SitesBLAST

S152 (= S141) mutation to A: 2-3-fold decrease in beta-ketotyrosine product formation.
Y164 (= Y153) mutation to F: 50-fold reduction in catalytic activity.
K168 (= K157) mutation to I: Does not alter the catalytic turnover.

6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii (see paper)
43% identity, 99% coverage: 1:249/252 of query aligns to 1:240/244 of 6wprA

query
sites
6wprA

M

M

T

T

T

Q

H

E

Q

R

R

K

T

V

A

A

V

L

V

V

T

T

G
|
G

A

A

A
x
S

R
|
R

G
|
G

I

I

G

G

A

A

L

I

A

A

Q

Q

R

Q

L

L

A

I

A

Q

D

D

G

G

M

Y

A

F

V

V

A

V

A

G

V

T

D

A

L
x
T

S

S

A

E

D

S

A

G

C

A

S

Q

D

K

V

L

V

T

E

D

A

S

I

F

T

G

A

E

A

Q

G

G

G

A

T

-

A

-

R

-

A

G

Y

L

A

A

A
x
L

D
|
D

V
|
V

A

R

D

N

E

L

A

D

S

E

V

I

A

E

G

A

L

V

V

V

E

S

A

H

V

I

A

E

A

Q

E

N

L

Y

G

G

P

P

P

V

T

L

V

V

L

L

V

V

N

N

N
|
N

A
|
A

G
|
G

V
x
I

L

T

R

K

D

D

N

N

L

L

F

L

R

R

M

M

S

S

A

E

D

D

W

W

D

D

T

D

V

I

M

L

N

N

V

I

H

H

L

L

R

K

G

A

H

V

F

Y

L

R

M

L

S

S

R

K

A

R

V

V

Q

L

A

K

H

G

M

M

T

T

E

K

Q

A

G

R

W

F

G

G

R

R

I

I

V

I

N

N

I
|
I

S

S

S
|
S

T

V

S

V

A

A

-

H

L

F

G

A

N

N

R

P

G

G

Q

Q

A

A

N

N

Y
|
Y

A

S

A

A

K
|
K

A

A

G

G

I

I

Q

E

G

A

F

F

T

S

K

R

T

S

L

L

A

A

I

K

E

E

L

M

G

G

K

S

F

R

G

Q

V

I

T

T

V

V

N

N

A

S

I

V

A

A

P
|
P

G

G

L

F

I

I

E

A

T

T

A

E

M

M

T

T

R

D

A

A

T

L

A

S

E

-

R

-

M

-

G

-

V

-

P

-

Y

-

E

E

Q

D

F

I

V

R

E

K

K

K

A

M

A

S

Q

D

Q

Q

I

V

P

A

V

L

A

N

R

R

T

L

G

G

T

E

P

P

E

Q

D

D

I

I

A

A

A

N

A

A

A

V

S

S

F

F

F

L

A

A

R

S

E

D

D

K

A

A

S

G

F

Y

V

I

S

T

G

G

Q

T

V

V

L

L

Y

H

V

V

A

N

G

G

active site: G16 (= G16), S138 (= S141), Y151 (= Y153)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (≠ A14), R15 (= R15), T37 (≠ L37), L58 (≠ A61), D59 (= D62), V60 (= V63), N86 (= N89), A87 (= A90), G88 (= G91), I89 (≠ V92), I136 (= I139), Y151 (= Y153), K155 (= K157), P181 (= P183)

6t62A Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
43% identity, 99% coverage: 1:249/252 of query aligns to 1:240/244 of 6t62A

query
sites
6t62A

M

M

T

A

T

Q

H

E

Q

R

R

K

T

V

A

A

V

L

V

V

T

T

G
|
G

A

A

A
x
S

R
|
R

G
|
G

I

I

G

G

A

A

L

I

A

A

Q

Q

R

Q

L

L

A

I

A

Q

D

D

G

G

M

Y

A

F

V

V

A

V

A

G

V

T

D
x
A

L
x
T

S

S

A

E

D

S

A

G

C

A

S

Q

D

K

V

L

V

T

E

D

A

S

I

F

T

G

A

E

A

Q

G

G

G

A

T

-

A

-

R

-

A

G

Y

L

A

A

A
x
L

D
|
D

V
|
V

A

R

D

N

E

L

A

D

S

E

V

I

A

E

G

A

L

V

V

V

E

S

A

H

V

I

A

E

A

Q

E

N

L

Y

G

G

P

P

P

V

T

L

V

V

L

L

V

V

N

N

N
|
N

A
|
A

G
|
G

V
x
I

L

T

R

K

D

D

N

N

L

L

F

L

R

R

M

M

S

S

A

E

D

D

W

W

D

D

T

D

V

I

M

L

N

N

V

I

H

H

L

L

R

K

G

A

H

V

F

Y

L

R

M

L

S

S

R

K

A

R

V

V

Q

L

A

K

H

G

M

M

T

T

E

K

Q

A

G

R

W

F

G

G

R

R

I

I

V

I

N

N

I
|
I

S
|
S

T

V

S

V

A

A

-

H

L

F

G

A

N

N

R

P

G

G

Q

Q

A

A

N

N

Y
|
Y

A

S

A

A

K
|
K

A

A

G

G

I

I

Q

E

G

A

F

F

T

S

K

R

T

S

L

L

A

A

I

K

E

E

L

M

G

G

K

S

F

R

G

Q

V

I

T

T

V

V

N

N

A

S

I

V

A

A

P
|
P

G
|
G

L

F

I
|
I

E

A

T

T

A

E

M
|
M

T

T

R

D

A

A

T

L

A

S

E

-

R

-

M

-

G

-

V

-

P

-

Y

-

E

E

Q

D

F

I

V

R

E

K

K

K

A

M

A

S

Q

D

Q

Q

I

V

P

A

V

L

A

N

R

R

T

L

G

G

T

E

P

P

E

Q

D

D

I

I

A

A

A

N

A

A

A

V

S

S

F

F

F

L

A

A

R

S

E

D

D

K

A

A

S

G

F

Y

V

I

S

T

G

G

Q

T

V

V

L

L

Y

H

V

V

A

N

G

G

active site: G16 (= G16), S138 (= S141), Y151 (= Y153)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (≠ A14), R15 (= R15), A36 (≠ D36), T37 (≠ L37), L58 (≠ A61), D59 (= D62), V60 (= V63), N86 (= N89), A87 (= A90), G88 (= G91), I89 (≠ V92), I136 (= I139), S137 (= S140), S138 (= S141), Y151 (= Y153), K155 (= K157), P181 (= P183), G182 (= G184), I184 (= I186), M188 (= M190)

Q9KJF1 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase subunit BbsD; (S,R)-2-(alpha-hydroxybenzyl)succinyl-CoA dehydrogenase subunit BbsD; EC 1.1.1.429 from Thauera aromatica (see 2 papers)
43% identity, 99% coverage: 1:249/252 of query aligns to 1:242/248 of Q9KJF1

query
sites
Q9KJF1

M
|
M

T

G

T

I

H

Q

Q

N

R

R

T

V

A

A

V

L

V

I

T

T

G

G

A

S

A

A

R
x
S

G

G

I

M

G

G

A

K

A

Q

L

T

A

A

Q

L

R

R

L

F

A

A

A

E

D

Q

G

G

M

A

A

A

V

V

A

V

A

I

V

N

D
|
D

L

I

S

D

A

A

D

E

A

K

C

V

S

R

D

A

V

T

V

V

E

D

A

E

I

F

T

S

A

A

A

R

G

G

G

H

T

R

A

V

R

L

A

G

Y

A

A

V

A

A

D
|
D

V
x
I

A

G

D

N

E

K

A

A

S

A

V

V

A

D

G

G

L

M

V

V

E

K

A

Q

V

T

A

I

A

D

E

A

L

F

G

G

P

R

P

I

T

D

V

I

L

L

V

V

N

N

N
|
N

A

A

G

G

V

M

L

E

R

R

D

A

N

G

L

A

L

L

F

R

R

K

M

L

S

S

A

E

D

A

D

D

W

W

D

D

T

V

V

T

M

I

N

N

V

V

H

N

L

L

R

K

G

G

H

T

F

F

L

L

M

C

S

T

R

Q

A

A

V

V

Q

H

A

G

H

H

M

M

T

V

E

E

Q

N

G

K

W

H

G

G

R

R

I

I

V

V

N

N

I

I

S

A

S

S

T

R

S

A

A

W

L

L

G

G

N

G

R

A

G

G

Q

Q

A

T

N

P

Y
|
Y

A

S

A

A

K
|
K

A

A

G

G

I

V

Q

V

G

G

F

M

T

T

K

R

T

A

L

L

A

A

I

I

E

E

L

L

G

G

K

R

F

A

G

G

V

I

T

T

V

V

N

N

A

C

I

V

A

A

P

P

G

G

L

L

I

I

E

H

T

T

A

P

M

M

T

W

R

D

A

E

T

L

A

P

E

E

R

K

M

-

G

-

V

-

P

-

Y

D

E

Q

Q

Q

F

F

V

L

E

-

K

-

A

-

A

L

Q

S

Q

R

I

Q

P

P

V

T

A

G

R

K

T

L

G

G

T

E

P

P

E

D

D

D

I

I

A

A

A

N

A

T

A

L

S

L

F

F

F

L

A

A

R

D

E

D

D

D

A

S

S

G

F

F

V

V

S

T

G

G

Q

Q

V

V

L

L

Y

Y

V

V

A

C

G

G

M1 (= M1) modified: Initiator methionine, Removed
S15 (≠ R15) binding NAD(+)
D36 (= D36) binding NAD(+)
D62 (= D62) binding NAD(+)
I63 (≠ V63) binding NAD(+)
N89 (= N89) binding NAD(+)
Y153 (= Y153) binding NAD(+)
K157 (= K157) binding NAD(+)

4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution (see paper)
44% identity, 99% coverage: 1:249/252 of query aligns to 8:250/254 of 4ag3A

query
sites
4ag3A

M

M

T

S

T

L

H

Q

Q

G

R

K

T

V

A

A

V

L

V

V

T

T

G
|
G

A

A

A
x
S

R
|
R

G
|
G

I
|
I

G

G

A

Q

A

A

L

I

A

A

Q

L

R

E

L

L

A

G

A

R

D

L

G

G

M

A

A

V

V

V

A

I

A

G

V

T

D

A

L
x
T

S

S

A

A

D

S

A

G

C

A

S

E

D

K

V

I

V

A

E

E

A

T

I

L

T

K

A

A

A

N

G

G

G

V

T

E

A

G

R

A

A

G

Y

L

A

V

A
x
L

D
|
D

V
|
V

A

S

D

S

E

D

A

E

S

S

V

V

A

A

G

A

L

T

V

L

E

E

A

H

V

I

A

Q

E

H

L

L

G

G

P

Q

P

P

T

L

V

I

L

V

V

V

N

N

N
|
N

A
|
A

G

G

V

I

L

T

R

R

D

D

N

N

L

L

F

V

R

R

M

M

S

K

A

D

D

D

D

E

W

W

D

F

T

D

V

V

M

V

N

N

V

T

H

N

L

L

R

N

G

S

H

L

F

Y

L

R

M

L

S

S

R

K

A

A

V

V

Q

L

A

R

H

G

M

M

T

T

E

K

Q

A

G

R

W

W

G

G

R

R

I

I

V

I

N

N

I
|
I

S

G

S
|
S

-

V

T

V

S

G

A

A

L

M

G

G

N

N

R

A

G

G

Q

Q

A

T

N

N

Y
|
Y

A

A

K
|
K

A

A

G

G

I

L

Q

E

G

G

F

F

T

T

K

R

T

A

L

L

A

A

I

R

E

E

L

V

G

G

K

S

F

R

G

A

V

I

T

T

V

V

N

N

A

A

I

V

A

A

P
|
P

G
|
G

L
x
F

I
|
I

E

D

T
|
T

A

D

M
|
M

T
|
T

R

R

A

E

T

-

A

-

E

-

R

-

M

-

G

-

V

L

P

P

Y

E

E

A

Q

Q

F

R

V

-

E

E

K

A

A

L

Q

G

Q

Q

I

I

P

P

V

L

A

G

R

R

T

L

G

G

T

Q

P

A

E

E

D

E

I

I

A

A

A

K

A

V

S

G

F

F

F

L

A

A

R

S

E

D

D

G

A

A

S

A

F

Y

V

V

S

T

G

G

Q

A

V

T

L

V

Y

P

V

V

A

N

G

G

active site: G23 (= G16), S148 (= S141), Y161 (= Y153), K165 (= K157)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G12), S21 (≠ A14), R22 (= R15), G23 (= G16), I24 (= I17), T44 (≠ L37), L68 (≠ A61), D69 (= D62), V70 (= V63), N96 (= N89), A97 (= A90), I146 (= I139), S148 (= S141), Y161 (= Y153), K165 (= K157), P191 (= P183), G192 (= G184), F193 (≠ L185), I194 (= I186), T196 (= T188), M198 (= M190), T199 (= T191)

7pcsB Structure of the heterotetrameric sdr family member bbscd (see paper)
43% identity, 98% coverage: 4:249/252 of query aligns to 3:241/247 of 7pcsB

query
sites
7pcsB

H

Q

Q

N

R

R

T

V

A

A

V

L

V

I

T

T

G
|
G

A

S

A

A

R

S

G

G

I
x
M

G

G

A

K

A

Q

L

T

A

A

Q

L

R

R

L

F

A

A

A

E

D

Q

G

G

M

A

A

A

V

V

A

V

A

I

V

N

D
|
D

L
x
I

S

D

A

A

D

E

A

K

C

V

S

R

D

A

V

T

V

V

E

D

A

E

I

F

T

S

A

A

A

R

G

G

G

H

T

R

A

V

R

L

A

G

Y

A

A

V

A

A

D

D

V
x
I

A

G

D

N

E

K

A

A

S

A

V

V

A

D

G

G

L

M

V

V

E

K

A

Q

V

T

A

I

A

D

E

A

L

F

G

G

P

R

P

I

T

D

V

I

L

L

V

V

N

N

N
|
N

A

A

G
|
G

V

M

L

E

R

R

D

A

N

G

L

A

L

L

F

R

R

K

M

L

S

S

A

E

D

A

D

D

W

W

D

D

T

V

V

T

M

I

N

N

V

V

H

N

L

L

R

K

G

G

H

T

F

F

L

L

M

C

S

T

R

Q

A

A

V

V

Q

H

A

G

H

H

M

M

T

V

E

E

Q

N

G

K

W

H

G

G

R

R

I

I

V

V

N

N

I
|
I

S

A

S
|
S

T

R

S

A

A

W

L

L

G

G

N

G

R

A

G

G

Q

Q

A

T

N

P

Y
|
Y

A

S

A

A

K
|
K

A

A

G

G

I

V

Q

V

G

G

F

M

T

T

K

R

T

A

L

L

A

A

I

I

E

E

L

L

G

G

K

R

F

A

G

G

V

I

T

T

V

V

N

N

A

C

I

V

A

A

P

P

G

G

L

L

I
|
I

E

H

T

T

A

P

M

M

T

W

R

D

A

E

T

L

A

P

E

E

R

K

M

-

G

-

V

-

P

-

Y

D

E

Q

Q

Q

F

F

V

L

E

-

K

-

A

-

A

L

Q

S

Q

R

I

Q

P

P

V

T

A

G

R

K

T

L

G

G

T

E

P

P

E

D

D

D

I

I

A

A

A

N

A

T

A

L

S

L

F

F

F

L

A

A

R

D

E

D

D

D

A

S

S

G

F

F

V

V

S

T

G

G

Q

Q

V

V

L

L

Y

Y

V

V

A

C

G

G

binding nicotinamide-adenine-dinucleotide: G11 (= G12), M16 (≠ I17), D35 (= D36), I36 (≠ L37), I62 (≠ V63), N88 (= N89), G90 (= G91), I138 (= I139), S140 (= S141), Y152 (= Y153), K156 (= K157), I185 (= I186)

6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
43% identity, 99% coverage: 1:249/252 of query aligns to 1:240/244 of 6t77A

query
sites
6t77A

M

M

T

S

T

F

H

E

Q

G

R

K

T

I

A

A

V

L

V

V

T

T

G
|
G

A

A

A
x
S

R
|
R

G
|
G

I

I

G

G

A

R

A

A

L

I

A

A

Q

E

R

T

L

L

A

V

A

A

D

R

G

G

M

A

A

K

V

V

-

I

-

G

-

T

A

A

A
x
T

V

S

D

E

L

S

S

G

A

A

D

Q

A

A

C

I

S

S

D

D

V

Y

V

L

E

-

A

-

I

-

T

-

A

-

G

G

G

A

T

N

A

G

R

K

A

G

Y

L

A

M

A
x
L

D
x
N

V
|
V

A

T

D

D

E

P

A

A

S

S

V

I

A

E

G

S

L

V

V

L

E

E

A

N

V

V

A

R

A

A

E

E

L

F

G

G

P

E

P

V

T

D

V

I

L

L

V

V

N

N

A
|
A

G
|
G

V
x
I

L

T

R

R

D

D

N

N

L

L

F

M

R

R

M

M

S

K

A

D

D

D

D

E

W

W

D

N

T

D

V

I

M

I

N

E

V

T

H

N

L

L

R

S

G

S

H

V

F

F

L

R

M

L

S

S

R

K

A

A

V

V

Q

M

A

R

H

A

M

M

T

M

E

K

Q

K

G

R

W

H

G

G

R

R

I

I

V

I

N

T

I

I

S

G

S
|
S

-

V

T

V

S

G

A

T

L

M

G

G

N

N

R

A

G

G

Q

Q

A

A

N

N

Y
|
Y

A

A

K

K

A

A

G

G

I

L

Q

I

G

G

F

F

T

S

K

K

T

S

L

L

A

A

I

R

E

E

L

V

G

A

K

S

F

R

G

G

V

I

T

T

V

V

N

N

A

V

I

V

A

A

P

P

G

G

L

F

I

I

E

E

T

T

A

D

M

M

T

T

R

R

A

A

T

L

A

T

E

D

R

-

M

-

G

-

V

-

P

-

Y

-

E

E

Q

Q

F

R

V

A

E

G

K

T

A

L

A

A

Q

-

Q

A

I

V

P

P

V

A

A

G

R

R

T

L

G

G

T

T

P

P

E

N

D

E

I

I

A

A

A

S

A

A

A

V

S

A

F

F

F

L

A

A

R

S

E

D

D

E

A

A

S

S

F

Y

V

I

S

T

G

G

Q

E

V

T

L

L

Y

H

V

V

A

N

G

G

active site: G16 (= G16), S138 (= S141), Y151 (= Y153)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (≠ A14), R15 (= R15), T37 (≠ A34), L58 (≠ A61), N59 (≠ D62), V60 (= V63), A87 (= A90), G88 (= G91), I89 (≠ V92)

P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
41% identity, 99% coverage: 1:249/252 of query aligns to 1:240/244 of P0A2C9

query
sites
P0A2C9

M

M

T

S

T

F

H

E

Q

G

R

K

T

I

A

A

V

L

V

V

T

T

G

G

A

A

A

S

R

R

G

G

I

I

G

G

A

R

A

A

L

I

A

A

Q

E

R

T

L

L

A

V

A

A

D

R

G

G

M

A

A

K

V

V

A

I

A

G

V

T

D

A

L

T

S

S

A

E

D

N

A

G

C

A

S

K

D

N

V

I

V

S

E

D

A

Y

I

L

T

G

A

A

A

N

G

G

G

-

T

-

A

-

R

K

A

G

Y

L

A

M

A

L

D

N

V

V

A

T

D

D

E

P

A

A

S

S

V

I

A

E

G

S

L

V

V

L

E

E

A

N

V

I

A

R

A

A

E

E

L

F

G

G

P

E

P

V

T

D

V

I

L

L

V

V

N

N

A

A

G

G

V

I

L

T

R

R

D

D

N

N

L

L

F

M

R

R

M

M

S

K

A

D

D

D

D

E

W

W

D

N

T

D

V

I

M

I

N

E

V

T

H

N

L

L

R

S

G

S

H

V

F

F

L

R

M

L

S

S

R

K

A

A

V

V

Q

M

A

R

H

A

M
|
M

T

M

E

K

Q

K

G

R

W

C

G

G

R

R

I

I

V

I

N

T

I

I

S

G

S

S

-

V

T

V

S

G

A

T

L

M

G

G

N

N

R

A

G

G

Q

Q

A

A

N

N

Y

Y

A

A

K

K

A

A

G

G

I

L

Q

I

G

G

F

F

T

S

K

K

T

S

L

L

A

A

I

R

E

E

L

V

G

A

K

S

F

R

G

G

V

I

T

T

V

V

N

N

A

V

I

V

A

A

P

P

G

G

L

F

I

I

E

E

T

T

A

D

M

M

T

T

R

R

A

A

T

L

A

S

-

D

E

Q

R

R

M

A

G

G

V

I

P

-

Y

-

E

-

Q

-

F

-

V

-

E

-

K

-

A

-

A

L

Q

A

Q

Q

I

V

P

P

V

A

A

G

R

R

T

L

G

G

T

G

P

A

E

Q

D

E

I

I

A

A

A

S

A

A

A

V

S

A

F

F

F

L

A
|
A

R
x
S

E

D

D

E

A

A

S

S

F

Y

V

I

S

T

G

G

Q

E

V

T

L

L

Y

H

V

V

A

N

G

G

M125 (= M128) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
A223 (= A232) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
S224 (≠ R233) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.

4bo4C Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
43% identity, 99% coverage: 1:249/252 of query aligns to 14:251/255 of 4bo4C

query
sites
4bo4C

M

M

T

S

T

L

H

Q

Q

G

R

K

T

V

A

A

V

L

V

V

T

T

G

G

A

A

A

S

R

R

G
|
G

I

I

G

G

A

Q

A

A

L

I

A

A

Q

L

R

E

L

L

A

G

A

R

D

L

G

G

M

A

A

V

V

V

A

I

A

G

V

T

D

A

L

T

S

S

A

A

D

S

A

G

C

A

S

E

D

K

V

I

V

A

E

E

A

T

I

L

T

K

A

A

A

N

G

G

G

V

T

E

A

G

R

A

A

G

Y

L

A

V

A

L

D

D

V

V

A

S

D

S

E

D

A

E

S

S

V

V

A

A

G

A

L

T

V

L

E

E

A

H

V

I

A

Q

E

H

L

L

G

G

P

Q

P

P

T

L

V

I

L

V

V

V

N

N

A

A

G

G

V

I

L

T

R

R

D

D

N

N

L

L

F

V

R

R

M

M

S

K

A

D

D

D

D

E

W

W

D

F

T

D

V

V

M
x
V

N

N

V

T

H

N

L
|
L

R

N

G

S

H

L

F

Y

L

R

M

L

S

S

R

K

A

A

V

V

Q

L

A

R

H

G

M

M

T

T

E

K

Q

A

G

R

W

W

G

G

R

R

I

I

V

I

N

N

I

I

S

G

S
|
S

T

V

S

V

A

G

L

-

G

G

N

N

R

A

G

G

Q

Q

A

T

N

N

Y
|
Y

A

A

K
|
K

A

A

G
|
G

I

L

Q

E

G
|
G

F
|
F

T

T

K

R

T

A

L

L

A

A

I

R

E

E

L

V

G

G

K

S

F

R

G

A

V

I

T

T

V

V

N

N

A

A

I

V

A

A

P

P

G

G

L

F

I

I

E

D

T

T

A

D

M

M

T

T

R

R

A

-

T

E

A

A

E

Q

R

R

M

-

G

-

V

-

P

-

Y

-

E

-

Q

-

F

-

V

-

E

E

K

A

A

L

Q

G

Q

Q

I

I

P

P

V

L

A

G

R

R

T

L

G

G

T

Q

P

A

E

E

D

E

I

I

A

A

A

K

A

V

S

G

F

F

F

L

A

A

R

S

E

D

D

G

A

A

S

A

F

Y

V

V

S

T

G

G

Q

A

V

T

L

V

Y

P

V

V

A

N

G

G

active site: G29 (= G16), S154 (= S141), Y165 (= Y153), K169 (= K157)
binding N-(2-methoxyphenyl)-3,4-dihydro-2H-quinoline-1-carboxamide: V123 (≠ M110), L127 (= L114), G171 (= G159), G174 (= G162), F175 (= F163)

4nbuB Crystal structure of fabg from bacillus sp (see paper)
45% identity, 97% coverage: 6:249/252 of query aligns to 8:241/244 of 4nbuB

query
sites
4nbuB

R

K

T

V

A

A

V

I

T

T

G
|
G

A

A

R
x
N

G
|
G

I
|
I

G

G

A

L

A

E

L

A

A

A

Q

R

R

V

L

F

A

M

A

K

D

E

G

G

M

A

A

K

V

V

A

V

A

I

V

A

D
|
D

L
x
F

S

N

A

E

D

A

A

A

C

G

S

K

D

E

V

A

V

V

E

E

A

A

I

-

T

-

A

-

G

N

G

P

T

G

A

V

R

V

A

F

Y

I

A

R

A
x
V

D
|
D

V
|
V

A

S

D

D

E

R

A

E

S

S

V

V

A

H

G

R

L

L

V

V

E

E

A

N

V

V

A

A

A

E

E

R

L

F

G

G

P

K

P

I

T

D

V

I

L

L

V

I

N

N

N
|
N

A
|
A

G
|
G

V
x
I

L

T

R

R

D
|
D

N

S

L

M

L

L

F

S

R
x
K

M

M

S

T

A

V

D

D

D

Q

W

F

D

Q

T

Q

V

V

M

I

N

N

V

V

H
x
N

L

L

R

T

G

G

H

V

F

F

L

H

M

C

S

T

R

Q

A

A

V

V

Q

L

A

P

H

Y

M

M

T

A

E

E

Q

Q

G

G

W

K

G

G

R

K

I

I

V

I

N

N

I
x
T

S

S

S
|
S

-

V

T

T

S

G

A

T

L

Y

G

G

N
|
N

R
x
V

G

G

Q
|
Q

A

T

N

N

Y
|
Y

A

A

K
|
K

A

A

G

G

I

V

Q

I

G

G

F

M

T

T

K

K

T

T

L

W

A

A

I

K

E

E

L

L

G

A

K

R

F

K

G

G

V

I

T

N

V

V

N

N

A

A

I

V

A

A

P
|
P

G

G

L
x
F

I
x
T

E

E

T
|
T

A

A

M
|
M

T

-

R

-

A

-

T

V

A

A

E

E

R

-

M

-

G

-

V

V

P

P

Y

-

E

E

Q

K

F

V

V

I

E

E

K
|
K

A

M

A

K

Q

A

Q

Q

I

V

P

P

V

M

A

G

R

R

T

L

G

G

T

K

P

P

E

E

D

D

I

I

A

A

A

N

A

A

A

Y

S

L

F

F

F

L

A

A

R

S

E

H

D

E

A

S

S

D

F

Y

V

V

S

N

G

G

Q

H

V

V

L

L

Y

H

V

V

A

D

G

G

active site: G18 (= G16), N111 (≠ H113), S139 (= S141), Q149 (= Q150), Y152 (= Y153), K156 (= K157)
binding acetoacetyl-coenzyme a: D93 (= D95), K98 (≠ R100), S139 (= S141), N146 (= N147), V147 (≠ R148), Q149 (= Q150), Y152 (= Y153), F184 (≠ L185), M189 (= M190), K200 (= K208)
binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G12), N17 (≠ R15), G18 (= G16), I19 (= I17), D38 (= D36), F39 (≠ L37), V59 (≠ A61), D60 (= D62), V61 (= V63), N87 (= N89), A88 (= A90), G89 (= G91), I90 (≠ V92), T137 (≠ I139), S139 (= S141), Y152 (= Y153), K156 (= K157), P182 (= P183), F184 (≠ L185), T185 (≠ I186), T187 (= T188), M189 (= M190)

3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
42% identity, 99% coverage: 1:249/252 of query aligns to 4:243/247 of 3op4A

query
sites
3op4A

M

M

T

N

T

L

H

E

Q

G

R

K

T

V

A

A

V

L

V

V

T

T

G
|
G

A

A

A
x
S

R
|
R

G

G

I
|
I

G

G

A

K

A

A

L

I

A

A

Q

E

R

L

L

L

A

A

A

E

D

R

G

G

M

A

A

K

V

V

-

I

-

G

-

T

A

A

A
x
T

V

S

D

E

L

S

S

G

A

A

D

Q

A

A

C

I

S

S

D

D

V

Y

V

L

E

-

A

-

I

-

T

-

A

-

G

G

G

D

T

N

A

G

R

K

A

G

Y

M

A

A

A

L

D
x
N

V
|
V

A

T

D

N

E

P

A

E

S

S

V

I

A

E

G

A

L

V

V

L

E

K

A

A

V

I

A

T

A

D

E

E

L

F

G

G

P

G

P

V

T

D

V

I

L

L

V

V

N

N

N
|
N

A
|
A

G

G

V
x
I

L

T

R

R

D

D

N

N

L

L

F

M

R

R

M

M

S

K

A

E

D

E

W

W

D

S

T

D

V

I

M

M

N

E

V

T

H

N

L

L

R

T

G

S

H

I

F

F

L

R

M

L

S

S

R

K

A

A

V

V

Q

L

A

R

H

G

M

M

T

M

E

K

Q

K

G

R

W

Q

G

G

R

R

I

I

V

I

N

N

I
x
V

S

G

S
|
S

-

V

T

V

S

G

A

T

L

M

G

G

N

N

R

A

G

G

Q

Q

A

A

N

N

Y
|
Y

A

A

K
|
K

A

A

G

G

I

V

Q

I

G

G

F

F

T

T

K

K

T

S

L

M

A

A

I

R

E

E

L

V

G

A

K

S

F

R

G

G

V

V

T

T

V

V

N

N

A

T

I

V

A

A

P
|
P

G
|
G

L

F

I
|
I

E

E

T
|
T

A

D

M
|
M

T

T

R

K

A

A

T

L

A

N

E

D

R

-

M

-

G

-

V

-

P

-

Y

-

E

E

Q

Q

F

R

V

T

E

A

K

T

A

L

A

A

Q

-

Q

Q

I

V

P

P

V

A

A

G

R

R

T

L

G

G

T

D

P

P

E

R

D

E

I

I

A

A

A

S

A

A

A

V

S

A

F

F

F

L

A

A

R

S

E

P

D

E

A

A

S

A

F

Y

V

I

S

T

G

G

Q

E

V

T

L

L

Y

H

V

V

A

N

G

G

binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G12), S17 (≠ A14), R18 (= R15), I20 (= I17), T40 (≠ A34), N62 (≠ D62), V63 (= V63), N89 (= N89), A90 (= A90), I92 (≠ V92), V139 (≠ I139), S141 (= S141), Y154 (= Y153), K158 (= K157), P184 (= P183), G185 (= G184), I187 (= I186), T189 (= T188), M191 (= M190)

7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
42% identity, 99% coverage: 1:249/252 of query aligns to 4:244/247 of 7tzpG

query
sites
7tzpG

M

M

T

K

T

L

H

A

Q

S

R

K

T

T

A

A

V

I

V

V

T

T

G
|
G

A

A

R
|
R

G
|
G

I
|
I

G

G

A

F

A

G

L

I

A

A

Q

Q

R

V

L

L

A

A

A

R

D

E

G

G

M

A

A

R

V

V

A

I

V

A

D
|
D

L
x
R

S

D

A

A

D

H

A

G

C

-

S

E

D

A

V

A

E

A

A

S

I

L

T

R

A

E

A

S

G

G

G

A

T

Q

A

A

R

L

A

F

Y

I

A

S

A
x
C

D

N

V
x
I

A

A

D

E

E

K

A

T

S

Q

V

V

A

E

G

A

L

L

V

F

E

S

A

Q

V

A

A

E

E

A

L

F

G

G

P

P

P

V

T

D

V

I

L

L

V

V

N

N

N
|
N

A

A

G
|
G

V
x
I

L

N

R

R

D

D

N

A

L

M

L

L

F

H

R

K

M

L

S

T

A

E

D

A

D

D

W

W

D

D

T

T

V

V

M

I

N

D

V
|
V

H

N

L

L

R

K

G

G

H

T

F

F

L

L

M

C

S

M

R

Q

A

Q

V

A

Q

A

A

I

H

R

M

M

T

R

E

E

Q

R

G

G

W

A

G

G

R

R

I

I

V

I

N

N

I

I

S

A

S

S

T

A

S

S

A

W

L

L

G

G

N

N

R

V

G

G

Q

Q

A

T

N

N

Y
|
Y

A

S

A

A

A

S

K
|
K

A

A

G

G

I

V

Q

V

G

G

F

M

T

T

K

K

T

T

L

A

A

C

I

R

E

E

L

L

G

A

K

K

F

K

G

G

V

V

T

T

V

V

N

N

A

A

I

I

A

C

P

P

G

G

L

F

I
|
I

E

D

T
|
T

A

D

M

M

T
|
T

R

R

A

-

T

-

A

-

E

-

R

-

M

-

G

G

V

V

P

P

Y

-

E

E

Q

N

F

V

V

W

E

Q

K

I

A

M

A

V

Q

S

Q

K

I

I

P

P

V

A

A

G

R

Y

T

A

G

G

T

E

P

A

E

K

D

D

I

V

A

G

A

E

A

C

A

V

S

A

F

F

F

L

A

A

R

S

E

D

D

G

A

A

S

R

F

Y

V

I

S

N

G

G

Q

E

V

V

L

I

Y

N

V

V

A

G

G

G

binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G12), R18 (= R15), G19 (= G16), I20 (= I17), D39 (= D36), R40 (≠ L37), C63 (≠ A61), I65 (≠ V63), N91 (= N89), G93 (= G91), I94 (≠ V92), V114 (= V112), Y155 (= Y153), K159 (= K157), I188 (= I186), T190 (= T188), T193 (= T191)

P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
42% identity, 99% coverage: 1:249/252 of query aligns to 1:240/244 of P0AEK2

query
sites
P0AEK2

M

M

T

N

T

F

H

E

Q

G

R

K

T

I

A

A

V

L

V

V

T

T

G
|
G

A
|
A

A
x
S

R
|
R

G

G

I

I

G

G

A

R

A

A

L

I

A

A

Q

E

R

T

L

L

A

A

D

R

G

G

M

A

A

K

V

V

-

I

-

G

-

T

A

A

A
x
T

V

S

D

E

L

N

S

G

A

A

D

Q

A

A

C

I

S

S

D

D

V

Y

V

L

E

-

A

-

I

-

T

-

A

-

G

G

G

A

T

N

A

G

R

K

A

G

Y

L

A

M

A

L

D
x
N

V
|
V

A

T

D

D

E

P

A

A

S

S

V

I

A

E

G

S

L

V

V

L

E

E

A

K

V

I

A

R

A

A

E

E

L

F

G

G

P

E

P

V

T

D

V

I

L

L

V

V

N

N

N
|
N

A

A

G

G

V

I

L

T

R

R

D

D

N

N

L

L

F

M

R

R

M

M

S

K

A

D

D

E

W

W

D

N

T

D

V

I

M

I

N

E

V

T

H

N

L

L

R

S

G

S

H

V

F

F

L

R

M

L

S

S

R

K

A

A

V

V

Q

M

A

R

H

A

M

M

T

M

E

K

Q

K

G

R

W

H

G

G

R

R

I

I

V

I

N

T

I

I

S

G

S

S

-

V

T

V

S

G

A

T

L

M

G

G

N

N

R

G

G

G

Q

Q

A

A

N

N

Y
|
Y

A
|
A

K
|
K

A

A

G

G

I

L

Q

I

G

G

F

F

T

S

K

K

T

S

L

L

A

A

I

R

E

E

L

V

G

A

K

S

F

R

G

G

V

I

T

T

V

V

N

N

A

V

I

V

A

A

P

P

G

G

L

F

I
|
I

E

E

T

T

A

D

M

M

T

T

R

R

A

A

T

L

A

S

-

D

E

Q

R

R

M

A

G

G

V

I

P

-

Y

-

E

-

Q

-

F

-

V

-

E

-

K

-

A

-

A

L

Q

A

Q

Q

I

V

P

P

V

A

A

G

R

R

T

L

G

G

T

G

P

A

E

Q

D

E

I

I

A

A

A

N

A

A

A

V

S

A

F

F

F

L

A

A

R

S

E

D

D

E

A

A

S

A

F

Y

V

I

S

T

G

G

Q
x
E

V

T

L

L

Y

H

V

V

A

N

G

G

GASR 12:15 (≠ GAAR 12:15) binding NADP(+)
T37 (≠ A34) binding NADP(+)
NV 59:60 (≠ DV 62:63) binding NADP(+)
N86 (= N89) binding NADP(+)
Y151 (= Y153) mutation to F: Defect in the affinity for NADPH.
YAAAK 151:155 (= YAAAK 153:157) binding NADP(+)
A154 (= A156) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
K155 (= K157) mutation to A: Defect in the affinity for NADPH.
I184 (= I186) binding NADP(+)
E233 (≠ Q242) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.

3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
43% identity, 97% coverage: 6:249/252 of query aligns to 5:243/246 of 3osuA

query
sites
3osuA

R

K

T

S

A

A

V

L

V

V

T

T

G

G

A

A

A

S

R

R

G
|
G

I

I

G

G

A

R

A

S

L

I

A

A

Q

L

R

Q

L

L

A

A

A

E

D

E

G

G

M

Y

A

N

V

V

A

A

A

-

V

V

D

N

L

Y

-

A

-

G

S

S

A

K

D

E

A

K

C

A

S

E

D

A

V

V

E

E

A

E

I

I

T

K

A

A

A

K

G

G

G

V

T

D

A

S

R

F

A

A

Y

I

A

Q

A

A

D

N

V

V

A

A

D

D

E

A

A

D

S

E

V

V

A

K

G

A

L

M

V

I

E

K

A

E

V

V

A

V

A

S

E

Q

L

F

G

G

P

S

P

L

T

D

V

V

L

L

V

V

N

N

N
|
N

A

A

G

G

V

I

L

T

R

R

D

D

N

N

L

L

F

M

R

R

M

M

S

K

A

E

D

Q

D

E

W

W

D

D

T

D

V

V

M

I

N

D

V

T

H

N

L

L

R

K

G

G

H

V

F

F

L

N

M

C

S

I

R

Q

A

K

V

A

Q

T

A

P

H

Q

M

M

T

L

E

R

Q

Q

G

R

W

S

G

G

R

A

I

I

V

I

N

N

I

L

S

S

S
|
S

-

V

T

V

S

G

A

A

L

V

G

G

N

N

R

P

G

G

Q
|
Q

A

A

N

N

Y
|
Y

A

V

A

A

A

T

K
|
K

A

A

G

G

I

V

Q

I

G

G

F

L

T

T

K

K

T

S

L

A

A

A

I

R

E

E

L

L

G

A

K

S

F

R

G

G

V

I

T

T

V

V

N

N

A

A

I

V

A

A

P

P

G

G

L

F

I

I

E

V

T

S

A

D

M

M

T

T

R

D

A

A

T

L

A

S

E

D

R

E

M

L

G

K

V

-

P

-

Y

-

E

-

Q

-

F

-

V

-

E

E

K

Q

A

M

A

L

Q

T

Q

Q

I

I

P

P

V

L

A

A

R

R

T

F

G

G

T

Q

P

D

E

T

D

D

I

I

A

A

A

N

A

T

A

V

S

A

F

F

F

L

A

A

R

S

E

D

D

K

A

A

S

K

F

Y

V

I

S

T

G

G

Q

Q

V

T

L

I

Y

H

V

V

A

N

G

G

active site: G15 (= G16), S141 (= S141), Q151 (= Q150), Y154 (= Y153), K158 (= K157)
binding magnesium ion: N89 (= N89), K158 (= K157)

5vt6A Crystal structure of acetoacetyl-coa reductase from burkholderia pseudomallei 1710b complexed with NADP
45% identity, 97% coverage: 5:249/252 of query aligns to 1:241/245 of 5vt6A

query
sites
5vt6A

Q

K

R

R

T

V

A

A

V

F

V

V

T

T

G
|
G

A

G

A

M

R
x
G

G
|
G

I
x
L

G

G

A

A

L

I

A

S

Q

R

R

R

L

L

A

H

A

D

D

A

G

G

M

M

A

A

V

V

A

A

A

V

V

S

D
x
H

L
x
S

S

E

-

R

A
x
N

D

D

A

H

C

V

S

S

D

T

V

W

V

L

E

M

A

H

I

E

T

R

A

D

A

A

G

G

G

R

T

D

A

F

R

K

A

A

Y

Y

A

A

A
x
V

D
|
D

V
|
V

A

A

D

D

E

F

A

E

S

S

V

C

A

E

G

R

L

C

V

A

E

E

A

K

V

V

A

L

A

A

E

D

L

F

G

G

P

K

P

V

T

D

V

V

L

L

V

I

N

N

N
|
N

A
|
A

G
|
G

V
x
I

L

T

R

R

D

D

N

A

L

T

L

F

F

M

R

K

M

M

S

T

A

K

D

G

D
|
D

W

W

D

D

T

A

V

V

M

M

N

R

V

T

H

D

L

L

R

D

G

A

H

M

F

F

L

N

M

V

S

T

R

K

A

Q

V

F

Q

I

A

A

H

G

M

M

T

V

E

E

Q

R

G

R

W

F

G

G

R

R

I

I

V

V

N

N

I
|
I

S

G

S
|
S

T

V

S

N

-

G

A

S

L

R

G

G

N

A

R

F

G

G

Q

Q

A

A

N

N

Y
|
Y

A

A

A

S

A

A

K
|
K

A

A

G

G

I

I

Q

H

G

G

F

F

T

T

K

K

T

T

L

L

A

A

I

L

E

E

L

T

G

A

K

K

F

R

G

G

V

I

T

T

V

V

N

N

A

T

I

V

A

S

P
|
P

G

G

L
x
Y

I
x
L

E

A

T
|
T

A

A

M

M

T

V

R

E

A

A

T

-

A

-

E

-

R

-

M

-

G

-

V

V

P

P

Y

Q

E

D

Q

V

F

L

V

E

E

A

K

K

A

I

A

L

Q

P

Q

Q

I

I

P

P

V

V

A

G

R

R

T

L

G

G

T

R

P

P

E

D

D

E

I

V

A

A

A

L

A

I

S

A

F

F

F

L

A

C

R

S

E

D

D

D

A

A

S

G

F

F

V

V

S

T

G

G

Q

A

V

D

L

L

Y

A

V

I

A

N

G

G

active site: G12 (= G16), D102 (= D105), S138 (= S141), Y151 (= Y153), K155 (= K157)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G12), G11 (≠ R15), G12 (= G16), L13 (≠ I17), H32 (≠ D36), S33 (≠ L37), N36 (≠ A39), V58 (≠ A61), D59 (= D62), V60 (= V63), N86 (= N89), A87 (= A90), G88 (= G91), I89 (≠ V92), I136 (= I139), Y151 (= Y153), K155 (= K157), P181 (= P183), Y183 (≠ L185), L184 (≠ I186), T186 (= T188)

1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
42% identity, 97% coverage: 6:249/252 of query aligns to 5:239/243 of 1q7bA

query
sites
1q7bA

R

K

T

I

A

A

V

L

V

V

T

T

G
|
G

A

A

A
x
S

R
|
R

G
|
G

I

I

G

G

A

R

A

A

L

I

A

A

Q

E

R

T

L

L

A

A

D

R

G

G

M

A

A

K

V

V

-

I

-

G

-

T

A

A

A
x
T

V

S

D

E

L

N

S

G

A

A

D

Q

A

A

C

I

S

S

D

D

V

Y

V

L

E

-

A

-

I

-

T

-

A

-

G

G

G

A

T

N

A

G

R

K

A

G

Y

L

A

M

A

L

D
x
N

V
|
V

A

T

D

D

E

P

A

A

S

S

V

I

A

E

G

S

L

V

V

L

E

E

A

K

V

I

A

R

A

A

E

E

L

F

G

G

P

E

P

V

T

D

V

I

L

L

V

V

N

N

N
|
N

A
|
A

G
|
G

V
x
I

L

T

R

R

D

D

N

N

L

L

F

M

R

R

M

M

S

K

A

D

D

E

D
x
E

W

W

D

N

T

D

V

I

M

I

N

E

V

T

H

N

L

L

R

S

G

S

H

V

F

F

L

R

M

L

S

S

R

K

A

A

V

V

Q

M

A

R

H

A

M

M

T

M

E

K

Q

K

G

R

W

H

G

G

R

R

I

I

V

I

N

T

I

I

S

G

S
|
S

-

V

T

V

S

G

A

T

L

M

G

G

N

N

R

G

G

G

Q
|
Q

A

A

N

N

Y
|
Y

A

A

K
|
K

A

A

G

G

I

L

Q

I

G

G

F

F

T

S

K

K

T

S

L

L

A

A

I

R

E

E

L

V

G

A

K

S

F

R

G

G

V

I

T

T

V

V

N

N

A

V

I

V

A

A

P
|
P

G
|
G

L

F

I
|
I

E

E

T

T

A

D

M

M

T

T

R

R

A

A

T

L

A

S

-

D

E

Q

R

R

M

A

G

G

V

I

P

-

Y

-

E

-

Q

-

F

-

V

-

E

-

K

-

A

-

A

L

Q

A

Q

Q

I

V

P

P

V

A

A

G

R

R

T

L

G

G

T

G

P

A

E

Q

D

E

I

I

A

A

A

N

A

A

A

V

S

A

F

F

F

L

A

A

R

S

E

D

D

E

A

A

S

A

F

Y

V

I

S

T

G

G

Q
x
E

V
x
T

L

L

Y

H

V

V

A

N

G

G

active site: G15 (= G16), E101 (≠ D105), S137 (= S141), Q147 (= Q150), Y150 (= Y153), K154 (= K157)
binding calcium ion: E232 (≠ Q242), T233 (≠ V243)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G12), S13 (≠ A14), R14 (= R15), T36 (≠ A34), N58 (≠ D62), V59 (= V63), N85 (= N89), A86 (= A90), G87 (= G91), I88 (≠ V92), S137 (= S141), Y150 (= Y153), K154 (= K157), P180 (= P183), G181 (= G184), I183 (= I186)

1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
42% identity, 97% coverage: 6:249/252 of query aligns to 5:239/243 of 1q7cA

query
sites
1q7cA

R

K

T

I

A

A

V

L

V

V

T

T

G
|
G

A

A

A
x
S

R
|
R

G
|
G

I

I

G

G

A

R

A

A

L

I

A

A

Q

E

R

T

L

L

A

A

D

R

G

G

M

A

A

K

V

V

-

I

-

G

-

T

A
|
A

A
x
T

V

S

D

E

L

N

S

G

A

A

D

Q

A

A

C

I

S

S

D

D

V

Y

V

L

E

-

A

-

I

-

T

-

A

-

G

G

G

A

T

N

A

G

R

K

A

G

Y

L

A

M

A
x
L

D
x
N

V
|
V

A

T

D

D

E

P

A

A

S

S

V

I

A

E

G

S

L

V

V

L

E

E

A

K

V

I

A

R

A

A

E

E

L

F

G

G

P

E

P

V

T

D

V

I

L

L

V

V

N

N

A

A

G
|
G

V
x
I

L

T

R

R

D

D

N

N

L

L

F

M

R

R

M

M

S

K

A

D

D

E

W

W

D

N

T

D

V

I

M

I

N

E

V

T

H

N

L

L

R

S

G

S

H

V

F

F

L

R

M

L

S

S

R

K

A

A

V

V

Q

M

A

R

H

A

M

M

T

M

E

K

Q

K

G

R

W

H

G

G

R

R

I

I

V

I

N

T

I

I

S

G

S
|
S

-

V

T

V

S

G

A

T

L

M

G

G

N

N

R

G

G

G

Q
|
Q

A

A

N

N

Y
x
F

A

A

K
|
K

A

A

G

G

I

L

Q

I

G

G

F

F

T

S

K

K

T

S

L

L

A

A

I

R

E

E

L

V

G

A

K

S

F

R

G

G

V

I

T

T

V

V

N

N

A

V

I

V

A

A

P

P

G

G

L

F

I

I

E

E

T

T

A

D

M

M

T

T

R

R

A

A

T

L

A

S

-

D

E

Q

R

R

M

A

G

G

V

I

P

-

Y

-

E

-

Q

-

F

-

V

-

E

-

K

-

A

-

A

L

Q

A

Q

Q

I

V

P

P

V

A

A

G

R

R

T

L

G

G

T

G

P

A

E

Q

D

E

I

I

A

A

A

N

A

A