SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_068167016.1 NCBI__GCF_001592305.1:WP_068167016.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

7kb1C Complex of o-acety-l-homoserine aminocarboxypropyltransferase (mety) from thermotoga maritima and a key reaction intermediate (see paper)
49% identity, 98% coverage: 8:432/435 of query aligns to 6:428/428 of 7kb1C

query
sites
7kb1C

G

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binding pyridoxal-5'-phosphate: Y57 (= Y57), R59 (= R59)
binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: G87 (= G87), Q88 (= Q88), Y112 (= Y112), N160 (= N159), D185 (= D184), S206 (= S206), T208 (= T208), K209 (= K209), N369 (= N373), I370 (≠ V374), R404 (= R408)

7kb1A Complex of o-acety-l-homoserine aminocarboxypropyltransferase (mety) from thermotoga maritima and a key reaction intermediate (see paper)
49% identity, 98% coverage: 8:432/435 of query aligns to 6:428/428 of 7kb1A

query
sites
7kb1A

G

G

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binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: Y57 (= Y57), R59 (= R59), G87 (= G87), Q88 (= Q88), Y112 (= Y112), N160 (= N159), D185 (= D184), S206 (= S206), T208 (= T208), K209 (= K209), N369 (= N373), I370 (≠ V374), R404 (= R408)

8wkoA Crystal structure of o-acetylhomoserine sulfhydrylase from lactobacillus plantarum in the closed form (see paper)
47% identity, 96% coverage: 9:427/435 of query aligns to 9:422/425 of 8wkoA

query
sites
8wkoA

F

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M

L

S

N

D

E

E

Q

A

E

L

L

A

L

G

A

A

A

G

G

I

V

G

T

P

P

G

D

T

L

I

I

R

R

L

I

S

S

I

V

G

G

L

V

E

E

D

N

P

A

D

D

D

D

L

L

I

I

D

A

D

D

L

L

K

D

R

Q

A

A

L

L

binding (2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid: G87 (= G87), S88 (≠ Q88), Y112 (= Y112), E155 (= E155), D184 (= D184), T186 (= T186), S206 (= S206), A207 (= A207), T208 (= T208), F209 (= F210), G212 (= G213), M217 (≠ I218), V369 (= V374), A370 (≠ G375)
binding proline: H213 (= H214), Q284 (= Q286), S288 (≠ T290)

O13326 Homocysteine synthase; O-acetylhomoserine sulfhydrylase; OAH SHL; OAH sulfhydrylase; EC 2.5.1.49 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
48% identity, 97% coverage: 9:430/435 of query aligns to 8:429/429 of O13326

query
sites
O13326

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Q

T

E

P

P

D

D

A

A

-

A

T

T

G

S

A

S

R

R

A

A

V

V

P

P

I

I

H

Y

L

A

T

T

T

T

S

S

F

Y

V

V

F

F

E

R

S

D

S

C

D

D

H

H

A

G

A

G

S

R

L

L

F

F

N

G

L

L

E

Q

R

E

A

P

G

G

H

Y

V

I

Y

Y

S

S

R

R

I

M

S

M

N

N

P

P

T

T

N

A

A

D

V

V

F

F

E

E

Q

K

R

R

M

I

A

A

A

A

L

L

E

E

G

H

G

G

I

A

G

A

A

A

I

I

A

A

V

T

A

S

S

S

G

G

Q

T

A

S

A

A

L

L

H

F

L

M

S

A

I

L

A

T

T

T

L

L

M

A

G

K

A

A

G

G

S

D

H

N

I

I

V

V

A

S

S

T

T

S

A

Y

L

L

Y

Y

G

G

G

G

S

T

Q

Y

N

N

L

L

L

F

H

K

Y

V

T

T

L

L

R

P

R

R

F

L

G

G

I

I

E

T

T

T

T

K

F

F

V

V

K

N

P

G

G

D

D

D

I

P

D

N

G

D

W

L

R

A

A

A

A

Q

V

I

R

D

P

E

N

N

T

T

R

K

L

A

F

V

F

Y

G

V

E

E

T

S

V

I

G

G

N

N

P

P

G

M

L

Y

D

N

V

V

L

P

D

D

I

F

P

E

T

R

V

I

A

A

Q

E

I

V

A

A

H

H

E

A

A

A

K

G

V

V

P

P

L

L

L

M

V

V

D

D

S

N

T

T

L

F

-

G

T

G

T

G

P

G

Y

Y

L

L

M

V

K

R

P

P

L

I

E

D

L

H

G

G

A

A

D

D

I

I

V

V

Y

T

H

H

S

S

A

A

T

T

K

K

F

W

L

I

S

G

G

G

H

H

G

G

T

T

V

T

I

I

G

G

G

G

V

V

V

I

V

V

D

D

G

S

G

G

S

K

F

F

D

D

W

W

E

K

A

K

S

N

G

S

K

K

-

R

F

F

P

P

E

E

L

F

T

N

E

E

P

P

Y

H

D

P

G

G

F

Y

H

H

G

G

M

M

T

V

F

F

S

T

E

E

E

T

S

F

T

G

V

N

G

L

A

A

F

Y

L

A

L

F

R

A

A

C

R

R

R

T

E

Q

G

T

L

L

R

R

D

D

F

V

G

G

A

G

C

N

L

A

S

N

P

P

H

F

S

G

A

V

W

F

L

L

I

L

L

L

Q

Q

G

G

I

L

E

E

T

T

L

L

P

S

L

L

R

R

M

M

E

E

R

R

H

H

M

V

A

Q

N

N

T

A

E

F

K

A

V

L

V

A

S

K

F

Y

L

L

A

E

S

K

H

H

P

P

L

K

V

V

G

N

R

W

V

V

G

S

H

Y

P

P

L

G

L

L

E

E

S

S

H

H

P

V

S

S

H

H

A

K

L

L

A

A

Q

K

K

K

L

Y

L

L

R

K

H

N

G

-

A

-

K

-

G

G

A

Y

G

G

S

A

V

V

F

L

S

S

F

F

D

G

I

A

Q

K

G

G

S

G

R

P

A

D

Q

Q

G

S

K

R

A

K

F

V

I

V

E

N

A

A

L

L

K

K

L

L

F

A

S

S

H

Q

L

L

A

A

N

N

V

V

G

G

D

D

C

A

R

K

S

T

L

L

V

V

I

I

H

A

P

P

A

A

S

Y

T

T

T

T

H

H

F

L

R

Q

M

L

S

T

D

D

E

E

A

E

L

Q

A

I

G

S

A

A

G

G

I

V

G

T

P

K

G

D

T

L

I

I

R

R

L

V

S

A

I

V

G
|
G

L

I

E

E

D

H

P

I

D

D

D

D

L

I

I

I

D

A

D

D

L

F

K

A

R

Q

A

A

L

L

K

E

A

V

A

A

G411 (= G412) mutation to D: Impairs homocysteine synthase activity.

8erbK Crystal structure of fub7 in complex with vinylglycine ketimine (see paper)
49% identity, 97% coverage: 8:430/435 of query aligns to 5:427/429 of 8erbK

query
sites
8erbK

G

N

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

T

T

P

P

D

D

A

P

-

H

T

T

G

R

A

S

R

T

A

A

V

V

P

P

I

I

H

Y

L

A

T

T

T

S

S

S

F

Y

V

T

F

F

E

N

S

D

S

S

D

A

H

H

A

G

A

A

S

R

L

L

F

F

N

G

L

L

E

K

R

E

A

L

G

G

H

N

V

I

Y
|
Y

S

S

R
|
R

I

L

S

M

N

N

P

P

T

T

N

V

A

D

V

V

F

F

E

E

Q

K

R

R

M

I

A

A

A

A

L

L

E

E

G

G

G

G

I

I

G

A

A

A

I

A

A

A

V

T

A

S

S

S

G
|
G

Q
|
Q

A

A

A

A

L
x
Q

H

F

L

L

S

T

I

I

A

A

T

T

L

L

M

A

G

K

A

A

G

G

S

D

H

N

I

I

V

V

A

A

S

S

T

S

A

H

L

L

Y
|
Y

G

G

G

G

S

T

Q

Y

N

N

L

Q

L

L

H

N

Y

V

T

L

L

L

R

P

R

R

F

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

K

R

P

S

G

G

D

K

I

L

D

E

G

D

W

Y

R

A

A

A

A

A

V

I

R

D

P

D

N

Q

T

T

R

R

L

A

F

I

F

Y

G

V

E

E

T

S

V

M

G

S

N
|
N

P

P

G

D

L

Y

D

V

V

V

L

P

D

D

I

F

P

E

T

G

V

I

A

A

Q

K

I

I

A

A

H

H

E

E

A

H

K

G

V

I

P

P

L

L

L

V

V

V

D
|
D

S

N

T

T

L

L

-

G

T

A

T

G

P

G

Y

Y

L

Y

M

I

K

R

P

P

L

I

E

E

L

H

G

G

A

A

D

D

I

I

V

V

Y

V

H

H

S
|
S

A

A

T
|
T

K
|
K

F

W

L

I

S

G

G

G

H

H

G

G

T

T

V

T

I

I

G

G

G

G

V

V

V

I

V

V

D

D

G

S

G

G

S

R

F

F

D

N

W

W

E

N

A

K

-

H

S

S

G

D

K

R

F

F

P

P

E

E

L

M

T

V

E

E

P

P

Y

S

D

P

G

S

F

Y

H

H

G

G

M

L

T

K

F

Y

S

W

E

E

E

A

S

F

T

G

V

P

G

A

A

T

F

F

L

I

L

T

R

R

A

I

R

R

R

V

E

E

G

M

L

L

R

R

D

D

F

I

G

G

A

A

C

C

L

L

S

S

P

P

H

F

S

S

A

A

W

Q

L

Q

I

L

L

L

Q

L

G

G

I

I

E

E

T

T

L

L

P

G

L

L

R

R

M

A

E

E

R

R

H

H

M

A

A

Q

N

N

T

T

E

E

K

K

V

L

V

S

S

K

F

Y

L

F

A

E

S

S

H

S

P

P

L

N

V

V

G

S

R

W

V

V

G

L

H

W

P

P

L

G

L

S

E

E

S

S

H

H

P

P

S

T

H

Y

A

S

L

Q

A

A

Q

K

K

K

L

Y

L

L

R

-

H

-

G

-

A

T

K

R

G

G

A

F

G

G

S

A

V

M

F

L

S

S

F

I

D

G

I

V

Q

K

G

G

S

D

R

A

A

S

Q

A

G

G

K

S

A

K

F

V

I

V

E

D

A

G

L

L

K

K

L

L

F

V

S

S

H

N

L

L

A

A

N

N

V

V

G

G

D

D

C

A

R

K

S

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T
|
T

H

H

F

E

R

Q

M

L

S

S

D

E

E

D

A

E

L

R

A

L

G

A

A

S

G

G

I

V

G

T

P

E

G

D

T

M

I

I

R
|
R

L

I

S

S

I

V

G

G

L

I

E

E

D

H

P

V

D

D

D

D

L

I

I

I

D

A

D

D

L

F

K

E

R

Q

A

S

L

F

K

Q

A

K

A

A

binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: Y55 (= Y57), R57 (= R59), G85 (= G87), Q86 (= Q88), Q89 (≠ L91), Y110 (= Y112), N157 (= N159), D182 (= D184), S205 (= S206), T207 (= T208), K208 (= K209), T385 (= T388), R405 (= R408)

8erjB Crystal structure of fub7 in complex with e-2-aminocrotonate (see paper)
49% identity, 97% coverage: 8:430/435 of query aligns to 4:426/428 of 8erjB

query
sites
8erjB

G

N

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

T

T

P

P

D

D

A

P

-

H

T

T

G

R

A

S

R

T

A

A

V

V

P

P

I

I

H

Y

L

A

T

T

T

S

S

S

F

Y

V

T

F

F

E

N

S

D

S

S

D

A

H

H

A

G

A

A

S

R

L

L

F

F

N

G

L

L

E

K

R

E

A

L

G

G

H

N

V

I

Y

Y

S

S

R

R

I

L

S

M

N

N

P

P

T

T

N

V

A

D

V

V

F

F

E

E

Q

K

R

R

M

I

A

A

A

A

L

L

E

E

G

G

G

G

I

I

G

A

A

A

I

A

A

A

V

T

A

S

S

S

G
|
G

Q
|
Q

A

A

A

A

L
x
Q

H

F

L

L

S

T

I

I

A

A

T

T

L

L

M

A

G

K

A

A

G

G

S

D

H

N

I

I

V

V

A

A

S

S

T

S

A

H

L

L

Y
|
Y

G

G

G

G

S

T

Q

Y

N

N

L

Q

L

L

H

N

Y

V

T

L

L

L

R

P

R

R

F

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

K

R

P

S

G

G

D

K

I

L

D

E

G

D

W

Y

R

A

A

A

A

A

V

I

R

D

P

D

N

Q

T

T

R

R

L

A

F

I

F

Y

G

V

E

E

T

S

V

M

G

S

N

N

P

P

G

D

L

Y

D

V

V

V

L

P

D

D

I

F

P

E

T

G

V

I

A

A

Q

K

I

I

A

A

H

H

E

E

A

H

K

G

V

I

P

P

L

L

L

V

V

V

D
|
D

S

N

T

T

L

L

-

G

T

A

T

G

P

G

Y

Y

L

Y

M

I

K

R

P

P

L

I

E

E

L

H

G

G

A

A

D

D

I

I

V

V

Y

V

H

H

S
|
S

A

A

T

T

K
|
K

F

W

L

I

S

G

G

G

H

H

G

G

T

T

V

T

I

I

G

G

G

G

V

V

V

I

V

V

D

D

G

S

G

G

S

R

F

F

D

N

W

W

E

N

A

K

-

H

S

S

G

D

K

R

F

F

P

P

E

E

L

M

T

V

E

E

P

P

Y

S

D

P

G

S

F

Y

H

H

G

G

M

L

T

K

F

Y

S

W

E

E

E

A

S

F

T

G

V

P

G

A

A

T

F

F

L

I

L

T

R

R

A

I

R

R

R

V

E

E

G

M

L

L

R

R

D

D

F

I

G

G

A

A

C

C

L

L

S

S

P

P

H

F

S

S

A

A

W

Q

L

Q

I

L

L

L

Q

L

G

G

I

I

E

E

T

T

L

L

P

G

L

L

R

R

M

A

E

E

R

R

H

H

M

A

A

Q

N

N

T

T

E

E

K

K

V

L

V

S

S

K

F

Y

L

F

A

E

S

S

H

S

P

P

L

N

V

V

G

S

R

W

V

V

G

L

H

W

P

P

L

G

L

S

E

E

S

S

H

H

P

P

S

T

H

Y

A

S

L

Q

A

A

Q

K

K

K

L

Y

L

L

R

-

H

-

G

-

A

T

K

R

G

G

A

F

G

G

S

A

V

M

F

L

S

S

F

I

D

G

I

V

Q

K

G

G

S

D

R

A

A

S

Q

A

G

G

K

S

A

K

F

V

I

V

E

D

A

G

L

L

K

K

L

L

F

V

S

S

H

N

L

L

A
|
A

N
|
N

V

V

G

G

D

D

C

A

R

K

S

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T
|
T

H

H

F

E

R

Q

M

L

S

S

D

E

E

D

A

E

L

R

A

L

G

A

A

S

G

G

I

V

G

T

P

E

G

D

T

M

I

I

R
|
R

L

I

S

S

I

V

G

G

L

I

E

E

D

H

P

V

D

D

D

D

L

I

I

I

D

A

D

D

L

F

K

E

R

Q

A

S

L

F

K

Q

A

K

A

A

binding (2S)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]but-3-enoic acid: G84 (= G87), Q85 (= Q88), Q88 (≠ L91), Y109 (= Y112), D181 (= D184), S204 (= S206), K207 (= K209), A368 (= A372), N369 (= N373), T384 (= T388), R404 (= R408)

8erjA Crystal structure of fub7 in complex with e-2-aminocrotonate (see paper)
49% identity, 97% coverage: 8:430/435 of query aligns to 4:426/428 of 8erjA

query
sites
8erjA

G

N

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

T

T

P

P

D

D

A

P

-

H

T

T

G

R

A

S

R

T

A

A

V

V

P

P

I

I

H

Y

L

A

T

T

T

S

S

S

F

Y

V

T

F

F

E

N

S

D

S

S

D

A

H

H

A

G

A

A

S

R

L

L

F

F

N

G

L

L

E

K

R

E

A

L

G

G

H

N

V

I

Y

Y

S

S

R

R

I

L

S

M

N

N

P

P

T

T

N

V

A

D

V

V

F

F

E

E

Q

K

R

R

M

I

A

A

A

A

L

L

E

E

G

G

G

G

I

I

G

A

A

A

I

A

A

A

V

T

A

S

S
|
S

G
|
G

Q
|
Q

A

A

A

A

L
x
Q

H

F

L

L

S

T

I

I

A

A

T

T

L

L

M

A

G

K

A

A

G

G

S

D

H

N

I

I

V

V

A

A

S

S

T

S

A

H

L

L

Y
|
Y

G

G

G

G

S

T

Q

Y

N

N

L

Q

L

L

H

N

Y

V

T

L

L

L

R

P

R

R

F

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

K

R

P

S

G

G

D

K

I

L

D

E

G

D

W

Y

R

A

A

A

A

A

V

I

R

D

P

D

N

Q

T

T

R

R

L

A

F

I

F

Y

G

V

E

E

T

S

V

M

G

S

N
|
N

P

P

G

D

L

Y

D

V

V

V

L

P

D

D

I

F

P

E

T

G

V

I

A

A

Q

K

I

I

A

A

H

H

E

E

A

H

K

G

V

I

P

P

L

L

L

V

V

V

D
|
D

S

N

T

T

L

L

-

G

T

A

T

G

P

G

Y

Y

L

Y

M

I

K

R

P

P

L

I

E

E

L

H

G

G

A

A

D

D

I

I

V

V

Y

V

H

H

S
|
S

A

A

T
|
T

K
|
K

F

W

L

I

S

G

G

G

H

H

G

G

T

T

V

T

I

I

G

G

G

G

V

V

V

I

V

V

D

D

G

S

G

G

S

R

F

F

D

N

W

W

E

N

A

K

-

H

S

S

G

D

K

R

F

F

P

P

E

E

L

M

T

V

E

E

P

P

Y

S

D

P

G

S

F

Y

H

H

G

G

M

L

T

K

F

Y

S

W

E

E

E

A

S

F

T

G

V

P

G

A

A

T

F

F

L

I

L

T

R

R

A

I

R

R

R

V

E

E

G

M

L

L

R

R

D

D

F

I

G

G

A

A

C

C

L

L

S

S

P

P

H

F

S

S

A

A

W

Q

L

Q

I

L

L

L

Q

L

G

G

I

I

E

E

T

T

L

L

P

G

L

L

R

R

M

A

E

E

R

R

H

H

M

A

A

Q

N

N

T

T

E

E

K

K

V

L

V

S

S

K

F

Y

L

F

A

E

S

S

H

S

P

P

L

N

V

V

G

S

R

W

V

V

G

L

H

W

P

P

L

G

L

S

E

E

S

S

H

H

P

P

S

T

H

Y

A

S

L

Q

A

A

Q

K

K

K

L

Y

L

L

R

-

H

-

G

-

A

T

K

R

G

G

A

F

G

G

S

A

V

M

F

L

S

S

F

I

D

G

I

V

Q

K

G

G

S

D

R

A

A

S

Q

A

G

G

K

S

A

K

F

V

I

V

E

D

A

G

L

L

K

K

L

L

F

V

S

S

H

N

L

L

A

A

N

N

V

V

G

G

D

D

C

A

R

K

S

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T

T

H

H

F

E

R

Q

M

L

S

S

D

E

E

D

A

E

L

R

A

L

G

A

A

S

G

G

I

V

G

T

P

E

G

D

T

M

I

I

R
|
R

L

I

S

S

I

V

G

G

L

I

E

E

D

H

P

V

D

D

D

D

L

I

I

I

D

A

D

D

L

F

K

E

R

Q

A

S

L

F

K

Q

A

K

A

A

binding (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid: S83 (= S86), G84 (= G87), Q85 (= Q88), Q88 (≠ L91), Y109 (= Y112), N156 (= N159), D181 (= D184), S204 (= S206), T206 (= T208), K207 (= K209), R404 (= R408)

2ctzA Crystal structure of o-acetyl homoserine sulfhydrylase from thermus thermophilus hb8
48% identity, 96% coverage: 9:427/435 of query aligns to 3:420/421 of 2ctzA

query
sites
2ctzA

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

T

E

P

P

D

E

A

P

T

T

G

T

-

L

A

S

R

R

A

Q

V

V

P

P

I

I

H

Y

L

P

T

T

T

T

S

S

F

Y

V

V

F

F

E

K

S

S

S

P

D

E

H

H

A

A

A

A

S

N

L

L

F

F

N

A

L

L

E

K

R

E

A

F

G

G

H

N

V

I

Y

Y

S

S

R
|
R

I

I

S

M

N

N

P

P

T

T

N

V

A

D

V

V

F

L

E

E

Q

K

R

R

M

L

A

A

A

A

L

L

E

E

G

G

G

G

I

K

G

A

A

A

I

L

A

A

V

T

A

A

S
|
S

G
|
G

Q
x
H

A

A

A

A

L
x
Q

H

F

L

L

S

A

I

L

A

T

T

T

L

L

M

A

G

Q

A

A

G

G

S

D

H

N

I

I

V

V

A

S

S

T

T

P

A

N

L

L

Y
|
Y

G

G

G

G

S

T

Q

F

N

N

L

Q

L

F

H

K

Y

V

T

T

L

L

R

K

R

R

F

L

G

G

I

I

E

E

T

V

T

R

F

F

V

T

-

S

K

R

P

E

G

E

D

R

I

P

D

E

G

E

W

F

R

L

A

A

A

L

V

T

R

D

P

E

N

K

T

T

R

R

L

A

F

W

F

W

G

V

E

E

T

S

V

I

G

G

N

N

P

P

G

A

L

L

D

N

V

I

L

P

D

D

I

L

P

E

T

A

V

L

A

A

Q

Q

I

A

A

A

H

R

E

E

A

K

K

G

V

V

P

A

L

L

L

I

V

V

D
|
D

S

N

T
|
T

L

F

-

G

T

M

T

G

P

G

Y

Y

L

L

M

L

K

R

P

P

L

L

E

A

L

W

G

G

A

A

D

A

I

L

V

V

Y

T

H

H

S
|
S

A

L

T
|
T

K
|
K

F

W

L

V

S

G

G

G

H

H

G

G

T

A

V

V

I

I

G

A

G

G

V

A

V

I

V

V

D

D

G

G

G

G

S

N

F

F

D

P

W

W

E

E

A

G

S

-

G

G

K

R

F

Y

P

P

E

L

L

L

T

T

E

E

P

P

Y

Q

D

P

G

G

F

Y

H

H

G

G

M

L

T

R

F

L

S

T

E

E

E

A

S

F

T

G

V

E

G

L

A

A

F

F

L

I

L

V

R

K

A

A

R

R

R

V

E

D

G

G

L

L

R

R

D

D

F

Q

G

G

A

Q

C

A

L

L

S

G

P

P

H

F

S

E

A

A

W

W

L

V

I

V

L

L

Q

L

G

G

I

M

E

E

T

T

L

L

P

S

L

L

R

R

M

A

E

E

R

R

H

H

M

V

A

E

N

N

T

T

E

L

K

H

V

L

V

A

S

H

F

W

L

L

A

L

S

E

H

Q

P

P

L

Q

V

V

G

A

R

W

V

V

G

N

H

Y

P

P

L

G

L

L

E

P

S

H

H

H

P

P

S

H

H

H

A

D

L

R

A

A

Q

Q

K

K

L

Y

L

F

R

K

H

-

G

-

A

-

K

G

G

K

A

P

G

G

S

A

V

V

F

L

S

T

F

F

D

G

I

L

Q

K

G

G

S

G

R

Y

A

E

Q

A

G

A

K

K

A

R

F

F

I

I

E

S

A

R

L

L

K

K

L

L

F

I

S

S

H

H

L

L

A

A

N

N

V

V

G

G

D

D

C

T

R

R

S

T

L

L

V

A

I

I

H

H

P

P

A

A

S

S

T

T

T

T

H

H

F

S

R

Q

M

L

S

S

D

P

E

E

A

E

L

Q

A

A

G

Q

A

A

G

G

I

V

G

S

P

P

G

E

T

M

I

V

R

R

L

L

S

S

I

V

G

G

L

L

E

E

D

H

P

V

D

E

D

D

L

L

I

K

D

A

D

E

L

L

K

K

R

E

A

A

L

L

active site: R54 (= R59), Y107 (= Y112), D180 (= D184), K206 (= K209)
binding pyridoxal-5'-phosphate: S81 (= S86), G82 (= G87), H83 (≠ Q88), Q86 (≠ L91), Y107 (= Y112), D180 (= D184), T182 (= T186), S203 (= S206), T205 (= T208), K206 (= K209)

Q5SK88 O-acetyl-L-homoserine sulfhydrylase 1; OAH-sulfhydrylase 1; EC 2.5.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
48% identity, 96% coverage: 9:427/435 of query aligns to 3:420/421 of Q5SK88

query
sites
Q5SK88

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

T

E

P

P

D

E

A

P

T

T

G

T

-

L

A

S

R

R

A

Q

V

V

P

P

I

I

H

Y

L

P

T

T

T

T

S

S

F

Y

V

V

F

F

E

K

S

S

S

P

D

E

H

H

A

A

A

A

S

N

L

L

F

F

N

A

L

L

E

K

R

E

A

F

G

G

H

N

V

I

Y

Y

S

S

R

R

I

I

S

M

N

N

P

P

T

T

N

V

A

D

V

V

F

L

E

E

Q

K

R

R

M

L

A

A

A

A

L

L

E

E

G

G

G

G

I

K

G

A

A

A

I

L

A

A

V

T

A

A

S

S

G

G

Q

H

A

A

A

A

L

Q

H

F

L

L

S

A

I

L

A

T

T

T

L

L

M

A

G

Q

A

A

G

G

S

D

H

N

I

I

V

V

A

S

S

T

T

P

A

N

L

L

Y

Y

G

G

G

G

S

T

Q

F

N

N

L

Q

L

F

H

K

Y

V

T

T

L

L

R

K

R

R

F

L

G

G

I

I

E

E

T

V

T

R

F

F

V

T

-

S

K

R

P

E

G

E

D

R

I

P

D

E

G

E

W

F

R

L

A

A

A

L

V

T

R

D

P

E

N

K

T

T

R

R

L

A

F

W

F

W

G

V

E

E

T

S

V

I

G

G

N

N

P

P

G

A

L

L

D

N

V

I

L

P

D

D

I

L

P

E

T

A

V

L

A

A

Q

Q

I

A

A

A

H

R

E

E

A

K

K

G

V

V

P

A

L

L

L

I

V

V

D

D

S

N

T

T

L

F

-

G

T

M

T

G

P

G

Y

Y

L

L

M

L

K

R

P

P

L

L

E

A

L

W

G

G

A

A

D

A

I

L

V

V

Y

T

H

H

S

S

A

L

T

T

K
|
K

F

W

L

V

S

G

G

G

H

H

G

G

T

A

V

V

I

I

G

A

G

G

V

A

V

I

V

V

D

D

G

G

G

G

S

N

F

F

D

P

W

W

E

E

A

G

S

-

G

G

K

R

F

Y

P

P

E

L

L

L

T

T

E

E

P

P

Y

Q

D

P

G

G

F

Y

H

H

G

G

M

L

T

R

F

L

S

T

E

E

E

A

S

F

T

G

V

E

G

L

A

A

F

F

L

I

L

V

R

K

A

A

R

R

R

V

E

D

G

G

L

L

R

R

D

D

F

Q

G

G

A

Q

C

A

L

L

S

G

P

P

H

F

S

E

A

A

W

W

L

V

I

V

L

L

Q

L

G

G

I

M

E

E

T

T

L

L

P

S

L

L

R

R

M

A

E

E

R

R

H

H

M

V

A

E

N

N

T

T

E

L

K

H

V

L

V

A

S

H

F

W

L

L

A

L

S

E

H

Q

P

P

L

Q

V

V

G

A

R

W

V

V

G

N

H

Y

P

P

L

G

L

L

E

P

S

H

H

H

P

P

S

H

H

H

A

D

L

R

A

A

Q

Q

K

K

L

Y

L

F

R

K

H

-

G

-

A

-

K

G

G

K

A

P

G

G

S

A

V

V

F

L

S

T

F

F

D

G

I

L

Q

K

G

G

S

G

R

Y

A

E

Q

A

G

A

K

K

A

R

F

F

I

I

E

S

A

R

L

L

K

K

L

L

F

I

S

S

H

H

L

L

A

A

N

N

V

V

G

G

D

D

C

T

R

R

S

T

L

L

V

A

I

I

H

H

P

P

A

A

S

S

T

T

T

T

H

H

F

S

R

Q

M

L

S

S

D

P

E

E

A

E

L

Q

A

A

G

Q

A

A

G

G

I

V

G

S

P

P

G

E

T

M

I

V

R

R

L

L

S

S

I

V

G

G

L

L

E

E

D

H

P

V

D

E

D

D

L

L

I

K

D

A

D

E

L

L

K

K

R

E

A

A

L

L

K206 (= K209) modified: N6-(pyridoxal phosphate)lysine

4omaA The crystal structure of methionine gamma-lyase from citrobacter freundii in complex with l-cycloserine pyridoxal-5'-phosphate (see paper)
41% identity, 97% coverage: 8:430/435 of query aligns to 7:395/396 of 4omaA

query
sites
4omaA

G

G

F

F

D

N

T

T

L

Q

A

I

L

V

H

H

A

A

G

G

A

Q

T

Q

P

P

D

D

-

P

A

S

T

T

G

G

A

A

R

L

A

S

V

T

P

P

I

I

H

F

L

Q

T

T

T

S

S

T

F

F

V

V

F

F

E

D

S

S

S

A

D

E

H

Q

A

G

A

A

S

A

L

R

F

F

N

A

L

L

E

E

R

E

A

S

G

G

H

Y

V

I

Y

Y

S

T

R
|
R

I

L

S

G

N

N

P

P

T

T

N

T

A

D

V

A

F

L

E

E

Q

K

R

K

M

L

A

A

A

V

L

L

E

E

G

R

G

G

I

E

G

A

A

G

I

L

A

A

V

T

A

A

S

S

G
|
G

Q
x
I

A

S

A

A

L

I

H

T

L

T

S

T

I

L

A

L

T

T

L

L

M

C

G

Q

A

Q

G

G

S

D

H

H

I

I

V

V

A

S

S

A

T

S

A

A

L

I

Y
|
Y

G

G

G

C

S

T

Q

H

N

A

L

F

L

L

H

S

Y

H

T

S

L

M

R

P

R

K

F

F

G

G

I

I

E

N

T

V

T

S

F

F

V

V

K

D

P

A

G

A

D

K

I

P

D

E

G

E

W

I

R

R

A

A

A

A

V

M

R

R

P

P

N

E

T

T

R

K

L

V

F

V

F

Y

G

I

E

E

T

T

V

P

G

A

N

N

P

P

G

T

L

L

D

S

V

L

L

V

D

D

I

I

P

E

T

T

V

V

A

A

Q

G

I

I

A

A

H

H

E

Q

A

Q

K

G

V

A

P

L

L

L

L

V

V

V

D
|
D

S

N

T

T

L

F

T

M

T

S

P

P

Y

Y

L

C

M

Q

K

Q

P

P

L

L

E

Q

L

L

G

G

A

A

D

D

I

I

V

V

Y

V

H

H

S
|
S

A

V

T
|
T

K
|
K

F

Y

L

I

S

N

G

G

H

H

G

G

T

D

V

V

I

I

G

G

G

G

V

I

V

I

V

V

D

-

G

-

G

-

S

-

F

-

D

-

W

-

E

-

A

-

S

-

G

G

K

K

F

-

P

-

E

-

L

-

T

-

E

-

P

-

Y

-

D

-

G

-

F

-

H

-

G

-

M

-

T

-

F

-

S

-

E

-

E

-

S

-

T

-

V

-

G

Q

A

E

F

F

L

I

L

D

R

Q

A

A

R

R

R

F

E

V

G

G

L

L

R

K

D

D

F

I

-

T

G

G

A

G

C

C

L

M

S

S

P

P

H

F

S

N

A

A

W

W

L

L

I

T

L

L

Q

R

G

G

I

V

E

K

T

T

L

L

P

G

L

I

R

R

M

M

E

E

R

R

H

H

M

C

A

E

N

N

T

A

E

L

K

K

V

I

V

A

S

R

F

F

L

L

A

E

S

G

H

H

P

P

L

S

V

I

G

T

R

R

V

V

G

Y

H

Y

P

P

L

G

L

L

E

S

S

S

H

H

P

P

S

Q

H

Y

A

E

L

L

A

G

Q

Q

K

R

L

Q

L

M

R

S

H

L

G

-

A

-

K

-

G

-

A

P

G

G

S

G

V

I

F

I

S

S

F

F

D

E

I

I

Q

A

G

G

S

G

R

L

A

E

Q

A

G

G

K

R

A

R

F

M

I

I

E

N

A

S

L

V

K

E

L

L

F

C

S

L

H

L

L

A

A
x
V

N
x
S

V

L

G

G

D

D

C

T

R

E

S

T

L

L

V

I

I

Q

H

H

P

P

A

A

S

S

T

M

T

T

H

H

F

S

R

P

M

V

S

A

D

P

E

E

A

E

L

R

A

L

G

K

A

A

G

G

I

I

G

T

P

D

G

G

T

L

I

I

R
|
R

L

L

S

S

I

V

G

G

L

L

E

E

D

D

P

P

D

E

D

D

L

I

I

I

D

N

D

D

L

L

K

E

R

H

A

A

L

I

K

R

A

K

A

A

active site: R59 (= R59), Y112 (= Y112), D184 (= D184), K209 (= K209)
binding [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate: G87 (= G87), I88 (≠ Q88), Y112 (= Y112), D184 (= D184), S206 (= S206), T208 (= T208), K209 (= K209), V337 (≠ A372), S338 (≠ N373), R373 (= R408)

3jwbA Crystal structure of l-methionine gamma-lyase from citrobacter freundii with norleucine (see paper)
41% identity, 97% coverage: 8:430/435 of query aligns to 7:395/396 of 3jwbA

query
sites
3jwbA

G

G

F

F

D

N

T

T

L

Q

A

I

L

V

H

H

A

A

G

G

A

Q

T

Q

P

P

D

D

-

P

A

S

T

T

G

G

A

A

R

L

A

S

V

T

P

P

I

I

H

F

L

Q

T

T

T

S

S

T

F

F

V

V

F

F

E

D

S

S

S

A

D

E

H

Q

A

G

A

A

S

A

L

R

F

F

N

A

L

L

E

E

R

E

A

S

G

G

H

Y

V

I

Y

Y

S

T

R
|
R

I

L

S

G

N

N

P

P

T

T

N

T

A

D

V

A

F

L

E

E

Q

K

R

K

M

L

A

A

A

V

L

L

E

E

G

R

G

G

I

E

G

A

A

G

I

L

A

A

V

T

A

A

S

S

G

G

Q

I

A

S

A

A

L

I

H

T

L

T

S

T

I

L

A

L

T

T

L

L

M

C

G

Q

A

Q

G

G

S

D

H

H

I

I

V

V

A

S

S

A

T

S

A

A

L

I

Y
|
Y

G

G

G

C

S

T

Q

H

N

A

L

F

L

L

H

S

Y

H

T

S

L

M

R

P

R

K

F

F

G

G

I

I

E

N

T

V

T

S

F

F

V

V

K

D

P

A

G

A

D

K

I

P

D

E

G

E

W

I

R

R

A

A

A

A

V

M

R

R

P

P

N

E

T

T

R

K

L

V

F

V

F

Y

G

I

E

E

T

T

V

P

G

A

N

N

P

P

G

T

L

L

D

S

V

L

L

V

D

D

I

I

P

E

T

T

V

V

A

A

Q

G

I

I

A

A

H

H

E

Q

A

Q

K

G

V

A

P

L

L

L

L

V

V

V

D
|
D

S

N

T

T

L

F

T

M

T

S

P

P

Y

Y

L

C

M

Q

K

Q

P

P

L

L

E

Q

L

L

G

G

A

A

D

D

I

I

V

V

Y

V

H

H

S

S

A

V

T

T

K
|
K

F

Y

L

I

S

N

G

G

H

H

G

G

T

D

V

V

I

I

G

G

G

G

V

I

V

I

V

V

D

-

G

-

G

-

S

-

F

-

D

-

W

-

E

-

A

-

S

-

G

G

K

K

F

-

P

-

E

-

L

-

T

-

E

-

P

-

Y

-

D

-

G

-

F

-

H

-

G

-

M

-

T

-

F

-

S

-

E

-

E

-

S

-

T

-

V

-

G

Q

A

E

F

F

L

I

L

D

R

Q

A

A

R

R

R

F

E

V

G

G

L

L

R

K

D

D

F

I

-

T

G

G

A

G

C

C

L

M

S

S

P

P

H

F

S

N

A

A

W

W

L

L

I

T

L

L

Q

R

G

G

I

V

E

K

T

T

L

L

P

G

L

I

R

R

M

M

E

E

R

R

H

H

M

C

A

E

N

N

T

A

E

L

K

K

V

I

V

A

S

R

F

F

L

L

A

E

S

G

H

H

P

P

L

S

V

I

G

T

R

R

V

V

G

Y

H

Y

P

P

L

G

L

L

E

S