Comparing WP_066604084.1 NCBI__GCF_001046645.1:WP_066604084.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 8 hits to proteins with known functional sites (download)
1wyuB Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in holo form (see paper)
49% identity, 92% coverage: 37:516/524 of query aligns to 4:471/473 of 1wyuB
4lhdA Crystal structure of synechocystis sp. Pcc 6803 glycine decarboxylase (p-protein), holo form with pyridoxal-5'-phosphate and glycine, closed flexible loop (see paper)
38% identity, 83% coverage: 64:496/524 of query aligns to 476:900/952 of 4lhdA
Sites not aligning to the query:
Q94B78 Glycine dehydrogenase (decarboxylating) 1, mitochondrial; Glycine cleavage system P protein 1; Glycine decarboxylase 1; Glycine decarboxylase P-protein 1; AtGLDP1; Glycine dehydrogenase (aminomethyl-transferring) 1; EC 1.4.4.2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
38% identity, 83% coverage: 76:510/524 of query aligns to 550:986/1037 of Q94B78
Sites not aligning to the query:
6i35A Crystal structure of human glycine decarboxylase (p-protein) bound with pyridoxyl-glycine-5'-monophosphate
39% identity, 77% coverage: 76:480/524 of query aligns to 478:876/953 of 6i35A
Sites not aligning to the query:
P15505 Glycine dehydrogenase (decarboxylating), mitochondrial; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring); EC 1.4.4.2 from Gallus gallus (Chicken) (see paper)
38% identity, 77% coverage: 76:480/524 of query aligns to 514:912/1004 of P15505
6i34B Crystal structure of neanderthal glycine decarboxylase (p-protein)
39% identity, 77% coverage: 76:480/524 of query aligns to 480:878/954 of 6i34B
Sites not aligning to the query:
6i33A Crystal structure of human glycine decarboxylase (p-protein)
39% identity, 77% coverage: 76:480/524 of query aligns to 479:873/950 of 6i33A
Sites not aligning to the query:
6i33B Crystal structure of human glycine decarboxylase (p-protein)
38% identity, 77% coverage: 76:480/524 of query aligns to 480:849/925 of 6i33B
Sites not aligning to the query:
>WP_066604084.1 NCBI__GCF_001046645.1:WP_066604084.1
MTMLKEGRPTAPTPVKDAHMAPATATGNRALMLEEALIFEIGSTATTGVDFAPAPSVASR
LGKLARTDAIGLPGLSEQETVRHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLNEKVARMP
GFADLHPLAPQSTVQGALGVINELAVWLIKLTGMHGVAMTPKAGAHGELCGLLCIRAALE
ARGDARQVVLVPESAHGTNPATAAFCGYKVEDIPATPEGRVDLEALKARLGPDVAAVMIT
NPNTCGLFERDMKTISDAVHAAGAFVYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFST
PHGGGGPGSGPVVLSEALSPFGPLPYTARMADGSIHLIEEENVGEEMPQSFGRMSAFHGQ
MGMFTRALAYILSHGADGLRQVAEDAVLNANYILRSLDDVLDAPFGDSGPCMHEALFSDK
GLAEGFTTLDIAKGLIDEGFHPMTMYFPLVVHGAMLVEPTETESKAALDQFILALRSLAE
RAKAGDEALKGAPYHAPRRRLDETLAARKPVLTWTDPALAVAAE
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory