SitesBLAST
Comparing WP_068166973.1 NCBI__GCF_001592305.1:WP_068166973.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
O28608 Alanine dehydrogenase; AlaDH; EC 1.4.1.1 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
38% identity, 100% coverage: 1:328/329 of query aligns to 1:320/322 of O28608
1omoA Alanine dehydrogenase dimer w/bound NAD (archaeal) (see paper)
38% identity, 100% coverage: 1:328/329 of query aligns to 1:320/320 of 1omoA
- active site: R52 (≠ D53), D219 (= D227)
- binding nicotinamide-adenine-dinucleotide: T109 (= T114), G134 (= G139), T135 (≠ K140), Q136 (= Q141), Y156 (≠ W161), D157 (= D162), V158 (≠ H163), R159 (≠ H164), T195 (= T203), P196 (≠ R204), G217 (= G225), D219 (= D227), K223 (= K231), S290 (= S298), T291 (= T299), G292 (= G300)
6t3eB Structure of thermococcus litoralis delta(1)-pyrroline-2-carboxylate reductase in complex with nadh and l-proline (see paper)
37% identity, 98% coverage: 4:327/329 of query aligns to 2:325/325 of 6t3eB
- binding 1,4-dihydronicotinamide adenine dinucleotide: S82 (= S85), T111 (= T114), G136 (= G139), V137 (≠ K140), Q138 (= Q141), D159 (= D162), I160 (≠ H163), A199 (≠ T202), T200 (= T203), T201 (≠ R204), A202 (≠ G205), V206 (≠ L209), V221 (≠ M224), G222 (= G225), W223 (≠ T226), S296 (= S298), V297 (≠ T299), G298 (= G300)
- binding proline: R39 (≠ Y41), M54 (≠ K55), K67 (= K68), R110 (= R113)
A1B8Z0 Iminosuccinate reductase; EC 1.4.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
39% identity, 79% coverage: 54:312/329 of query aligns to 53:305/320 of A1B8Z0
- R110 (= R113) binding NAD(+)
- HQ 137:138 (≠ KQ 140:141) binding NAD(+)
- N159 (≠ D162) binding NAD(+)
- S199 (≠ R204) binding NAD(+)
- MGTD 219:222 (= MGTD 224:227) binding NAD(+)
- K226 (= K231) binding NAD(+)
- G291 (≠ S298) binding NAD(+)
6rqaB Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+ (see paper)
39% identity, 79% coverage: 54:312/329 of query aligns to 55:307/322 of 6rqaB
- binding Tb-Xo4: N76 (= N76)
- binding nicotinamide-adenine-dinucleotide: T113 (= T114), G138 (= G139), Q140 (= Q141), P162 (≠ H163), H163 (= H164), I199 (≠ T202), T200 (= T203), S201 (≠ R204), S202 (≠ G205), M221 (= M224), G222 (= G225), D224 (= D227), K228 (= K231), G293 (≠ S298), T294 (= T299), G295 (= G300)
Sites not aligning to the query:
6rqaA Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+ (see paper)
39% identity, 79% coverage: 54:312/329 of query aligns to 55:307/322 of 6rqaA
- binding nicotinamide-adenine-dinucleotide: H85 (≠ G86), T113 (= T114), G138 (= G139), H139 (≠ K140), Q140 (= Q141), N161 (≠ D162), P162 (≠ H163), H163 (= H164), M166 (≠ N167), I199 (≠ T202), T200 (= T203), S201 (≠ R204), S202 (≠ G205), M221 (= M224), G222 (= G225), D224 (= D227), K228 (= K231), G293 (≠ S298)
2i99A Crystal structure of human mu_crystallin at 2.6 angstrom (see paper)
29% identity, 89% coverage: 20:313/329 of query aligns to 22:306/312 of 2i99A
- active site: G59 (≠ D53), S228 (≠ D227)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: D81 (≠ N76), S90 (= S85), H91 (≠ G86), R118 (= R113), T119 (= T114), G142 (= G137), A143 (≠ T138), G144 (= G139), V145 (≠ K140), Q146 (= Q141), N167 (≠ D162), R168 (≠ H163), T169 (≠ H164), V203 (≠ T202), T204 (= T203), L205 (≠ R204), A206 (≠ G205), V225 (≠ M224), G226 (= G225), S291 (= S298), L292 (≠ T299), G293 (= G300)
Q14894 Ketimine reductase mu-crystallin; NADP-regulated thyroid-hormone-binding protein; EC 1.5.1.25 from Homo sapiens (Human) (see paper)
29% identity, 89% coverage: 20:313/329 of query aligns to 23:307/314 of Q14894
4bv9A Crystal structure of the NADPH form of mouse mu-crystallin. (see paper)
29% identity, 89% coverage: 20:313/329 of query aligns to 21:298/303 of 4bv9A
- active site: G58 (≠ D53), S220 (≠ D227)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: S82 (= S85), H83 (≠ G86), T111 (= T114), G134 (= G137), G136 (= G139), V137 (≠ K140), Q138 (= Q141), N159 (≠ D162), R160 (≠ H163), T161 (≠ H164), V195 (≠ T202), T196 (= T203), M197 (≠ R204), A198 (≠ G205), V217 (≠ M224), G218 (= G225), S283 (= S298), L284 (≠ T299), G285 (= G300)
- binding pyruvic acid: R45 (≠ Y41), M60 (≠ K55), K73 (= K68), R110 (= R113)
4mp6A Staphyloferrin b precursor biosynthetic enzyme sbnb bound to citrate and NAD+ (see paper)
29% identity, 93% coverage: 21:327/329 of query aligns to 23:333/334 of 4mp6A
- active site: I60 (vs. gap), M236 (≠ D227)
- binding nicotinamide-adenine-dinucleotide: R92 (≠ S85), R120 (= R113), T121 (= T114), G146 (= G139), L147 (vs. gap), I148 (vs. gap), D170 (= D162), Q171 (≠ H163), C211 (≠ T202), T212 (= T203), V213 (≠ R204), I233 (≠ M224), G306 (= G300)
4mpdA Staphyloferrin b precursor biosynthetic enzyme sbnb bound a- ketoglutarate and NAD+ (see paper)
29% identity, 80% coverage: 64:327/329 of query aligns to 59:317/318 of 4mpdA
- active site: M224 (≠ D227)
- binding 2-oxoglutaric acid: K64 (≠ A69), I66 (≠ S71), R80 (≠ S85), M289 (≠ T299)
- binding nicotinamide-adenine-dinucleotide (acidic form): R80 (≠ S85), R108 (= R113), T109 (= T114), G134 (= G139), I136 (vs. gap), D158 (= D162), Q159 (≠ H163), F160 (≠ H164), T200 (= T203), V201 (≠ R204), I221 (≠ M224)
Sites not aligning to the query:
4bvaA Crystal structure of the NADPH-t3 form of mouse mu-crystallin. (see paper)
30% identity, 70% coverage: 85:313/329 of query aligns to 81:297/303 of 4bvaA
- active site: S219 (≠ D227)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: T106 (= T110), R109 (= R113), T110 (= T114), G135 (= G139), V136 (≠ K140), Q137 (= Q141), N158 (≠ D162), R159 (≠ H163), T160 (≠ H164), N163 (= N167), V194 (≠ T202), T195 (= T203), M196 (≠ R204), A197 (≠ G205), V216 (≠ M224), S282 (= S298), L283 (≠ T299), G284 (= G300)
- binding 3,5,3'triiodothyronine: S219 (≠ D227), R220 (≠ T228), W223 (≠ K231), E247 (= E254)
Sites not aligning to the query:
5gziA Cyclodeaminase_pa
29% identity, 97% coverage: 1:320/329 of query aligns to 5:326/354 of 5gziA
- binding nicotinamide-adenine-dinucleotide: Y85 (≠ G73), T97 (≠ S85), R125 (= R113), T126 (= T114), G151 (= G139), A152 (≠ K140), Q153 (= Q141), D174 (= D162), T175 (≠ H163), H179 (vs. gap), A212 (≠ T202), T213 (= T203), S214 (≠ R204), V215 (vs. gap), V237 (≠ M224), G238 (= G225), A239 (≠ T226), S305 (= S298), T306 (= T299), G307 (= G300)
- binding (2S)-piperidine-2-carboxylic acid: R53 (≠ T42), K81 (= K68), R125 (= R113), A239 (≠ T226), T306 (= T299), G307 (= G300)
5yu4A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
29% identity, 97% coverage: 1:320/329 of query aligns to 1:322/344 of 5yu4A
- binding 2,4-diaminobutyric acid: E63 (≠ F54), K77 (= K68), R121 (= R113), T302 (= T299), G303 (= G300)
- binding nicotinamide-adenine-dinucleotide: Y81 (≠ G73), T93 (≠ S85), I94 (≠ G86), R121 (= R113), T122 (= T114), G147 (= G139), A148 (≠ K140), Q149 (= Q141), D170 (= D162), T171 (≠ H163), H175 (vs. gap), A208 (≠ T202), T209 (= T203), S210 (≠ R204), V211 (vs. gap), V218 (≠ L209), V233 (≠ M224), A235 (≠ T226), S301 (= S298), T302 (= T299), G303 (= G300)
5yu3A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
29% identity, 97% coverage: 1:320/329 of query aligns to 1:322/344 of 5yu3A