Comparing WP_064573828.1 NCBI__GCF_001655005.1:WP_064573828.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 7 hits to proteins with known functional sites (download)
P00946 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Escherichia coli (strain K12) (see paper)
67% identity, 100% coverage: 1:391/391 of query aligns to 1:391/391 of P00946
3h1yA Crystal structure of mannose 6-phosphate isomerase from salmonella typhimurium bound to substrate (f6p)and metal atom (zn)
66% identity, 100% coverage: 1:391/391 of query aligns to 3:391/391 of 3h1yA
3h1mA Crystal structure of mannose 6-phosphate isomerase (holo; zinc bound)
66% identity, 100% coverage: 1:391/391 of query aligns to 3:392/392 of 3h1mA
P29952 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
32% identity, 91% coverage: 9:364/391 of query aligns to 13:399/429 of P29952
Sites not aligning to the query:
P34948 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
31% identity, 94% coverage: 9:374/391 of query aligns to 14:426/441 of P34948
5nw7A Crystal structure of candida albicans phosphomannose isomerase in complex with inhibitor (see paper)
31% identity, 94% coverage: 9:374/391 of query aligns to 13:425/440 of 5nw7A
1zx5A The structure of a putative mannosephosphate isomerase from archaeoglobus fulgidus
35% identity, 24% coverage: 13:106/391 of query aligns to 20:108/300 of 1zx5A
Sites not aligning to the query:
>WP_064573828.1 NCBI__GCF_001655005.1:WP_064573828.1
MQKMINAVQNYAWGSHDALSNLYGFPNPDNKPMAELWMGAHPLSSSMVLDKNGHKVSLRD
EIAKDLNGNLGNAVAKRFGELPFLFKVLCAAQPLSIQVHPSKHAAEEGFAREESAGIAIN
AANRNYKDPNHKPELVYALTPFKAMNGFRELTEIAQLLQPVADAHPDIAQFIQHPDEQHL
AALFGNLLSMTGEQKAHALSVLAEALNHQQGSAWDAIRSIAQVYPDDSGLFSPLLLNTIE
LTPGQSMFLYAETPHAYLNGVGLEIMANSDNVLRAGLTPKYIDVPELLANVKFVPKPANS
LLTTPIITGNETRFPIPVEDFAFAVHTLTDAPQSLAQESAAVLFCIEGEATLSKGEQRIT
LAPGESCYLPANESPVIAQGHGQLARVFNEL
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory