SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_068331063.1 NCBI__GCF_001650345.1:WP_068331063.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 18 hits to proteins with known functional sites (download)

4pd7A Structure of vccnt bound to zebularine (see paper)
80% identity, 99% coverage: 2:416/421 of query aligns to 1:404/404 of 4pd7A

query
sites
4pd7A

S

S

L

L

F

F

M

M

S

S

L

L

V

I

G

G

M

M

A

A

V

V

L

L

L

L

A

G

I

I

A

A

V

V

L

L

L

L

S

S

D

S

N

N

R

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

F

F

A

A

I

I

Q

Q

F

F

C

S

L

L

G

G

A

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

R

Q

D

E

V

L

L

L

Y

R

G

G

M

F

S

S

Q

D

A

A

V

V

A

S

N

N

V

V

I

I

S

N

Y

Y

G

G

N

N

D

D

G

G

I

T

N

S

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

G

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

I

F

F

A

A

L

F

R

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

A

A

L

L

I

I

S

S

V

V

L

L

Y

Y

Y

Y

M

L

G

G

I

V

M

M

Q

Q

F

W

V

V

I

I

N

R

I

I

L

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

F

V

V

P

P

K

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

C

G

G

G

G

L

L

A

A

S

S

V

I

A

A

G

G

G

G

V

V

L

L

A

A

G

G

Y

Y

A

A

S

S

M

M

G

G

V

V

P

K

L

I

E

E

Y

Y

L

L

I

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

M

K

M

P

P

E

E

T

T

E

E

E

K

P

P

I

-

E

-

Q

-

L

-

A

-

G

-

D

-

D

-

A

-

N

-

G

-

D

Q

D

D

K

K

P

P

A

A

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

Q

Q

L

L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

I

I

G

G

L

L

I

I

A

A

L

L

I

I

N

N

G

G

M

M

L

L

G

G

G

G

I

I

G

G

G

G

W

W

F

F

G

G

M

M

P

P

E

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

V

L

F

F

S

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

E

N

E

E

A

A

T

T

I

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

L

T

V

V

V

A

N

N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

A

T

D

E

G

A

A

A

E

P

V

V

V

V

L

L

S

S

A

E

K

K

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

S

S

S

V

I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

G

S

L

L

A

A

P

P

S

K

R

R

R

R

H

G

D

D

I

I

A

A

R

R

F

M

G

G

M

V

K

K

A

A

V

V

A

I

A

A

G

G

T

T

L

L

S

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

V

L

binding Zebularine: Q153 (= Q154), E320 (= E332), F321 (= F333), F354 (= F366), I362 (= I374)

3tijA Crystal structure of a concentrative nucleoside transporter from vibrio cholerae (see paper)
80% identity, 99% coverage: 2:416/421 of query aligns to 1:404/404 of 3tijA

query
sites
3tijA

S

S

L

L

F

F

M

M

S

S

L

L

V

I

G

G

M

M

A

A

V

V

L

L

L

L

A

G

I

I

A

A

V

V

L

L

L

L

S

S

D

S

N

N

R

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

F

F

A

A

I

I

Q

Q

F

F

C

S

L

L

G

G

A

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

R

Q

D

E

V

L

L

L

Y

R

G

G

M

F

S

S

Q

D

A

A

V

V

A

S

N

N

V

V

I

I

S

N

Y

Y

G

G

N

N

D

D

G

G

I

T

N

S

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

G

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

I

F

F

A

A

L

F

R

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

A

A

L

L

I

I

S

S

V

V

L

L

Y

Y

Y

Y

M

L

G

G

I

V

M

M

Q

Q

F

W

V

V

I

I

N

R

I

I

L

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N
|
N

I

I

F

F

V
|
V

G
|
G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

F

V

V

P

P

K

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

C

G

G

G

G

L

L

A

A

S
|
S

V
x
I

A

A

G

G

G

G

V

V

L

L

A

A

G

G

Y

Y

A

A

S

S

M

M

G

G

V

V

P

K

L

I

E

E

Y

Y

L

L

I

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

M

K

M

P

P

E

E

T

T

E

E

E

K

P

P

I

-

E

-

Q

-

L

-

A

-

G

-

D

-

D

-

A

-

N

-

G

-

D

Q

D

D

K

K

P

P

A

A

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

Q

Q

L

L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

I

I

G

G

L

L

I

I

A

A

L

L

I

I

N

N

G

G

M

M

L

L

G

G

G

G

I

I

G

G

G

G

W

W

F

F

G

G

M

M

P

P

E

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

V

L

F

F

S

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

E

N

E

E

A

A

T

T

I

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

L

T

V

V

V

A

N

N

E
|
E

F

F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

A

T

D

E

G

A

A

A

E

P

V

V

V

V

L

L

S

S

A

E

K

K

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

S

S
|
S

V

I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

G

S

L

L

A

A

P

P

S

K

R

R

R

R

H

G

D

D

I

I

A

A

R

R

F

M

G

G

M

V

K

K

A

A

V

V

A

I

A

A

G

G

T

T

L

L

S

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

V

L

binding sodium ion: N148 (= N149), V151 (= V152), G152 (= G153), S182 (= S183), I183 (≠ V184)
binding uridine: Q153 (= Q154), E320 (= E332), F354 (= F366), S359 (= S371), I362 (= I374)

4pdaA Structure of vccnt-7c8c bound to cytidine (see paper)
80% identity, 99% coverage: 2:416/421 of query aligns to 1:404/404 of 4pdaA

query
sites
4pdaA

S

S

L

L

F

F

M

M

S

S

L

C

V

C

G

G

M

M

A

A

V

V

L

L

L

L

A

G

I

I

A

A

V

V

L

L

L

L

S

S

D

S

N

N

R

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

F

F

A

A

I

I

Q

Q

F

F

C

S

L

L

G

G

A

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

R

Q

D

E

V

L

L

L

Y

R

G

G

M

F

S

S

Q

D

A

A

V

V

A

S

N

N

V

V

I

I

S

N

Y

Y

G

G

N

N

D

D

G

G

I

T

N

S

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

G

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

I

F

F

A

A

L

F

R

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

A

A

L

L

I

I

S

S

V

V

L

L

Y

Y

Y

Y

M

L

G

G

I

V

M

M

Q

Q

F

W

V

V

I

I

N

R

I

I

L

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

F

V

V

P

P

K

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

C

G

G

G

G

L

L

A

A

S

S

V

I

A

A

G

G

G

G

V

V

L

L

A

A

G

G

Y

Y

A

A

S

S

M

M

G

G

V

V

P

K

L

I

E

E

Y

Y

L

L

I

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

M

K

M

P

P

E

E

T

T

E

E

E

K

P

P

I

-

E

-

Q

-

L

-

A

-

G

-

D

-

D

-

A

-

N

-

G

-

D

Q

D

D

K

K

P

P

A

A

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

Q

Q

L

L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

I

I

G

G

L

L

I

I

A

A

L

L

I

I

N

N

G

G

M

M

L

L

G

G

G

G

I

I

G

G

G

G

W

W

F

F

G

G

M

M

P

P

E

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

V

L

F

F

S

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

E

N

E

E

A

A

T

T

I

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

L

T

V

V

V

A

N

N

E
|
E

F

F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

A

T

D

E

G

A

A

A

E

P

V

V

V

V

L

L

S

S

A

E

K

K

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

S

S
|
S

V

I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

G

S

L

L

A

A

P

P

S

K

R

R

R

R

H

G

D

D

I

I

A

A

R

R

F

M

G

G

M

V

K

K

A

A

V

V

A

I

A

A

G

G

T

T

L

L

S

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

V

L

binding 4-amino-1-beta-d-ribofuranosyl-2(1h)-pyrimidinone: Q153 (= Q154), E320 (= E332), F354 (= F366), S359 (= S371), I362 (= I374)

4pd9A Structure of vccnt-7c8c bound to adenosine (see paper)
80% identity, 99% coverage: 2:416/421 of query aligns to 1:404/404 of 4pd9A

query
sites
4pd9A

S

S

L

L

F

F

M

M

S

S

L

C

V

C

G

G

M

M

A

A

V

V

L

L

L

L

A

G

I

I

A

A

V

V

L

L

L

L

S

S

D

S

N

N

R

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

F

F

A

A

I

I

Q

Q

F

F

C

S

L

L

G

G

A

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

R

Q

D

E

V

L

L

L

Y

R

G

G

M

F

S

S

Q

D

A

A

V

V

A

S

N

N

V

V

I

I

S

N

Y

Y

G

G

N

N

D

D

G

G

I

T

N

S

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

G

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

I

F

F

A

A

L

F

R

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

A

A

L

L

I

I

S

S

V

V

L

L

Y

Y

Y

Y

M

L

G

G

I

V

M

M

Q

Q

F

W

V

V

I

I

N

R

I

I

L

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

F

V

V

P

P

K

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

C

G

G

G

G

L

L

A

A

S

S

V

I

A

A

G

G

G

G

V

V

L

L

A

A

G

G

Y

Y

A

A

S

S

M

M

G

G

V

V

P

K

L

I

E

E

Y

Y

L

L

I

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

M

K

M

P

P

E

E

T

T

E

E

E

K

P

P

I

-

E

-

Q

-

L

-

A

-

G

-

D

-

D

-

A

-

N

-

G

-

D

Q

D

D

K

K

P

P

A

A

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

Q

Q

L

L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

I

I

G

G

L

L

I

I

A

A

L

L

I

I

N

N

G

G

M

M

L

L

G

G

G

G

I

I

G

G

G

G

W

W

F

F

G

G

M

M

P

P

E

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

V

L

F

F

S

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

E

N

E

E

A

A

T

T

I

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

L

T

V

V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

A

T

D

E

G

A

A

A

E

P

V

V

V

V

L

L

S

S

A

E

K

K

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

S

S
|
S

V

I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

G

S

L

L

A

A

P

P

S

K

R

R

R

R

H

G

D

D

I

I

A

A

R

R

F

M

G

G

M

V

K

K

A

A

V

V

A

I

A

A

G

G

T

T

L

L

S

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

V

L

binding adenosine: Q153 (= Q154), N319 (= N331), E320 (= E332), F321 (= F333), F354 (= F366), S359 (= S371), I362 (= I374)

4pd8A Structure of vccnt-7c8c bound to pyrrolo-cytidine (see paper)
80% identity, 99% coverage: 2:416/421 of query aligns to 1:404/404 of 4pd8A

query
sites
4pd8A

S

S

L

L

F

F

M

M

S

S

L

C

V

C

G

G

M

M

A

A

V

V

L

L

L

L

A

G

I

I

A

A

V

V

L

L

L

L

S

S

D

S

N

N

R

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

F

F

A

A

I

I

Q

Q

F

F

C

S

L

L

G

G

A

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

R

Q

D

E

V

L

L

L

Y

R

G

G

M

F

S

S

Q

D

A

A

V

V

A

S

N

N

V

V

I

I

S

N

Y

Y

G

G

N

N

D

D

G

G

I

T

N

S

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

G

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

I

F

F

A

A

L

F

R

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

A

A

L

L

I

I

S

S

V

V

L

L

Y

Y

Y

Y

M

L

G

G

I

V

M

M

Q

Q

F

W

V

V

I

I

N

R

I

I

L

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

F

V

V

P

P

K

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

C

G

G

G

G

L

L

A

A

S

S

V

I

A
|
A

G

G

G

G

V

V

L

L

A

A

G

G

Y

Y

A

A

S

S

M

M

G

G

V

V

P

K

L

I

E

E

Y

Y

L

L

I

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

M

K

M

P

P

E

E

T

T

E

E

E

K

P

P

I

-

E

-

Q

-

L

-

A

-

G

-

D

-

D

-

A

-

N

-

G

-

D

Q

D

D

K

K

P

P

A

A

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

Q

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

I

I

G

G

L

L

I

I

A

A

L

L

I

I

N

N

G

G

M

M

L

L

G

G

G

G

I

I

G

G

G

G

W

W

F

F

G

G

M

M

P

P

E

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

V

L

F

F

S

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

E

N

E

E

A

A

T

T

I

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

L

T

V

V

V

A

N

N

E
|
E

F

F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

A

T

D

E

G

A

A

A

E

P

V

V

V

V

L

L

S

S

A

E

K

K

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

S

S
|
S

V

I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

G

S

L

L

A

A

P

P

S

K

R

R

R

R

H

G

D

D

I

I

A

A

R

R

F

M

G

G

M

V

K

K

A

A

V

V

A

I

A

A

G

G

T

T

L

L

S

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

V

L

binding 6-methyl-3-(beta-D-ribofuranosyl)-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one: Q153 (= Q154), A184 (= A185), L247 (= L259), E320 (= E332), F354 (= F366), S359 (= S371), I362 (= I374)

4pb2A Structure of vccnt-7c8c bound to 5-fluorouridine (see paper)
80% identity, 99% coverage: 2:416/421 of query aligns to 1:404/404 of 4pb2A

query
sites
4pb2A

S

S

L

L

F

F

M

M

S

S

L

C

V

C

G

G

M

M

A

A

V

V

L

L

L

L

A

G

I

I

A

A

V

V

L

L

L

L

S

S

D

S

N

N

R

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

F

F

A

A

I

I

Q

Q

F

F

C

S

L

L

G

G

A

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

R

Q

D

E

V

L

L

L

Y

R

G

G

M

F

S

S

Q

D

A

A

V

V

A

S

N

N

V

V

I

I

S

N

Y

Y

G

G

N

N

D

D

G

G

I

T

N

S

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

G

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

I

F

F

A

A

L

F

R

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

A

A

L

L

I

I

S

S

V

V

L

L

Y

Y

Y

Y

M

L

G

G

I

V

M

M

Q

Q

F

W

V

V

I

I

N

R

I

I

L

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

F

V

V

P

P

K

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

C

G

G

G

G

L

L

A

A

S

S

V

I

A

A

G

G

G

G

V

V

L

L

A

A

G

G

Y

Y

A

A

S

S

M

M

G

G

V

V

P

K

L

I

E

E

Y

Y

L

L

I

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

M

K

M

P

P

E

E

T

T

E

E

E

K

P

P

I

-

E

-

Q

-

L

-

A

-

G

-

D

-

D

-

A

-

N

-

G

-

D

Q

D

D

K

K

P

P

A

A

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

Q

Q

L

L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

I

I

G

G

L

L

I

I

A

A

L

L

I

I

N

N

G

G

M

M

L

L

G

G

G

G

I

I

G

G

G

G

W

W

F

F

G

G

M

M

P

P

E

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

V

L

F

F

S

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

E

N

E

E

A

A

T

T

I

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

L

T

V

V

V

A

N

N

E
|
E

F

F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

A

T

D

E

G

A

A

A

E

P

V

V

V

V

L

L

S

S

A

E

K

K

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

S

S
|
S

V

I

A

A

I

I

L

L

L

L

G

G

G

G

L

L

G

G

G

S

L

L

A

A

P

P

S

K

R

R

R

R

H

G

D

D

I

I

A

A

R

R

F

M

G

G

M

V

K

K

A

A

V

V

A

I

A

A

G

G

T

T

L

L

S

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

V

L

binding 5-fluorouridine: Q153 (= Q154), E320 (= E332), F354 (= F366), S359 (= S371)

4pb1A Structure of vccnt-7c8c bound to ribavirin (see paper)
80% identity, 99% coverage: 2:416/421 of query aligns to 1:404/404 of 4pb1A

query
sites
4pb1A

S

S

L

L

F

F

M

M

S

S

L

C

V

C

G

G

M

M

A

A

V

V

L

L

L

L

A

G

I

I

A

A

V

V

L

L

L

L

S

S

D

S

N

N

R

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

F

F

A

A

I

I

Q

Q

F

F

C

S

L

L

G

G

A

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

R

Q

D

E

V

L

L

L

Y

R

G

G

M

F

S

S

Q

D

A

A

V

V

A

S

N

N

V

V

I

I

S

N

Y

Y

G

G

N

N

D

D

G

G

I

T

N

S

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

G

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

I

F

F

A

A

L

F

R

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

A

A

L

L

I

I

S

S

V

V

L

L

Y

Y

Y

Y

M

L

G

G

I

V

M

M

Q

Q

F

W

V

V

I

I

N

R

I

I

L

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q

Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

F

V

V

P

P

K

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

C

G

G

G

G

L

L

A

A

S

S

V

I

A

A

G

G

G

G

V

V

L

L

A

A

G

G

Y

Y

A

A

S

S

M

M

G

G

V

V

P

K

L

I

E

E

Y

Y

L

L

I

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

M

K

M

P

P

E

E

T

T

E

E

E

K

P

P

I

-

E

-

Q

-

L

-

A

-

G

-

D

-

D

-

A

-

N

-

G

-

D

Q

D

D

K

K

P

P

A

A

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

Q

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

I

I

G

G

L

L

I

I

A

A

L

L

I

I

N

N

G

G

M

M

L

L

G

G

G

G

I

I

G

G

G

G

W

W

F

F

G

G

M

M

P

P

E

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

V

L

F

F

S

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

E

N

E

E

A

A

T

T

I

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

L

T

V

V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

A

T

D

E

G

A

A

A

E

P

V

V

V

V

L

L

S

S

A

E

K

K

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

S

S

S

V

I

A

A

I

I

L

L

L

L

G

G

G

G

L

L

G

G

G

S

L

L

A

A

P

P

S

K

R

R

R

R

H

G

D

D

I

I

A

A

R

R

F

M

G

G

M

V

K

K

A

A

V

V

A

I

A

A

G

G

T

T

L

L

S

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

V

L

binding 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide: L247 (= L259), N319 (= N331), E320 (= E332), F321 (= F333), F354 (= F366)

4pd5A Crystal structure of vccnt-7c8c bound to gemcitabine (see paper)
80% identity, 98% coverage: 3:416/421 of query aligns to 1:403/403 of 4pd5A

query
sites
4pd5A

L

L

F

F

M

M

S

S

L

C

V

C

G

G

M

M

A

A

V

V

L

L

L

L

A

G

I

I

A

A

V

V

L

L

L

L

S

S

D

S

N

N

R

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

F

F

A

A

I

I

Q

Q

F

F

C

S

L

L

G

G

A

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

R

Q

D

E

V

L

L

L

Y

R

G

G

M

F

S

S

Q

D

A

A

V

V

A

S

N

N

V

V

I

I

S

N

Y

Y

G

G

N

N

D

D

G

G

I

T

N

S

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

G

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

I

F

F

A

A

L

F

R

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

A

A

L

L

I

I

S

S

V

V

L

L

Y

Y

Y

Y

M

L

G

G

I

V

M

M

Q

Q

F

W

V

V

I

I

N

R

I

I

L

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

F

V

V

P

P

K

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

C

G

G

G

G

L

L

A

A

S

S

V

I

A

A

G

G

G

G

V

V

L

L

A

A

G

G

Y

Y

A

A

S

S

M

M

G

G

V

V

P

K

L

I

E

E

Y

Y

L

L

I

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

M

K

M

P

P

E

E

T

T

E

E

E

K

P

P

I

-

E

-

Q

-

L

-

A

-

G

-

D

-

D

-

A

-

N

-

G

-

D

Q

D

D

K

K

P

P

A

A

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

Q

Q

L

L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

I

I

G

G

L

L

I

I

A

A

L

L

I

I

N

N

G

G

M

M

L

L

G

G

G

G

I

I

G

G

G

G

W

W

F

F

G

G

M

M

P

P

E

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

V

L

F

F

S

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

E

N

E

E

A

A

T

T

I

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

L

T

V
|
V

V

A

N

N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

A

T

D

E

G

A

A

A

E

P

V

V

V

V

L

L

S

S

A

E

K

K

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

S

S

S

V

I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

G

S

L

L

A

A

P

P

S

K

R

R

R

R

H

G

D

D

I

I

A
|
A

R

R

F

M

G

G

M

V

K

K

A

A

V

V

A

I

A

A

G

G

T

T

L

L

S

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

V

L

binding decyl-beta-d-maltopyranoside: V316 (= V329), A378 (= A391)
binding gemcitabine: Q152 (= Q154), E319 (= E332), F320 (= F333), F353 (= F366), I361 (= I374)

5l26A Structure of cntnw in an inward-facing substrate-bound state (see paper)
68% identity, 100% coverage: 1:419/421 of query aligns to 3:416/419 of 5l26A

query
sites
5l26A

M

M

S

V

L

V

F

L

M

H

S

S

L

L

V

L

G

G

M

M

A

A

V

V

L

L

L

I

A

A

I

I

A

A

V

V

L

L

L

L

S

S

D

T

N

D

R

R

K

K

A

A

I

I

N

N

L

I

R

R

T

T

V

V

G

A

G

G

A

A

F

F

A

L

I

I

Q

Q

F

V

C

A

L
|
L

G

G

A

A

F

L

V

V

L

L

Y

Y

V

V

P

P

V

Q

G

G

R

R

D

D

V

M

L

L

Y

G

G

E

M

A

S

S

Q

K

A
x
T

V
x
I

A

S

N

N

V

V

I

I

S

A

Y

Y

G

G

N

N

D

N

G

G

I

V

N

D

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

E

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

V

F

F

A

A

L

L

R

R

V

V

L

L

P

P

V

M

I

I

V

V

F

F

F

F

S

S

A

S

L

L

I

M

S

A

V

V

L

L

Y

Y

Y
|
Y

M
x
I

G

G

I

V

M

M

Q

Q

F

L

V

L

I

I

N

K

I
x
V

L

I

G

G

G

G

G
x
F

L

L

Q

Q

K

K

A

M

L

L

G

G

T

T

S

S

R

K

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

Y

V

I

P

R

K

R

M

M

T

T

Q

E

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

S

G

G

G

G

L

L

A

A

S

S

V

V

A

A

G

G

G

S

V

V

L

L

A

A

G

G

Y

Y

A

V

S

Q

M

M

G

G

V

V

P

P

L

L

E

P

Y

Y

L

L

I

I

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

L

K

V

P

P

E

E

T

T

E

E

E

R

P

T

I

Q

E

N

Q

D

L

A

A

E

G

V

D

L

D

A

A

E

N

N

G

E

D

D

D

E

K

K

P

P

A

T

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

S

G

G

A

A

S

V

S

T

G

G

M

A

Q

Q

L

I

A

A

L

I

N

A

V

V

G

G

A

A

M

S

L

L

L

L

A

A

F

F

I

V

G

A

L

L

I

I

A

A

L

M

I

I

N

N

G

G

M

I

L

I

G

G

G

G

I

V

G

-

G

-

W

-

F

-

G

-

M

G

P

G

E

D

L

L

T

T

L

L

E

Q

L

A

I

I

L

L

G

G

Y

W

V

L

F

F

S

S

P

P

L

L

A

A

F

W

L

V

I

I

G

G

V

V

P

P

W

W

E

S

E

E

A

A

T

G

I

I

A

A

G

G

S

S

F

L

I

I

G

G

Q

Q

K

K

L

V

V

V

V

I

N

N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

E

F

F

A

V

P

K

Y

Y

L

L

A

K

D

P

G

E

A

A

E

A

V

V

V

Q

L

L

S

S

A

D

K

T

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L

L

S

G

S
|
S

V

I

A

A

I
x
V

L

L

L

V

G

G

G

G

L

L

G

S

G

I

L

M

A

A

P

P

S

K

R

R

R

R

H

K

D

D

I

V

A

A

R

R

F

L

G

G

M

I

K

K

A

A

V

V

A

V

A

A

G

G

T

S

L

L

S

S

N

N

L

L

M

M

S

S

A

A

T

V

I

I

A

A

G

G

L

L

F

F

V

T

A

G

V

L

N

S

binding 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside: L44 (= L42), T64 (≠ A62), I65 (≠ V63), Y119 (= Y117), I120 (≠ M118), V129 (≠ I127), F133 (≠ G131)
binding uridine: Q156 (= Q154), E329 (= E332), F330 (= F333), F363 (= F366), S368 (= S371), V371 (≠ I374)

5l2aA Structure of cntnw n149s,f366a in an outward-facing state (see paper)
68% identity, 100% coverage: 1:419/421 of query aligns to 4:422/422 of 5l2aA

query
sites
5l2aA

M

M

S

V

L

V

F

L

M

H

S

S

L

L

V

L

G

G

M

M

A

A

V

V

L

L

L

I

A

A

I

I

A

A

V

V

L

L

L

L

S

S

D

T

N

D

R

R

K

K

A

A

I

I

N

N

L

I

R

R

T

T

V

V

G

A

G

G

A

A

F

F

A

L

I

I

Q

Q

F

V

C

A

L

L

G

G

A

A

F

L

V

V

L

L

Y

Y

V

V

P

P

V

Q

G

G

R

R

D

D

V
x
M

L

L

Y

G

G
x
E

M

A

S

S

Q

K

A
x
T

V

I

A

S

N

N

V

V

I

I

S

A

Y

Y

G

G

N

N

D

N

G

G

I

V

N

D

F

F

L

L

F

F

G

G

G

G

L

L

T

V

S

S

D

E

K

K

M

M

F

F

E

E

V

V

F

F

G

G

G

G

G

G

G

G

F

F

V

V

F

F

A

A

L

L

R

R

V

V

L

L

P

P

V

M

I

I

V

V

F

F

F

F

S

S

A

S

L

L

I

M

S

A

V

V

L

L

Y

Y

Y

Y

M

I

G

G

I

V

M

M

Q

Q

F

L

V

L

I

I

N

K

I

V

L

I

G

G

G

G

G

F

L

L

Q

Q

K

K

A

M

L

L

G

G

T

T

S

S

R

K

A

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

S

I

I

F

F

V

V

G

G

Q

Q

T

T

E

E

A

A

P

P

L

L

V

V

I

V

R

R

P

P

F

Y

V

I

P

R

K

R

M

M

T

T

Q

E

S

S

E

E

L

L

F

F

A

A

V

V

M

M

C

S

G

G

G

G

L

L

A

A

S

S

V

V

A

A

G

G

G

S

V

V

L

L

A

A

G

G

Y

Y

A

V

S

Q

M

M

G

G

V

V

P

P

L

L

E

P

Y

Y

L

L

I

I

A

A

A

A

S

S

F
|
F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

F

F

A

A

K

K

I

L

I

L

K

V

P

P

E

E

T

T

E

E

E

R

P

T

I

Q

E

N

Q

D

L

A

A

E

G

V

D

L

D

A

A

E

N

N

G

E

D

D

D

E

K

K

P

P

A

T

N

N

V

V

I

I

D

D

A

A

A

A

A

A

A

S

G

G

A

A

S

V

S

T

G

G

M

A

Q

Q

L

I

A

A

L

I

N

A

V

V

G

G

A

A

M

S

L

L

L

L

A

A

F

F

I

V

G

A

L

L

I

I

A

A

L

M

I

I

N

N

G

G

M

I

L

I

G

G

G

G

I

V

G

G

G

G

W

W

F

F

G

G

M

H

P

G

E

D

L

L

T

T

L

L

E

Q

L

A

I

I

L

L

G

G

Y

W

V

L

F

F

S

S

P

P

L

L

A

A

F

W

L

V

I

I

G

G

V

V

P

P

W

W

E

S

E

E

A

A

T

G

I

I

A

A

G

G

S

S

F

L

I

I

G

G

Q

Q

K

K

L

V

V

V

V

I

N

N

E

E

F

F

V

V

A

A

Y

Y

L

S

N

E

F

F

A

V

P

K

Y

Y

L

L

A

K

D

P

G

E

A

A

E

A

V

V

V

Q

L

L

S

S

A

D

K

T

T

T

E

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F

A

A

A

N

N

L

L

S

G

S

S

V

I

A

A

I

V

L

L

L

V

G

G

G

G

L

L

G

S

G

I

L

M

A

A

P

P

S

K

R

R

R

R

H

K

D

D

I

V

A

A

R

R

F

L

G

G

M

I

K

K

A

A

V

V

A

V

A

A

G

G

T

S

L

L

S

S

N

N

L

L

M

M

S

S

A

A

T

V

I

I

A

A

G

G

L

L

F

F

V

T

A

G

V

L

N

S

binding 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside: M58 (≠ V55), E61 (≠ G58), T65 (≠ A62), F210 (= F207)

8tz7A Cryo-em structure of bovine concentrative nucleoside transporter 3 in complex with molnupiravir, condition 1, int1-int1-int1 conformation (see paper)
40% identity, 84% coverage: 61:414/421 of query aligns to 175:528/533 of 8tz7A

query
sites
8tz7A

Q

K

A

Q

V

V

A

Q

N

T

V

F

I

L

S

G

Y

Y

G

S

N

D

D

A

G

G

I

A

N

S

F

F

L

V

F

F

G

G

G

E

L

K

T

Y

S

T

D

D

K

H

M

F

F

F

E

-

V

-

F

-

G

-

G

-

G

-

G

-

F

-

V

-

F

-

A

A

L

F

R

K

V

V

L

L

P

P

V

I

I

V

V

I

F

F

F

F

S

S

A

T

L

V

I

M

S

S

V

M

L

L

Y

Y

Y

Y

M

L

G

G

I

L

M

M

Q

Q

F

W

V

I

I

I

N

R

I

K

L

V

G

G

G

W

G

V

L

M

Q

L

K

V

A

T

L

M

G

G

T

T

S

S

R

P

A

V

E

E

S

S

M

V

S

V

A

A

T

S

A

G

N

N

I

I

F

F

V

I

G

G

Q
|
Q

T

T

E

E

A

S

P

P

L

L

V

L

I

V

R

R

P

P

F

Y

V

L

P

P

K

Y

M

V

T

T

Q

K

S

S

E

E

L

L

F

H

A

A

V

I

M

M

C

T

G

A

G

G

L

F

A

S

S

T

V

I

A

A

G

G

G

S

V

V

L

L

A

G

G

A

Y

Y

A

I

S

S

M

F

G

G

V

V

P

S

L

S

E

S

Y

H

L

L

I

L

A

T

A

A

S

S

F

V

M

M

A

S

A

A

P

P

G

A

G

A

L

L

L

A

F

I

A

S

K

K

I

L

I

F

K

W

P

P

E

E

T

T

E

E

E

T

P

P

I

K

E

I

Q

N

L

L

-

K

-

N

A

A

G

M

D

K

D

M

A

E

N

S

G

G

D

D

D

S

K

R

P

-

A

-

N

N

V

L

I

L

D

E

A

A

A

A

A

T

A

Q

G

G

A

A

S

S

S

S

G

S

M

I

Q

S

L

L

A

V

L

A

N

N

V
x
I

G

A

A

V

M

N

L

L

L

I

A

A

F

F

I

L

G

A

L

L

I

L

A

S

L

F

I

M

N

N

G

S

M

A

L

L

G

S

G

W

I

L

G

G

G

N

W

M

F

F

G

D

M

Y

P

P

E

Q

L

L

T

S

L

F

E

E

L

V

I

I

L

C

G

S

Y

Y

V

V

F

F

S

M

P

P

L

F

A

A

F

F

L

M

I

M

G

G

V

V

P

D

W

W

E

Q

E

D

A

S

T

F

I

M

A

V

G

A

S

K

F

L

I

I

G

G

Q

Y

K

K

L

T

V

F

V

F

N
|
N

E
|
E

F

F

V

V

A

A

Y

Y

L

Q

N

Q

F

L

A

S

-

K

-

L

-

I

-

S

-

L

-

R

-

Q

-

V

-

G

-

G

P

P

Y

K

L

F

A

V

D

D

G

G

A

V

E

Q

V

Q

V

Y

L

M

S

S

A

M

K

R

T

S

E

E

A

A

I

I

I

S

S

T

F

Y

A

A

L

L

C

C

G

G

F

F

A

A

N

N

L

F

S

G

S

S

V

L

A

G

I

I

L

V

L

I

G

G

G

G

L

L

G

T

G

S

L

M

A

A

P

P

S

S

R

R

R

K

H

R

D

D

I

I

A

T

R

A

F

G

G

A

M

M

K

R

A

A

V

L

A

I

A

A

G

G

T

T

L

I

S

A

N

C

L

F

M

L

S

T

A

A

T

C

I

I

A

A

G

G

L

M

binding N-hydroxy-5'-O-(2-methylpropanoyl)cytidine: Q258 (= Q154), I367 (≠ V263), N435 (= N331), E436 (= E332)

Sites not aligning to the query:

binding 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine: 105, 142, 144, 148, 151

8tz6A Cryo-em structure of bovine concentrative nucleoside transporter 3 in complex with psi-6206 (see paper)
40% identity, 84% coverage: 61:414/421 of query aligns to 175:528/533 of 8tz6A

query
sites
8tz6A

Q

K

A

Q

V

V

A

Q

N

T

V

F

I

L

S

G

Y

Y

G

S

N

D

D

A

G

G

I

A

N

S

F

F

L

V

F

F

G

G

G

E

L

K

T

Y

S

T

D

D

K

H

M

F

F

F

E

-

V

-

F

-

G

-

G

-

G

-

G

-

F

-

V

-

F

-

A

A

L

F

R

K

V

V

L

L

P

P

V

I

I

V

V

I

F

F

F

F

S

S

A

T

L

V

I

M

S

S

V

M

L

L

Y

Y

Y

Y

M

L

G

G

I

L

M

M

Q

Q

F

W

V

I

I

I

N

R

I

K

L

V

G

G

G

W

G

V

L

M

Q

L

K

V

A

T

L

M

G

G

T

T

S

S

R

P

A

V

E

E

S

S

M

V

S

V

A

A

T

S

A

G

N

N

I

I

F

F

V

I

G

G

Q

Q

T

T

E

E

A

S

P

P

L

L

V

L

I

V

R

R

P

P

F

Y

V

L

P

P

K

Y

M

V

T

T

Q

K

S

S

E

E

L

L

F

H

A

A

V

I

M

M

C

T

G

A

G

G

L

F

A

S

S

T

V

I

A

A

G

G

G

S

V

V

L

L

A

G

G

A

Y

Y

A

I

S

S

M

F

G

G

V

V

P

S

L

S

E

S

Y

H

L

L

I

L

A

T

A

A

S

S

F

V

M

M

A

S

A

A

P

P

G

A

G

A

L

L

L

A

F

I

A