SitesBLAST
Comparing WP_068461577.1 NCBI__GCF_001541235.1:WP_068461577.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P36204 Bifunctional PGK/TIM; EC 2.7.2.3; EC 5.3.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
49% identity, 97% coverage: 8:397/402 of query aligns to 5:394/654 of P36204
- R36 (= R39) binding substrate
- R118 (= R121) binding substrate
- R151 (= R154) binding substrate
1vpeA Crystallographic analysis of phosphoglycerate kinase from the hyperthermophilic bacterium thermotoga maritima (see paper)
49% identity, 97% coverage: 8:397/402 of query aligns to 4:393/398 of 1vpeA
- active site: R35 (= R39), K196 (= K200), G353 (= G357), G376 (= G380)
- binding phosphoaminophosphonic acid-adenylate ester: G194 (= G198), A195 (= A199), K196 (= K200), K200 (= K204), G218 (= G222), A219 (≠ G223), N316 (= N319), P318 (= P321), G320 (= G323), V321 (≠ A324), E323 (= E326), G352 (= G356), G353 (= G357), D354 (= D358), S355 (≠ T359)
P40924 Phosphoglycerate kinase; EC 2.7.2.3 from Bacillus subtilis (strain 168) (see paper)
47% identity, 98% coverage: 5:397/402 of query aligns to 2:391/394 of P40924
- S183 (≠ E186) modified: Phosphoserine
- T299 (≠ S302) modified: Phosphothreonine
1phpA Structure of the adp complex of the 3-phosphoglycerate kinase from bacillus stearothermophilus at 1.65 angstroms (see paper)
48% identity, 98% coverage: 5:397/402 of query aligns to 2:391/394 of 1phpA
- active site: R36 (= R39), K197 (= K200), G351 (= G357), G374 (= G380)
- binding adenosine-5'-diphosphate: G195 (= G198), K201 (= K204), G219 (= G222), G220 (= G223), L237 (= L240), N316 (= N319), P318 (= P321), G320 (= G323), V321 (≠ A324), E323 (= E326), G350 (= G356), D352 (= D358), S353 (≠ T359)
P18912 Phosphoglycerate kinase; EC 2.7.2.3 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
48% identity, 98% coverage: 5:397/402 of query aligns to 2:391/394 of P18912
4feyA An x-ray structure of a putative phosphogylcerate kinase with bound adp from francisella tularensis subsp. Tularensis schu s4
44% identity, 97% coverage: 8:397/402 of query aligns to 5:386/392 of 4feyA
- active site: R36 (= R39), K193 (= K200), G346 (= G357), G369 (= G380)
- binding adenosine-5'-diphosphate: G191 (= G198), S192 (≠ A199), K197 (= K204), G215 (= G222), G316 (= G323), V317 (≠ A324), E319 (= E326), D347 (= D358)
P07378 Phosphoglycerate kinase, glycosomal; Phosphoglycerate kinase C; EC 2.7.2.3 from Trypanosoma brucei brucei (see 2 papers)
40% identity, 99% coverage: 1:397/402 of query aligns to 1:416/440 of P07378
- DFN 24:26 (≠ DLN 24:26) binding substrate
- R39 (= R39) binding substrate
- HLGR 62:65 (≠ HFGR 62:65) binding substrate
- R135 (= R121) binding substrate
- R172 (= R154) binding substrate
- K223 (= K204) binding ATP
- N338 (= N319) binding ATP
- E345 (= E326) binding ATP
- GGDS 375:378 (≠ GGDT 356:359) binding ATP
16pkA Phosphoglycerate kinase from trypanosoma brucei bisubstrate analog (see paper)
41% identity, 97% coverage: 7:397/402 of query aligns to 3:412/415 of 16pkA
- active site: R35 (= R39), K215 (= K200), G372 (= G357), G395 (= G380)
- binding 1,1,5,5-tetrafluorophosphopentylphosphonic acid adenylate ester: G213 (= G198), A214 (= A199), K219 (= K204), A238 (≠ G223), Y241 (≠ N226), L311 (= L296), P336 (= P321), G338 (= G323), V339 (≠ A324), E341 (= E326), G393 (≠ A378), G394 (= G379), G395 (= G380)
13pkA Ternary complex of phosphoglycerate kinase from trypanosoma brucei (see paper)
41% identity, 97% coverage: 7:397/402 of query aligns to 3:412/415 of 13pkA
- active site: R35 (= R39), K215 (= K200), G372 (= G357), G395 (= G380)
- binding adenosine-5'-diphosphate: G213 (= G198), A214 (= A199), K219 (= K204), L311 (= L296), P336 (= P321), G338 (= G323), V339 (≠ A324), E341 (= E326), G371 (= G356), D373 (= D358), S374 (≠ T359)
4ng4B Structure of phosphoglycerate kinase (cbu_1782) from coxiella burnetii (see paper)
43% identity, 98% coverage: 8:399/402 of query aligns to 4:386/389 of 4ng4B
- active site: R35 (= R39), K191 (= K200), G344 (= G357), G367 (= G380)
- binding adenosine-5'-diphosphate: G189 (= G198), K195 (= K204), G213 (= G222), I286 (= I295), N310 (= N319), G311 (= G320), P312 (= P321), V315 (≠ A324), E317 (= E326), G343 (= G356), D345 (= D358), T346 (= T359)
- binding magnesium ion: D288 (= D297), G314 (= G323), F321 (= F330), S322 (≠ G331), T325 (= T334)
6yjeA Plasmoodium vivax phosphoglycerate kinase bound to nitrofuran inhibitor from peg3350 and ammonium acetate at ph 5.5
41% identity, 98% coverage: 5:397/402 of query aligns to 4:413/416 of 6yjeA
- active site: R39 (= R39), K215 (= K200), G373 (= G357), G396 (= G380)
- binding (2~{S})-2-(5-nitrofuran-2-yl)-2,3,5,6,7,8-hexahydro-1~{H}-[1]benzothiolo[2,3-d]pyrimidin-4-one: G237 (= G222), G238 (= G223), Y241 (≠ N226), L256 (= L240), F291 (= F275), M311 (= M294), G312 (≠ I295), L313 (= L296), G340 (= G323), V341 (≠ A324)
1ltkC Crystal structure of phosphoglycerate kinase from plasmodium falciparum, in the open conformation
41% identity, 97% coverage: 8:397/402 of query aligns to 15:421/424 of 1ltkC
- active site: R47 (= R39), K223 (= K200), G381 (= G357), G404 (= G380)
- binding adenosine monophosphate: G221 (= G198), A222 (= A199), K223 (= K200), G245 (= G222), G246 (= G223), G348 (= G323), V349 (≠ A324), E351 (= E326), D382 (= D358)
1zmrA Crystal structure of the e. Coli phosphoglycerate kinase (see paper)
42% identity, 97% coverage: 9:397/402 of query aligns to 5:380/386 of 1zmrA
P0A799 Phosphoglycerate kinase; EC 2.7.2.3 from Escherichia coli (strain K12) (see 3 papers)
42% identity, 97% coverage: 9:397/402 of query aligns to 6:381/387 of P0A799
- K84 (≠ L86) modified: N6-acetyllysine
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
P09041 Phosphoglycerate kinase 2; Phosphoglycerate kinase, testis specific; EC 2.7.2.3 from Mus musculus (Mouse) (see paper)
42% identity, 97% coverage: 8:397/402 of query aligns to 8:414/417 of P09041
2paaA Crystal structure of phosphoglycerate kinase-2 bound to atp and 3pg (see paper)
41% identity, 97% coverage: 8:397/402 of query aligns to 4:410/413 of 2paaA
- active site: R35 (= R39), K212 (= K200), G370 (= G357), G393 (= G380)
- binding adenosine-5'-triphosphate: G210 (= G198), A211 (= A199), K216 (= K204), G235 (= G223), L253 (= L240), G309 (≠ I295), L310 (= L296), G334 (= G320), G337 (= G323), V338 (≠ A324), E340 (= E326), D371 (= D358)
O60101 Phosphoglycerate kinase; EC 2.7.2.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
41% identity, 99% coverage: 1:397/402 of query aligns to 1:411/414 of O60101
- Y75 (≠ M74) modified: Phosphotyrosine
- S76 (= S75) modified: Phosphoserine
- S143 (vs. gap) modified: Phosphoserine
- S172 (≠ A157) modified: Phosphoserine
- S173 (= S158) modified: Phosphoserine
- S183 (≠ A170) modified: Phosphoserine
- S253 (= S239) modified: Phosphoserine
- S260 (≠ L246) modified: Phosphoserine
- T299 (≠ V284) modified: Phosphothreonine
- S328 (≠ C313) modified: Phosphoserine
- S351 (≠ G336) modified: Phosphoserine
- T373 (= T359) modified: Phosphothreonine
- S387 (≠ T373) modified: Phosphoserine
- S390 (= S376) modified: Phosphoserine
Sites not aligning to the query:
- 412 modified: Phosphoserine
- 413 modified: Phosphoserine
2wzcA The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with adp, 3pg and aluminium tetrafluoride (see paper)
40% identity, 98% coverage: 3:397/402 of query aligns to 1:402/405 of 2wzcA
- active site: R37 (= R39), K204 (= K200), G362 (= G357), G385 (= G380)
- binding adenosine-5'-diphosphate: G202 (= G198), A203 (= A199), K204 (= K200), K208 (= K204), G226 (= G222), G227 (= G223), N325 (= N319), P327 (= P321), G329 (= G323), V330 (≠ A324), E332 (= E326), G361 (= G356), D363 (= D358), T364 (= T359)
- binding tetrafluoroaluminate ion: R37 (= R39), K204 (= K200), K208 (= K204), G361 (= G356), G362 (= G357), G384 (= G379)
2wzbA The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with adp, 3pg and magnesium trifluoride (see paper)
40% identity, 98% coverage: 3:397/402 of query aligns to 1:402/405 of 2wzbA
- active site: R37 (= R39), K204 (= K200), G362 (= G357), G385 (= G380)
- binding adenosine-5'-diphosphate: G202 (= G198), A203 (= A199), K204 (= K200), K208 (= K204), G226 (= G222), G227 (= G223), N325 (= N319), P327 (= P321), G329 (= G323), V330 (≠ A324), E332 (= E326), G361 (= G356), D363 (= D358), T364 (= T359)
- binding trifluoromagnesate: K204 (= K200), K208 (= K204), G361 (= G356), G384 (= G379), G385 (= G380)
P00558 Phosphoglycerate kinase 1; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2; EC 2.7.2.3 from Homo sapiens (Human) (see 16 papers)
39% identity, 99% coverage: 1:397/402 of query aligns to 1:414/417 of P00558
- M1 (= M1) modified: Initiator methionine, Removed
- DFN 24:26 (≠ DLN 24:26) binding substrate
- R39 (= R39) binding substrate
- HLGR 63:66 (≠ HFGR 62:65) binding substrate
- L88 (= L86) to P: in PGK1D; with congenital non-spherocytic anemia; variant Matsue; dbSNP:rs137852531
- K97 (≠ P95) modified: N6-(2-hydroxyisobutyryl)lysine; alternate
- R123 (= R121) binding substrate
- K131 (= K128) modified: N6-malonyllysine; alternate
- G158 (= G141) to V: in PGK1D; with chronic hemolytic anemia; variant Shizuoka; dbSNP:rs137852532
- D164 (= D147) to V: in PGK1D; with chronic hemolytic anemia and intellectual disability; variant Amiens; dbSNP:rs137852538
- R171 (= R154) binding substrate
- K191 (≠ I175) natural variant: Missing (in PGK1D; with chronic hemolytic anemia; variant Alabama)
- R206 (= R190) to P: in PGK1D; with chronic hemolytic anemia; variant Uppsala; dbSNP:rs137852529
- K216 (= K200) modified: N6-(2-hydroxyisobutyryl)lysine
- K220 (= K204) binding ATP; modified: N6-(2-hydroxyisobutyryl)lysine
- E252 (≠ D235) to A: in PGK1D; with chronic hemolytic anemia; variant Antwerp
- V266 (≠ A249) to M: in PGK1D; with chronic non-spherocytic hemolytic anemia; variant Tokyo; dbSNP:rs431905501
- D268 (≠ E251) to N: in Munchen; 21% of activity; dbSNP:rs137852528
- D285 (= D268) to V: in PGK1D; with chronic hemolytic anemia; variant Herlev; 50% of activity; dbSNP:rs137852535
- G313 (≠ I295) binding ATP
- D315 (= D297) to N: in PGK1D; with rhabdomyolysis; variant Creteil
- C316 (≠ V298) to R: in PGK1D; with chronic hemolytic anemia; variant Michigan; dbSNP:rs137852533
- K323 (≠ H305) modified: N6-(2-hydroxyisobutyryl)lysine
- E344 (= E326) binding ATP
- T352 (= T334) to N: in dbSNP:rs137852530
- GGDT 373:376 (= GGDT 356:359) binding ATP
Query Sequence
>WP_068461577.1 NCBI__GCF_001541235.1:WP_068461577.1
MQVTNLKSIADVDVAGKRVLVRADLNVPVADGKVSDATRLERILDGLKDLSQRGARVVVI
SHFGRPKGAPNPEMSLAPVAAKLGELLGKPVTFVPACIGDEAESAVAALQPGAIAVLENL
RFHAGEEKNDDAFVAALARSGDLYVNDAFSAAHRAHASTEGLARVLPAYAGPLMIEEINA
LRAVLENPQRPVAALVGGAKVSSKIPILKHLIGKVDKLIIGGGMANTFLMSHGVDVGRSL
AEPDLLETAREIMAAAKAHNCAVVLPEDVVIAREFKSGVANAVVPILAVPSDAMILDVGP
RSIEHNCAVLKECRTLLWNGPMGAFEISPFGEGTFGLAREAARLTREGKLVTVAGGGDTV
AALNAAGATPDFTYVSTAGGAFLEWLEGRELPGVAALVRAQA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory