SitesBLAST
Comparing WP_073040739.1 NCBI__GCF_900129305.1:WP_073040739.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
2y27B Crystal structure of paak1 in complex with atp from burkholderia cenocepacia (see paper)
46% identity, 97% coverage: 14:437/439 of query aligns to 8:427/427 of 2y27B
- binding adenosine-5'-triphosphate: K65 (≠ R72), S90 (= S97), S91 (= S98), G92 (= G99), T93 (= T100), T94 (≠ S101), F138 (≠ L145), A211 (≠ G218), E212 (= E219), P213 (= P220), D232 (= D239), I233 (≠ N240), Y234 (= Y241), G235 (= G242), L236 (≠ I243), S237 (= S244), D302 (= D308), I320 (= I329), R323 (= R332), K419 (≠ R429)
- binding magnesium ion: V200 (≠ K207), S202 (≠ L209), L204 (= L211), M226 (≠ L233), G227 (≠ F234), Q347 (≠ V356), L350 (≠ E359)
2y4nA Paak1 in complex with phenylacetyl adenylate (see paper)
46% identity, 97% coverage: 14:437/439 of query aligns to 8:425/426 of 2y4nA
- binding 5'-o-[hydroxy(phenylacetyl)phosphoryl]adenosine: Y131 (≠ F140), F136 (≠ L145), G138 (= G147), G208 (≠ A217), A209 (≠ G218), E210 (= E219), P211 (= P220), I231 (≠ N240), Y232 (= Y241), G233 (= G242), L234 (≠ I243), S235 (= S244), P240 (= P249), D300 (= D308), R321 (= R332), K417 (≠ R429)
- binding magnesium ion: V198 (≠ K207), S200 (≠ L209), Q345 (≠ V356), L348 (≠ E359)
4r1mA Crystal structure of a putative acyl-coa ligase (bt_0428) from bacteroides thetaiotaomicron vpi-5482 at 2.48 a resolution
42% identity, 99% coverage: 5:437/439 of query aligns to 3:433/435 of 4r1mA
- binding adenosine monophosphate: A215 (≠ G218), E216 (= E219), P217 (= P220), N236 (≠ D239), S237 (≠ N240), F238 (≠ Y241), G239 (= G242), M240 (≠ I243), T241 (≠ S244), D305 (= D308), R329 (= R332), I335 (≠ V338), N340 (= N343)
- binding zinc ion: C252 (= C255), H259 (= H262), C314 (= C317), C316 (= C319)
2y4oA Crystal structure of paak2 in complex with phenylacetyl adenylate (see paper)
44% identity, 93% coverage: 14:423/439 of query aligns to 10:417/433 of 2y4oA
- binding 5'-o-[hydroxy(phenylacetyl)phosphoryl]adenosine: F135 (= F140), F140 (≠ L145), A213 (≠ G218), E214 (= E219), P215 (= P220), I235 (≠ N240), G237 (= G242), L238 (≠ I243), S239 (= S244), P244 (= P249), D304 (= D308), R325 (= R332), I331 (≠ V338), N336 (= N343)
4r1lA Crystal structure of a putative acyl-coa ligase (bt_0428) from bacteroides thetaiotaomicron vpi-5482 at 2.42 a resolution
43% identity, 95% coverage: 5:423/439 of query aligns to 3:419/433 of 4r1lA
- binding adenosine-5'-diphosphate: A215 (≠ G218), E216 (= E219), P217 (= P220), S237 (≠ N240), F238 (≠ Y241), G239 (= G242), M240 (≠ I243), T241 (≠ S244), D305 (= D308), R329 (= R332), N340 (= N343)
- binding adenosine monophosphate: A215 (≠ G218), E216 (= E219), P217 (= P220), S237 (≠ N240), F238 (≠ Y241), G239 (= G242), M240 (≠ I243), T241 (≠ S244), D305 (= D308), R329 (= R332), N340 (= N343)
- binding coenzyme a: S136 (≠ T139), A164 (≠ V167), G165 (= G168), N166 (≠ R169), S167 (≠ T170), I185 (≠ T188), Y188 (= Y191), K337 (= K340), T408 (≠ V412)
- binding zinc ion: C252 (= C255), H259 (= H262), C314 (= C317), C316 (= C319)
2y4oB Crystal structure of paak2 in complex with phenylacetyl adenylate (see paper)
44% identity, 93% coverage: 14:423/439 of query aligns to 10:417/432 of 2y4oB
- binding 5'-o-[hydroxy(phenylacetyl)phosphoryl]adenosine: F135 (= F140), F140 (≠ L145), G212 (≠ A217), A213 (≠ G218), E214 (= E219), P215 (= P220), I235 (≠ N240), G237 (= G242), L238 (≠ I243), S239 (= S244), P244 (= P249), D304 (= D308), R325 (= R332), I331 (≠ V338), N336 (= N343)
- binding magnesium ion: S204 (≠ L209), V228 (≠ L233)
6he0A Crystal structure of 2-hydroxyisobutyryl-coa ligase (hcl) in complex with 2-hib-amp and coa in the thioesterfication state (see paper)
30% identity, 95% coverage: 9:425/439 of query aligns to 25:453/477 of 6he0A
- binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] 2-methyl-2-oxidanyl-propanoate: S241 (≠ A217), G242 (= G218), E243 (= E219), P244 (= P220), G267 (≠ Y241), S268 (≠ G242), M269 (≠ I243), A270 (≠ S244), D335 (= D308), I357 (= I329), N371 (= N343)
- binding adenosine monophosphate: G242 (= G218), E243 (= E219), P244 (= P220), C266 (≠ N240), G267 (≠ Y241), S268 (≠ G242), A270 (≠ S244), E271 (= E245), D335 (= D308), N371 (= N343)
- binding coenzyme a: Y166 (≠ L145), A188 (≠ V167), G189 (= G168), P191 (vs. gap), S194 (≠ T170), Y210 (≠ V186), G211 (≠ S187), T212 (= T188), Y215 (= Y191), H218 (≠ I194), R368 (≠ K340), G369 (= G341), M401 (≠ L373), V439 (≠ I411), R440 (≠ V412)
6hdyA Crystal structure of 2-hydroxyisobutyryl-coa ligase (hcl) in the postadenylation state in complex with s3-hb-amp (see paper)
29% identity, 98% coverage: 9:437/439 of query aligns to 25:461/474 of 6hdyA
- binding (3s)-3-hydroxybutanoic acid: Y162 (≠ L145), S237 (≠ A217), G263 (≠ Y241), S264 (≠ G242), M265 (≠ I243), A266 (≠ S244), F271 (vs. gap)
- binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (3~{S})-3-oxidanylbutanoate: Y162 (≠ L145), G164 (= G147), S237 (≠ A217), G238 (= G218), E239 (= E219), P240 (= P220), C262 (≠ N240), G263 (≠ Y241), S264 (≠ G242), A266 (≠ S244), F271 (vs. gap), D331 (= D308), I353 (= I329), R356 (= R332), K453 (≠ R429)
6hdxA Crystal structure of 2-hydroxyisobutyryl-coa ligase (hcl) in the postadenylation state in complex with r3-hib-amp (see paper)
29% identity, 98% coverage: 9:437/439 of query aligns to 25:461/474 of 6hdxA
- binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2~{R})-2-methyl-3-oxidanyl-propanoate: Y162 (≠ L145), G164 (= G147), S237 (≠ A217), G238 (= G218), E239 (= E219), P240 (= P220), C262 (≠ N240), G263 (≠ Y241), S264 (≠ G242), A266 (≠ S244), F271 (vs. gap), D331 (= D308), I353 (= I329), R356 (= R332), K453 (≠ R429)
- binding (2r)-3-hydroxy-2-methylpropanoic acid: Y162 (≠ L145), G164 (= G147), S237 (≠ A217), G263 (≠ Y241), S264 (≠ G242), A266 (≠ S244), F271 (vs. gap)
6sixB Paak family amp-ligase with anp (see paper)
26% identity, 92% coverage: 19:423/439 of query aligns to 16:405/437 of 6sixB
- binding phosphoaminophosphonic acid-adenylate ester: S88 (= S97), S89 (= S98), A213 (≠ G218), E214 (= E219), P215 (= P220), E236 (≠ N240), Y237 (= Y241), G238 (= G242), S239 (≠ I243), T240 (≠ S244), E241 (= E245), D300 (= D308), V320 (≠ I329), R323 (= R332)
- binding magnesium ion: R79 (≠ L88), E80 (≠ R89), P121 (≠ H132), T150 (≠ S161)
- binding zinc ion: C249 (= C255), H255 (= H262), C309 (= C317), C311 (= C319)
6siwA Paak family amp-ligase with amp (see paper)
26% identity, 92% coverage: 19:423/439 of query aligns to 11:400/432 of 6siwA
- binding adenosine monophosphate: S84 (= S98), A208 (≠ G218), E209 (= E219), P210 (= P220), E231 (≠ N240), Y232 (= Y241), G233 (= G242), S234 (≠ I243), T235 (≠ S244), D295 (= D308), V315 (≠ I329)
- binding magnesium ion: E75 (≠ R89), L77 (≠ V91), S83 (= S97), P116 (≠ H132), G143 (= G159), T145 (≠ S161), E236 (= E245)
- binding zinc ion: C244 (= C255), H250 (= H262), C304 (= C317), C306 (= C319)
6siyA Paak family amp-ligase with amp and substrate (see paper)
26% identity, 92% coverage: 19:423/439 of query aligns to 12:401/433 of 6siyA
- binding 3-hydroxyanthranilic acid: T125 (≠ F140), P126 (≠ A141), T132 (≠ G147), L135 (≠ G150), R153 (vs. gap), N177 (≠ T188), A209 (≠ G218), E232 (≠ N240), G234 (= G242), S235 (≠ I243)
- binding adenosine monophosphate: S85 (= S98), A209 (≠ G218), E210 (= E219), P211 (= P220), E232 (≠ N240), Y233 (= Y241), G234 (= G242), S235 (≠ I243), T236 (≠ S244), D296 (= D308), V316 (≠ I329)
- binding magnesium ion: R75 (≠ L88), E76 (≠ R89), L78 (≠ V91), P117 (≠ H132), G144 (= G159), A145 (= A160), T146 (≠ S161)
Query Sequence
>WP_073040739.1 NCBI__GCF_900129305.1:WP_073040739.1
MTVESRPIWEPEKECMDRGELEQLQLERLQATLNRVYRNVAFYRKRFREIDFVPEDDLTE
LADLKRLPFTTRDDVSNSYPYDMFAVPLREVVRVHTSSGTSVNPRVVGYTKRDLKNWAQL
TARVLASAGVTHDDVIQITFAYGLLSGGLGIHYGAERLGASVLPTSVGRTERQIKIMQDF
RTTALVSTPSYALIIADRMEELGVDPKQLSLRFAICAGEPWTEEMRREIEERLFVTATDN
YGISEVMGPGVAGECLEKTGMHFQEDHFLLEVIDPETGRECEPGELGELVITTLTKEAFP
VIRYRTGDLCRIVPGTCPCGRTFRRISRIEGRCDNVVVIKGVNIIPERIGDILEQVKGER
PVYQLVATRRGRLDQLEIWIEITERLFFDKMREQRTLVDEMRQKVANFIGIVPRIKLVER
GSLEREGDRVIPFVDRRSE
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory