SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_067073433.1 NCBI__GCF_001602375.1:WP_067073433.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8biqA Crystal structure of acyl-coa synthetase from metallosphaera sedula in complex with acetyl-amp
45% identity, 91% coverage: 26:543/567 of query aligns to 36:542/562 of 8biqA

query
sites
8biqA

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binding adenosine monophosphate: G320 (= G321), E321 (= E322), P322 (≠ A323), G344 (= G345), Q345 (= Q346), T346 (= T347), D427 (= D428), F439 (= F440), K448 (= K449), R453 (= R454)

8bitA Crystal structure of acyl-coa synthetase from metallosphaera sedula in complex with coenzyme a and acetyl-amp
45% identity, 91% coverage: 26:543/567 of query aligns to 37:543/562 of 8bitA

query
sites
8bitA

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binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] ethanoate: W252 (= W252), G321 (= G321), E322 (= E322), P323 (≠ A323), D342 (≠ E342), F343 (≠ G343), Y344 (= Y344), Q346 (= Q346), T347 (= T347), D428 (= D428), F440 (= F440), K449 (= K449), R454 (= R454)
binding coenzyme a: N128 (≠ M115), W247 (= W247), K249 (= K249), K273 (≠ R273), L274 (≠ F274), Q300 (≠ M300), D452 (≠ G452), Y453 (= Y453), R483 (= R483), P517 (= P517)

8biqB Crystal structure of acyl-coa synthetase from metallosphaera sedula in complex with acetyl-amp
45% identity, 91% coverage: 26:543/567 of query aligns to 35:541/561 of 8biqB

query
sites
8biqB

Y

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Y

Y

P

P

L

V

G

G

H

S

L

I

V

T

T

T

A

A

Q

S

L

I

W

V

H

-

D

G

L

V

H

R

P

E

N

S

D

D

L

L

H

H

L

L

T

N

I

L

S

S

D

A

T

T

G

G

W

W

G

A

K

K

S

F

A

A

W

W

G

S

K

S

L

F

F

F

G

S

Q

P

W

L

I

L

V

V

G

G

A

A

C

T

I

V

F

V

V

G

Y

I

D

N

I

Y

R

E

G

G

R

K

F

L

H

D

A

T

T

R

E

R

I

Y

L

L

P

G

L

E

L

V

E

E

K

N

Y

L

G

G

V

V

T

T

T

S

F

F

C

C

C

A

P

P

P

P

T

T

I

A

Y

W

R

R

M

Q

L

F

I

I

L

T

A

L

D

D

L

L

D

D

K

Q

F

F

D

R

L

F

A

E

D

R

M

L

R

R

H

S

C

V

C

V

S

S

A

A

G
|
G

E
|
E

A
x
P

L

L

N

N

P

P

E

E

V

V

I

I

R

K

A

I

W

W

E

K

E

D

G

K

T

F

G

N

R

L

T

T

I

I

Y

R

E
x
D

G
x
F

Y
|
Y

G
|
G

Q
|
Q

T
|
T

E

E

T

T

V

T

L

A

C

M

I

V

G

G

T

N

L

F

P

P

G

F

M

L

K

K

T

V

K

K

P

P

G

G

S

S

M

M

G

G

R

K

P

P

M

H

P

P

G

L

W

Y

Q

D

I

I

E

R

L

L

L

L

D

D

D

D

D

E

G

G

N

K

P

E

V

I

G

T

V

K

G

P

E

Y

E

E

-

V

G

G

R

H

I

I

A

T

I

V

R

K

V

L

D

N

P

P

R

R

P

P

V

I

G

G

L

L

F

F

S

L

G

G

Y

Y

L

-

N

S

N

D

G

E

D

K

E

K

N

N

H

M

K

E

V

S

F

F

S

R

N

E

G

G

F

Y

Y

Y

F

Y

T

T

G

G

D
|
D

K

K

A

A

Y

Y

V

F

D

D

E

E

D

E

G

G

Y

Y

F

F

W

Y

F
|
F

I

V

G

G

R

R

D

G

D

D

D

D

V

V

I

I

K
|
K

S

T

S

S

G

D

Y

Y

R
|
R

I

V

G

G

P

P

F

F

E

E

V

V

E

E

S

S

A

A

L

L

M

L

E

E

H

H

P

P

A

A

V

V

Q

A

E

E

A

A

A

A

V

V

V

V

G

G

S

V

P

P

D

D

V

T

L

V

R

R

G

W

L

Q

V

L

V

V

K

K

A

A

F

Y

I

I

V

V

L

L

K

K

P

K

G

G

Y

Y

R

M

P

P

T

S

E

K

S

E

L

L

V

A

K

E

E

E

I

I

Q

R

K

E

Q

K

V

M

K

K

R

T

V

L

T

L

A

S

P

P

Y

Y

K

K

Y

V

P

P

R

R

L

I

I

I

E

E

F

F

V

V

E

D

S

E

L

L

P

P

K

K

T

T

I

I

S

S

G

G

K

K

I

I

K

R

R

R

H

V

E

E

L

L

binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] ethanoate: G319 (= G321), E320 (= E322), P321 (≠ A323), D340 (≠ E342), F341 (≠ G343), Y342 (= Y344), G343 (= G345), Q344 (= Q346), T345 (= T347), D426 (= D428), F438 (= F440), K447 (= K449), R452 (= R454)

3eq6A Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in a ternary complex with products (see paper)
42% identity, 93% coverage: 21:549/567 of query aligns to 3:533/533 of 3eq6A

query
sites
3eq6A

D

E

V

V

P

P

E

A

Y

K

Y

F

N

N

F

F

G

A

F

S

D

D

V

V

I

L

D

D

A

H

W

W

A

A

K

D

K

M

D

E

R

K

N

A

-

G

-

K

-

R

-

P

-

P

K

S

L

P

A

A

M

L

I

W

W

W

V

V

D

N

Q

G

K

K

G

G

N

K

E

E

K

L

K

M

Y

W

T

N

F

F

F

R

D

E

L

L

M

S

R

E

L

N

S

S

N

Q

Q

Q

A

A

V

A

N

N

I

V

C

L

L

S

-

G

K

A

Y

C

G

G

I

L

K

Q

K

R

G

G

D

D

R

R

V

V

M

A

L

V

M

V

L

L

P

P

R

R

T

V

P

P

E

E

W

W

W

W

I

L

F

V

T

I

I

L

A

G

L

C

I

I

K

R

L

A

G

G

A

L

V

I

Y

F

C

M

P

P

A

G

T

T

T

I

M

Q

L

M

T

K

P

S

K

T

D

D

L

I

K

L

Y

Y

R

R

I

L

Q

Q

A

M

A

S

D

K

I

A

R

K

M

A

I

I

I

V

T

A

M

G

A

D

E

E

H

V

A

I

D

Q

K

E

V

V

E

D

E

T

I

V

R

A

E

S

E

E

C

C

P

P

T

S

L

L

A

R

V

I

R

K

L

L

M

L

-

V

T

S

D

E

G

K

V

S

R

C

D

D

G

G

W

W

V

L

S

N

Y

F

P

K

V

K

E

L

L

L

D

N

Y

-

P

E

A

A

P

S

C

T

S

T

H

H

K

H

L

C

V

V

N

-

L

-

P

-

G

-

M

-

H

-

R

E

T

T

K

G

A

S

T

Q

D

E

P

A

L

S

L

A

I

I

F

Y

F

F

T
|
T

S

S

G

G

T

T

T

S

G

G

E

L

P

P

K

K

M

M

V

A

V

E

H

H

A

S

H

Y

S

S

Y

-

P

S

L

L

G

G

H

-

L

-

V

L

T

K

A

A

Q

K

L

M

-

D

-

A

-

G

W

W

H

T

D

G

L

L

H

Q

P

A

N

S

D

D

L

I

H

M

L

W

T

T

I

I

S

S

D

D

T

T

G

G

W
|
W

G

I

K

L

S

N

A

I

W

L

G

C

K

S

L

L

F

M

G

E

Q

P

W

W

I

A

V

L

G

G

A

A

C

C

I

T

F

F

V

V

Y

H

D

-

I

L

R

L

G

P

R

K

F
|
F

H

D

A

P

T

L

E

V

I

I

L

L

P

K

L

T

L

L

E

S

K

S

Y

Y

G

P

V

I

T

K

T

S

F

M

C

M

C

G

P

A

P

P

T
x
I

I

V

Y

Y

R

R

M

M

L

L

I

L

L

Q

A

Q

D

D

L

L

D

S

K

S

F

Y

D

K

L

F

A

P

D

H

M

L

R

Q

H

N

C

C

C

V

S

T

A
x
V

G
|
G

E
|
E

A
x
S

L

L

N

L

P

P

E

E

V

T

I

L

R

E

A

N

W

W

E

R

E

A

G

Q

T

T

G

G

R

L

T

D

I

I

Y

R

E
|
E

G
x
S

Y
|
Y

G
|
G

Q
|
Q

T
|
T

E
|
E

T

T

V

G

L

L

C

T

I

C

G

M

T

V

L

S

P

K

G

T

M

M

K

K

T

I

K

K

P

P

G

G

S

Y

M

M

G

G

R

T

P

A

M

A

P

S

G

C

W

Y

Q

D

I

V

E

Q

L

I

L

I

D

D

D

D

D

K

G

G

N

N

P

V

V

L

G

P

V

P

G

G

E

T

E

E

G

G

R

D

I

I

A

G

I

I

R

R

V

V

D

K

P

P

-

I

R

R

P

P

V

I

G

G

L

I

F

F

S

S

G

G

Y

Y

L

V

N

D

N

N

G

P

D

D

E

K

N

T

H

A

K

A

V

N

F

I

S

R

N

G

G

D

F

F

Y

W

F

L

T

L

G

G

D
|
D

K

R

A

G

Y

I

V

K

D

D

E

E

D

D

G

G

Y

Y

F

F

W

Q

F
|
F

I

M

G

G

R
|
R

D

A

D

D

D

D

V

I

I

I

K
x
N

S

S

S
|
S

G
|
G

Y
|
Y

R
|
R

I

I

G

G

P

P

F

S

E

E

V

V

E

E

S

N

A

A

L

L

M

M

E

E

H

H

P

P

A

A

V

V

Q

V

E

E

A

T

A

A

V

V

V

I

G

S

S

S

P

P

D

D

V

P

L

V

R

R

G

G

L

E

V

V

V

V

K

K

A

A

F

F

I

V

V

V

L

L

K

A

P

S

G

Q

Y

F

-

L

-

S

R

H

P

D

T

P

E

E

S

Q

L

L

V

T

K

K

E

E

I

L

Q

Q

K

Q

Q

H

V

V

K

K

R

S

V

V

T

T

A

A

P
|
P

Y
|
Y

K

K

Y
|
Y

P

P

R
|
R

L

K

I

I

E

E

F

F

V

V

E

L

S

N

L

L

P

P

K

K

T

T

I

V

S

T

G

G

K
|
K

I

I

K

Q

R

R

H

A

E

K

L

L

R

R

E

D

L

K

E

E

M

W

R

K

active site: T185 (= T203), T328 (= T347), E329 (= E348), N431 (≠ K449), R436 (= R454), K521 (= K537)
binding adenosine monophosphate: G302 (= G321), E303 (= E322), S304 (≠ A323), E323 (= E342), S324 (≠ G343), Y325 (= Y344), G326 (= G345), Q327 (= Q346), T328 (= T347), D410 (= D428), F422 (= F440), R425 (= R443), R436 (= R454)
binding Butyryl Coenzyme A: W229 (= W247), F255 (= F274), I277 (≠ T296), V301 (≠ A320), S433 (= S451), G434 (= G452), Y435 (= Y453), P501 (= P517), Y502 (= Y518), Y504 (= Y520), R506 (= R522)

2wd9A Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with ibuprofen (see paper)
42% identity, 93% coverage: 21:549/567 of query aligns to 3:533/533 of 2wd9A

query
sites
2wd9A

D

E

V

V

P

P

E

A

Y

K

Y

F

N

N

F

F

G

A

F

S

D

D

V

V

I

L

D

D

A

H

W

W

A

A

K

D

K

M

D

E

R

K

N

A

-

G

-

K

-

R

-

P

-

P

K

S

L

P

A

A

M

L

I

W

W

W

V

V

D

N

Q

G

K

K

G

G

N

K

E

E

K

L

K

M

Y

W

T

N

F

F

F

R

D

E

L

L

M

S

R

E

L

N

S

S

N

Q

Q

Q

A

A

V

A

N

N

I

V

C

L

L

S

-

G

K

A

Y

C

G

G

I

L

K

Q

K

R

G

G

D

D

R

R

V

V

M

A

L

V

M

V

L

L

P

P

R

R

T

V

P

P

E

E

W

W

W

W

I

L

F

V

T

I

I

L

A

G

L

C

I

I

K

R

L

A

G

G

A

L

V

I

Y

F

C

M

P

P

A

G

T

T

T

I

M

Q

L

M

T

K

P

S

K

T

D

D

L

I

K

L

Y

Y

R

R

I

L

Q

Q

A

M

A

S

D

K

I

A

R

K

M

A

I

I

I

V

T

A

M

G

A

D

E

E

H

V

A

I

D

Q

K

E

V

V

E

D

E

T

I

V

R

A

E

S

E

E

C

C

P

P

T

S

L

L

A

R

V

I

R

K

L

L

M

L

-

V

T

S

D

E

G

K

V

S

R

C

D

D

G

G

W

W

V

L

S

N

Y

F

P

K

V

K

E

L

L

L

D

N

Y

-

P

E

A

A

P

S

C

T

S

T

H

H

K

H

L

C

V

V

N

-

L

-

P

-

G

-

M

-

H

-

R

E

T

T

K

G

A

S

T

Q

D

E

P

A

L

S

L

A

I

I

F

Y

F

F

T
|
T

S

S

G

G

T

T

T

S

G

G

E

L

P

P

K

K

M

M

V

A

V

E

H

H

A

S

H

Y

S

S

Y

-

P

S

L

L

G

G

H

-

L

-

V

L

T

K

A

A

Q

K

L

M

-

D

-

A

-

G

W

W

H

T

D

G

L

L

H

Q

P

A

N

S

D

D

L

I

H

M

L

W

T

T

I

I

S

S

D

D

T

T

G

G

W

W

G
x
I

K
x
L

S

N

A

I

W

L

G

C

K

S

L

L

F

M

G

E

Q

P

W

W

I

A

V

L

G

G

A

A

C

C

I

T

F

F

V

V

Y

H

D

-

I

L

R

L

G

P

R

K

F

F

H

D

A

P

T

L

E

V

I

I

L

L

P

K

L

T

L

L

E

S

K

S

Y

Y

G

P

V

I

T

K

T

S

F

M

C

M

C

G

P

A

P

P

T

I

I

V

Y

Y

R

R

M

M

L

L

I

L

L

Q

A

Q

D

D

L

L

D

S

K

S

F

Y

D

K

L

F

A

P

D

H

M

L

R

Q

H

N

C

C

C

V

S

T

A

V

G

G

E

E

A

S

L

L

N

L

P

P

E

E

V

T

I

L

R

E

A

N

W

W

E

R

E

A

G

Q

T

T

G

G

R

L

T

D

I

I

Y

R

E

E

G

S

Y

Y

G
|
G

Q
|
Q

T
|
T

E
|
E

T

T

V

G

L

L

C

T

I

C

G

M

T

V

L

S

P

K

G

T

M

M

K

K

T

I

K

K

P

P

G

G

S

Y

M

M

G

G

R

T

P

A

M

A

P

S

G

C

W

Y

Q

D

I

V

E

Q

L

I

L

I

D

D

D

D

D

K

G

G

N

N

P

V

V

L

G

P

V

P

G

G

E

T

E

E

G

G

R

D

I

I

A

G

I

I

R

R

V

V

D

K

P

P

-

I

R

R

P

P

V

I

G

G

L

I

F

F

S

S

G

G

Y

Y

L

V

N

D

N

N

G

P

D

D

E

K

N

T

H

A

K

A

V

N

F

I

S

R

N

G

G

D

F

F

Y

W

F

L

T

L

G

G

D

D

K

R

A

G

Y

I

V

K

D

D

E

E

D

D

G

G

Y

Y

F

F

W

Q

F

F

I

M

G

G

R

R

D

A

D

D

D

D

V

I

I

I

K
x
N

S

S

S

S

G

G

Y

Y

R
|
R

I

I

G

G

P

P

F

S

E

E

V

V

E

E

S

N

A

A

L

L

M

M

E

E

H

H

P

P

A

A

V

V

Q

V

E

E

A

T

A

A

V

V

V

I

G

S

S

S

P

P

D

D

V

P

L

V

R

R

G

G

L

E

V

V

V

V

K

K

A

A

F

F

I

V

V

V

L

L

K

A

P

S

G

Q

Y

F

-

L

-

S

R

H

P

D

T

P

E

E

S

Q

L

L

V

T

K

K

E

E

I

L

Q

Q

K

Q

Q

H

V

V

K

K

R

S

V

V

T

T

A

A

P

P

Y

Y

K

K

Y

Y

P

P

R

R

L

K

I

I

E

E

F

F

V

V

E

L

S

N

L

L

P

P

K

K

T

T

I

V

S

T

G

G

K
|
K

I

I

K

Q

R

R

H

A

E

K

L

L

R

R

E

D

L

K

E

E

M

W

R

K

active site: T185 (= T203), T328 (= T347), E329 (= E348), N431 (≠ K449), R436 (= R454), K521 (= K537)
binding ibuprofen: I230 (≠ G248), L231 (≠ K249), G326 (= G345), Q327 (= Q346), T328 (= T347), R436 (= R454)

2vzeA Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with amp (see paper)
42% identity, 93% coverage: 21:549/567 of query aligns to 3:533/533 of 2vzeA

query
sites
2vzeA

D

E

V

V

P

P

E

A

Y

K

Y

F

N

N

F

F

G

A

F

S

D

D

V

V

I

L

D

D

A

H

W

W

A

A

K

D

K

M

D

E

R

K

N

A

-

G

-

K

-

R

-

P

-

P

K

S

L

P

A

A

M

L

I

W

W

W

V

V

D

N

Q

G

K

K

G

G

N

K

E

E

K

L

K

M

Y

W

T

N

F

F

F

R

D

E

L

L

M

S

R

E

L

N

S

S

N

Q

Q

Q

A

A

V

A

N

N

I

V

C

L

L

S

-

G

K

A

Y

C

G

G

I

L

K

Q

K

R

G

G

D

D

R

R

V

V

M

A

L

V

M

V

L

L

P

P

R

R

T

V

P

P

E

E

W

W

W

W

I

L

F

V

T

I

I

L

A

G

L

C

I

I

K

R

L

A

G

G

A

L

V

I

Y

F

C

M

P

P

A

G

T

T

T

I

M

Q

L

M

T

K

P

S

K

T

D

D

L

I

K

L

Y

Y

R

R

I

L

Q

Q

A

M

A

S

D

K

I

A

R

K

M

A

I

I

I

V

T

A

M

G

A

D

E

E

H

V

A

I

D

Q

K

E

V

V

E

D

E

T

I

V

R

A

E

S

E

E

C

C

P

P

T

S

L

L

A

R

V

I

R

K

L

L

M

L

-

V

T

S

D

E

G

K

V

S

R

C

D

D

G

G

W

W

V

L

S

N

Y

F

P

K

V

K

E

L

L

L

D

N

Y

-

P

E

A

A

P

S

C

T

S

T

H

H

K

H

L

C

V

V

N

-

L

-

P

-

G

-

M

-

H

-

R

E

T

T

K

G

A

S

T

Q

D

E

P

A

L

S

L

A

I

I

F

Y

F

F

T
|
T

S

S

G

G

T

T

T

S

G

G

E

L

P

P

K

K

M

M

V

A

V

E

H

H

A

S

H

Y

S

S

Y

-

P

S

L

L

G

G

H

-

L

-

V

L

T

K

A

A

Q

K

L

M

-

D

-

A

-

G

W

W

H

T

D

G

L

L

H

Q

P

A

N

S

D

D

L

I

H

M

L

W

T

T

I

I

S

S

D

D

T

T

G

G

W
|
W

G

I

K

L

S

N

A

I

W

L

G

C

K

S

L

L

F

M

G

E

Q

P

W

W

I

A

V

L

G

G

A

A

C

C

I

T

F

F

V

V

Y

H

D

-

I

L

R

L

G

P

R

K

F

F

H

D

A

P

T

L

E

V

I

I

L

L

P

K

L

T

L

L

E

S

K

S

Y

Y

G

P

V

I

T

K

T

S

F

M

C

M

C

G

P

A

P

P

T

I

I

V

Y

Y

R

R

M

M

L

L

I

L

L

Q

A

Q

D

D

L

L

D

S

K

S

F

Y

D

K

L

F

A

P

D

H

M

L

R

Q

H

N

C

C

C

V

S

T

A

V

G
|
G

E
|
E

A
x
S

L

L

N

L

P

P

E

E

V

T

I

L

R

E

A

N

W

W

E

R

E

A

G

Q

T

T

G

G

R

L

T

D

I

I

Y

R

E
|
E

G

S

Y
|
Y

G
|
G

Q
|
Q

T
|
T

E
|
E

T

T

V

G

L

L

C

T

I

C

G

M

T

V

L

S

P

K

G

T

M

M

K

K

T

I

K

K

P

P

G

G

S

Y

M

M

G

G

R

T

P

A

M

A

P

S

G

C

W

Y

Q

D

I

V

E

Q

L

I

L

I

D

D

D

D

D

K

G

G

N

N

P

V

V

L

G

P

V

P

G

G

E

T

E

E

G

G

R

D

I

I

A

G

I

I

R

R

V

V

D

K

P

P

-

I

R

R

P

P

V

I

G

G

L

I

F

F

S

S

G

G

Y

Y

L

V

N

D

N

N

G

P

D

D

E

K

N

T

H

A

K

A

V

N

F

I

S

R

N

G

G

D

F

F

Y

W

F

L

T

L

G

G

D
|
D

K

R

A

G

Y

I

V

K

D

D

E

E

D

D

G

G

Y

Y

F

F

W

Q

F
|
F

I

M

G

G

R
|
R

D

A

D

D

D

D

V

I

I

I

K
x
N

S

S

S

S

G

G

Y

Y

R
|
R

I

I

G

G

P

P

F

S

E

E

V

V

E

E

S

N

A

A

L

L

M

M

E

E

H

H

P

P

A

A

V

V

Q

V

E

E

A

T

A

A

V

V

V

I

G

S

S

S

P

P

D

D

V

P

L

V

R

R

G

G

L

E

V

V

V

V

K

K

A

A

F

F

I

V

V

V

L

L

K

A

P

S

G

Q

Y

F

-

L

-

S

R

H

P

D

T

P

E

E

S

Q

L

L

V

T

K

K

E

E

I

L

Q

Q

K

Q

Q

H

V

V

K

K

R

S

V

V

T

T

A

A

P

P

Y

Y

K

K

Y

Y

P

P

R

R

L

K

I

I

E

E

F

F

V

V

E

L

S

N

L

L

P

P

K

K

T

T

I

V

S

T

G

G

K
|
K

I

I

K

Q

R

R

H

A

E

K

L

L

R

R

E

D

L

K

E

E

M

W

R

K

active site: T185 (= T203), T328 (= T347), E329 (= E348), N431 (≠ K449), R436 (= R454), K521 (= K537)
binding adenosine monophosphate: W229 (= W247), G302 (= G321), E303 (= E322), S304 (≠ A323), E323 (= E342), Y325 (= Y344), G326 (= G345), Q327 (= Q346), T328 (= T347), D410 (= D428), F422 (= F440), R425 (= R443), R436 (= R454)

3c5eA Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with atp (see paper)
42% identity, 93% coverage: 21:549/567 of query aligns to 6:536/536 of 3c5eA

query
sites
3c5eA

D

E

V

V

P

P

E

A

Y

K

Y

F

N

N

F

F

G

A

F

S

D

D

V

V

I

L

D

D

A

H

W

W

A

A

K

D

K

M

D

E

R

K

N

A

-

G

-

K

-

R

-

P

-

P

K

S

L

P

A

A

M

L

I

W

W

W

V

V

D

N

Q

G

K

K

G

G

N

K

E

E

K

L

K

M

Y

W

T

N

F

F

F

R

D

E

L

L

M

S

R

E

L

N

S

S

N

Q

Q

Q

A

A

V

A

N

N

I

V

C

L

L

S

-

G

K

A

Y

C

G

G

I

L

K

Q

K

R

G

G

D

D

R

R

V

V

M

A

L

V

M

V

L

L

P

P

R

R

T

V

P

P

E

E

W

W

W

W

I

L

F

V

T

I

I

L

A

G

L

C

I

I

K

R

L

A

G

G

A

L

V

I

Y

F

C

M

P

P

A

G

T

T

T

I

M

Q

L

M

T

K

P

S

K

T

D

D

L

I

K

L

Y

Y

R

R

I

L

Q

Q

A

M

A

S

D

K

I

A

R

K

M

A

I

I

I

V

T

A

M

G

A

D

E

E

H

V

A

I

D

Q

K

E

V

V

E

D

E

T

I

V

R

A

E

S

E

E

C

C

P

P

T

S

L

L

A

R

V

I

R

K

L

L

M

L

-

V

T

S

D

E

G

K

V

S

R

C

D

D

G

G

W

W

V

L

S

N

Y

F

P

K

V

K

E

L

L

L

D

N

Y

-

P

E

A

A

P

S

C

T

S

T

H

H

K

H

L

C

V

V

N

-

L

-

P

-

G

-

M

-

H

-

R

E

T

T

K

G

A

S

T

Q

D

E

P

A

L

S

L

A

I

I

F

Y

F

F

T
|
T

S
|
S

G
|
G

T
|
T

T
x
S

G

G

E

L

P

P

K

K

M

M

V

A

V

E

H

H

A

S

H

Y

S

S

Y

-

P

S

L

L

G

G

H

-

L

-

V

L

T

K

A

A

Q

K

L

M

-

D

-

A

-

G

W

W

H

T

D

G

L

L

H

Q

P

A

N

S

D

D

L

I

H

M

L

W

T

T

I

I

S

S

D

D

T

T

G

G

W

W

G

I

K

L

S

N

A

I

W

L

G

C

K

S

L

L

F

M

G

E

Q

P

W

W

I

A

V

L

G

G

A

A

C

C

I

T

F

F

V

V

Y

H

D

-

I

L

R

L

G

P

R

K

F

F

H

D

A

P

T

L

E

V

I

I

L

L

P

K

L

T

L

L

E

S

K

S

Y

Y

G

P

V

I

T

K

T

S

F

M

C

M

C

G

P

A

P

P

T

I

I

V

Y

Y

R

R

M

M

L

L

I

L

L

Q

A

Q

D

D

L

L

D

S

K

S

F

Y

D

K

L

F

A

P

D

H

M

L

R

Q

H

N

C

C

C

V

S

T

A

V

G
|
G

E
|
E

A
x
S

L

L

N

L

P

P

E

E

V

T

I

L

R

E

A

N

W

W

E

R

E

A

G

Q

T

T

G

G

R

L

T

D

I

I

Y

R

E

E

G

S

Y

Y

G
|
G

Q
|
Q

T
|
T

E
|
E

T

T

V

G

L

L

C

T

I

C

G

M

T

V

L

S

P

K

G

T

M

M

K

K

T

I

K

K

P

P

G

G

S

Y

M

M

G

G

R

T

P

A

M

A

P

S

G

C

W

Y

Q

D

I

V

E

Q

L

I

L

I

D

D

D

D

D

K

G

G

N

N

P

V

V

L

G

P

V

P

G

G

E

T

E

E

G

G

R

D

I

I

A

G

I

I

R

R

V

V

D

K

P

P

-

I

R

R

P

P

V

I

G

G

L

I

F

F

S

S

G

G

Y

Y

L

V

N

D

N

N

G

P

D

D

E

K

N

T

H

A

K

A

V

N

F

I

S

R

N

G

G

D

F

F

Y

W

F

L

T

L

G

G

D
|
D

K

R

A

G

Y

I

V

K

D

D

E

E

D

D

G

G

Y

Y

F

F

W

Q

F
|
F

I

M

G

G

R
|
R

D

A

D

D

D

D

V

I

I

I

K
x
N

S

S

S

S

G

G

Y

Y

R
|
R

I

I

G

G

P

P

F

S

E

E

V

V

E

E

S

N

A

A

L

L

M
|
M

E

E

H
|
H

P

P

A

A

V
|
V

Q

V

E

E

A

T

A

A

V

V

V

I

G

S

S

S

P

P

D

D

V

P

L

V

R

R

G

G

L

E

V

V

V

V

K

K

A

A

F

F

I

V

V

V

L

L

K

A

P

S

G

Q

Y

F

-

L

-

S

R

H

P

D

T

P

E

E

S

Q

L

L

V

T

K

K

E

E

I

L

Q

Q

K

Q

Q

H

V

V

K

K

R

S

V

V

T

T

A

A

P

P

Y

Y

K

K

Y

Y

P

P

R

R

L

K

I

I

E

E

F

F

V

V

E

L

S

N

L

L

P

P

K

K

T

T

I

V

S

T

G

G

K
|
K

I

I

K

Q

R

R

H

A

E

K

L

L

R

R

E

D

L

K

E

E

M

W

R

K

active site: T188 (= T203), T331 (= T347), E332 (= E348), N434 (≠ K449), R439 (= R454), K524 (= K537)
binding adenosine-5'-triphosphate: T188 (= T203), S189 (= S204), G190 (= G205), T191 (= T206), S192 (≠ T207), G305 (= G321), E306 (= E322), S307 (≠ A323), G329 (= G345), Q330 (= Q346), T331 (= T347), D413 (= D428), F425 (= F440), R428 (= R443), K524 (= K537)
binding magnesium ion: M450 (= M465), H452 (= H467), V455 (= V470)

3b7wA Crystal structure of human acyl-coa synthetase medium-chain family member 2a, with l64p mutation (see paper)
42% identity, 93% coverage: 21:549/567 of query aligns to 7:537/537 of 3b7wA

query
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3b7wA

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active site: T189 (= T203), T332 (= T347), E333 (= E348), N435 (≠ K449), R440 (= R454), K525 (= K537)
binding magnesium ion: M451 (= M465), H453 (= H467), V456 (= V470)

Q08AH3 Acyl-coenzyme A synthetase ACSM2A, mitochondrial; Acyl-CoA synthetase medium-chain family member 2A; Benzoate--CoA ligase; Butyrate--CoA ligase 2A; Butyryl-coenzyme A synthetase 2A; Middle-chain acyl-CoA synthetase 2A; EC 6.2.1.2; EC 6.2.1.25 from Homo sapiens (Human) (see 4 papers)
42% identity, 93% coverage: 21:549/567 of query aligns to 39:569/577 of Q08AH3

query
sites
Q08AH3

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