SitesBLAST
Comparing WP_068170917.1 NCBI__GCF_001592305.1:WP_068170917.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4ktoA Crystal structure of a putative isovaleryl-coa dehydrogenase (psi- nysgrc-012251) from sinorhizobium meliloti 1021
69% identity, 98% coverage: 6:391/393 of query aligns to 5:377/377 of 4ktoA
- active site: M130 (= M131), S131 (= S132), E239 (= E248), A360 (= A374), R372 (= R386)
- binding flavin-adenine dinucleotide: L128 (= L129), M130 (= M131), S131 (= S132), M155 (= M161), W156 (= W162), T158 (= T164), R265 (= R274), F268 (= F277), I272 (= I281), F275 (= F284), M278 (≠ I287), Q333 (= Q347), A334 (≠ I348), G337 (= G351), L355 (= L369), G359 (= G373), T362 (= T376), E364 (= E378)
1ivhA Structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity (see paper)
63% identity, 97% coverage: 11:391/393 of query aligns to 8:387/387 of 1ivhA
- active site: M130 (= M131), S131 (= S132), E249 (= E248), A370 (= A374), R382 (= R386)
- binding coenzyme a persulfide: S137 (= S138), S185 (≠ A184), R186 (= R185), V239 (≠ A238), Y240 (≠ K239), M243 (= M242), E249 (= E248), R250 (= R249), G369 (= G373), A370 (= A374), G371 (= G375), V375 (≠ I379)
- binding flavin-adenine dinucleotide: L128 (= L129), M130 (= M131), S131 (= S132), G136 (= G137), S137 (= S138), W161 (= W162), T163 (= T164), R275 (= R274), F278 (= F277), F285 (= F284), M288 (≠ I287), Q343 (= Q347), C344 (≠ I348), G347 (= G351), T372 (= T376), E374 (= E378)
8sgrA Human liver mitochondrial isovaleryl-coa dehydrogenase (see paper)
63% identity, 97% coverage: 11:391/393 of query aligns to 12:391/393 of 8sgrA
- binding flavin-adenine dinucleotide: S135 (= S132), G140 (= G137), S141 (= S138), W165 (= W162), T167 (= T164), R279 (= R274), F282 (= F277), I286 (= I281), F289 (= F284), Q347 (= Q347), C348 (≠ I348), G351 (= G351), L369 (= L369), G375 (= G375), T376 (= T376), L382 (≠ M382)
P26440 Isovaleryl-CoA dehydrogenase, mitochondrial; IVD; Butyryl-CoA dehydrogenase; EC 1.3.8.4; EC 1.3.8.1 from Homo sapiens (Human) (see 5 papers)
63% identity, 97% coverage: 11:391/393 of query aligns to 45:424/426 of P26440
- 165:174 (vs. 129:138, 90% identical) binding FAD
- S174 (= S138) binding substrate
- WIT 198:200 (= WIT 162:164) binding FAD
- SR 222:223 (≠ AR 184:185) binding substrate
- G250 (= G212) to A: in IVA; uncertain significance
- Y277 (≠ K239) binding substrate
- DLER 284:287 (≠ DYER 246:249) binding substrate
- E286 (= E248) active site, Proton acceptor; mutation to D: Residual isovaleryl-CoA dehydrogenase activity.; mutation to G: Loss of isovaleryl-CoA dehydrogenase activity. Does not affect isovaleryl-CoA dehydrogenase activity; when associated with 407-E.; mutation to Q: Loss of isovaleryl-CoA dehydrogenase activity.
- A291 (≠ T253) to V: in IVA; uncertain significance; dbSNP:rs886042098
- R312 (= R274) binding FAD
- Q323 (= Q285) binding FAD
- I379 (≠ V346) to T: in IVA; uncertain significance
- QCFGG 380:384 (≠ QIYGG 347:351) binding FAD
- R398 (= R365) to Q: in IVA; uncertain significance; dbSNP:rs1477527791
- Y403 (= Y370) to N: in IVA; uncertain significance
- A407 (= A374) mutation to E: Does not affect isovaleryl-CoA dehydrogenase activity; when associated with 286-D.
- AG 407:408 (= AG 374:375) binding substrate
- TSE 409:411 (= TSE 376:378) binding FAD
Sites not aligning to the query:
- 1:32 modified: transit peptide, Mitochondrion
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
43% identity, 95% coverage: 18:389/393 of query aligns to 9:373/374 of 5lnxD
- active site: L122 (≠ M131), T123 (≠ S132), G239 (≠ E248), E358 (≠ A374), K370 (≠ R386)
- binding flavin-adenine dinucleotide: L122 (≠ M131), T123 (≠ S132), G128 (= G137), S129 (= S138), F153 (≠ W162), T155 (= T164), R265 (= R274), Q267 (= Q276), F268 (= F277), I272 (= I281), N275 (≠ F284), I278 (= I287), Q331 (= Q347), I332 (= I348), G335 (= G351), Y357 (≠ G373), T360 (= T376), E362 (= E378)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
39% identity, 95% coverage: 18:389/393 of query aligns to 11:377/378 of 5ol2F
- active site: L124 (≠ M131), T125 (≠ S132), G241 (≠ E248), G374 (≠ R386)
- binding calcium ion: E29 (= E36), E33 (≠ S40), R35 (≠ Q42)
- binding coenzyme a persulfide: L238 (= L245), R242 (= R249), E362 (≠ A374), G363 (= G375)
- binding flavin-adenine dinucleotide: F122 (≠ L129), L124 (≠ M131), T125 (≠ S132), P127 (= P134), T131 (≠ S138), F155 (≠ W162), I156 (= I163), T157 (= T164), E198 (≠ L205), R267 (= R274), F270 (= F277), L274 (≠ I281), F277 (= F284), Q335 (= Q347), L336 (≠ I348), G338 (= G350), G339 (= G351), Y361 (≠ G373), T364 (= T376), E366 (= E378)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
38% identity, 97% coverage: 8:389/393 of query aligns to 4:380/384 of 1jqiA
- active site: G377 (≠ R386)
- binding acetoacetyl-coenzyme a: L95 (= L99), F125 (≠ L129), S134 (= S138), F234 (≠ A238), M238 (= M242), Q239 (≠ S243), L241 (= L245), D242 (= D246), R245 (= R249), Y364 (≠ G373), E365 (≠ A374), G366 (= G375)
- binding flavin-adenine dinucleotide: F125 (≠ L129), L127 (≠ M131), S128 (= S132), G133 (= G137), S134 (= S138), W158 (= W162), T160 (= T164), R270 (= R274), F273 (= F277), L280 (≠ F284), Q338 (= Q347), I339 (= I348), G342 (= G351), I360 (≠ L369), T367 (= T376), E369 (= E378), I370 (= I379)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
37% identity, 97% coverage: 8:389/393 of query aligns to 31:407/412 of P15651
- 152:161 (vs. 129:138, 70% identical) binding FAD
- S161 (= S138) binding substrate
- WIT 185:187 (= WIT 162:164) binding FAD
- DMGR 269:272 (≠ DYER 246:249) binding substrate
- R297 (= R274) binding FAD
- QILGG 365:369 (≠ QIYGG 347:351) binding FAD
- E392 (≠ A374) active site, Proton acceptor
- TSE 394:396 (= TSE 376:378) binding FAD
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
38% identity, 97% coverage: 7:389/393 of query aligns to 1:378/380 of 4l1fA
- active site: L125 (≠ M131), T126 (≠ S132), G242 (≠ E248), E363 (≠ A374), R375 (= R386)
- binding coenzyme a persulfide: T132 (≠ S138), H179 (≠ R185), F232 (≠ A238), M236 (= M242), E237 (≠ S243), L239 (= L245), D240 (= D246), R243 (= R249), Y362 (≠ G373), E363 (≠ A374), G364 (= G375), R375 (= R386)
- binding flavin-adenine dinucleotide: F123 (≠ L129), L125 (≠ M131), T126 (≠ S132), G131 (= G137), T132 (≠ S138), F156 (≠ W162), I157 (= I163), T158 (= T164), R268 (= R274), Q270 (= Q276), F271 (= F277), I275 (= I281), F278 (= F284), L281 (≠ I287), Q336 (= Q347), I337 (= I348), G340 (= G351), I358 (≠ L369), Y362 (≠ G373), T365 (= T376), Q367 (≠ E378)
- binding 1,3-propandiol: L5 (= L11), Q10 (≠ D16)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
38% identity, 97% coverage: 8:389/393 of query aligns to 31:407/412 of P16219
- G90 (= G67) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E81) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 129:138, 70% identical) binding in other chain
- R171 (≠ E148) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (= WIT 162:164) binding in other chain
- A192 (= A169) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G186) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R274) binding FAD
- Q308 (= Q285) binding in other chain
- R325 (= R302) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (≠ A335) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QIYGG 347:351) binding FAD
- R380 (= R362) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (= TSE 376:378) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
8sgsA Human liver mitochondrial short-chain specific acyl-coa dehydrogenase (see paper)
38% identity, 97% coverage: 8:389/393 of query aligns to 1:377/381 of 8sgsA