SitesBLAST
Comparing WP_073040460.1 NCBI__GCF_900129305.1:WP_073040460.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6dntA Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
34% identity, 95% coverage: 8:324/333 of query aligns to 3:306/310 of 6dntA
- active site: S120 (= S131), S121 (≠ A132), A122 (= A133), Y144 (= Y158), K148 (= K162), A187 (≠ G199)
- binding (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid: A80 (≠ V91), S120 (= S131), S121 (≠ A132), Y144 (= Y158), F172 (= F184), N173 (= N185), A187 (≠ G199), V188 (= V200), K191 (≠ R203), V203 (≠ T215), I204 (= I216), Y205 (≠ F217), Q210 (= Q222), R212 (= R224), I246 (≠ V264), R269 (= R287), D272 (= D290)
- binding nicotinamide-adenine-dinucleotide: G10 (= G15), G13 (= G18), F14 (= F19), I15 (≠ V20), D33 (= D39), N34 (= N40), L35 (≠ F41), S36 (≠ F42), S37 (= S43), G38 (= G44), D57 (≠ N69), L58 (= L70), L76 (= L87), A77 (= A88), A78 (= A89), A80 (≠ V91), S118 (≠ A129), S119 (≠ G130), Y144 (= Y158), K148 (= K162), Y171 (≠ C183), V174 (≠ I186)
- binding zinc ion: E209 (≠ R221), H275 (= H293)
4zrnA Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
34% identity, 95% coverage: 10:325/333 of query aligns to 2:305/309 of 4zrnA
- active site: T117 (≠ S131), G119 (vs. gap), A120 (= A133), Y143 (= Y158), K147 (= K162), Y181 (≠ S194), G185 (= G199)
- binding nicotinamide-adenine-dinucleotide: G7 (= G15), G10 (= G18), F11 (= F19), I12 (≠ V20), D31 (= D39), N32 (= N40), S34 (≠ F42), S35 (= S43), G36 (= G44), S51 (= S64), I52 (≠ V65), L73 (= L87), A74 (= A88), A75 (= A89), T92 (≠ V106), S115 (≠ A129), S116 (≠ G130), Y143 (= Y158), K147 (= K162), Y170 (≠ C183), V173 (≠ I186)
- binding uridine-5'-diphosphate-glucose: T117 (≠ S131), G119 (vs. gap), A120 (= A133), Y143 (= Y158), N172 (= N185), G185 (= G199), V186 (= V200), H201 (≠ T215), F203 (= F217), Y208 (≠ Q222), R210 (= R224), V244 (= V264), R267 (= R287), D270 (= D290)
Q7BJX9 UDP-N-acetylglucosamine 4-epimerase; UDP-GalNAc 4-epimerase; EC 5.1.3.7 from Plesiomonas shigelloides (Aeromonas shigelloides) (see 2 papers)
36% identity, 94% coverage: 10:323/333 of query aligns to 21:338/345 of Q7BJX9
- GVAGFI 26:31 (≠ GAAGFV 15:20) binding NAD(+)
- DNFSTG 50:55 (≠ DNFFSG 39:44) binding NAD(+)
- DI 81:82 (≠ SV 64:65) binding NAD(+)
- QAA 101:103 (≠ LAA 87:89) binding NAD(+)
- T120 (≠ V106) binding NAD(+)
- SS 145:146 (≠ SA 131:132) binding substrate
- S147 (≠ A133) mutation to T: No effect on epimerase activity.
- Y169 (= Y158) binding NAD(+)
- K173 (= K162) binding NAD(+)
- YFN 196:198 (≠ CFN 183:185) binding substrate
- V199 (≠ I186) binding NAD(+)
- VIPK 213:216 (≠ VISR 200:203) binding substrate
- YIN 228:230 (≠ TIF 215:217) binding substrate
- S236 (≠ T223) mutation to G: No effect on epimerase activity.
- R237 (= R224) binding substrate
- R271 (= R261) mutation to G: No effect on epimerase activity.
- RSGD 302:305 (≠ RPGD 287:290) binding substrate
- R307 (= R292) mutation to A: No effect on epimerase activity.
- H308 (= H293) mutation to A: No effect on epimerase activity.
- S309 (= S294) mutation to Y: Abolishes epimerase activity.
3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
35% identity, 94% coverage: 10:323/333 of query aligns to 18:330/336 of 3ruhA
- active site: S142 (= S131), S143 (≠ A132), S144 (≠ A133), Y166 (= Y158), K170 (= K162), N204 (≠ S194)
- binding nicotinamide-adenine-dinucleotide: G23 (= G15), G26 (= G18), F27 (= F19), I28 (≠ V20), D47 (= D39), N48 (= N40), S50 (≠ F42), T51 (≠ S43), G52 (= G44), D78 (≠ S64), I79 (≠ V65), Q98 (≠ L87), A99 (= A88), A100 (= A89), T117 (≠ V106), A140 (= A129), A141 (≠ G130), S142 (= S131), Y166 (= Y158), K170 (= K162), Y193 (≠ C183), V196 (≠ I186)
- binding [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl][(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3-(2-oxidanylidenepropyl)oxan-2-yl] hydrogen phosphate: G102 (≠ V91), S103 (= S92), S142 (= S131), S143 (≠ A132), S144 (≠ A133), Y166 (= Y158), Y193 (≠ C183), N195 (= N185), A209 (≠ G199), V210 (= V200), K213 (≠ R203), W214 (≠ F204), Y225 (≠ T215), I226 (= I216), N227 (≠ F217), R234 (= R224), L271 (≠ V264), R294 (= R287), D297 (= D290), V298 (≠ I291), S301 (= S294)
3rufA Alternative analogs as viable substrates of udp-hexose 4-epimerases
35% identity, 94% coverage: 10:323/333 of query aligns to 18:330/336 of 3rufA
- active site: S142 (= S131), S143 (≠ A132), S144 (≠ A133), Y166 (= Y158), K170 (= K162), N204 (≠ S194)
- binding nicotinamide-adenine-dinucleotide: G23 (= G15), G26 (= G18), F27 (= F19), I28 (≠ V20), D47 (= D39), N48 (= N40), S50 (≠ F42), T51 (≠ S43), G52 (= G44), D78 (≠ S64), I79 (≠ V65), Q98 (≠ L87), A99 (= A88), A100 (= A89), T117 (≠ V106), A140 (= A129), Y166 (= Y158), K170 (= K162), Y193 (≠ C183), V196 (≠ I186)
- binding uridine-5'-diphosphate: N195 (= N185), A209 (≠ G199), V210 (= V200), K213 (≠ R203), W214 (≠ F204), Y225 (≠ T215), I226 (= I216), N227 (≠ F217), R234 (= R224), L271 (≠ V264), R294 (= R287), D297 (= D290)
3lu1A Crystal structure analysis of wbgu: a udp-galnac 4-epimerase (see paper)
35% identity, 94% coverage: 10:323/333 of query aligns to 18:330/336 of 3lu1A
- active site: S142 (= S131), S143 (≠ A132), S144 (≠ A133), Y166 (= Y158), K170 (= K162), N204 (≠ S194)
- binding glycine: Q135 (≠ S124), K187 (≠ R177)
- binding nicotinamide-adenine-dinucleotide: G23 (= G15), G26 (= G18), F27 (= F19), I28 (≠ V20), D47 (= D39), N48 (= N40), S50 (≠ F42), T51 (≠ S43), G52 (= G44), D78 (≠ S64), I79 (≠ V65), Q98 (≠ L87), A99 (= A88), A100 (= A89), A140 (= A129), A141 (≠ G130), S142 (= S131), Y166 (= Y158), K170 (= K162), Y193 (≠ C183), N195 (= N185)
- binding uridine-diphosphate-n-acetylgalactosamine: S103 (= S92), S142 (= S131), S143 (≠ A132), S144 (≠ A133), Y166 (= Y158), N195 (= N185), V210 (= V200), W214 (≠ F204), Y225 (≠ T215), I226 (= I216), N227 (≠ F217), R234 (= R224), L271 (≠ V264), R294 (= R287), D297 (= D290)
6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac (see paper)
38% identity, 94% coverage: 11:324/333 of query aligns to 3:307/307 of 6wjaA
- active site: A118 (≠ S131), A119 (= A132), A120 (= A133), F143 (≠ Y158), K147 (= K162)
- binding nicotinamide-adenine-dinucleotide: G7 (= G15), G10 (= G18), F11 (= F19), I12 (≠ V20), D31 (= D39), D32 (≠ N40), S34 (≠ F42), T35 (≠ S43), G36 (= G44), A55 (≠ R63), L74 (= L87), A75 (= A88), A76 (= A89), S93 (≠ V106), F143 (≠ Y158), K147 (= K162), F170 (≠ C183), F171 (= F184), I173 (= I186)
- binding uridine-diphosphate-n-acetylgalactosamine: V80 (= V93), A120 (= A133), N172 (= N185), G186 (= G199), V187 (= V200), F191 (= F204), T202 (= T215), F204 (= F217), R211 (= R224), L247 (≠ V264), R270 (= R287), D273 (= D290)
6wj9B Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
38% identity, 94% coverage: 11:324/333 of query aligns to 4:308/308 of 6wj9B
- active site: A119 (≠ S131), A120 (= A132), A121 (= A133), F144 (≠ Y158), K148 (= K162)
- binding nicotinamide-adenine-dinucleotide: G8 (= G15), G11 (= G18), F12 (= F19), I13 (≠ V20), D32 (= D39), D33 (≠ N40), S35 (≠ F42), T36 (≠ S43), G37 (= G44), D55 (≠ E62), A56 (≠ R63), L75 (= L87), A76 (= A88), A77 (= A89), S94 (≠ V106), A117 (= A129), A119 (≠ S131), F144 (≠ Y158), K148 (= K162), F171 (≠ C183), F172 (= F184), I174 (= I186)
- binding uridine-diphosphate-n-acetylglucosamine: V81 (= V93), N173 (= N185), G187 (= G199), V188 (= V200), F192 (= F204), T203 (= T215), L204 (≠ I216), F205 (= F217), R212 (= R224), L248 (≠ V264), R271 (= R287), D274 (= D290)
1sb9A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-glucose (see paper)
32% identity, 94% coverage: 12:323/333 of query aligns to 19:334/340 of 1sb9A
- active site: S141 (= S131), S142 (≠ A132), S143 (≠ A133), Y165 (= Y158), K169 (= K162), N203 (≠ S194)
- binding nicotinamide-adenine-dinucleotide: G22 (= G15), G25 (= G18), F26 (= F19), I27 (≠ V20), D46 (= D39), N47 (= N40), F48 (= F41), T50 (≠ S43), G51 (= G44), D77 (≠ S64), I78 (≠ V65), Q97 (≠ L87), A99 (= A89), T116 (≠ V106), A139 (= A129), A140 (≠ G130), Y165 (= Y158), K169 (= K162), Y192 (≠ C183), N194 (= N185), V195 (≠ I186)
- binding uridine-5'-diphosphate-glucose: S141 (= S131), Y165 (= Y158), N194 (= N185), A208 (≠ G199), V209 (= V200), W213 (≠ F204), Y224 (≠ T215), I225 (= I216), N226 (≠ F217), L270 (≠ V264), R298 (= R287), D301 (= D290)
1sb8A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-n-acetylgalactosamine (see paper)
32% identity, 94% coverage: 12:323/333 of query aligns to 20:335/341 of 1sb8A
- active site: S142 (= S131), S143 (≠ A132), S144 (≠ A133), Y166 (= Y158), K170 (= K162), N204 (≠ S194)
- binding nicotinamide-adenine-dinucleotide: G23 (= G15), G26 (= G18), F27 (= F19), I28 (≠ V20), D47 (= D39), N48 (= N40), F49 (= F41), T51 (≠ S43), G52 (= G44), D78 (≠ S64), I79 (≠ V65), Q98 (≠ L87), A100 (= A89), T117 (≠ V106), A140 (= A129), A141 (≠ G130), Y166 (= Y158), K170 (= K162), Y193 (≠ C183), N195 (= N185), V196 (≠ I186)
- binding uridine-diphosphate-n-acetylgalactosamine: S103 (= S92), S142 (= S131), S143 (≠ A132), S144 (≠ A133), Y166 (= Y158), N195 (= N185), A209 (≠ G199), V210 (= V200), W214 (≠ F204), Y225 (≠ T215), I226 (= I216), N227 (≠ F217), R234 (= R224), L271 (≠ V264), R299 (= R287), D302 (= D290), S306 (= S294)
2b69A Crystal structure of human udp-glucoronic acid decarboxylase
33% identity, 95% coverage: 11:325/333 of query aligns to 4:305/312 of 2b69A
- active site: T115 (≠ S131), S116 (≠ A132), E117 (≠ A133), Y144 (= Y158), K148 (= K162), R185 (≠ G199)
- binding nicotinamide-adenine-dinucleotide: G8 (= G15), G11 (= G18), F12 (= F19), V13 (= V20), D32 (= D39), N33 (= N40), T36 (≠ S43), G37 (= G44), D57 (≠ S64), V58 (= V65), L72 (= L87), A73 (= A88), S74 (≠ A89), A76 (≠ V91), T91 (≠ V106), T115 (≠ S131), Y144 (= Y158), K148 (= K162), I171 (vs. gap), N173 (= N185), R185 (≠ G199)
- binding uridine-5'-diphosphate: P61 (≠ R68), L62 (≠ N69), Y63 (≠ L70), P78 (≠ V93), N98 (≠ R113), G101 (≠ E116), L102 (≠ E117), K104 (≠ R119), R105 (≠ N120), Y158 (≠ G173), N173 (= N185), R185 (≠ G199), V186 (= V200), N189 (≠ R203), T201 (= T215), Y203 (≠ F217), Q208 (= Q222), R210 (= R224), I244 (≠ V264), D270 (= D290)
Q8NBZ7 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; hUXS; hUXS1; EC 4.1.1.35 from Homo sapiens (Human) (see 4 papers)
33% identity, 95% coverage: 11:325/333 of query aligns to 91:392/420 of Q8NBZ7
- G98 (= G18) binding NAD(+)
- F99 (= F19) binding NAD(+)
- V100 (= V20) binding NAD(+)
- D119 (= D39) binding NAD(+)
- N120 (= N40) binding NAD(+)
- F122 (= F42) binding NAD(+)
- T123 (≠ S43) binding NAD(+)
- G124 (= G44) binding NAD(+)
- D144 (≠ S64) binding NAD(+)
- V145 (= V65) binding NAD(+)
- L149 (≠ N69) binding UDP-alpha-D-glucuronate
- Y150 (≠ L70) binding UDP-alpha-D-glucuronate
- L159 (= L87) binding NAD(+)
- S161 (≠ A89) binding NAD(+)
- K177 (≠ E105) binding UDP-alpha-D-glucuronate
- T178 (≠ V106) binding NAD(+)
- N185 (≠ R113) binding UDP-alpha-D-glucuronate
- G188 (≠ E116) binding UDP-alpha-D-glucuronate
- K191 (≠ R119) binding UDP-alpha-D-glucuronate
- R192 (≠ N120) binding UDP-alpha-D-glucuronate
- A200 (= A129) binding NAD(+)
- E204 (≠ A133) mutation to A: Reduced UDP-glucuronic acid decarboxylase activity.
- Y231 (= Y158) active site, Proton acceptor; binding NAD(+); mutation to F: Abolished UDP-glucuronic acid decarboxylase activity.
- K235 (= K162) binding NAD(+)
- R236 (= R164) mutation to H: Strongly reduced UDP-glucuronic acid decarboxylase activity, caused by a local unfolding of the active site that allows for a rotation of the dimer interface, leading to the formation of a homohexamer.
- Y245 (≠ G173) binding UDP-alpha-D-glucuronate
- Q248 (≠ P176) binding UDP-alpha-D-glucuronate
- E249 (≠ R177) binding UDP-alpha-D-glucuronate
- T261 (≠ I186) binding NAD(+)
- H267 (≠ D192) binding NAD(+)
- R272 (≠ G199) binding NAD(+)
- R361 (≠ S294) mutation to Q: Strongly reduced UDP-glucuronic acid decarboxylase activity.
Sites not aligning to the query:
- 1 modified: N-acetylmethionine
7ysmA Crystal structure of udp-glucose 4-epimerase (rv3634c) co-crystallized with udp-n-acetylglucosamine from mycobacterium tuberculosis
35% identity, 95% coverage: 11:327/333 of query aligns to 3:311/311 of 7ysmA
- binding nicotinamide-adenine-dinucleotide: G7 (= G15), G10 (= G18), F11 (= F19), I12 (≠ V20), D31 (= D39), N32 (= N40), T35 (≠ S43), G36 (= G44), D56 (≠ S64), I57 (≠ V65), L77 (= L87), A78 (= A88), A79 (= A89), I81 (≠ V91), T119 (≠ A129), Y146 (= Y158), K150 (= K162), P173 (≠ C183), N175 (= N185), V176 (≠ I186)
- binding uridine-diphosphate-n-acetylgalactosamine: I81 (≠ V91), R84 (≠ P94), S121 (= S131), G123 (≠ A133), S124 (≠ E134), Y146 (= Y158), A174 (≠ F184), N175 (= N185), G188 (= G199), V189 (= V200), F193 (= F204), R204 (≠ T215), V205 (≠ I216), F206 (= F217), N211 (≠ Q222), R213 (= R224), D248 (≠ V264), R271 (= R287)
7ys9A Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chaina from mycobacterium tuberculosis
35% identity, 95% coverage: 11:325/333 of query aligns to 3:309/310 of 7ys9A
- binding galactose-uridine-5'-diphosphate: I81 (≠ V91), R84 (≠ P94), S121 (= S131), G123 (≠ A133), Y146 (= Y158), A174 (≠ F184), N175 (= N185), A187 (≠ S198), G188 (= G199), V189 (= V200), F193 (= F204), R204 (≠ T215), F206 (= F217), N211 (≠ Q222), R213 (= R224), D248 (≠ V264), R271 (= R287)
- binding nicotinamide-adenine-dinucleotide: G7 (= G15), G10 (= G18), F11 (= F19), I12 (≠ V20), D31 (= D39), N32 (= N40), A34 (≠ F42), T35 (≠ S43), G36 (= G44), D56 (≠ S64), I57 (≠ V65), L77 (= L87), A78 (= A88), A79 (= A89), I81 (≠ V91), T119 (≠ A129), Y146 (= Y158), K150 (= K162), P173 (≠ C183), A174 (≠ F184), V176 (≠ I186)
- binding uridine-5'-diphosphate-glucose: I81 (≠ V91), R84 (≠ P94), S121 (= S131), G123 (≠ A133), Y146 (= Y158), A174 (≠ F184), N175 (= N185), A187 (≠ S198), G188 (= G199), V189 (= V200), F193 (= F204), R204 (≠ T215), F206 (= F217), N211 (≠ Q222), R213 (= R224), D248 (≠ V264), R271 (= R287)
7ystA Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chain b from mycobacterium tuberculosis
35% identity, 95% coverage: 11:328/333 of query aligns to 3:312/312 of 7ystA
- binding nicotinamide-adenine-dinucleotide: G7 (= G15), G10 (= G18), F11 (= F19), I12 (≠ V20), D31 (= D39), N32 (= N40), T35 (≠ S43), G36 (= G44), D56 (≠ S64), I57 (≠ V65), L77 (= L87), A78 (= A88), A79 (= A89), I81 (≠ V91), V96 (= V106), T119 (≠ A129), Y146 (= Y158), K150 (= K162), P173 (≠ C183), A174 (≠ F184), N175 (= N185), V176 (≠ I186)
- binding uridine-5'-diphosphate-glucose: I81 (≠ V91), R84 (≠ P94), S121 (= S131), G123 (≠ A133), Y146 (= Y158), A174 (≠ F184), N175 (= N185), A187 (≠ S198), G188 (= G199), V189 (= V200), F193 (= F204), R204 (≠ T215), V205 (≠ I216), F206 (= F217), R213 (= R224), D248 (≠ V264), R271 (= R287)
Q6GMI9 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UXS-1; EC 4.1.1.35 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
32% identity, 94% coverage: 11:323/333 of query aligns to 89:388/418 of Q6GMI9
- R234 (= R164) mutation to H: In Man o' war (mow) mutant; characterized by severe craniofacial defects. Fishes show defective organization and morphogenesis of chondrocytes, perichondrium and bone.
6pmhA Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
34% identity, 95% coverage: 8:324/333 of query aligns to 8:317/330 of 6pmhA
- active site: S127 (= S131), C129 (vs. gap), G130 (≠ A133), Y153 (= Y158), K157 (= K162)
- binding adenosine monophosphate: G16 (= G15), G19 (= G18), D40 (= D39), N41 (= N40), S43 (≠ F42), S44 (= S43), S45 (≠ G44), D62 (≠ S64), I63 (≠ V65), A84 (= A88), F87 (≠ V91), R194 (≠ S198)
- binding uridine-5'-diphosphate: C129 (vs. gap), N182 (= N185), N195 (≠ G199), V196 (= V200), F200 (= F204), P211 (≠ T215), I212 (= I216), T213 (≠ F217), R220 (= R224), V256 (= V264), R279 (= R287)
6pnlA Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
34% identity, 95% coverage: 8:324/333 of query aligns to 14:323/336 of 6pnlA
- active site: S133 (= S131), C135 (vs. gap), G136 (≠ A133), Y159 (= Y158), K163 (= K162)
- binding nicotinamide-adenine-dinucleotide: G22 (= G15), G25 (= G18), C26 (≠ F19), D46 (= D39), N47 (= N40), L48 (≠ F41), S49 (≠ F42), S50 (= S43), S51 (≠ G44), D68 (≠ S64), I69 (≠ V65), L89 (= L87), A91 (= A89), F93 (≠ V91), V108 (= V106), S131 (≠ A129), S133 (= S131), Y159 (= Y158), K163 (= K162), F186 (≠ C183), N188 (= N185), V189 (≠ I186), R200 (≠ S198)
- binding uridine-5'-diphosphate: N188 (= N185), N201 (≠ G199), V202 (= V200), F206 (= F204), P217 (≠ T215), I218 (= I216), T219 (≠ F217), R226 (= R224), V262 (= V264), R285 (= R287)
2p5uA Crystal structure of thermus thermophilus hb8 udp-glucose 4-epimerase complex with NAD
35% identity, 95% coverage: 11:326/333 of query aligns to 3:309/311 of 2p5uA
- active site: T117 (≠ S131), G119 (≠ A132), A120 (= A133), Y143 (= Y158), K147 (= K162), H181 (≠ S194), G185 (= G199)
- binding nicotinamide-adenine-dinucleotide: G10 (= G18), F11 (= F19), I12 (≠ V20), D31 (= D39), N32 (= N40), L33 (≠ F41), A34 (≠ F42), T35 (≠ S43), G36 (= G44), D51 (≠ F59), L52 (≠ F60), Q73 (≠ L87), A74 (= A88), A75 (= A89), A77 (≠ V91), S116 (≠ G130), Y143 (= Y158), K147 (= K162), V173 (≠ I186)
2q1sA Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with nadh (see paper)
30% identity, 97% coverage: 7:330/333 of query aligns to 6:320/336 of 2q1sA
- active site: A126 (= A132), P141 (≠ K162), Y142 (= Y163), K146 (= K167), R185 (= R190)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G15), G17 (= G18), F18 (= F19), V19 (= V20), D39 (= D39), N40 (= N40), L41 (≠ F41), S43 (= S43), S61 (= S64), I62 (≠ V65), L81 (= L87), A82 (= A88), T83 (≠ A89), H85 (≠ V91), N100 (≠ V106), S124 (≠ G130), Y142 (= Y163), K146 (= K167), F169 (≠ C183), V172 (≠ I186), R193 (≠ S198)
Query Sequence
>WP_073040460.1 NCBI__GCF_900129305.1:WP_073040460.1
MPKEGSGNGTCVVTGAAGFVGSHLCRRLLDLGCRVIGVDNFFSGHRDNMQEFQDHPRFFF
HERSVTERNLLSDLAVDYGPPSVIFHLAAIVSVPYSVEHPQETREVNYLATVRLLEEARN
LGCSRFVFAGSAAEYGNDMRLPLKEAYAGGETSWLSPYGEAKYRSSKAVGACGYGPRGVA
LRCFNIYGPRQDPSSPYSGVISRFAELAVQGEPLTIFGDGRQTRDFVYVSDVVEAYCRAA
GLDPSAPKVPAGIYNVGSGTRTSVLELARLILNLTERGESIRFYPERPGDIRHSVASIDA
IQAAMAWRPHISLEEGLRRTLRWMQGRRAVKPA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory