dihydronicotinamide adenine dinucleotide: 471, 478, 1196
- binding uric acid: 773, 851, 885, 980, 981, 1050, 1232
1rm6B Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
27% identity, 71% coverage: 1:208/292 of query aligns to 1:246/323 of 1rm6B
- binding flavin-adenine dinucleotide: P29 (≠ V31), G31 (≠ A33), A32 (≠ G34), G33 (= G35), T34 (≠ H36), D35 (≠ S37), L36 (= L38), L53 (≠ I55), V101 (≠ I102), A102 (= A103), A110 (≠ G111), T111 (= T112), G114 (= G115), N115 (≠ S116), C117 (= C118), Q118 (= Q119), D162 (= D125), L207 (= L168), V231 (≠ G191), D232 (= D192), F233 (≠ W193)
- binding iron/sulfur cluster: C122 (vs. gap), F124 (vs. gap), C138 (vs. gap), C146 (vs. gap), H147 (vs. gap), V148 (vs. gap), C155 (vs. gap), Y156 (vs. gap), A157 (= A120)
Query Sequence
>WP_058932300.1 NCBI__GCF_001484605.1:WP_058932300.1
MQIPAPFDYVRATTVDNALELLARHGPDSRVIAGGHSLLPMMKLRLARPEWLIDINDLYE
LDFILRDGDRLRIGAMTRHTTLLESAEVAGHFPIVRDAESVIADPIVRNRGTIGGSLCQA
DPAEDLSTVCKVLGAEAVIRGPGGERILSMVDFHRGPYETAVGPDELLCEVRFPIRTRSG
SAYEKVERRVGDWAVGAAGAAVSLAEDGTIDDASVGLTALGLDHTVAEAAALLRGQLPQE
ELFVEAGRLAAAACDPVQDQRGPIDYKRHLADELTRRVLRLACSRAAQTQEG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory