SitesBLAST
Comparing WP_073950325.1 NCBI__GCF_001906585.1:WP_073950325.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4f3xA Crystal structure of putative aldehyde dehydrogenase from sinorhizobium meliloti 1021 complexed with NAD
47% identity, 94% coverage: 18:495/511 of query aligns to 1:475/476 of 4f3xA
- active site: N150 (= N168), K173 (= K191), E247 (= E266), C281 (= C300), E379 (= E399), D456 (= D476)
- binding nicotinamide-adenine-dinucleotide: I146 (= I164), A147 (= A165), P148 (= P166), W149 (= W167), K173 (= K191), E176 (= E194), G205 (= G224), G209 (= G228), I213 (≠ V232), I223 (≠ F242), G225 (= G244), D226 (≠ S245), T229 (≠ V248), G249 (= G268), C281 (= C300), Q328 (≠ H347), R331 (= R350), E379 (= E399), F381 (= F401)
P77674 Gamma-aminobutyraldehyde dehydrogenase; ABALDH; 1-pyrroline dehydrogenase; 4-aminobutanal dehydrogenase; 5-aminopentanal dehydrogenase; EC 1.2.1.19; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
50% identity, 92% coverage: 25:495/511 of query aligns to 7:474/474 of P77674
1wndA Escherichia coli ydcw gene product is a medium-chain aldehyde dehydrogenase as determined by kinetics and crystal structure (see paper)
50% identity, 92% coverage: 25:495/511 of query aligns to 7:474/474 of 1wndA
- active site: N149 (= N168), K172 (= K191), E246 (= E266), C280 (= C300), E378 (= E399), D455 (= D476)
- binding calcium ion: G249 (= G269), K250 (= K270), A251 (= A271), G405 (= G426), L406 (= L427), A407 (= A428), Y427 (≠ A448)
1wnbB Escherichia coli ydcw gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde) (see paper)
50% identity, 92% coverage: 25:495/511 of query aligns to 7:474/474 of 1wnbB
- active site: N149 (= N168), K172 (= K191), E246 (= E266), C280 (= C300), E378 (= E399), D455 (= D476)
- binding betaine aldehyde: D279 (= D299), F436 (≠ I457), L438 (≠ I459)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I145 (= I164), A146 (= A165), W148 (= W167), K172 (= K191), G204 (= G224), G208 (= G228), D209 (≠ E229), T223 (= T243), G224 (= G244), S225 (= S245), T228 (≠ V248), H231 (≠ R251), G248 (= G268), E378 (= E399)
1wnbA Escherichia coli ydcw gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde) (see paper)
50% identity, 92% coverage: 25:495/511 of query aligns to 7:474/474 of 1wnbA
- active site: N149 (= N168), K172 (= K191), E246 (= E266), C280 (= C300), E378 (= E399), D455 (= D476)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I145 (= I164), A146 (= A165), W148 (= W167), K172 (= K191), G204 (= G224), G208 (= G228), D209 (≠ E229), G224 (= G244), S225 (= S245), T228 (≠ V248), H231 (≠ R251), G248 (= G268), F380 (= F401)
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
42% identity, 94% coverage: 17:494/511 of query aligns to 2:481/489 of 4cazA
- active site: N152 (= N168), K175 (= K191), E251 (= E266), C285 (= C300), E386 (= E399), E463 (≠ D476)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I164), G149 (≠ A165), W151 (= W167), N152 (= N168), K175 (= K191), E178 (= E194), G208 (= G224), G212 (= G228), F226 (= F242), T227 (= T243), G228 (= G244), G229 (≠ S245), T232 (≠ V248), V236 (= V252), E251 (= E266), L252 (= L267), C285 (= C300), E386 (= E399), F388 (= F401)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
42% identity, 94% coverage: 17:494/511 of query aligns to 2:481/489 of 2woxA
- active site: N152 (= N168), K175 (= K191), E251 (= E266), C285 (= C300), E386 (= E399), E463 (≠ D476)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I164), G149 (≠ A165), W151 (= W167), N152 (= N168), K175 (= K191), S177 (≠ A193), E178 (= E194), G208 (= G224), G212 (= G228), F226 (= F242), T227 (= T243), G228 (= G244), G229 (≠ S245), T232 (≠ V248), V236 (= V252), E251 (= E266), L252 (= L267), C285 (= C300), E386 (= E399), F388 (= F401)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
42% identity, 94% coverage: 17:494/511 of query aligns to 2:481/489 of 2wmeA
- active site: N152 (= N168), K175 (= K191), E251 (= E266), C285 (= C300), E386 (= E399), E463 (≠ D476)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ A165), W151 (= W167), K175 (= K191), S177 (≠ A193), E178 (= E194), G208 (= G224), G212 (= G228), F226 (= F242), G228 (= G244), G229 (≠ S245), T232 (≠ V248), V236 (= V252)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
42% identity, 94% coverage: 17:494/511 of query aligns to 3:482/490 of Q9HTJ1
- GAWN 150:153 (≠ APWN 165:168) binding NADPH
- K162 (= K177) active site, Charge relay system
- KPSE 176:179 (≠ KPAE 191:194) binding NADPH
- G209 (= G224) binding NADPH
- GTST 230:233 (≠ STAV 245:248) binding NADPH
- E252 (= E266) active site, Proton acceptor
- C286 (= C300) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E399) binding NADPH
- E464 (≠ D476) active site, Charge relay system
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 92% coverage: 24:494/511 of query aligns to 20:489/491 of 5gtlA