SitesBLAST
Comparing WP_068168371.1 NCBI__GCF_001592305.1:WP_068168371.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
3dmeA Crystal structure of conserved exported protein from bordetella pertussis. Northeast structural genomics target ber141
60% identity, 98% coverage: 3:364/368 of query aligns to 2:361/366 of 3dmeA
- binding flavin-adenine dinucleotide: I8 (= I9), G9 (= G10), G11 (= G12), V12 (= V13), V13 (= V14), E32 (= E33), A33 (≠ R34), T41 (= T42), S42 (= S43), R44 (= R45), N45 (= N46), S46 (= S47), V48 (= V49), H50 (= H51), P170 (≠ S170), L171 (≠ G171), A203 (= A201), I313 (≠ M316), R314 (= R317), I346 (= I349), E347 (= E350), S348 (= S351), P349 (= P352), G350 (= G353), L351 (= L354), T352 (= T355)
8w7fB Structure of drosophila melanogaster l-2-hydroxyglutarate dehydrogenase bound with fad and a sulfate ion (see paper)
36% identity, 70% coverage: 17:273/368 of query aligns to 16:274/412 of 8w7fB
- binding flavin-adenine dinucleotide: E34 (= E33), K35 (≠ R34), H42 (≠ G41), Q43 (≠ T42), S44 (= S43), H46 (≠ R45), N47 (= N46), S48 (= S47), V50 (= V49), H52 (= H51), V173 (= V172), G205 (≠ A201), G206 (= G202), Q208 (≠ H204), Y231 (= Y230)
Sites not aligning to the query:
8w78A Structure of drosophila melanogaster l-2-hydroxyglutarate dehydrogenase in complex with fad and 2-oxoglutarate (see paper)
37% identity, 70% coverage: 17:273/368 of query aligns to 16:272/410 of 8w78A
- binding 2-oxoglutaric acid: S48 (= S47), H52 (= H51), Y245 (= Y244), F254 (≠ G255), L255 (= L256), H258 (= H259)
- binding flavin-adenine dinucleotide: E34 (= E33), K35 (≠ R34), H42 (≠ G41), Q43 (≠ T42), S44 (= S43), N47 (= N46), S48 (= S47), V50 (= V49), H52 (= H51), V173 (= V172), G203 (≠ A201), G204 (= G202), Q206 (≠ H204)
Sites not aligning to the query:
Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 4 papers)
23% identity, 57% coverage: 2:210/368 of query aligns to 48:257/866 of Q9UI17
- CV 59:60 (≠ VV 13:14) binding FAD
- EK 80:81 (≠ RE 34:35) binding FAD
- 87:95 (vs. 41:49, 11% identical) binding FAD
- H91 (≠ R45) modified: Tele-8alpha-FAD histidine
- H109 (≠ C66) to R: in DMGDHD; shows 10 fold lower catalytic efficiency due to lower cofactor saturation and reduced thermal stability; dbSNP:rs121908331
- V219 (= V172) binding FAD
Sites not aligning to the query:
- 279 S → P: in dbSNP:rs532964
- 397:402 binding FAD
- 530 A → G: in dbSNP:rs1805073
- 646 S → P: in dbSNP:rs1805074
Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 2 papers)
24% identity, 57% coverage: 2:210/368 of query aligns to 41:250/857 of Q63342
- CV 52:53 (≠ VV 13:14) binding FAD
- EK 73:74 (≠ ER 33:34) binding FAD
- 80:88 (vs. 38:46, 11% identical) binding FAD
- H84 (≠ T42) modified: Tele-8alpha-FAD histidine
- V212 (= V172) binding FAD
- W244 (≠ H204) binding FAD
Sites not aligning to the query:
- 390:395 binding FAD
- 573:575 binding (6S)-5,6,7,8-tetrahydrofolate
- 669 binding (6S)-5,6,7,8-tetrahydrofolate
- 676:678 binding (6S)-5,6,7,8-tetrahydrofolate
- 737 binding (6S)-5,6,7,8-tetrahydrofolate
4pabB Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
24% identity, 57% coverage: 2:210/368 of query aligns to 4:213/824 of 4pabB
- active site: T53 (≠ E48), E102 (≠ G101)
- binding flavin-adenine dinucleotide: I11 (= I9), G12 (= G10), G14 (= G12), C15 (≠ V13), V16 (= V14), L35 (= L32), E36 (= E33), K37 (≠ R34), G43 (≠ I38), S44 (≠ G39), T45 (= T40), H47 (≠ T42), A48 (≠ S43), A49 (≠ S44), G50 (≠ R45), L51 (≠ N46), V175 (= V172), A204 (= A201), G205 (= G202), W207 (≠ H204)
Sites not aligning to the query:
- active site: 226, 255, 536
- binding flavin-adenine dinucleotide: 226, 228, 326, 328, 353, 355, 356, 357, 358
- binding (6s)-5,6,7,8-tetrahydrofolate: 523, 536, 538, 550, 612, 613, 632, 639, 680, 700
Query Sequence
>WP_068168371.1 NCBI__GCF_001592305.1:WP_068168371.1
MESVDVVVIGAGVVGLAVARSLALAGREVMVLEREAAIGTGTSSRNSEVIHAGIYYPQGS
LKARLCVRGRELLYAYCTERGIAHRRCGKLMVANTASQVQGLPGILARAEANGVPDLMPL
TRAEARALEPQLECLAALHSPSTGIVDSHGLMLSLQGDLEHAAGLVACRSGVASLRATGA
GVEVLMQDGTALLARGVVNAAGLHACELARNAQGLNPAHVPRAWYAKGSYFTLSGRSPFG
RLIYPVPDPASHLAGLGVHLTIDLGGQAKFGPDVQWTDDPDDLSVNPGSADGFYAAVRQY
WPGLPDAALVPGYAGMRPKISGPHEPAADFRIDGPAAHGVPGLVNLLGIESPGLTSCLAI
GEHVATLL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory