Comparing WP_066326687.1 NCBI__GCF_900100165.1:WP_066326687.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 11 hits to proteins with known functional sites (download)
1wa3D Mechanism of the class i kdpg aldolase (see paper)
37% identity, 85% coverage: 13:202/223 of query aligns to 6:190/203 of 1wa3D
1euaA Schiff base intermediate in kdpg aldolase from escherichia coli (see paper)
28% identity, 84% coverage: 27:214/223 of query aligns to 26:208/213 of 1euaA
P0A955 KHG/KDPG aldolase; (4S)-4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG aldolase; 2-keto-4-hydroxyglutarate aldolase; KHG aldolase; Ketohydroxyglutarate aldolase; Entner-Douderoff aldolase; Oxaloacetate decarboxylase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase; EC 4.1.3.42; EC 4.1.2.14; EC 4.1.1.112 from Escherichia coli (strain K12) (see 5 papers)
28% identity, 84% coverage: 27:214/223 of query aligns to 26:208/213 of P0A955
3vcrA Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica (see paper)
29% identity, 89% coverage: 18:216/223 of query aligns to 14:213/216 of 3vcrA
2c0aB Mechanism of the class i kdpg aldolase (see paper)
28% identity, 84% coverage: 27:214/223 of query aligns to 27:209/214 of 2c0aB
Sites not aligning to the query:
1wauA Structure of kdpg aldolase e45n mutant (see paper)
28% identity, 84% coverage: 27:214/223 of query aligns to 26:208/213 of 1wauA
2v82A Kdpgal complexed to kdpgal (see paper)
34% identity, 55% coverage: 73:195/223 of query aligns to 60:181/205 of 2v82A
Sites not aligning to the query:
Q6BF16 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal aldolase; EC 4.1.2.21 from Escherichia coli (strain K12) (see paper)
34% identity, 55% coverage: 73:195/223 of query aligns to 61:182/205 of Q6BF16
Sites not aligning to the query:
1mxsA Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. (see paper)
31% identity, 80% coverage: 40:217/223 of query aligns to 41:213/216 of 1mxsA
5xsfA Crystal structure of the 2-keto-3-deoxy-6-phosphogluconate aldolase of zymomonas mobilis zm4 with 3-phosphoglycerate
26% identity, 93% coverage: 8:215/223 of query aligns to 4:202/209 of 5xsfA
6oviA Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate
24% identity, 86% coverage: 18:208/223 of query aligns to 14:199/210 of 6oviA
>WP_066326687.1 NCBI__GCF_900100165.1:WP_066326687.1
MAQFTRIEVATAMKETGMIPLFFSNDLELSKNVLKACYDGGARLMEFTARGDFAHEVFAE
LTKYAIKELPGMIMGVGSVTDAAAASLYMQLGANFIVTPVFREDIAIACNRRKVLWSPGC
GTLSEIARAEELGCEIVKLFPGEIYGPQFIKGVKGPCPWTNIMPTGGVSTERDNLKSWFD
AGAYCVGIGSQLISASVLQSRDYEGLTQKVKETIAIIADLRKK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory