SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_061534208.1 NCBI__GCF_001584165.1:WP_061534208.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

Q58097 (5-formylfuran-3-yl)methyl phosphate transaminase; 4-HFC-P:alanine aminotransferase; EC 2.6.1.108 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
34% identity, 98% coverage: 8:393/394 of query aligns to 2:370/370 of Q58097

query
sites
Q58097

L

L

A

S

S

K

R

R

L

L

D

L

N

N

I

F

A

E

P

S

F

F

H

E

V

V

M

M

E

D

L

I

A

L

K

A

M

L

A

A

A

Q

A

K

L

L

E

E

R

S

E

E

G

G

H

K

H

K

I

V

I

I

H

H

M

L

G

E

I

I

G

G

E

E

P

P

D

D

F

F

T

N

A

T

A

P

P

K

L

P

V

I

I

V

E

D

A

E

A

G

A

I

K

K

A

S

M

L

A

K

D

E

G

G

K

K

M

T

Q

H

Y

Y

T

T

S

D

A

S

T

R

G

G

L

I

P

L

A

E

L

L

R

R

A

E

A

K

I

I

S

S

A

E

H

L

Y

Y

R

K

Q

D

V

K

F

Y

G

K

L

A

D

D

I

I

A

I

P

P

E

D

R

N

I

I

V

I

V

I

T

T

A

G

G

G

A

S

S

S

A

L

A

G

L

L

L

F

L

F

A

A

C

L

A

S

A

S

L

I

V

I

E

D

K

D

G

G

S

D

E

E

V

V

L

L

M

I

P

Q

D

N

P

P

S

C

Y

Y

P

P

C

C

N

Y

R

K

H

N

F

F

V

I

A

-

A

R

F

F

D

L

G

G

Q

A

A

K

K

P

M

V

I

F

A

C

S

D

G

F

P

T

A

V

E

E

R

S

F

L

Q

E

L

-

S

-

D

-

D

-

M

-

V

-

R

-

E

E

H

A

W

L

G

S

E

D

H

K

T

T

R

K

G

A

V

I

L

I

L

I

A

N

S

S

P

P

S

S

N

N

P

P

T

L

G

G

T

E

S

V

I

I

L

D

H

R

S

-

E

-

L

-

A

-

K

E

I

I

I

Y

A

E

T

F

V

A

R

Y

D

E

K

N

G

I

G

P

F

Y

S

I

I

I

V

S

D

D

E

E

I

I

Y

Y

Q

N

G

G

L

L

S

V

Y

Y

D

E

A

G

E

K

P

C

F

Y

S

S

A

A

L

I

S

E

L

F

G

D

D

E

D

N

I

L

-

E

-

K

-

T

I

I

V

L

I

I

N

N

S

G

F

F

S

S

K
|
K

Y

L

F

Y

N

A

M

M

T

T

G

G

W

W

R

R

L

I

G

G

W

Y

L

V

V

I

L

S

P

N

E

D

A

E

L

I

V

I

P

E

P

A

I

I

E

L

K

K

L

L

A

Q

Q

Q

N

N

L

L

F

F

I

I

C

S

P

A

S

P

S

T

I

I

A

S

Q

Q

H

Y

A

A

A

A

L

L

A

K

C

A

F

F

E

E

K

K

D

E

S

T

L

E

A

R

L

E

Y

I

E

N

A

S

R

M

K

I

D

K

E

E

F

F

K

D

R

R

R

R

R

R

D

R

Y

L

L

V

V

L

P

K

A

Y

L

V

I

K

A

D

L

F

G

G

F

W

K

E

V

V

P

N

V

N

I

-

P

P

D

I

G

G

A

A

F

Y

Y

Y

V

V

Y

F

A

P

D

N

C

I

S

-

D

-

L

-

L

-

K

-

D

-

G

G

G

E

D

D

A

G

D

R

S

E

L

F

V

A

K

Y

D

K

I

L

L

L

N

K

R

E

V

K

G

F

V

V

S

A

M

L

V

T

S

P

G

G

L

I

D

G

F

F

G

G

A

S

H

K

T

-

A

G

Q

K

H

N

Y

Y

I

I

R

R

L

I

S

S

Y

Y

A

A

T

N

S

S

M

Y

E

E

N

N

L

I

Q

K

E

E

A

G

V

L

R

E

R

R

L

I

G

K

N

E

Y

F

L

L

G

N

K

K

K222 (= K237) modified: N6-(pyridoxal phosphate)lysine

5yhvA Crystal structure of an aminotransferase from mycobacterium tuberculosis
36% identity, 96% coverage: 14:391/394 of query aligns to 16:391/394 of 5yhvA

query
sites
5yhvA

N

G

I

V

A

P

P

P

F

F

H

Y

V

V

M

M

E

D

L

V

A

W

K

L

M

A

A

A

A

A

A

E

L

R

E

Q

R

R

E

T

G

H

H

G

H

D

I

L

I

V

H

N

M

L

G

S

I

A

G

G

E

Q

P

P

D

S

F

A

T

G

A

A

A

P

P

E

L

P

V

V

I

R

E

A

A

A

A

A

A

A

K

A

A

A

M

L

A

H

D

L

G

N

K

Q

M

L

Q

G

Y
|
Y

T

S

S

V

A

A

T

L

G

G

L

I

P

P

A

E

L

L

R

R

A

D

A

A

I

I

S

A

A

A

H

D

Y

Y

R

Q

Q

R

V

R

F
x
H

G

G

L

I

D

T

I

V

A

E

P

P

E

D

R

A

I

V

V

V

V

I

T

T

A

T

G
|
G

A
x
S

S
|
S

A

G

A

G

L

F

L

L

L

L

A

A

C

F

A

L

A

A

L

C

V

F

E

D

K

A

G

G

S

D

E

R

V

V

L

A

M

M

P

A

D

S

P

P

S

G

Y
|
Y

P

P

C

C

N

Y

R

R

H

N

F

I

V

L

A

S

A

A

F

L

D

G

G

C

Q

E

A

V

K

V

M

E

I

I

A

P

S

C

G

G

P

P

A

Q

E

T

R

R

F

F

Q

Q

L

P

S

T

D

A

D

Q

M

M

V

L

R

A

E

E

H

I

W

-

G

D

E

P

H

P

T

L

R

R

G

G

V

V

L

V

L

V

A

A

S

S

P

P

S

A

N
|
N

P

P

T

T

G

G

T

T

S

V

I

I

L

P

H

P

S

E

E

E

L

L

A

A

K

A

I

I

I

A

A

S

T

W

V

C

R

D

D

A

K

S

G

D

G

V

F

R

S

L

I

I

V

S

D

D

E

E

I

V

Y
|
Y

Q
x
H

G

G

L

L

S

V

Y

Y

D

Q

A

G

E

A

P

P

F

Q

S

T

-

S

-

C

A

A

L

W

S

Q

L

T

G

S

D

R

D

N

I

A

I

V

V

V

I

V

N

N

S
|
S

F

F

S
|
S

K
|
K

Y

Y

F

Y

N

A

M

M

T

T

G

G

W

W

R
|
R

L

L

G

G

W

W

L

L

V

L

L

V

P

P

E

T

A

V

L

L

V

R

P

R

P

A

I

V

E

D

K

C

L

L

A

T

Q

G

N

N

L

F

F

T

I
|
I

C

C

P

P

S

P

S

V

I

L

A

S

Q

Q

H

I

A

A

A

A

L

V

A

S

C

A

F

F

E

T

K

P

D

E

S

A

L

T

A

A

L

E

Y

A

E

D

A

G

R

N

K

L

D

A

E

S

F

Y

K

A

R

I

R

N

R

R

D

S

Y

L

L

L

V

L

P

D

A

G

L

L

I

R

A

R

L

I

G

G

F

I

K

D

V

R

P

L

V

A

I

P

P

T

D

D

G

G

A

A

F

F

Y

Y

V

V

Y

Y

A

A

D

D

C

V

S

S

D

D

L

F

L

T

K

S

D

-

G

-

G

-

D

D

A

S

D

L

S

A

L

F

V

C

K

S

D

K

I

L

L

L

N

A

R

D

V

T

G

G

V

V

S

A

M

I

V

A

S

P

G

G

L

I

D

D

F

F

G

D

A

T

H

A

T

R

A

G

Q

G

H

S

Y

F

I

V

R

R

L

I

S

S

Y

F

A

A

T

G

S

P

M

S

E

G

N

D

L

I

Q

E

E

E

A

A

V

L

R

R

R

R

L

I

G

G

N

S

Y

W

L

L

binding glutamic acid: H91 (≠ F89), H212 (≠ Q211)
binding pyridoxal-5'-phosphate: Y70 (= Y68), G105 (= G103), S106 (≠ A104), S107 (= S105), Y131 (= Y129), N180 (= N179), Y211 (= Y210), S237 (= S234), S239 (= S236), K240 (= K237), R248 (= R245), I271 (= I268)

P96847 Valine--pyruvate aminotransferase; Alanine--valine transaminase; EC 2.6.1.66 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
36% identity, 96% coverage: 14:391/394 of query aligns to 10:385/388 of P96847

query
sites
P96847

N

G

I

V

A

P

P

P

F

F

H

Y

V

V

M

M

E

D

L

V

A

W

K

L

M

A

A

A

A

A

A

E

L

R

E

Q

R

R

E

T

G

H

H

G

H

D

I

L

I

V

H

N

M

L

G

S

I

A

G

G

E

Q

P

P

D

S

F

A

T

G

A

A

A

P

P

E

L

P

V

V

I

R

E

A

A

A

A

A

A

A

K

A

A

A

M

L

A

H

D

L

G

N

K

Q

M

L

Q

G

Y

Y

T

S

S

V

A

A

T

L

G

G

L

I

P

P

A

E

L

L

R

R

A

D

A

A

I

I

S

A

A

A

H

D

Y

Y

R

Q

Q

R

V

R

F

H

G

G

L

I

D

T

I

V

A

E

P

P

E

D

R

A

I

V

V

V

V

I

T

T

A

T

G

G

A

S

S

S

A

G

A

G

L

F

L

L

L

L

A

A

C

F

A

L

A

A

L

C

V

F

E

D

K

A

G

G

S

D

E

R

V

V

L

A

M

M

P

A

D

S

P

P

S

G

Y

Y

P

P

C

C

N

Y

R

R

H

N

F

I

V

L

A

S

A

A

F

L

D

G

G

C

Q

E

A

V

K

V

M

E

I

I

A

P

S

C

G

G

P

P

A

Q

E

T

R

R

F

F

Q

Q

L

P

S

T

D

A

D

Q

M

M

V

L

R

A

E

E

H

I

W

-

G

D

E

P

H

P

T

L

R

R

G

G

V

V

L

V

L

V

A

A

S

S

P

P

S

A

N

N

P

P

T

T

G

G

T

T

S

V

I

I

L

P

H

P

S

E

E

E

L

L

A

A

K

A

I

I

I

A

A

S

T

W

V

C

R

D

D

A

K

S

G

D

G

V

F

R

S

L

I

I

V

S

D

D

E

E

I

V

Y

Y

Q

H

G

G

L

L

S

V

Y

Y

D

Q

A

G

E

A

P

P

F

Q

S

T

-

S

-

C

A

A

L

W

S

Q

L

T

G

S

D

R

D

N

I

A

I

V

V

V

I

V

N

N

S

S

F

F

S

S

K
|
K

Y

Y

F

Y

N

A

M

M

T

T

G

G

W

W

R

R

L

L

G

G

W

W

L

L

V

L

L

V

P

P

E

T

A

V

L

L

V

R

P

R

P

A

I

V

E

D

K

C

L

L

A

T

Q

G

N

N

L

F

F

T

I

I

C

C

P

P

S

P

S

V

I

L

A

S

Q

Q

H

I

A

A

A

A

L

V

A

S

C

A

F

F

E

T

K

P

D

E

S

A

L

T

A

A

L

E

Y

A

E

D

A

G

R

N

K

L

D

A

E

S

F

Y

K

A

R

I

R

N

R

R

D

S

Y

L

L

L

V

L

P

D

A

G

L

L

I

R

A

R

L

I

G

G

F

I

K

D

V

R

P

L

V

A

I

P

P

T

D

D

G

G

A

A

F

F

Y

Y

V

V

Y

Y

A

A

D

D

C

V

S

S

D

D

L

F

L

T

K

S

D

-

G

-

G

-

D

D

A

S

D

L

S

A

L

F

V

C

K

S

D

K

I

L

L

L

N

A

R

D

V

T

G

G

V

V

S

A

M

I

V

A

S

P

G

G

L

I

D

D

F

F

G

D

A

T

H

A

T

R

A

G

Q

G

H

S

Y

F

I

V

R

R

L

I

S

S

Y

F

A

A

T

G

S

P

M

S

E

G

N

D

L

I

Q

E

E

E

A

A

V

L

R

R

R

R

L

I

G

G

N

S

Y

W

L

L

K234 (= K237) modified: N6-(pyridoxal phosphate)lysine

5yhvB Crystal structure of an aminotransferase from mycobacterium tuberculosis
36% identity, 96% coverage: 14:391/394 of query aligns to 9:384/387 of 5yhvB

query
sites
5yhvB

N

G

I

V

A

P

P

P

F

F

H

Y

V

V

M

M

E

D

L

V

A

W

K

L

M

A

A

A

A

A

A

E

L

R

E

Q

R

R

E

T

G

H

H

G

H

D

I

L

I

V

H

N

M

L

G

S

I

A

G

G

E

Q

P

P

D

S

F

A

T

G

A

A

A

P

P

E

L

P

V

V

I

R

E

A

A

A

A

A

A

A

K

A

A

A

M

L

A

H

D

L

G

N

K

Q

M

L

Q

G

Y
|
Y

T

S

S

V

A

A

T

L

G

G

L

I

P

P

A

E

L

L

R

R

A

D

A

A

I

I

S

A

A

A

H

D

Y
|
Y

R

Q

Q

R

V

R

F
x
H

G

G

L

I

D

T

I

V

A

E

P

P

E

D

R

A

I

V

V

V

V

I

T

T

A

T

G
|
G

A
x
S

S
|
S

A

G

A

G

L

F

L

L

L

L

A

A

C

F

A

L

A

A

L

C

V

F

E

D

K

A

G

G

S

D

E

R

V

V

L

A

M

M

P

A

D

S

P

P

S

G

Y
|
Y

P

P

C

C

N

Y

R

R

H

N

F

I

V

L

A

S

A

A

F

L

D

G

G

C

Q

E

A

V

K

V

M

E

I

I

A

P

S

C

G

G

P

P

A

Q

E

T

R

R

F

F

Q

Q

L

P

S

T

D

A

D

Q

M

M

V

L

R

A

E

E

H

I

W

-

G

D

E

P

H

P

T

L

R

R

G

G

V

V

L

V

L

V

A

A

S

S

P

P

S

A

N
|
N

P

P

T

T

G

G

T

T

S

V

I

I

L

P

H

P

S

E

E

E

L

L

A

A

K

A

I

I

I

A

A

S

T

W

V

C

R

D

D

A

K

S

G

D

G

V

F

R

S

L

I

I

V

S

D
|
D

E

E

I
x
V

Y
|
Y

Q
x
H

G

G

L

L

S

V

Y

Y

D

Q

A

G

E

A

P

P

F

Q

S
x
T

-

S

-

C

A

A

L

W

S

Q

L

T

G

S

D

R

D

N

I

A

I

V

V

V

I

V

N
|
N

S
|
S

F

F

S
|
S

K
|
K

Y

Y

F

Y

N

A

M

M

T

T

G

G

W

W

R
|
R

L

L

G

G

W

W

L

L

V

L

L

V

P

P

E

T

A

V

L

L

V

R

P

R

P

A

I

V

E

D

K

C

L

L

A

T

Q

G

N

N

L

F

F

T

I
|
I

C

C

P

P

S

P

S

V

I

L

A

S

Q

Q

H

I

A

A

A

A

L

V

A

S

C

A

F

F

E

T

K

P

D

E

S

A

L

T

A

A

L

E

Y

A

E

D

A

G

R

N

K

L

D

A

E

S

F

Y

K

A

R

I

R

N

R

R

D

S

Y

L

L

L

V

L

P

D

A

G

L

L

I

R

A

R

L

I

G

G

F

I

K

D

V

R

P

L

V

A

I

P

P

T

D

D

G

G

A

A

F

F

Y

Y

V

V

Y

Y

A

A

D

D

C

V

S

S

D

D

L

F

L

T

K

S

D

-

G

-

G

-

D

D

A

S

D

L

S

A

L

F

V

C

K

S

D

K

I

L

L

L

N

A

R

D

V

T

G

G

V

V

S

A

M

I

V

A

S

P

G

G

L

I

D

D

F

F

G

D

A

T

H

A

T

R

A

G

Q

G

H

S

Y

F

I

V

R

R

L

I

S

S

Y

F

A

A

T

G

S

P

M

S

E

G

N

D

L

I

Q

E

E

E

A

A

V

L

R

R

R

R

L

I

G

G

N

S

Y

W

L

L

binding 2-oxoglutaric acid: Y80 (= Y85), H84 (≠ F89), H205 (≠ Q211), T215 (≠ S221), N229 (= N233)
binding pyridoxal-5'-phosphate: Y63 (= Y68), G98 (= G103), S99 (≠ A104), S100 (= S105), Y124 (= Y129), N173 (= N179), D201 (= D207), V203 (≠ I209), Y204 (= Y210), S230 (= S234), S232 (= S236), K233 (= K237), R241 (= R245), I264 (= I268)

Q56232 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.78 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 3 papers)
33% identity, 98% coverage: 8:393/394 of query aligns to 4:384/385 of Q56232

query
sites
Q56232

L

L

A

S

S

R

R

R

L

V

D

Q

N

A

I

M

A
x
K

P

P

F

S

H

A

V

T

M

V

E

A

L

V

A

N

K

A

M

K

A

A

A

L

A

E

L

L

E

R

R

R

E

Q

G

G

H

V

H

D

I

L

I

V

H

A

M

L

G

T

I

A

G

G

E

E

P

P

D

D

F

F

T

D

A

T

A

P

P

E

L

H

V

V

I

K

E

E

A

A

A

A

A

R

K

R

A

A

M

L

A

A

D

Q

G

G

K

K

M

T

Q

K

Y

Y

T

A

S

P

A

P

T

A

G

G

L

I

P

P

A

E

L

L

R

R

A

E

A

A

I

L

S

A

A

E

H

K

Y

F

R

R

Q

R

V

E

F

N

G

G

L

L

D

S

I

V

A

T

P

P

E

E

R

E

I

T

V

I

V

V

T

T

A

V

G

G

A

G

S

K

A

Q

A

A

L

L

L

F

L

N

A

L

C

F

A

Q

A

A

L

I

V

L

E

D

K

P

G

G

S

D

E

E

V

V

L

I

M

V

P

L

D

S

P

P

S

Y

Y

W

P

V

C

S

N

Y

R

P

H

E

F

M

V

V

A

R

A

F

F

A

D

G

G

G

Q

V

A

V

K

V

M

E

I

V

A

E

S

T

G

L

P

P

A

E

E

E

R

G

F

F

Q

V

L

P

S

D

D

P

D

E

M

R

V

V

R

R

E

R

H

A

W

I

G

T

E

P

H

R

T

T

R

K

G

A

V

L

L

V

L

V

A

N

S

S

P

P

S

N

N

N

P

P

T

T

G

G

T

-

S

A

I

V

L

Y

H

P

S

K

E

E

L

V

A

L

K

E

I

A

I

L

A

A

T

R

V

L

R

A

D

V

K

E

G

H

G

D

F

F

S

Y

I

L

V

V

-

S

D

D

E

E

I

I

Y

Y

Q

E

G

H

L

L

S

L

Y

Y

D

E

A

G

E

E

P

H

F

F

S

S

A

P

L

G

S

R

L

V

G

A

D

P

D

E

-

H

I

T

I

L

V

T

I

V

N

N

S

G

F

A

S

A

K
|
K

Y

A

F

F

N

A

M

M

T

T

G

G

W

W

R

R

L

I

G

G

W

Y

L

A

V

C

L

G

P

P

E

K

A

E

L

V

V

I

P

K

P

A

I

M

E

A

K

S

L

V

A

S

Q

S

N

Q

L

S

F

T

I

T

C

S

P

P

S

D

S

T

I

I

A

A

Q

Q

H

W

A

A

A

T

L

L

A

E

C

A

F

L

-

T

-

N

E

Q

K

E

D

A

S

S

L

R

A

A

L

F

Y

V

E

E

A

M

R

A

K

R

D

E

E

A

F

Y

K

R

R

R

R

R

R

R

D

D

Y

L

L

L

V

L

P

E

A

G

L

L

I

T

A

A

L

L

G

G

F

L

K

K

V

A

P

-

V

V

I

R

P

P

D

S

G

G

A

A

F

F

Y

Y

V

V

Y

L

A

M

D

D

C

T

S

S

D

P

L

I

L

A

K

P

D

D

G

-

G

-

D

-

A

-

D

E

S

V

L

R

V

A

K

A

D

E

I

R

L

L

N

L

R

E

V

A

G

G

V

V

S

A

M

V

V

V

S

P

G

G

L

T

D

D

F

F

G

A

A

A

H

F

T

-

A

-

Q

-

H

G

Y

H

I

V

R

R

L

L

S

S

Y

Y

A

A

T

T

S

S

M

E

E

E

N

N

L

L

Q

R

E

K

A

A

V

L

R

E

R

R

L

F

G

A

N

R

Y

V

L

L

G

G

K

R

K12 (≠ A16) Important for prephenate aminotransferase activity; mutation to G: 10-fold increase in Km for prephenate. Does not affect Km for oxaloacetate.
K234 (= K237) modified: N6-(pyridoxal phosphate)lysine

1gc4A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with aspartate (see paper)
34% identity, 97% coverage: 8:391/394 of query aligns to 4:382/382 of 1gc4A

query
sites
1gc4A

L

L

A

S

S

R

R

R

L

V

D

Q

N

A

I

M

A

K

P

P

F

D

H

A

V

V

M

V

E

A

L

V

A

N

K

A

M

K

A

A

A

L

A

E

L

L

E

R

R

R

E

Q

G

G

H

V

H

D

I

L

I

V

H

A

M

L

G

T

I

A

G

G

E

E

P

P

D

D

F

F

T

D

A

T

A

P

P

E

L

H

V

V

I

K

E

E

A

A

A

A

A

R

K

R

A

A

M

L

A

A

D

Q

G

G

K

K

M

T

Q

K

Y
|
Y

T

A

S

P

A

P

T

A

G

G

L

I

P

P

A

E

L

L

R

R

A

E

A

A

I

L

S

A

A

E

H

K

Y

F

R

R

Q

R

V

E

F

N

G

G

L

L

D

S

I

V

A

T

P

P

E

E

R

E

I

T

V

I

V

V

T

T

A

V

G
|
G

A
x
G

S
|
S

A

Q

A

A

L

L

L

F

L

N

A

L

C

F

A

Q

A

A

L

I

V

L

E

D

K

P

G

G

S

D

E

E

V

V

L

I

M

V

P

L

D

S

P

P

S

Y

Y
x
W

P

V

C

S

N

Y

R

P

H

E

F

M

V

V

A

R

A

F

F

A

D

G

G

G

Q

V

A

V

K

V

M

E

I

V

A

E

S

T

G

L

P

P

A

E

E

E

R

G

F

F

Q

V

L

P

S

D

D

P

D

E

M

R

V

V

R

R

E

R

H

A

W

I

G

T

E

P

H

R

T

T

R

K

G

A

V

L

L

V

L

V

A

N

S

S

P

P

S

N

N
|
N

P

P

T

T

G

G

T

-

S

A

I

V

L

Y

H

P

S

K

E

E

L

V

A

L

K

E

I

A

I

L

A

A

T

R

V

L

R

A

D

V

K

E

G

H

G

D

F

F

S

Y

I

L

V

V

-

S

D
|
D

E

E

I

I

Y
|
Y

Q

E

G

H

L

L

S

L

Y

Y

D

E

A

G

E

E

P

H

F

F

S

S

A

P

L

G

S

R

L

V

G

A

D

P

D

E

-

H

I

T

I

L

V

T

I

V

N

N

S

G

F

A

S

A

K

K

Y

A

F

F

N

A

M

M

T

T

G

G

W

W

R
|
R

L

I

G

G

W

Y

L

A

V

C

L

G

P

P

E

K

A

E

L

V

V

I

P

K

P

A

I

M

E

A

K

S

L

V

A

S

Q
x
R

N

Q

L

S

F

T

I

T

C

S

P

P

S

D

S

T

I

I

A

A

Q

Q

H

W

A

A

A

T

L

L

A

E

C

A

F

L

-

T

-

N

E

Q

K

E

D

A

S

S

L

R

A

A

L

F

Y

V

E

E

A

M

R

A

K

R

D

E

E

A

F

Y

K

R

R

R

R

R

R

R

D

D

Y

L

L

L

V

L

P

E

A

G

L

L

I

T

A

A

L

L

G

G

F

L

K

K

V

A

P

-

V

V

I

R

P

P

D

S

G

G

A

A

F

F

Y
|
Y

V

V

Y

L

A

M

D

D

C

T

S

S

D

P

L

I

L

A

K

P

D

D

G

-

G

-

D

-

A

-

D

E

S

V

L

R

V

A

K

A

D

E

I

R

L

L

N

L

R

E

V

A

G

G

V

V

S

A

M

V

V

V

S

P

G

G

L

T

D

D

F

F

G

A

A

A

H

F

T

-

A

-

Q

-

H

G

Y

H

I

V

R
|
R

L

L

S

S

Y

Y

A

A

T

T

S

S

M

E

E

E

N

N

L

L

Q

R

E

K

A

A

V

L

R

E

R

R

L

F

G

A

N

R

Y

V

L

L

binding aspartic acid: Y64 (= Y68), W125 (≠ Y129), N175 (= N179), R261 (≠ Q264), Y322 (= Y324), R361 (= R370)
binding pyridoxal-5'-phosphate: G99 (= G103), G100 (≠ A104), S101 (= S105), W125 (≠ Y129), N175 (= N179), D203 (= D207), Y206 (= Y210), R242 (= R245)

1gc3A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with tryptophan (see paper)
34% identity, 97% coverage: 8:391/394 of query aligns to 4:382/382 of 1gc3A

query
sites
1gc3A

L

L

A

S

S

R

R

R

L

V

D

Q

N

A

I

M

A

K

P

P

F

D

H

A

V
|
V

M

V

E

A

L

V

A
x
N

K

A

M

K

A

A

A

L

A

E

L

L

E

R

R

R

E

Q

G

G

H

V

H

D

I

L

I

V

H

A

M

L

G
x
T

I
x
A

G
|
G

E
|
E

P

P

D

D

F

F

T

D

A

T

A

P

P

E

L

H

V

V

I

K

E

E

A

A

A

A

A

R

K

R

A

A

M

L

A

A

D

Q

G

G

K

K

M

T

Q

K

Y

Y

T

A

S

P

A

P

T

A

G

G

L

I

P

P

A

E

L

L

R

R

A

E

A

A

I

L

S

A

A

E

H

K

Y

F

R

R

Q

R

V

E

F

N

G

G

L

L

D

S

I

V

A

T

P

P

E

E

R

E

I

T

V

I

V

V

T

T

A

V

G

G

A
x
G

S
|
S

A

Q

A

A

L

L

L

F

L

N

A

L

C

F

A

Q

A

A

L

I

V

L

E

D

K

P

G

G

S

D

E

E

V

V

L

I

M

V

P

L

D

S

P

P

S

Y

Y
x
W

P

V

C

S

N

Y

R

P

H

E

F

M

V

V

A

R

A

F

F

A

D

G

G

G

Q

V

A

V

K

V

M

E

I

V

A

E

S

T

G

L

P

P

A

E

E

E

R

G

F

F

Q

V

L

P

S

D

D

P

D

E

M

R

V

V

R

R

E

R

H

A

W

I

G

T

E

P

H

R

T

T

R

K

G

A

V

L

L

V

L

V

A

N

S

S

P

P

S

N

N
|
N

P

P

T

T

G

G

T

-

S

A

I

V

L

Y

H

P

S

K

E

E

L

V

A

L

K

E

I

A

I

L

A

A

T

R

V

L

R

A

D

V

K

E

G

H

G

D

F

F

S

Y

I

L

V

V

-

S

D
|
D

E

E

I

I

Y
|
Y

Q

E

G

H

L

L

S

L

Y

Y

D

E

A

G

E

E

P

H

F

F

S

S

A

P

L

G

S

R

L

V

G

A

D

P

D

E

-

H

I

T

I

L

V

T

I

V

N

N

S

G

F

A

S

A

K
|
K

Y

A

F

F

N

A

M

M

T

T

G

G

W

W

R
|
R

L

I

G

G

W

Y

L

A

V

C

L

G

P

P

E

K

A

E

L

V

V

I

P

K

P

A

I

M

E

A

K

S

L

V

A

S

Q

R

N

Q

L

S

F

T

I

T

C

S

P

P

S

D

S

T

I

I

A

A

Q

Q

H

W

A

A

A

T

L

L

A

E

C

A

F

L

-

T

-

N

E

Q

K

E

D

A

S

S

L

R

A

A

L

F

Y

V

E

E

A

M

R

A

K

R

D

E

E

A

F

Y

K

R

R

R

R

R

R

R

D

D

Y

L

L

L

V

L

P

E

A

G

L

L

I

T

A

A

L

L

G

G

F

L

K

K

V

A

P

-

V

V

I

R

P

P

D

S

G

G

A

A

F

F

Y
|
Y

V

V

Y

L

A

M

D

D

C

T

S

S

D

P

L

I

L

A

K

P

D

D

G

-

G

-

D

-

A

-

D

E

S

V

L

R

V

A

K

A

D

E

I

R

L

L

N

L

R

E

V

A

G

G

V

V

S

A

M

V

V

V

S

P

G

G

L

T

D

D

F

F

G

A

A

A

H

F

T

-

A

-

Q

-

H

G

Y

H

I

V

R
|
R

L

L

S

S

Y

Y

A

A

T

T

S

S

M

E

E

E

N

N

L

L

Q

R

E

K

A

A

V

L

R

E

R

R

L

F

G

A

N

R

Y

V

L

L

binding pyridoxal-5'-phosphate: G100 (≠ A104), S101 (= S105), W125 (≠ Y129), N175 (= N179), D203 (= D207), Y206 (= Y210), K234 (= K237), R242 (= R245)
binding tryptophan: V16 (= V20), N20 (≠ A24), T37 (≠ G41), A38 (≠ I42), G39 (= G43), E40 (= E44), Y322 (= Y324), R361 (= R370)

1b5oA Thermus thermophilus aspartate aminotransferase single mutant 1 (see paper)
33% identity, 97% coverage: 8:391/394 of query aligns to 4:382/382 of 1b5oA

query
sites
1b5oA

L

L

A

S

S

R

R

R

L

V

D

Q

N

A

I

M

A

K

P

P

F

S

H

A

V

T

M

V

E

A

L

V

A

N

K

A

M

K

A

A

A

L

A

E

L

L

E

R

R

R

E

Q

G

G

H

V

H

D

I

L

I

V

H

A

M

L

G

T

I

A

G

G

E

E

P

P

D

D

F

F

T

D

A

T

A

P

P

E

L

H

V

V

I

K

E

E

A

A

A

A

A

R

K

R

A

A

M

L

A

A

D

Q

G

G

K

K

M

T

Q

K

Y

Y

T

A

S

P

A

P

T

A

G

G

L

I

P

P

A

E

L

L

R

R

A

E

A

A

I

L

S

A

A

E

H

K

Y

F

R

R

Q

R

V

E

F

N

G

G

L

L

D

S

I

V

A

T

P

P

E

E

R

E

I

T

V

I

V

V

T

T

A

V

G
|
G

A
x
G

S
|
S

A

Q

A

A

L

L

L

F

L

N

A

L

C

F

A

Q

A

A

L

I

V

L

E

D

K

P

G

G

S

D

E

E

V

V

L

I

M

V

P

L

D

S

P

P

S

Y

Y
x
W

P

V

C

S

N

Y

R

P

H

E

F

M

V

V

A

R

A

F

F

A

D

G

G

G

Q

V

A

V

K

V

M

E

I

V

A

E

S

T

G

L

P

P

A

E

E

E

R

G

F

F

Q

V

L

P

S

D

D

P

D

E

M

R

V

V

R

R

E

R

H

A

W

I

G

T

E

P

H

R

T

T

R

K

G

A

V

L

L

V

L

V

A

N

S

S

P

P

S

N

N
|
N

P

P

T

T

G

G

T

-

S

A

I

V

L

Y

H

P

S

K

E

E

L

V

A

L

K

E

I

A

I

L

A

A

T

R

V

L

R

A

D

V

K

E

G

H

G

D

F

F

S

Y

I

L

V

V

-

S

D
|
D

E

E

I
|
I

Y
|
Y

Q

E

G

H

L

L

S

L

Y

Y

D

E

A

G

E

E

P

H

F

F

S

S

A

P

L

G

S

R

L

V

G

A

D

P

D

E

-

H

I

T

I

L

V

T

I

V

N

N

S

G

F

A

S
x
A

K
|
K

Y

A

F

F

N

A

M

M

T

T

G

G

W

W

R
|
R

L

I

G

G

W

Y

L

A

V

C

L

G

P

P

E

K

A

E

L

V

V

I

P

K

P

A

I

M

E

A

K

S

L

V

A

S

Q

S

N

Q

L

S

F

T

I

T

C

S

P

P

S

D

S

T

I

I

A

A

Q

Q

H

W

A

A

A

T

L

L

A

E

C

A

F

L

-

T

-

N

E

Q

K

E

D

A

S

S

L

R

A

A

L

F

Y

V

E

E

A

M

R

A

K

R

D

E

E

A

F

Y

K

R

R

R

R

R

R

R

D

D

Y

L

L

L

V

L

P

E

A

G

L

L

I

T

A

A

L

L

G

G

F

L

K

K

V

A

P

-

V

V

I

R

P

P

D

S

G

G

A

A

F

F

Y

Y

V

V

Y

L

A

M

D

D

C

T

S

S

D

P

L

I

L

A

K

P

D

D

G

-

G

-

D

-

A

-

D

E

S

V

L

R

V

A

K

A

D

E

I

R

L

L

N

L

R

E

V

A

G

G

V

V

S

A

M

V

V

V

S

P

G

G

L

T

D

D

F

F

G

A

A

A

H

F

T

-

A

-

Q

-

H

G

Y

H

I

V

R

R

L

L

S

S

Y

Y

A

A

T

T

S

S

M

E

E

E

N

N

L

L

Q

R

E

K

A

A

V

L

R

E

R

R

L

F

G

A

N

R

Y

V

L

L

active site: W125 (≠ Y129), D203 (= D207), I205 (= I209), K234 (= K237)
binding pyridoxal-5'-phosphate: G99 (= G103), G100 (≠ A104), S101 (= S105), W125 (≠ Y129), N175 (= N179), D203 (= D207), I205 (= I209), Y206 (= Y210), A233 (≠ S236), K234 (= K237), R242 (= R245)

1bkgA Aspartate aminotransferase from thermus thermophilus with maleate (see paper)
33% identity, 97% coverage: 8:391/394 of query aligns to 4:382/382 of 1bkgA

query
sites
1bkgA

L

L

A

S

S

R

R

R

L

V

D

Q

N

A

I

M

A

K

P

P

F

S

H

A

V

T

M

V

E

A

L

V

A

N

K

A

M

K

A

A

A

L

A

E

L

L

E

R

R

R

E

Q

G

G

H

V

H

D

I

L

I

V

H

A

M

L

G

T

I

A

G

G

E

E

P

P

D

D

F

F

T

D

A

T

A

P

P

E

L

H

V

V

I

K

E

E

A

A

A

A

A

R

K

R

A

A

M

L

A

A

D

Q

G

G

K

K

M

T

Q

K

Y

Y

T

A

S

P

A

P

T

A

G

G

L

I

P

P

A

E

L

L

R

R

A

E

A

A

I

L

S

A

A

E

H

K

Y

F

R

R

Q

R

V

E

F

N

G

G

L

L

D

S

I

V

A

T

P

P

E

E

R

E

I

T

V

I

V

V

T

T

A

V

G
|
G

A
x
G

S
x
K

A

Q

A

A

L

L

L

F

L

N

A

L

C

F

A

Q

A

A

L

I

V

L

E

D

K

P

G

G

S

D

E

E

V

V

L

I

M

V

P

L

D

S

P

P

S

Y

Y
x
W

P

V

C

S

N

Y

R

P

H

E

F

M

V

V

A

R

A

F

F

A

D

G

G

G

Q

V

A

V

K

V

M

E

I

V

A

E

S

T

G

L

P

P

A

E

E

E

R

G

F

F

Q

V

L

P

S

D

D

P

D

E

M

R

V

V

R

R

E

R

H

A

W

I

G

T

E

P

H

R

T

T

R

K

G

A

V

L

L

V

L

V

A
x
N

S

S

P

P

S

N

N
|
N

P

P

T

T

G

G

T

-

S

A

I

V

L

Y

H

P

S

K

E

E

L

V

A

L

K

E

I

A

I

L

A

A

T

R

V

L

R

A

D

V

K

E

G

H

G

D

F

F

S

Y

I

L

V

V

-

S

D
|
D

E

E

I
|
I

Y
|
Y

Q

E

G

H

L

L

S

L

Y

Y

D

E

A

G

E

E

P

H

F

F

S

S

A

P

L

G

S

R

L

V

G

A

D

P

D

E

-

H

I

T

I

L

V

T

I

V

N

N

S

G

F

A

S

A

K
|
K

Y

A

F

F

N

A

M

M

T

T

G

G

W

W

R
|
R

L

I

G

G

W

Y

L

A

V

C

L

G

P

P

E

K

A

E

L

V

V

I

P

K

P

A

I

M

E

A

K

S

L

V

A

S

Q

S

N

Q

L

S

F

T

I

T

C

S

P

P

S

D

S

T

I

I

A

A

Q

Q

H

W

A

A

A

T

L

L

A

E

C

A

F

L

-

T

-

N

E

Q

K

E

D

A

S

S

L

R

A

A

L

F

Y

V

E

E

A

M

R

A

K

R

D

E

E

A

F

Y

K

R

R

R

R

R

R

R

D

D

Y

L

L

L

V

L

P

E

A

G

L

L

I

T

A

A

L

L

G

G

F

L

K

K

V

A

P

-

V

V

I

R

P

P

D

S

G

G

A

A

F

F

Y

Y

V

V

Y

L

A

M

D

D

C

T

S

S

D

P

L

I

L

A

K

P

D

D

G

-

G

-

D

-

A

-

D

E

S

V

L

R

V

A

K

A

D

E

I

R

L

L

N

L

R

E

V

A

G

G

V

V

S

A

M

V

V

V

S

P

G

G

L

T

D

D

F

F

G

A

A

A

H

F

T

-

A

-

Q

-

H

G

Y

H

I

V

R

R

L

L

S

S

Y

Y

A

A

T

T

S

S

M

E

E

E

N

N

L

L

Q

R

E

K

A

A

V

L

R

E

R

R

L

F

G

A

N

R

Y

V

L

L

active site: W125 (≠ Y129), D203 (= D207), I205 (= I209), K234 (= K237)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G99 (= G103), G100 (≠ A104), K101 (≠ S105), W125 (≠ Y129), N171 (≠ A175), N175 (= N179), D203 (= D207), I205 (= I209), Y206 (= Y210), K234 (= K237), R242 (= R245)

1bjwA Aspartate aminotransferase from thermus thermophilus (see paper)
33% identity, 97% coverage: 8:391/394 of query aligns to 4:382/382 of 1bjwA

query
sites
1bjwA

L

L

A

S

S

R

R

R

L

V

D

Q

N

A

I

M

A

K

P

P

F

S

H

A

V

T

M

V

E

A

L

V

A

N

K

A

M

K

A

A

A

L

A

E

L

L

E

R

R

R

E

Q

G

G

H

V

H

D

I

L

I

V

H

A

M

L

G

T

I

A

G
|
G

E

E

P

P

D

D

F

F

T

D

A

T

A

P

P

E

L

H

V

V

I

K

E

E

A

A

A

A

A

R

K

R

A

A

M

L

A

A

D

Q

G

G

K

K

M

T

Q

K

Y

Y

T

A

S

P

A

P

T

A

G

G

L

I

P

P

A

E

L

L

R

R

A

E

A

A

I

L

S

A

A

E

H

K

Y

F

R

R

Q

R

V

E

F

N

G

G

L

L

D

S

I

V

A

T

P

P

E

E

R

E

I

T

V

I

V

V

T

T

A

V

G

G

A

G

S

K

A

Q

A

A

L

L

L

F

L

N

A

L

C

F

A

Q

A

A

L

I

V

L

E

D

K

P

G

G

S

D

E

E

V

V

L

I

M

V

P

L

D

S

P

P

S

Y

Y
x
W

P

V

C

S

N

Y

R

P

H

E

F

M

V

V

A

R

A

F

F

A

D

G

G

G

Q

V

A

V

K

V

M

E

I

V

A

E

S

T

G

L

P

P

A

E

E

E

R

G

F

F

Q

V

L

P

S

D

D

P

D

E

M

R

V

V

R

R

E

R

H

A

W

I

G

T

E

P

H

R

T

T

R

K

G

A

V

L

L

V

L

V

A

N

S

S

P

P

S

N

N
|
N

P

P

T

T

G

G

T

-

S

A

I

V

L

Y

H

P

S

K

E

E

L

V

A

L

K

E

I

A

I

L

A

A

T

R

V

L

R

A

D

V

K

E

G

H

G

D

F

F

S

Y

I

L

V

V

-

S

D
|
D

E

E

I
|
I

Y

Y

Q

E

G

H

L

L

S

L

Y

Y

D

E

A

G

E

E

P

H

F

F

S

S

A

P

L

G

S

R

L

V

G

A

D

P

D

E

-

H

I

T

I

L

V

T

I

V

N

N

S

G

F

A

S

A

K
|
K

Y

A

F

F

N

A

M

M

T

T

G

G

W

W

R

R

L

I

G

G

W

Y

L

A

V

C

L

G

P

P

E

K

A

E

L

V

V

I

P

K

P

A

I

M

E

A

K

S

L

V

A

S

Q

S

N

Q

L

S

F

T

I

T

C

S

P

P

S

D

S

T

I

I

A

A

Q

Q

H

W

A

A

A

T

L

L

A

E

C

A

F

L

-

T

-

N

E

Q

K

E

D

A

S

S

L

R

A

A

L

F

Y

V

E

E

A

M

R

A

K

R

D

E

E

A

F

Y

K

R

R

R

R

R

R

R

D

D

Y

L

L

L

V

L

P

E

A

G

L

L

I

T

A

A

L

L

G

G

F

L

K

K

V

A

P

-

V

V

I

R

P

P

D

S

G

G

A

A

F

F

Y

Y

V

V

Y

L

A

M

D

D

C

T

S

S

D

P

L

I

L

A

K

P

D

D

G

-

G

-

D

-

A

-

D

E

S

V

L

R

V

A

K

A

D

E

I

R

L

L

N

L

R

E

V

A

G

G

V

V

S

A

M

V

V

V

S

P

G

G

L

T

D

D

F

F

G

A

A

A

H

F

T

-

A

-

Q

-

H

G

Y

H

I

V

R
|
R

L

L

S

S

Y

Y

A

A

T

T

S

S

M

E

E

E

N

N

L

L

Q

R

E

K

A

A

V

L

R

E

R

R

L

F

G

A

N

R

Y

V

L

L

active site: W125 (≠ Y129), D203 (= D207), I205 (= I209), K234 (= K237)
binding phosphate ion: G39 (= G43), W125 (≠ Y129), N175 (= N179), R361 (= R370)

1o4sB Crystal structure of aspartate aminotransferase (tm1255) from thermotoga maritima at 1.90 a resolution (see paper)
32% identity, 98% coverage: 8:392/394 of query aligns to 10:383/384 of 1o4sB

query
sites
1o4sB

L

V

A

S

S

R

R

R

L

I

D

S

N

E

I

I

A

P

P

I

F

S

H

K

V

T

M

M

E

E

L

L

A

D

K

A

M

K

A

A

A

K

A

A

L

L

E

I

R

K

E

K

G

G

H

E

H

D

I

V

I

I

H

N

M

L

G

T

I

A

G

G

E

E

P

P

D

D

F

F

T

P

A

T

A

P

P

E

L

P

V

V

I

V

E

E

A

E

A

A

A

V

K

R

A

F

M

L

A

Q

D

K

G

G

K

E

M

V

Q

K

Y

Y

T

T

S

D

A

P

T

R

G

G

L

I

P

Y

A

E

L

L

R

R

A

E

A

G

I

I

S

A

A

K

H

R

Y

I

R

G

Q

E

V

R

F

Y

G

K

L

K

D

D

I

I

A

S

P

P

E

D

R

Q

I

V

V

V

V

V

T

T

A

N

G
|
G

A
|
A

S
x
K

A

Q

A

A

L

L

L

F

L

N

A

A

C

F

A

M

A

A

L

L

V

L

E

D

K

P

G

G

S

D

E

E

V

V

L

I

M

V

P

F

D

S

P

P

S

V

Y
x
W

P

V

C

S

N

Y

R

I

H

P

F

Q

V

I

A

I

A

L

F

A

D

G

G

G

Q

T

A

V

K

N

M

V

I

V

A

E

S

T

G

F

P

M

A

S

E

K

R

N

F

F

Q

Q

L

P

S

S

D

L

D

E

M

E

V

V

R

E

E

G

H

L

W

L

G

V

E

G

H

K

T

T

R

K

G

A

V

V

L

L

L

I

A

N

S

S

P

P

S

N

N
|
N

P

P

T

T

G

G

T

V

S

V

I

Y

L

R

H

R

S

E

E

F

L

L

A

E

K

G

I

L

I

V

A

R

T

L

V

A

R

K

D

K

K

R

G

N

G

F

F

Y

S

I

I

I

V

S

D
|
D

E

E

I
x
V

Y
|
Y

Q

D

G

S

L

L

S

V

Y

Y

D

T

A

D

E

E

P

F

F

T

S

S

A

I

L

L

S

D

L

V

G

S

-

E

-

G

-

F

D

D

D

R

I

I

I

V

V

Y

I

I

N

N

S

G

F

F

S
|
S

K
|
K

Y

S

F

H

N

S

M

M

T

T

G

G

W

W

R
|
R

L

V

G

G

W

Y

L

L

V

I

L

S

P

S

E

E

A

K

L

V

V

A

P

T

P

A

I

V

E

S

K

K

L

I

A

Q

Q

S

N

H

L

T

F

T

I

S

C

C

P

I

S

N

S

T

I

V

A

A

Q

Q

H

Y

A

A

A

A

L

L

A

K

C

A

F

L

E

E

K

V

D

D

S

N

L

S

A

Y

L

M

Y

V

E

Q

A

T

R

-

K

-

D

-

E

-

F

F

K

K

R

E

R

R

R

K

D

N

Y

F

L

V

V

V

P

E

A

R

L

L

I

K

A

K

L

M

G

G

F

V

K

K

V

F

P

-

V

V

I

E

P

P

D

E

G

G

A

A

F

F

Y

Y

V

L

Y

F

A

-

D

-

C

-

S

-

D

-

L

-

L

F

K

K

D

V

G

R

G

G

D

D

A

D

D

V

S

K

L

F

V

C

K

E

D

R

I

L

L

L

N

E

R

E

V

K

G

K

V

V

S

A

M

L

V

V

S

P

G

G

L

-

D

-

F

-

G

S

A

A

H

F

T

L

A

K

Q

P

H

G

Y

F

I

V

R

R

L

L

S

S

Y

F

A

A

T

T

S

S

M

I

E

E

N

R

L

L

Q

T

E

E

A

A

V

L

R

D

R

R

L

I

G

E

N

D

Y

F

L

L

G

N

active site: W131 (≠ Y129), D209 (= D207), V211 (≠ I209), K242 (= K237)
binding pyridoxal-5'-phosphate: G105 (= G103), A106 (= A104), K107 (≠ S105), W131 (≠ Y129), N181 (= N179), D209 (= D207), V211 (≠ I209), Y212 (= Y210), S241 (= S236), K242 (= K237), R250 (= R245)

P14909 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
31% identity, 90% coverage: 36:390/394 of query aligns to 36:394/402 of P14909

query
sites
P14909

H

K

I

I

I

I

H

D

M

F

G

G

I

I

G

G

E

Q

P

P

D

D

F

L

T

P

A

T

A

F

P

K

L

R

V

I

I

R

E

D

A

A

A

A

A

K

K

E

A

A

M

L

A

D

D

Q

G

G

K

F

M

T

Q

F

Y

Y

T

T

S

S

A

A

T

F

G

G

L

I

P

D

A

E

L

L

R

R

A

E

A

K

I

I

S

A

A

Q

H

Y

Y

L

R

N

Q

T

V

R

F

Y

G

G

L

T

D

D

I

V

A

K

P

K

E

E

R

E

I

V

V

I

V

V

T

T

A

P

G

G

A

A

S

K

A

P

A

A

L

L

L

F

L

L

A

V

C

F

A

I

A

L

L

Y

V

I

E

N

K

P

G

S

S

D

E

E

V

V

L

I

M

L

P

P

D

D

P

P

S

S

Y

F

P

Y

C

S

N

Y

R

A

H

E

F

V

V

V

A

K

A

L

F

L

D

G

G

G

Q

K

A

P

-

I

-

Y

K

A

M

N

I

L

A

K

S

W

G

S

P

R

A

E

E

E

R

G

F

F

Q

S

L

I

S

D

D

V

D

D

M

D

V

L

R

Q

E

S

H

K

W

I

G

S

E

K

H

R

T

T

R

K

G

M

V

I

L

V

L

F

A

N

S

N

P

P

S

H

N

N

P

P

T

T

G

G

T

T

S

L

I

F

L

S

H

P

S

N

E

D

L

V

A

K

K

K

I

I

I

V

A

D

T

I

V

S

R

R

D

D

K

N

G
x
K

G

I

F

I

S

L

I

L

V

S

D

D

E

E

I

I

Y

Y

Q

D

G

N

L

F

S

V

Y

Y

D

E

A

G

E

K

P

M

F

R

S

S

A

T

L

L

S

E

-

D

-

S

-

D

L

W

G

R

D

D

D

F

I

L

I

I

V

Y

I

V

N

N

S

G

F

F

S

S

K

K

Y

T

F

F

N

S

M

M

T

T

G

G

W

W

R

R

L

L

G

G

W

Y

L

I

V

V

L

A

P

K

E

R

A

E

L

I

V

I

P

Q

P

K

I

M

E

G

K

I

L

L

A

A

Q

A

N

N

L

V

F

Y

I

T

C

A

P

P

S

T

S

S

I

F

A

V

Q

Q

H

K

A

A

A

A

L

V

A

K

C

A

F

F

E

-

K

-

D

D

S

T

L

F

A

D

L

E

Y

V

E

N

A

Q

R

M

K

V

D

S

E

L

F

F

K

K

R

K

R

R

R

R

D

D

Y

V

L

M

V

Y

P

D

A

E

L

L

I

T

A

K

L

V

-

K

G

G

F

V

K

E

V

V

P

S

V

K

I

-

P

P

D

N

G

G

A

A

F

F

Y

Y

V

M

Y

F

A

P

D

N

C

V

S

S

D

K

L

I

L

L

K

K

D

T

G

S

G

G

-

F

D

D

A

V

D

K

S

S

L

L

V

A

K

I

D

K

I

L

L

I

N

E

R

E

V

K

G

G

V</