SitesBLAST
Comparing WP_068168204.1 NCBI__GCF_001592305.1:WP_068168204.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6wsbA Crystal structure of a betaine aldehyde dehydrogenase from burkholderia pseudomallei bound to cofactor NAD (see paper)
60% identity, 95% coverage: 19:478/485 of query aligns to 20:482/489 of 6wsbA
- active site: N152 (= N150), E250 (= E247), C284 (= C281), E462 (= E458)
- binding nicotinamide-adenine-dinucleotide: I148 (= I146), G149 (= G147), A150 (= A148), W151 (= W149), N152 (= N150), K175 (= K173), E178 (= E176), G208 (= G206), G211 (= G209), A212 (= A210), F225 (≠ V223), T226 (= T224), G227 (= G225), G228 (≠ S226), T231 (= T229), V235 (= V233), E250 (= E247), L251 (= L248), G252 (= G249), C284 (= C281), E385 (= E381), F387 (= F383)
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
57% identity, 98% coverage: 9:482/485 of query aligns to 9:487/489 of 4cazA
- active site: N152 (= N150), K175 (= K173), E251 (= E247), C285 (= C281), E386 (= E381), E463 (= E458)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I146), G149 (= G147), W151 (= W149), N152 (= N150), K175 (= K173), E178 (= E176), G208 (= G206), G212 (= G209), F226 (≠ V223), T227 (= T224), G228 (= G225), G229 (≠ S226), T232 (= T229), V236 (= V233), E251 (= E247), L252 (= L248), C285 (= C281), E386 (= E381), F388 (= F383)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
57% identity, 98% coverage: 9:482/485 of query aligns to 9:487/489 of 2woxA
- active site: N152 (= N150), K175 (= K173), E251 (= E247), C285 (= C281), E386 (= E381), E463 (= E458)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I146), G149 (= G147), W151 (= W149), N152 (= N150), K175 (= K173), S177 (= S175), E178 (= E176), G208 (= G206), G212 (= G209), F226 (≠ V223), T227 (= T224), G228 (= G225), G229 (≠ S226), T232 (= T229), V236 (= V233), E251 (= E247), L252 (= L248), C285 (= C281), E386 (= E381), F388 (= F383)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
57% identity, 98% coverage: 9:482/485 of query aligns to 9:487/489 of 2wmeA
- active site: N152 (= N150), K175 (= K173), E251 (= E247), C285 (= C281), E386 (= E381), E463 (= E458)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (= G147), W151 (= W149), K175 (= K173), S177 (= S175), E178 (= E176), G208 (= G206), G212 (= G209), F226 (≠ V223), G228 (= G225), G229 (≠ S226), T232 (= T229), V236 (= V233)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
57% identity, 98% coverage: 9:482/485 of query aligns to 10:488/490 of Q9HTJ1
- GAWN 150:153 (= GAWN 147:150) binding NADPH
- K162 (= K159) active site, Charge relay system
- KPSE 176:179 (= KPSE 173:176) binding NADPH
- G209 (= G206) binding NADPH
- GTST 230:233 (≠ SVPT 226:229) binding NADPH
- E252 (= E247) active site, Proton acceptor
- C286 (= C281) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E381) binding NADPH
- E464 (= E458) active site, Charge relay system
8skfA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (lattice translocation disorder)
57% identity, 97% coverage: 9:478/485 of query aligns to 17:491/497 of 8skfA
- binding calcium ion: T33 (≠ S24), I34 (≠ V25), D100 (= D91), V187 (≠ L177)
- binding nicotinamide-adenine-dinucleotide: I156 (= I146), G157 (= G147), A158 (= A148), W159 (= W149), K183 (= K173), E186 (= E176), G216 (= G206), G220 (= G209), T235 (= T224), G236 (= G225), G237 (≠ S226), S240 (≠ T229), K243 (≠ R232), E259 (= E247), C293 (= C281), F396 (= F383)
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
57% identity, 97% coverage: 9:478/485 of query aligns to 8:482/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
57% identity, 97% coverage: 9:478/485 of query aligns to 8:482/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
57% identity, 97% coverage: 9:478/485 of query aligns to 8:482/488 of 8vqzA
8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
57% identity, 97% coverage: 9:478/485 of query aligns to 8:482/488 of 8vqwC