SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_074200863.1 NCBI__GCF_900141795.1:WP_074200863.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1bxrA Structure of carbamoyl phosphate synthetase complexed with the atp analog amppnp (see paper)
71% identity, 100% coverage: 1:1071/1071 of query aligns to 1:1069/1073 of 1bxrA

query
sites
1bxrA

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active site: R129 (= R129), R169 (= R169), M174 (≠ L174), G176 (= G176), K202 (≠ N202), E215 (= E215), H243 (= H243), N283 (= N283), Q285 (= Q285), E299 (= E299), N301 (= N301), R303 (= R303), S307 (= S307), D338 (= D338), G507 (= G510), K634 (= K636), R715 (= R717), G721 (= G723), G722 (= G724), S745 (= S747), E761 (= E763), D769 (= D771), Q829 (= Q831), E841 (= E843), N843 (= N845), R848 (= R850), P901 (≠ L903)
binding phosphoaminophosphonic acid-adenylate ester: R129 (= R129), I167 (= I167), R169 (= R169), M174 (≠ L174), G175 (= G175), G176 (= G176), L210 (≠ I210), I211 (= I211), E215 (= E215), M240 (= M240), G241 (= G241), H243 (= H243), T244 (= T244), Q285 (= Q285), E299 (= E299), R306 (= R306), T376 (= T376), R675 (= R677), V713 (= V715), R715 (= R717), L720 (= L722), G721 (= G723), G722 (= G724), M725 (= M727), D753 (= D755), F755 (= F757), L756 (= L758), E761 (= E763), A785 (= A787), G786 (= G788), V787 (≠ I789), H788 (= H790), Q829 (= Q831), E841 (= E843), N843 (= N845), R848 (= R850)
binding manganese (ii) ion: E299 (= E299), N301 (= N301), Q829 (= Q831), E841 (= E843), E841 (= E843), N843 (= N845)
binding L-ornithine: E783 (= E785), D791 (= D793), E892 (= E894), L907 (= L909), D1041 (≠ T1043), T1042 (= T1044)

P00968 Carbamoyl phosphate synthase large chain; Carbamoyl phosphate synthetase ammonia chain; EC 6.3.4.16; EC 6.3.5.5 from Escherichia coli (strain K12) (see 6 papers)
71% identity, 100% coverage: 1:1071/1071 of query aligns to 1:1069/1073 of P00968

query
sites
P00968

M
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P

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M1 (= M1) modified: Initiator methionine, Removed
R129 (= R129) binding ATP
R169 (= R169) binding ATP
G175 (= G175) binding ATP
G176 (= G176) binding ATP
E208 (= E208) binding ATP
L210 (≠ I210) binding ATP
E215 (= E215) binding ATP
G241 (= G241) binding ATP
I242 (≠ V242) binding ATP
H243 (= H243) binding ATP
Q285 (= Q285) binding ATP; binding Mn(2+)
E299 (= E299) binding ATP; binding Mn(2+); binding Mn(2+)
N301 (= N301) binding Mn(2+)
R715 (= R717) binding ATP
H754 (≠ R756) binding ATP
L756 (= L758) binding ATP
E761 (= E763) binding ATP
G786 (= G788) binding ATP
V787 (≠ I789) binding ATP
H788 (= H790) binding ATP
S789 (= S791) binding ATP
Q829 (= Q831) binding ATP; binding Mn(2+)
E841 (= E843) binding ATP; binding Mn(2+); binding Mn(2+)
N843 (= N845) binding Mn(2+)

1t36A Crystal structure of e. Coli carbamoyl phosphate synthetase small subunit mutant c248d complexed with uridine 5'-monophosphate (see paper)
69% identity, 100% coverage: 1:1071/1071 of query aligns to 1:1054/1058 of 1t36A

query
sites
1t36A

M

M

P

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K

K

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D

D

E

E

L

L

K

M

N

N

D
|
D

I

I

T

T

G

G

G

G

A

R

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T

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P

A

A

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S

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F

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Y

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V

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F

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K

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L

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|
T

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M

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K

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V

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G

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L

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G

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L

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G

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G

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N

D

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M

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L

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|
K

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|
R

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-

Y

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|
M

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L

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|
F

L
|
L

D

D

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A

A

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|
E

V

V

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D

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|
D

G

G

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M

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I

I

G

G

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G

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I

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M

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H

H

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|
E

Q

Q

A
|
A

G
|
G

I
x
V

H
|
H

S

S

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G

D
|
D

S

S

A

A

C

C

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L

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G

G

L

L

M

M

N

N

T

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Q
|
Q

F

F

A

A

I

V

K

K

E

N

D

N

E

E

I

V

F

Y

V

L

L

I

E
|
E

V

V

N
|
N

P

P

R

R

A

A

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A

R
|
R

T

T

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V

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P

F

F

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S

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K

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G

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L

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K

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|
E

A

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L

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P

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F

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N

K

K

F

F

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x
P

G

G

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V

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D

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P

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L
|
L

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|
P

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|
T

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|
G

T
|
T

A

A

A

I

A

V

L

L

K

G

E

E

A

A

G

G

I

I

E

N

V

P

D

R

V

L

V

V

N

N

K
|
K

V

V

T

H

E

E

G

G

R

R

P

P

N

H

I

I

V

Q

D

D

L

R

I

I

K

K

N

N

G

G

E

E

I

Y

D

T

L

Y

I

I

V

I

N
|
N

T
|
T

S
x
T

D

S

G

G

S

R

V

R

S

A

I

I

K

E

D

D

S
|
S

A

R

D

V

I
|
I

R

R

R

R

E

S

A

A

L

L

M

Q

H

Y

K

K

V

V

C

H

Y

Y

T
x
D

T
|
T

T

T

I

L

A

N

G

G

A

G

F

F

A

A

M

T

V

A

A

M

A

A

M

L

D

N

Y

A

L

D

D

A

P

T

Q

E

P

K

V

V

Y

I

R

S

L

V

Q

Q

D

E

L

M

Q

H

active site: R129 (= R129), R169 (= R169), M174 (≠ L174), G176 (= G176), K202 (≠ N202), E215 (= E215), H243 (= H243), N283 (= N283), Q285 (= Q285), E299 (= E299), N301 (= N301), R303 (= R303), S307 (= S307), D338 (= D338), G507 (= G510), K634 (= K636), R715 (= R717), E746 (= E763), D754 (= D771), Q814 (= Q831), E826 (= E843), N828 (= N845), R833 (= R850), P886 (≠ L903)
binding adenosine-5'-diphosphate: R129 (= R129), I167 (= I167), R169 (= R169), M174 (≠ L174), G175 (= G175), G176 (= G176), E208 (= E208), L210 (≠ I210), I211 (= I211), E215 (= E215), M240 (= M240), G241 (= G241), I242 (≠ V242), H243 (= H243), Q285 (= Q285), I298 (= I298), E299 (= E299), T376 (= T376), R715 (= R717), M718 (= M727), F740 (= F757), L741 (= L758), E746 (= E763), A770 (= A787), G771 (= G788), V772 (≠ I789), H773 (= H790), E826 (= E843), P894 (= P911)
binding manganese (ii) ion: Q285 (= Q285), E299 (= E299), E299 (= E299), N301 (= N301), Q814 (= Q831), E826 (= E843)
binding L-ornithine: E768 (= E785), D776 (= D793), E877 (= E894), L892 (= L909), D1026 (≠ T1043), T1027 (= T1044)
binding phosphate ion: M174 (≠ L174), G175 (= G175), H243 (= H243), E299 (= E299), N301 (= N301), R303 (= R303), R306 (= R306)
binding uridine-5'-monophosphate: K939 (≠ R956), T959 (= T976), G961 (= G978), T962 (= T979), K978 (= K995), N1000 (= N1017), T1001 (= T1018), T1002 (≠ S1019), S1011 (= S1028), I1014 (= I1031)

1c3oA Crystal structure of the carbamoyl phosphate synthetase: small subunit mutant c269s with bound glutamine (see paper)
69% identity, 100% coverage: 1:1071/1071 of query aligns to 1:1054/1058 of 1c3oA

query
sites
1c3oA

M

M

P

P

K

K

R

R

T

T

D

D

I

I

E

K

S

S

I

I

L

L

I

I

I

L

G

G

A

A

G

G

P

P

I

I

I

V

I

I

G

G

Q

Q

A

A

C

C

E

E

F

F

D

D

Y

Y

S

S

G

G

V

A

Q

Q

A

A

V

C

K

K

A

A

L

L

K

R

E

E

E

E

G

G

Y

Y

R

R

V

V

I

I

L

L

V

V

N

N

S

S

N

N

P

P

A

A

T

T

I

I

M

M

T

T

D

D

P

P

D

E

L

M

A

A

D

D

A

A

T

T

Y

Y

I

I

E

E

P

P

I

I

E

H

W

W

R

E

T

V

I

V

E

R

K

K

I

I

I

I

E

E

K

K

E

E

R

R

P

P

D

D

A

A

I

V

L

L

P

P

T

T

M

M

G

G

G

G

Q

Q

T

T

A

A

L

L

N

N

T

C

A

A

L

L

D

E

L

L

A

E

R

R

H

Q

G

G

V

V

L

L

E

E

K

E

Y

F

G

G

V

V

E

T

L

M

I

I

G

G

A

A

N

T

E

A

D

D

A

A

I

I

D

D

K

K

A

A

E

E

N

D

R
|
R

D

R

R

R

F

F

R

D

A

V

A

A

M

M

Q

K

K

K

I

I

G

G

L

L

D

E

M

T

P

A

K

R

S

S

A

G

V

I

A

A

H

H

S

T

M

M

E

E

E

E

A

A

W

L

A

A

I

V

L

A

D

A

E

D

V

V

G

G

F

F

P

P

A

C

I
|
I

I

I

R
|
R

P

P

S

S

F

F

T

T

L
x
M

G
|
G

G
|
G

S

S

G

G

G

G

G

G

I

I

A

A

Y

Y

N

N

R

R

D

E

E

E

F

F

E

E

Q

E

I

I

C

C

K

A

F

R

G

G

L

L

D

D

L

L

S

S

P

P

T

T

N
x
K

E

E

L

L

L

L

I

I

E

D

E

E

S

S

I
x
L

I
|
I

G

G

W

W

K

K

E
|
E

Y

Y

E

E

M

M

E

E

V

V

I

V

R

R

D

D

R

K

N

N

D

D

N

N

A

C

I

I

I

I

V

V

C

C

S

S

I

I

E

E

N

N

L

F

D

D

P

A

M
|
M

G
|
G

V

I

H
|
H

T
|
T

G

G

D

D

S

S

I

I

T

T

V

V

A

A

P

P

A

A

Q

Q

T

T

L

L

T

T

D

D

K

K

E

E

Y

Y

Q

Q

I

I

M

M

R

R

N

N

A

A

S

S

L

M

A

A

V

V

L

L

R

R

E

E

I

I

G

G

V

V

E

E

T

T

G

G

G

G

S

S

N
|
N

V

V

Q
|
Q

F

F

A

A

V

V

N

N

P

P

E

K

T

N

G

G

R

R

M

L

I

I

I

V

I
|
I

E
|
E

M

M

N
|
N

P

P

R
|
R

V

V

S

S

R
|
R

S
|
S

S

S

A

A

L

L

A

A

S

S

K

K

A

A

T

T

G

G

F

F

P

P

I

I

A

A

K

K

V

V

A

A

A

A

K

K

L

L

A

A

V

V

G

G

Y

Y

T

T

L

L

D

D

E

E

L

L

K

M

N

N

D
|
D

I

I

T

T

G

G

G

G

A

R

T

T

P

P

A

A

S

S

F

F

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I

D

D

Y

Y

V

V

V

V

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T

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K

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I

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P

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F

F

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F

F

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E

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K

F

F

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A

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G

A

A

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N

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D

R

R

L

L

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T

T
|
T

Q

Q

M

M

K

K

S

S

V

V

G

G

E

E

V

V

M

M

A

A

M

I

G

G

R

R

N

T

F

Q

Q

Q

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E

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S

L

L

Q

Q

K

K

A

A

I

L

R

R

G

G

L

L

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T

V

G

G

R

A

T

T

G

G

L

F

N

D

E

P

M

K

L

V

D

-

L

-

N

-

T

S

L

L

D

D

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D

K

P

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A

R

L

D

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T

K

L

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L

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D

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A

G

G

P

A

D

D

R

R

L

I

W

W

Y

Y

V

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A

A

D

D

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F

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R

A

A

G

G

W

L

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S

L

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D

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V

H

F

D

N

A

L

C

T

D

N

I

I

D

D

P

R

W

W

F

F

L

L

A

V

Q

Q

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Q

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L

L

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V

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R

M

L

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D

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L

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A

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active site: R129 (= R129), R169 (= R169), M174 (≠ L174), G176 (= G176), K202 (≠ N202), E215 (= E215), H243 (= H243), N283 (= N283), Q285 (= Q285), E299 (= E299), N301 (= N301), R303 (= R303), S307 (= S307), D338 (= D338), G507 (= G510), K634 (= K636), R715 (= R717), E746 (= E763), D754 (= D771), Q814 (= Q831), E826 (= E843), N828 (= N845), R833 (= R850), P886 (≠ L903)
binding adenosine-5'-diphosphate: R129 (= R129), I167 (= I167), R169 (= R169), M174 (≠ L174), G176 (= G176), L210 (≠ I210), I211 (= I211), E215 (= E215), M240 (= M240), G241 (= G241),