SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_066918605.1 NCBI__GCF_001579945.1:WP_066918605.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5i92F Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
65% identity, 98% coverage: 4:418/424 of query aligns to 8:418/420 of 5i92F

query
sites
5i92F

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x
F

active site: V19 (= V15), Y142 (= Y138), E201 (= E200), D234 (= D233), M237 (= M236), K262 (= K261), A395 (= A395)
binding leucine: A417 (= A417), F418 (≠ L418)

Sites not aligning to the query:

binding leucine: 420

P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
64% identity, 97% coverage: 4:415/424 of query aligns to 8:420/426 of P23893

query
sites
P23893

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K265 (= K261) mutation to R: 2% of wild-type activity.

6w80A Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
63% identity, 96% coverage: 4:411/424 of query aligns to 15:419/430 of 6w80A

query
sites
6w80A

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active site: V26 (= V15), Y149 (= Y138), D241 (= D233), K269 (= K261)
binding pyridoxal-5'-phosphate: S121 (= S110), G122 (= G111), T123 (= T112), Y149 (= Y138), H150 (= H139), E208 (= E200), N213 (= N205), D241 (= D233), V243 (= V235), K269 (= K261)

Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
55% identity, 98% coverage: 3:419/424 of query aligns to 54:470/472 of Q42522

query
sites
Q42522

S

A

F

F

T

N

D

A

A

A

A

K

R

N

H

L

I

M

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

A

S

V

V

G

G

G

G

E

Q

P

P

I

V

F

V

I

M

E

D

R

S

A

A

G

K

G

G

A

S

L

R

I

I

H
x
R

D

D

E

I

H

D

G

G

R

N

S

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

A

A

H

D

P

D

E

E

V

V

I

L

R

A

T

A

V

L

Q

A

E

E

R

T

A

M

A

K

L

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

R

L

I

L

E

E

T

N

Q

V

L

L

A

A

R

E

K

M

I

V

G

I

E

S

L

A

M

V

P

P

S

S

I

I

E

E

L

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T

T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

G

R

K

D

Q

K

K

I

F

V

I

K

K

F

F

A

E

G

G

C

C

Y

Y

H

H

G

G

H

H

S

A

D

N

S

S

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

V

L

P

P

T

D

S

S

P

P

G

G

V

V

P

P

K

K

E

A

L

A

A

T

A

S

Q

D

T

T

L

L

T

T

L

A

A

P

Y

Y

N

N

D

D

A

I

A

A

E

A

V

V

K

E

Q

K

V

L

F

F

D

E

A

A

V

N

G

K

G

G

Q

E

I

I

A

A

C

A

I

I

I

I

V

L

E

E

P

P

V

V

A

V

G

G

N

N

M

S

N

G

C

F

V

I

P

T

P

P

A

K

P

P

G

E

F

F

L

I

E

E

T

G

L

I

R

R

S

R

V

I

C

T

D

K

Q

D

H

N

G

G

S

A

V

L

L

L

I

I

F

F

D

D

E

E

V

V

M

M

T

T

G

G

F

F

R

R

V

L

A

A

L

Y

G

G

G

G

A

A

Q

Q

A

E

L

Y

Y

F

G

G

I

I

K

T

P

P

D

D

L

L

T

T

T

T

L

L

G

G

K

K

I

I

V

I

G

G

G

G

G

G

M

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

R

R

R

R

D

D

I

I

M

M

E

E

Q

M

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

V

L

A

A

M

M

A

T

A

A

G

G

L

I

K

H

T

T

L

L

E

K

L

R

I

L

G

S

E

Q

P

P

D

G

F

T

H

Y

T

E

R

Y

L

L

A

D

Q

K

T

I

T

T

T

K

Q

E

L

L

V

T

E

N

G

G

L

I

A

L

E

E

A

A

A

G

R

K

D

K

A

T

G

G

V

H

A

A

F

M

S

C

T

G

N

G

H

Y

V

I

C

S

G

G

M

M

F

F

G

G

L

F

F

F

F

F

T

T

E

E

R

G

A

P

P

V

R

Y

S

D

F

F

T

S

E

D

V

A

M

K

A

K

S

S

D

D

A

T

D

E

R

K

F

F

R

G

R

K

F

F

F

F

H

R

A

G

M

M

L

L

R

E

E

E

G

G

V

V

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E

E

A

A

G

G

F

F

V

T

S

S

I

L

A

A

H

H

T

T

Q

S

E

E

H

D

I

I

A

Q

E

F

T

T

V

I

R

A

A

A

A

A

Q

E

A

K

A

V

L

L

Q

S

R92 (≠ H41) mutation to K: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with S-162.
G162 (= G111) mutation to S: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with K-92.

3bs8A Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
54% identity, 98% coverage: 2:418/424 of query aligns to 9:424/430 of 3bs8A

query
sites
3bs8A

S

T

S

A

F

F

T

K

D

E

A

A

A

Q

R

K

H

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

A

S

V

V

G

D

G

M

E

D

P

P

I

I

F

F

I

M

E

E

R

R

A

G

G

K

G

G

A

S

L

K

I

I

H

F

D

D

E

I

H

D

G

G

R

N

S

E

Y

Y

I

I

D

D

Y

Y

V

V

G

L

S

S

W

W

G

G

P

P

M

L

I

I

L

L

G

G

H

H

A

T

H

N

P

D

E

R

V

V

I

V

R

E

T

S

V

L

Q

K

E

K

R

V

A

A

A

E

L

Y

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

T

R

E

I

V

E

E

T

N

Q

E

L

L

A

A

R

K

K

L

I

V

G

I

E

D

L

R

M

V

P

P

S

S

I

V

E

E

L

I

V

V

R

R

M

M

V

V

S

S

S

S

G
|
G

T
|
T

E

E

A

A

T

T

M

M

S

S

A

A

I

L

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

R

R

D

N

K

K

I

I

V

L

K

K

F

F

A

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

S

G

D

D

S

S

L

L

L

L

V

I

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

V

L

P

P

T

D

S

S

P

P

G

G

V

V

P

P

K

E

E

G

L

I

A

A

A

K

Q

N

T

T

L

I

T

T

L

V

A

P

Y

Y

N

N

D

D

A

L

A

E

E

S

V

V

K

K

Q

L

V

A

F

F

D

Q

A

Q

V

F

G

G

G

E

Q

D

I

I

A

A

C

G

I

V

I

I

V

V

E
|
E

P

P

V

V

A

A

G

G

N
|
N

M

M

N

G

C

V

V

V

P

P

P

P

A

Q

P

E

G

G

F

F

L

L

E

Q

T

G

L

L

R

R

S

D

V

I

C

T

D

E

Q

Q

H

Y

G

G

S

S

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

V

A

D

L

Y

G

N

G

C

A

A

Q

Q

A

G

L

Y

Y

F

G

G

I

V

K

T

P

P

D

D

L

L

T

T

T

C

L

L

G

G

K
|
K

I

V

V

I

G

G

G

G

G

G

M

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

A

D

E

I

I

M

M

E

E

Q

Q

I

I

A

A

P

P

L

S

G

G

P

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

V

L

A

A

M

M

A

T

A

A

G

G

L

L

K

E

T

T

L

L

E

K

L

Q

I

L

G

-

E

T

P

P

D

D

F

S

H

Y

T

K

R

N

L

F

A

I

Q

K

T

K

T

G

T

D

Q

R

L

L

V

E

E

E

G

G

L

I

A

S

E

K

A

A

A

A

R

E

D

A

A

H

G

G

V

I

A

P

F

H

S

T

T

F

N

N

H

R

V

A

C

G

G

S

M

M

F

I

G

G

L

F

F

F

F

F

T

T

E

N

R

E

A

P

P

V

R

I

S

N

F

Y

T

E

E

T

V

A

M

K

A

A

S

S

D

D

A

L

D

K

R

L

F

F

R

A

R

S

F

Y

F

Y

H

K

A

G

M

M

L

A

R

N

E

E

G

G

V

V

Y

F

L

L

A

P

P

P

S

S

A

Q

F

F

E

E

A
x
G

G

L

F

F

V

L

S

S

I

T

A

A

H

H

T

T

Q

D

E

E

H

D

I

I

A

E

E

N

T

T

V

I

R

Q

A

A

A

A

Q

E

A

K

A

V

L

F

active site: V22 (= V15), Y145 (= Y138), E207 (= E200), D240 (= D233), M243 (= M236), K268 (= K261), G401 (≠ A395)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G111), T119 (= T112), Y145 (= Y138), H146 (= H139), E207 (= E200), N212 (= N205), D240 (= D233), V242 (= V235), K268 (= K261)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
54% identity, 99% coverage: 4:421/424 of query aligns to 10:427/427 of 2gsaB

query
sites
2gsaB

F

F

T

A

D

A

A

A

A

Q

R

K

H

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

R

K

A

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

E

D

R

R

A

V

G

K

G

D

A

A

L

Y

I

A

H

W

D

D

E

V

H

D

G

G

R

N

S

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

A

A

H

H

P

P

E

E

V

V

I

I

R

E

T

A

V

L

Q

K

E

V

R

A

A

M

A

E

L

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

R

A

I

L

E

E

T

N

Q

V

L

L

A

A

R

E

K

M

I

V

G

N

E

D

L

A

M

V

P

P

S

S

I

I

E

E

L

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

V

I

K

K

F

F

A

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

V

L

P

P

T

S

S

S

P

P

G

G

V

V

P

P

K

K

E

K

L

T

A

T

A

A

Q

N

T

T

L

L

T

T

L

T

A

P

Y

Y

N

N

D

D

A

L

A

E

E

A

V

V

K

K

Q

A

V

L

F

F

D

A

A

E

V

N

G

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

C

F

V

I

P

V

P

P

A

D

P

A

G

G

F

F

L

L

E

E

T

G

L

L

R

R

S

E

V

I

C

T

D

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

A

E

L

K

Y

F

G

G

I

V

K

T

P

P

D

D

L

L

T

T

T

T

L

L

G

G

K
|
K

I

I

V

I

G

G

G

G

G

G

M

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

Q

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

V

L

A

A

M

M

A

T

A

A

G

G

L

I

K

K

T

T

L

L

E

E

L

L

I

L

G

R

E

Q

P

P

D

G

F

T

H

Y

T

E

R

Y

L

L

A

D

Q

Q

T

I

T

T

T

K

Q

R

L

L

V

S

E

D

G

G

L

L

A

L

E

A

A

I

A

A

R

Q

D

E

A

T

G

G

V

H

A

A

F

A

S

C

T

G

N

G

H

Q

V

V

C

S

G

G

M

M

F

F

G

G

L

F

F

F

F

F

T

T

E

E

R

G

A

P

P

V

R

H

S

N

F

Y

T

E

E

D

V

A

M

K

A

K

S

S

D

D

A

L

D

Q

R

K

F

F

R

S

R

R

F

F

F

H

H

R

A

G

M

M

L

L

R

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E

E

A
|
A

G

G

F

F

V

T

S

S

I

L

A

A

H

H

T

T

Q

E

E

E

H

D

I

I

A

D

E

A

T

T

V

L

R

A

A

A

A

A

Q

R

A

T

A

V

L

M

Q

S

C

A

M

L

active site: V21 (= V15), Y144 (= Y138), E206 (= E200), D239 (= D233), M242 (= M236), K267 (= K261), A401 (= A395)
binding pyridoxal-5'-phosphate: G117 (= G111), T118 (= T112), Y144 (= Y138), E206 (= E200), N211 (= N205), D239 (= D233), V241 (= V235), M242 (= M236), K267 (= K261)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
54% identity, 99% coverage: 4:421/424 of query aligns to 10:427/427 of 2gsaA

query
sites
2gsaA

F

F

T

A

D

A

A

A

A

Q

R

K

H

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

R

K

A

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

E

D

R

R

A

V

G

K

G

D

A

A

L

Y

I

A

H

W

D

D

E

V

H

D

G

G

R

N

S

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

A

A

H

H

P

P

E

E

V

V

I

I

R

E

T

A

V

L

Q

K

E

V

R

A

A

M

A

E

L

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

R

A

I

L

E

E

T

N

Q

V

L

L

A

A

R

E

K

M

I

V

G

N

E

D

L

A

M

V

P

P

S

S

I

I

E

E

L

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

V

I

K

K

F

F

A

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

V

L

P

P

T

S

S

S

P

P

G

G

V

V

P

P

K

K

E

K

L

T

A

T

A

A

Q

N

T

T

L

L

T

T

L

T

A

P

Y

Y

N

N

D

D

A

L

A

E

E

A

V

V

K

K

Q

A

V

L

F

F

D

A

A

E

V

N

G

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

C

F

V

I

P

V

P

P

A

D

P

A

G

G

F

F

L

L

E

E

T

G

L

L

R

R

S

E

V

I

C

T

D

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

A

E

L

K

Y

F

G

G

I

V

K

T

P

P

D

D

L

L

T

T

T

T

L

L

G

G

K
|
K

I

I

V

I

G

G

G

G

G

G

M

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

Q

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

V

L

A

A

M

M

A

T

A

A

G

G

L

I

K

K

T

T

L

L

E

E

L

L

I

L

G

R

E

Q

P

P

D

G

F

T

H

Y

T

E

R

Y

L

L

A

D

Q

Q

T

I

T

T

T

K

Q

R

L

L

V

S

E

D

G

G

L

L

A

L

E

A

A

I

A

A

R

Q

D

E

A

T

G

G

V

H

A

A

F

A

S

C

T

G

N

G

H

Q

V

V

C

S

G

G

M

M

F

F

G

G

L

F

F

F

F

F

T

T

E

E

R

G

A

P

P

V

R

H

S

N

F

Y

T

E

E

D

V

A

M

K

A

K

S

S

D

D

A

L

D

Q

R

K

F

F

R

S

R

R

F

F

F

H

H

R

A

G

M

M

L

L

R

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E

E

A
|
A

G

G

F

F

V

T

S

S

I

L

A

A

H

H

T

T

Q

E

E

E

H

D

I

I

A

D

E

A

T

T

V

L

R

A

A

A

A

A

Q

R

A

T

A

V

L

M

Q

S

C

A

M

L

active site: V21 (= V15), Y144 (= Y138), E206 (= E200), D239 (= D233), M242 (= M236), K267 (= K261), A401 (= A395)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G111), T118 (= T112), Y144 (= Y138), H145 (= H139), G146 (= G140), N211 (= N205), D239 (= D233), V241 (= V235), K267 (= K261)

3usfA Crystal structure of dava-4
54% identity, 99% coverage: 4:421/424 of query aligns to 10:427/427 of 3usfA

query
sites
3usfA

F

F

T

A

D

A

A

A

A

Q

R

K

H

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

R

K

A

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

E

D

R

R

A

V

G

K

G

D

A

A

L

Y

I

A

H

W

D

D

E

V

H

D

G

G

R

N

S

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

A

A

H

H

P

P

E

E

V

V

I

I

R

E

T

A

V

L

Q

K

E

V

R

A

A

M

A

E

L

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

R

A

I

L

E

E

T

N

Q

V

L

L

A

A

R

E

K

M

I

V

G

N

E

D

L

A

M

V

P

P

S

S

I

I

E

E

L

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

V

I

K

K

F

F

A

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S
|
S

G

G

A

V

L

A

T

T

F

L

G

G

V

L

P

P

T

S

S

S

P

P

G

G

V

V

P

P

K

K

E

K

L

T

A

T

A

A

Q

N

T

T

L

L

T

T

L

T

A

P

Y

Y

N

N

D

D

A

L

A

E

E

A

V

V

K

K

Q

A

V

L

F

F

D

A

A

E

V

N

G

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

V

L

E

E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

C

F

V

I

P

V

P

P

A

D

P

A

G

G

F

F

L

L

E

E

T

G

L

L

R

R

S

E

V

I

C

T

D

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

A

E

L

K

Y

F

G

G

I

V

K

T

P

P

D

D

L

L

T

T

T

T

L

L

G

G

K
|
K

I

I

V

I

G

G

G

G

G

G

M

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

Q

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

V

L

A

A

M

M

A

T

A

A

G

G

L

I

K

K

T

T

L

L

E

E

L

L

I

L

G

R

E

Q

P

P

D

G

F

T

H

Y

T

E

R

Y

L

L

A

D

Q

Q

T

I

T

T

T

K

Q

R

L

L

V

S

E

D

G

G

L

L

A

L

E

A

A

I

A

A

R

Q

D

E

A

T

G

G

V

H

A

A

F

A

S

C

T

G

N

G

H

Q

V

V

C

S

G

G

M

M

F

F

G

G

L

F

F

F

F

F

T

T

E

E

R

G

A

P

P

V

R

H

S

N

F

Y

T

E

E

D

V

A

M

K

A

K

S

S

D

D

A

L

D

Q

R

K

F

F

R

S

R

R

F

F

F

H

H

R

A

G

M

M

L

L

R

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E
|
E

A
|
A

G

G

F

F

V

T

S

S

I

L

A

A

H

H

T

T

Q

E

E

E

H

D

I

I

A

D

E

A

T

T

V

L

R

A

A

A

A

A

Q

R

A

T

A

V

L

M

Q

S

C

A

M

L

active site: V21 (= V15), Y144 (= Y138), D239 (= D233), M242 (= M236), K267 (= K261), A401 (= A395)
binding (4s)-4,5-diaminopentanoic acid: S23 (= S17), V25 (= V19), S157 (= S151), K267 (= K261), E400 (= E394)
binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G111), T118 (= T112), Y144 (= Y138), N211 (= N205), D239 (= D233), V241 (= V235), K267 (= K261)

3fq7A Gabaculine complex of gsam (see paper)
54% identity, 99% coverage: 4:421/424 of query aligns to 10:427/427 of 3fq7A

query
sites
3fq7A

F

F

T

A

D

A

A

A

A

Q

R

K

H

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

R

K

A

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

E

D

R

R

A

V

G

K

G

D

A

A

L

Y

I

A

H

W

D

D

E

V

H

D

G

G

R

N

S

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

A

A

H

H

P

P

E

E

V

V

I

I

R

E

T

A

V

L

Q

K

E

V

R

A

A

M

A

E

L

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

R

A

I

L

E

E

T

N

Q

V

L

L

A

A

R

E

K

M

I

V

G

N

E

D

L

A

M

V

P

P

S

S

I

I

E

E

L

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

V

I

K

K

F

F

A

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

V

L

P

P

T

S

S

S

P

P

G

G

V

V

P

P

K

K

E

K

L

T

A

T

A

A

Q

N

T

T

L

L

T

T

L

T

A

P

Y

Y

N

N

D

D

A

L

A

E

E

A

V

V

K

K

Q

A

V

L

F

F

D

A

A

E

V

N

G

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

C

F

V

I

P

V

P

P

A

D

P

A

G

G

F

F

L

L

E

E

T

G

L

L

R

R

S

E

V

I

C

T

D

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

A

E

L

K

Y

F

G

G

I

V

K

T

P

P

D

D

L

L

T

T

T

T

L

L

G

G

K
|
K

I

I

V

I

G

G

G

G

G

G

M

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

Q

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

V

L

A

A

M

M

A

T

A

A

G

G

L

I

K

K

T

T

L

L

E

E

L

L

I

L

G

R

E

Q

P

P

D

G

F

T

H

Y

T

E

R

Y

L

L

A

D

Q

Q

T

I

T

T

T

K

Q

R

L

L

V

S

E

D

G

G

L

L

A

L

E

A

A

I

A

A

R

Q

D

E

A

T

G

G

V

H

A

A

F

A

S

C

T

G

N

G

H

Q

V

V

C

S

G

G

M

M

F

F

G

G

L

F

F

F

F

F

T

T

E

E

R

G

A

P

P

V

R

H

S

N

F

Y

T

E

E

D

V

A

M

K

A

K

S

S

D

D

A

L

D

Q

R

K

F

F

R

S

R

R

F

F

F

H

H

R

A

G

M

M

L

L

R

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E
|
E

A
|
A

G

G

F

F

V

T

S

S

I

L

A

A

H

H

T

T

Q

E

E

E

H

D

I

I

A

D

E

A

T

T

V

L

R

A

A

A

A

A

Q

R

A

T

A

V

L

M

Q

S

C

A

M

L

active site: V21 (= V15), Y144 (= Y138), D239 (= D233), M242 (= M236), K267 (= K261), A401 (= A395)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: S23 (= S17), V25 (= V19), W61 (= W55), G117 (= G111), T118 (= T112), Y144 (= Y138), H145 (= H139), E206 (= E200), N211 (= N205), D239 (= D233), V241 (= V235), M242 (= M236), K267 (= K261), G298 (= G292), T299 (= T293), E400 (= E394)

2hp2A Inter-subunit signaling in gsam (see paper)
54% identity, 99% coverage: 4:421/424 of query aligns to 10:427/427 of 2hp2A

query
sites
2hp2A

F

F

T

A

D

A

A

A

A

Q

R

K

H

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V

V

R

R

A

A

F

F

R

K

A

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

E

D

R

R

A

V

G

K

G

D

A

A

L

Y

I

A

H

W

D

D

E

V

H

D

G

G

R

N

S

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

A

A

H

H

P

P

E

E

V

V

I

I

R

E

T

A

V

L

Q

K

E

V

R

A

A

M

A

E

L

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

R

A

I

L

E

E

T

N

Q

V

L

L

A

A

R

E

K

M

I

V

G

N

E

D

L

A

M

V

P

P

S

S

I

I

E

E

L

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

V

I

K

K

F

F

A

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

V

L

P

P

T

S

S

S

P

P

G

G

V

V

P

P

K

K

E

K

L

T

A

T

A

A

Q

N

T

T

L

L

T

T

L

T

A

P

Y

Y

N

N

D

D

A

L

A

E

E

A

V

V

K

K

Q

A

V

L

F

F

D

A

A

E

V

N

G

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

C

F

V

I

P

V

P

P

A

D

P

A

G

G

F

F

L

L

E

E

T

G

L

L

R

R

S

E

V

I

C

T

D

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

A

E

L

K

Y

F

G

G

I

V

K

T

P

P

D

D

L

L

T

T

T

T

L

L

G

G

K
|
K

I

I

V

I

G

G

G

G

G

G

M

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

Q

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

V

L

A

A

M

M

A

T

A

A

G

G

L

I

K

K

T

T

L

L

E

E

L

L

I

L

G

R

E

Q

P

P

D

G

F

T

H

Y

T

E

R

Y

L

L

A

D

Q

Q

T

I

T

T

T

K

Q

R

L

L

V

S

E

D

G

G

L

L

A

L

E

A

A

I

A

A

R

Q

D

E

A

T

G

G

V

H

A

A

F

A

S

C

T

G

N

G

H

Q

V

V

C

S

G

G

M

M

F

F

G

G

L

F

F

F

F

F

T

T

E

E

R

G

A

P

P

V

R

H

S

N

F

Y

T

E

E

D

V

A

M

K

A

K

S

S

D

D

A

L

D

Q

R

K

F

F

R

S

R

R

F

F

F

H

H

R

A

G

M

M

L

L

R

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E

E

A
|
A

G

G

F

F

V

T

S

S

I

L

A

A

H

H

T

T

Q

E

E

E

H

D

I

I

A

D

E

A

T

T

V

L

R

A

A

A

A

A

Q

R

A

T

A

V

L

M

Q

S

C

A

M

L

active site: V21 (= V15), Y144 (= Y138), D239 (= D233), M242 (= M236), K267 (= K261), A401 (= A395)
binding (4s)-4,5-diaminopentanoic acid: G298 (= G292), T299 (= T293)
binding (4r)-5-amino-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S17), G117 (= G111), T118 (= T112), Y144 (= Y138), H145 (= H139), E206 (= E200), N211 (= N205), D239 (= D233), V241 (= V235), M242 (= M236), K267 (= K261)
binding pyridoxal-5'-phosphate: G298 (= G292), T299 (= T293)

2hp1A Inter-subunit signaling in gsam (see paper)
54% identity, 99% coverage: 4:421/424 of query aligns to 10:427/427 of 2hp1A

query
sites
2hp1A

F

F

T

A

D

A

A

A

A

Q

R

K

H

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

R

K

A

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

E

D

R

R

A

V

G

K

G

D

A

A

L

Y

I

A

H

W

D

D

E

V

H

D

G

G

R

N

S

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

A

A

H

H

P

P

E

E

V

V

I

I

R

E

T

A

V

L

Q

K

E

V

R

A

A

M

A

E

L

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

R

A

I

L

E

E

T

N

Q

V

L

L

A

A

R

E

K

M

I

V

G

N

E

D

L

A

M

V

P

P

S

S

I

I

E

E

L

M

V

V

R

R

M

F

V

V

S

N

S
|
S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

V

I

K

K

F

F

A

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

V

L

P

P

T

S

S

S

P

P

G

G

V

V

P

P

K

K

E

K

L

T

A

T

A

A

Q

N

T

T

L

L

T

T

L

T

A

P

Y

Y

N

N

D

D

A

L

A

E

E

A

V

V

K

K

Q

A

V

L

F

F

D

A

A

E

V

N

G

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

C

F

V

I

P

V

P

P

A

D

P

A

G

G

F

F

L

L

E

E

T

G

L

L

R

R

S

E

V

I

C

T

D

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

A

E

L

K

Y

F

G

G

I

V

K

T

P

P

D

D

L

L

T

T

T

T

L

L

G

G

K
|
K

I

I

V

I

G

G

G

G

G

G

M

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

Q

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

V

L

A

A

M

M

A

T

A

A

G

G

L

I

K

K

T

T

L

L

E

E

L

L

I

L

G

R

E

Q

P

P

D

G

F

T

H

Y

T

E

R

Y

L

L

A

D

Q

Q

T

I

T

T