SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_066328701.1 NCBI__GCF_900100165.1:WP_066328701.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 9 hits to proteins with known functional sites (download)

3gggD The crystal structure of a. Aeolicus prephenate dehydrogenase in complex with tyrosine and NAD+ (see paper)
33% identity, 95% coverage: 3:272/285 of query aligns to 16:287/293 of 3gggD

query
sites
3gggD

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binding nicotinamide-adenine-dinucleotide: V21 (≠ I8), G22 (= G9), F23 (≠ L10), M24 (≠ I11), D45 (= D32), I46 (≠ N33), S50 (≠ H37), S81 (= S65), S82 (≠ V66), P83 (= P67), V84 (= V68), T86 (≠ V70), Q107 (≠ V91), S109 (= S93), G134 (= G119), T135 (= T120)
binding tyrosine: G225 (= G210), G226 (≠ S211)

3ggoA Crystal structure of prephenate dehydrogenase from a. Aeolicus with hpp and nadh (see paper)
33% identity, 95% coverage: 3:272/285 of query aligns to 8:279/285 of 3ggoA

query
sites
3ggoA

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binding 3-(4-hydroxy-phenyl)pyruvic acid: G217 (= G210), G218 (≠ S211), G219 (= G212)
binding 1,4-dihydronicotinamide adenine dinucleotide: V13 (≠ I8), G14 (= G9), F15 (≠ L10), M16 (≠ I11), D37 (= D32), I38 (≠ N33), S42 (≠ H37), S73 (= S65), S74 (≠ V66), P75 (= P67), T78 (≠ V70), Q99 (≠ V91), S101 (= S93), A125 (= A118), G131 (= G124), M233 (= M226)

3ggpA Crystal structure of prephenate dehydrogenase from a. Aeolicus in complex with hydroxyphenyl propionate and NAD+ (see paper)
33% identity, 95% coverage: 3:272/285 of query aligns to 8:279/286 of 3ggpA

query
sites
3ggpA

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binding hydroxyphenyl propionic acid: G218 (≠ S211), G219 (= G212)
binding nicotinamide-adenine-dinucleotide: V13 (≠ I8), G14 (= G9), F15 (≠ L10), M16 (≠ I11), D37 (= D32), I38 (≠ N33), S42 (≠ H37), S73 (= S65), S74 (≠ V66), P75 (= P67), T78 (≠ V70), Q99 (≠ V91), S101 (= S93), G131 (= G124), M233 (= M226)

4wjiA Crystal structure of cyclohexadienyl dehydrogenase from sinorhizobium meliloti in complex with NADP and tyrosine
34% identity, 96% coverage: 3:276/285 of query aligns to 7:284/293 of 4wjiA

query
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4wjiA

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binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G7), G13 (= G9), L14 (= L10), I15 (= I11), T36 (≠ D32), R37 (≠ N33), S38 (≠ N34), T41 (≠ H37), S71 (= S65), V72 (= V66), P73 (= P67), A76 (≠ V70), V97 (= V91), S99 (= S93), A125 (= A118), S130 (= S123), M234 (= M226)
binding tyrosine: S99 (= S93), H122 (= H115), A125 (= A118), T127 (= T120), R226 (= R218)

6u60B Crystal structure of prephenate dehydrogenase tyra from bacillus anthracis in complex with NAD and l-tyrosine (see paper)
31% identity, 97% coverage: 2:278/285 of query aligns to 3:282/365 of 6u60B

query
sites
6u60B

K

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L

L

G

H

V

V

I

V

D

D

-

E

V

I

A

A

A

V

T

D

M

L

E

Q

D

H

-

A

L

C

S

E

E

E

A

A

D

H

F

L

V

I

I

V

V

F

S
x
A

V

S

P
|
P

V

V

N

E

V
x
E

A

T

I

K

G

K

L

L

L

L

P

H

K

K

V

L

L

A

D

S

L

F

-

H

V

L

G

R

D

E

N

D

A

V

I

I

V

V

F

T

E

D

V
|
V

G

G

S
|
S

T

T

K

K

N

G

P

S

I

I

C

M

-

N

Q

E

A

A

I

E

A

A

N

L

H

F

P

S

K

K

R

E

R

I

N

S

F

F

I

I

A

G

T

G

H

H

P

P

I

M

A

A

G

G

T

S

E

H

F
x
K

S

T

G
|
G

P

V

S

E

A

S

A

A

L

K

R

A

D

H

L

L

F

F

R

E

G

N

K

A

T

F

N

Y

I

I

I

L

C

T

E

P

V

M

E

H

K

H

T

V

A

P

F

N

K

E

L

H

Q

V

E

E

K

E

A

L

L

K

E

D

V

W

F

L

N

K

K

G

M

T

G

G

M

S

R

H

I

F

R

L

Y

V

M

L

D

N

P

T

K

E

S

E

H

H

D

D

K

Y

H

V

I

T

A

G

Y

I

V

V

S

S

H

H

L

F

S

P

H

H

I

L

S

I

S

A

F

A

M

G

L

L

G

V

K

K

T

Q

V

V

I

E

N

K

K

H

E

A

K

G

D

D

E

N

Q

P

D

L

I

I

F

H

D

Q

M

L

A

A

G

A

S

G

G

G

F

F

E

K

S

D

T

I

V

T

R

R

L

I

A

A

K

S

S

S

S

S

P

P

A

K

M

M

W

W

T

S

P

D

I

I

F

V

E

K

Q

Q

N

N

K

R

T

E

Q

H

V

L

L

M

E

V

S

L

L

L

E

K

E

E

Y

W

I

I

S

S

N

E

L

M

T

E

Q

D

F

L

R

Y

D

D

L

T

L

V

A

S

Q

S

D

G

D

D

Y

A

N

G

A

E

I

I

Y

Q

E

N

E

Y

M

F

A

A

S

D

V

A

N

K

K

E

I

Y

R

R

E

D

I

S

L

L

binding nicotinamide-adenine-dinucleotide: G10 (= G9), L11 (= L10), I12 (= I11), D32 (= D32), I33 (≠ N33), A67 (≠ S65), P69 (= P67), E72 (≠ V70), V94 (= V91), S96 (= S93), G128 (= G124)
binding tyrosine: K126 (≠ F122)

Sites not aligning to the query:

binding tyrosine: 301, 302, 303, 306, 307, 320, 321

5uyyA Crystal structure of prephenate dehydrogenase tyra from bacillus anthracis in complex with l-tyrosine (see paper)
31% identity, 97% coverage: 2:278/285 of query aligns to 11:290/373 of 5uyyA

query
sites
5uyyA

K

K

V

V

F

V

V

L

I

I

G

G

I

T

G

G

L

L

I

I

G

G

G

G

S

S

M

L

V

A

L

L

D

A

I

I

K

K

A

K

L

D

Y

H

P

D

G

-

A

V

T

T

I

I

Y

T

G

G

I

Y

D

D

N

I

N

F

E

Q

K

E

H

Q

L

V

Q

E

Q

R

A

A

L

K

E

E

L

L

G

H

V

V

I

V

D

D

-

E

V

I

A

A

A

V

T

D

M

L

E

Q

D

H

-

A

L

C

S

E

E

E

A

A

D

H

F

L

V

I

I

V

V

F

S

A

V

S

P

P

V

V

N

E

V

E

A

T

I

K

G

K

L

L

L

L

P

H

K

K

V

L

L

A

D

S

L

F

-

H

V

L

G

R

D

E

N

D

A

V

I

I

V

V

F

T

E

D

V

V

G

G

S

S

T

T

K

K

N

G

P

S

I

I

C

M

-

N

Q

E

A

A

I

E

A

A

N

L

H

F

P

S

K

K

R

E

R

I

N

S

F

F

I

I

A

G

T

G

H

H

P

P

I

M

A

A

G

G

T

S

E

H

F

K

S

T

G

G

P

V

S

E

A

S

A

A

L

K

R

A

D

H

L

L

F

F

R

E

G
x
N

K

A

T

F

N

Y

I

I

I

L

C

T

E

P

V

M

E

H

K

H

T

V

A

P

F

N

K

E

L

H

Q

V

E

E

K

E

A

L

L

K

E

D

V

W

F

L

N

K

K

G

M

T

G

G

M

S

R

H

I

F

R

L

Y

V

M

L

D

N

P

T

K

E

S

E

H

H

D

D

K

Y

H

V

I

T

A

G

Y

I

V

V

S

S

H

H

L

F

S

P

H

H

I

L

S

I

S

A

F

A

M

G

L

L

G

V

K

K

T

Q

V

V

I

E

N

K

K

H

E

A

K

G

D

D

E

N

Q

P

D

L

I

I

F

H

D

Q

M

L

A

A

G

A

S

G

G

G

F

F

E

K

S

D

T

I

V

T

R

R

L

I

A

A

K

S

S

S

S

S

P

P

A

K

M

M

W

W

T

S

P

D

I

I

F

V

E

K

Q

Q

N

N

K

R

T

E

Q

H

V

L

L

M

E

V

S

L

L

L

E

K

E

E

Y

W

I

I

S

S

N

E

L

M

T

E

Q

D

F

L

R

Y

D

D

L

T

L

V

A

S

Q

S

D

G

D

D

Y

A

N

G

A

E

I

I

Y

Q

E

N

E

Y

M

F

A

A

S

D

V

A

N

K

K

E

I

Y

R

R

E

D

I

S

L

L

binding tyrosine: N147 (≠ G135)

Sites not aligning to the query:

binding tyrosine: 309, 310, 311, 314, 315, 329, 336, 343

3b1fA Crystal structure of prephenate dehydrogenase from streptococcus mutans (see paper)
29% identity, 96% coverage: 3:277/285 of query aligns to 9:281/286 of 3b1fA

query
sites
3b1fA

V

I

F

Y

V

I

I

A

G

G

I

L

G
|
G

L
|
L

I
|
I

G

G

G

A

S

S

M

L

V

A

L

L

D

G

I

I

K

K

A

R

L

D

Y

H

P

P

G

H

A

Y

T

K

I

I

Y

V

G

G

I

Y

D
x
N

N
x
R

N

S

E

D

K

R

H

S

L

R

Q

D

Q

I

A

A

L

L

E

E

L

R

G

G

V

I

I

V

D

D

V

E

A

A

A

T

T

A

M

D

E

F

D

K

L

V

-

F

-

A

S

A

E

L

A

A

D

D

F

V

V

I

I

I

V

L

S

A

V

V

P
|
P

V

I

N

K

V
x
K

A

T

I

I

G

D

L

F

L

I

P

K

K

I

V

L

L

A

D

D

L

L

-

D

V

L

G

K

D

E

N

D

A

V

I

I

V

I

F

T

E

D

V
x
A

G

G

S
|
S

T

T

K

K

N

Y

P

E

I

I

C

V

Q

R

A

A

I

A

A

E

N

Y

H

Y

P

L

K

K

R

D

R

K

-

P

-

V

N

Q

F

F

I

V

A

G

T

S

H

H

P

P

I

M

A

A

G

-

T

-

E

-

F

-

S

S

G

G

P

A

S

V

A

A

A

A

L

N

R

V

D

N

L

L

F

F

R

E

G

N

K

A

T

Y

N

Y

I

I

I

F

-

S

-

P

-

S

C

C

E

L

V

T

E

K

K

P

T

N

A

T

F

I

K

P

L

A

Q

L

E

Q

K

D

A

L

L

L

E

S

V

-

F

-

N

-

K

-

M

-

G

G

M

L

R

H

I

A

R

R

Y

Y

-

V

-

E

M

I

D

D

P

A

K

A

S

E

H

H

D

D

K

C

H

V

I

T

A

S

Y

Q

V

I

S

S

H

H

L

F

S

P

H

H

I

I

S

I

S

A

F

S

M

S

L

L

G

M

K

K

T

Q

V

A

I

G

N

D

K

F

E

S

K

E

D

S

E

H

Q

E

D

M

I

T

F

K

D

H

M

F

A

A

G

A

S

G

G

G

F

F

E

R

S

D

T

M

V

T

R

R

L

I

A

A

K

E

S

S

S

E

P

P

A

G

M
|
M

W

W

T

T

P

S

I

I

F

L

E

L

Q

T

N

N

K

Q

T

E

Q

A

V

V

L

L

E

D

S

R

L

I

E

E

E

N

Y

F

I

K

S

Q

N

R

L

L

T

D

Q

E

F

V

R

S

D

N

L

L

L

I

A

K

Q

A

D

R

D

D

Y

E

N

N

A

A

I

I

Y

W

E

-

E

-

M

-

A

A

S

F

V

F

N

N

K

Q

I

S

R

R

E

Q

I

I

binding nicotinamide-adenine-dinucleotide: G15 (= G9), L16 (= L10), I17 (= I11), N38 (≠ D32), R39 (≠ N33), P75 (= P67), K78 (≠ V70), A100 (≠ V91), S102 (= S93), M233 (= M226)

2f1kA Crystal structure of synechocystis arogenate dehydrogenase (see paper)
28% identity, 97% coverage: 1:276/285 of query aligns to 1:275/279 of 2f1kA

query
sites
2f1kA

M

M

K

K

V

I

F

G

V

V

I

V

G
|
G

I

L

G
|
G

L
|
L

I
|
I

G

G

G

A

S

S

M

L

V

A

L

G

D

D

I

L

K

R

A

R

L

R

Y

-

P

-

G

G

A

H

T

Y

I

L

Y

I

G

G

I

V

D
x
S

N
x
R

N
x
Q

E

Q

K

S

H
x
T

L

C

Q

E

Q

K

A

A

L

V

E

E

L

R

G

Q

V

L

I

V

D

D

V

E

A

A

A

G

T

-

M

-

E

Q

D

D

L

L

S

S

-

L

-

L

-

Q

E

T

A

A

D

K

F

I

V

I

I

F

V

L

S

C

V
x
T

P
|
P

V

I

N

Q

V

L

A

I

I

L

G

P

L

T

L

L

P

E

K

K

V

L

L

I

D

P

L

H

V

L

G

S

D

P

N

T

A

A

I

I

V

V

F

T

E

D

V
|
V

G
x
A

S
|
S

T

V

K

K

N

T

P

A

I

I

C

A

Q

E

A

P

I

A

A

S

N

Q

H

-

P

-

K

L

R

W

R

S

N

G

F

F

I

I

A

G

T

G

H

H

P

P

I

M

A

A

G
|
G

T
|
T

E

A

F

A

S
x
Q

G
|
G

P

I

S

D

A

G

A

A

L

E

R

E

D

N

L

L

F

F

R

V

G

N

K

A

T

P

N

Y

I

V

I

L

C

T

E

P

V

T

E

E

K

Y

T

T

A

D

F

P

K

E

L

Q

Q

L

E

A

K

C

A

L

L

R

E

S

V

V

F

L

N

E

K

P

M

L

G

G

M

V

R

K

I

I

R

Y

Y

L

M

C

D

T

P

P

K

A

S

D

H

H

D

D

K

Q

H

A

I

V

A

A

Y

W

V

I

S

S

H

H

L

L

S

P

H

V

I

M

S

V

S

S

F

A

M

A

L

L

G

I

K

Q

T

A

V

C

I

A

N

G

K

-

E

E

K

K

D

D

E

G

Q

-

D

D

I

I

F

L

-

K

-

L

-

A

-

Q

D

N

M

L

A

A

G

S

S

S

G

G

F

F

E

R

S

D

T

T

V

S

R

R

L

V

A

G

K

G

S

G

S

N

P

P

A

E

M

L

W

G

T

T

P

M

I

M

F

A

E

T

Q

Y

N

N

K

Q

T

R

Q

A

V

L

L

L

E

K

S

S

L

L

E

Q

E

D

Y

Y

I

R

S

Q

N

H

L

L

T

D

Q

Q

F

L

R

I

D

T

L

L

L

I

A

S

Q

N

D

Q

D

Q

Y

W

N

P

A

E

I

L

Y

H

E

R

E

L

M

L

A

Q

S

Q

V

T

N

N

K

G

I

D

R

R

E

D

binding nadp nicotinamide-adenine-dinucleotide phosphate: G7 (= G7), G9 (= G9), L10 (= L10), I11 (= I11), S30 (≠ D32), R31 (≠ N33), Q32 (≠ N34), T35 (≠ H37), T65 (≠ V66), P66 (= P67), V90 (= V91), A91 (≠ G92), S92 (= S93), G116 (= G119), T117 (= T120), Q120 (≠ S123), G121 (= G124)

2pv7B Crystal structure of chorismate mutase / prephenate dehydrogenase (tyra) (1574749) from haemophilus influenzae rd at 2.00 a resolution (see paper)
23% identity, 51% coverage: 48:192/285 of query aligns to 43:176/280 of 2pv7B

query
sites
2pv7B

D

D

V

W

A

A

A

V

T

A

M

E

E

S

D

I

L

L

S

A

E

N

A

A

D

D

F

V

V

V

I

I

V

V

S

S

V
|
V

P
|
P

V
x
I

N

N

V

L

A

T

I

L

G

E

L

T

L

I

P

E

K

R

V

L

L

K

D

P

L

Y

V

L

G

T

D

E

N

N

A

M

I

L

V

L

F

A

E

D

V
x
L

G
x
T

S
|
S

T

V

K

K

N

R

-

E

P

P

I

L

C

A

Q

K

A

M

I

L

A

E

N

V

H

H

P

T

K

G

R

-

R

-

N

A

F

V

I

L

A

G

T

L

H
|
H

P

P

I

M

A
x
F

G

G

T

A

E

D

F

I

S

A

G

S

P

M

S

A

A

-

A

-

L

-

R

-

D

-

L

-

F

-

R

-

G

-

K

-

T

K

N

Q

I

V

I

V

C

V

E

R

V

C

E

D

K

G

T

R

A

F

F

P

K

E

L

R

Q

Y

E

E

K

W

A

L

L

L

E

E

V

Q

F

I

N

Q

K

I

M

W

G

G

M

A

R

K

I

I

R

Y

Y

Q

M

T

D

N

P

A

K

T

S

E

H

H

D

D

K

H

H

N

I

M

A

T

Y

Y

V

I

S
x
Q

H

A

L

L

S

R

H

H

I

F

S

S

S

T

F

F

M

A

L

N

G

G

binding nicotinamide-adenine-dinucleotide: V61 (= V66), P62 (= P67), I63 (≠ V68), L86 (≠ V91), T87 (≠ G92), S88 (= S93)
binding tyrosine: S88 (= S93), H109 (= H115), F112 (≠ A118), Q165 (≠ S181)

Sites not aligning to the query:

binding nicotinamide-adenine-dinucleotide: 16, 19, 20, 21, 40, 41, 214
binding tyrosine: 206, 210, 214, 215

Query Sequence

>WP_066328701.1 NCBI__GCF_900100165.1:WP_066328701.1
MKVFVIGIGLIGGSMVLDIKALYPGATIYGIDNNEKHLQQALELGVIDVAATMEDLSEAD
FVIVSVPVNVAIGLLPKVLDLVGDNAIVFEVGSTKNPICQAIANHPKRRNFIATHPIAGT
EFSGPSAALRDLFRGKTNIICEVEKTAFKLQEKALEVFNKMGMRIRYMDPKSHDKHIAYV
SHLSHISSFMLGKTVINKEKDEQDIFDMAGSGFESTVRLAKSSPAMWTPIFEQNKTQVLE
SLEEYISNLTQFRDLLAQDDYNAIYEEMASVNKIREILNGIGVKK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory