SitesBLAST
Comparing WP_068009499.1 NCBI__GCF_001623255.1:WP_068009499.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
57% identity, 100% coverage: 1:245/245 of query aligns to 3:247/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G13), S17 (≠ T15), R18 (≠ G16), I20 (= I18), T40 (= T38), N62 (= N60), V63 (≠ L61), N89 (= N87), A90 (= A88), I92 (= I90), V139 (≠ I137), S141 (= S139), Y154 (= Y152), K158 (= K156), P184 (= P182), G185 (= G183), I187 (= I185), T189 (= T187), M191 (= M189)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
57% identity, 100% coverage: 1:245/245 of query aligns to 3:243/243 of 4i08A
- active site: G19 (= G17), N113 (= N111), S141 (= S139), Q151 (= Q149), Y154 (= Y152), K158 (= K156)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G13), S17 (≠ T15), R18 (≠ G16), I20 (= I18), T40 (= T38), N62 (= N60), V63 (≠ L61), N89 (= N87), A90 (= A88), G140 (≠ T138), S141 (= S139), Y154 (= Y152), K158 (= K156), P184 (= P182), G185 (= G183), T189 (= T187)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
57% identity, 100% coverage: 2:245/245 of query aligns to 1:244/244 of P0AEK2
- GASR 12:15 (≠ GATG 13:16) binding NADP(+)
- T37 (= T38) binding NADP(+)
- NV 59:60 (≠ NL 60:61) binding NADP(+)
- N86 (= N87) binding NADP(+)
- Y151 (= Y152) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YSAAK 152:156) binding NADP(+)
- A154 (= A155) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K156) mutation to A: Defect in the affinity for NADPH.
- I184 (= I185) binding NADP(+)
- E233 (≠ Q234) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
57% identity, 100% coverage: 2:245/245 of query aligns to 1:244/244 of 6t77A
- active site: G16 (= G17), S138 (= S139), Y151 (= Y152)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G13), S14 (≠ T15), R15 (≠ G16), T37 (= T38), L58 (≠ A59), N59 (= N60), V60 (≠ L61), A87 (= A88), G88 (= G89), I89 (= I90)
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
58% identity, 99% coverage: 3:245/245 of query aligns to 1:243/243 of 1q7bA
- active site: G15 (= G17), E101 (= E103), S137 (= S139), Q147 (= Q149), Y150 (= Y152), K154 (= K156)
- binding calcium ion: E232 (≠ Q234), T233 (= T235)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G13), S13 (≠ T15), R14 (≠ G16), T36 (= T38), N58 (= N60), V59 (≠ L61), N85 (= N87), A86 (= A88), G87 (= G89), I88 (= I90), S137 (= S139), Y150 (= Y152), K154 (= K156), P180 (= P182), G181 (= G183), I183 (= I185)
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
57% identity, 99% coverage: 3:245/245 of query aligns to 1:243/243 of 1q7cA
- active site: G15 (= G17), S137 (= S139), Q147 (= Q149), F150 (≠ Y152), K154 (= K156)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G13), S13 (≠ T15), R14 (≠ G16), A35 (≠ G37), T36 (= T38), L57 (≠ A59), N58 (= N60), V59 (≠ L61), G87 (= G89), I88 (= I90)
7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
56% identity, 99% coverage: 3:245/245 of query aligns to 1:243/243 of 7emgB
P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
57% identity, 100% coverage: 2:245/245 of query aligns to 1:244/244 of P0A2C9
- M125 (= M126) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
- A223 (= A224) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
- S224 (= S225) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
50% identity, 98% coverage: 4:244/245 of query aligns to 3:247/247 of 4jroC
- active site: G16 (= G17), S142 (= S139), Q152 (= Q149), Y155 (= Y152), K159 (= K156)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G13), S14 (≠ T15), R15 (≠ G16), G16 (= G17), I17 (= I18), N35 (≠ S36), Y36 (vs. gap), N37 (vs. gap), G38 (= G37), S39 (≠ T38), N63 (= N60), V64 (≠ L61), N90 (= N87), A91 (= A88), I93 (= I90), I113 (≠ V110), S142 (= S139), Y155 (= Y152), K159 (= K156), P185 (= P182), I188 (= I185), T190 (= T187)
3tzcA Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg)(y155f) from vibrio cholerae (see paper)
52% identity, 99% coverage: 1:242/245 of query aligns to 3:223/224 of 3tzcA
4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution (see paper)
51% identity, 99% coverage: 2:244/245 of query aligns to 8:253/254 of 4ag3A
- active site: G23 (= G17), S148 (= S139), Y161 (= Y152), K165 (= K156)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G13), S21 (≠ T15), R22 (≠ G16), G23 (= G17), I24 (= I18), T44 (= T38), L68 (≠ D63), D69 (≠ R64), V70 (≠ D65), N96 (= N87), A97 (= A88), I146 (= I137), S148 (= S139), Y161 (= Y152), K165 (= K156), P191 (= P182), G192 (= G183), F193 (= F184), I194 (= I185), T196 (= T187), M198 (= M189), T199 (= T190)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
49% identity, 97% coverage: 7:244/245 of query aligns to 5:246/246 of 3osuA
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
49% identity, 97% coverage: 7:244/245 of query aligns to 2:239/239 of 3sj7A
- active site: G12 (= G17), S138 (= S139), Q148 (= Q149), Y151 (= Y152), K155 (= K156)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G13), S10 (≠ T15), R11 (≠ G16), I13 (= I18), N31 (vs. gap), Y32 (vs. gap), A33 (≠ S36), G34 (= G37), S35 (≠ T38), A58 (= A58), N59 (= N60), V60 (≠ L61), N86 (= N87), A87 (= A88), T109 (≠ V110), S138 (= S139), Y151 (= Y152), K155 (= K156), P181 (= P182), G182 (= G183)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii (see paper)
47% identity, 98% coverage: 5:244/245 of query aligns to 4:243/244 of 6wprA
- active site: G16 (= G17), S138 (= S139), Y151 (= Y152)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G13), S14 (≠ T15), R15 (≠ G16), T37 (= T38), L58 (≠ A59), D59 (≠ N60), V60 (≠ L61), N86 (= N87), A87 (= A88), G88 (= G89), I89 (= I90), I136 (= I137), Y151 (= Y152), K155 (= K156), P181 (= P182)
6t62A Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
47% identity, 98% coverage: 5:244/245 of query aligns to 4:243/244 of 6t62A
- active site: G16 (= G17), S138 (= S139), Y151 (= Y152)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G13), S14 (≠ T15), R15 (≠ G16), A36 (≠ G37), T37 (= T38), L58 (≠ A59), D59 (≠ N60), V60 (≠ L61), N86 (= N87), A87 (= A88), G88 (= G89), I89 (= I90), I136 (= I137), S137 (≠ T138), S138 (= S139), Y151 (= Y152), K155 (= K156), P181 (= P182), G182 (= G183), I184 (= I185), M188 (= M189)
4bo4C Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
51% identity, 99% coverage: 2:244/245 of query aligns to 14:254/255 of 4bo4C
4bnzA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-methyl-n-phenylindole- 3-carboxamide at 2.5a resolution (see paper)
49% identity, 99% coverage: 2:244/245 of query aligns to 3:240/241 of 4bnzA
4bnyA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 4-(2-phenylthieno(3,2-d) pyrimidin-4-yl)morpholine at 1.8a resolution (see paper)
49% identity, 99% coverage: 2:244/245 of query aligns to 2:238/239 of 4bnyA