SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_075618668.1 NCBI__GCF_001939075.1:WP_075618668.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

3c4jA Abc protein artp in complex with atp-gamma-s
34% identity, 89% coverage: 5:224/247 of query aligns to 4:226/242 of 3c4jA

query
sites
3c4jA

I

I

S

D

V

V

K

H

D

Q

L

L

F

K

V

K

S

S

Y
x
F

H

G

G

S

S

L

E

E

A
x
V

L

L

N

K

N

G

V

I

S

N

F

V

T

H

V

I

N

R

E

E

G

G

N

E

L

V

V

V

G

V

I

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

K

R

S

C

L

L

L

N

N

L

L

L

I

E

S

D

I

F

D

D

K

E

G

G

E

E

V

I

Q

I

I

I

L

D

G

G

K

I

S

N

I

L

K

K

-

A

-

K

-

D

-

T

-

N

-

L

-

N

E

K

M

V

R

R

T

E

K

E

V

V

A

G

Y

M

V

V

P

F

Q

Q

R

R

S

F

N

N

I

L

D

-

W

-

D

-

F

F

P

P

-

H

I

M

T

T

V

V

I

L

D

N

T

N

V

I

L

T

L

L

G

A

T

P

Y

-

P

-

N

-

L

M

G

K

I

V

F

R

K

K

R

W

P

P

K

R

K

E

S

K

D

A

K

E

A

A

W

K

A

A

L

M

E

E

C

L

L

L

E

D

K

K

V

V

G

G

I

L

A

K

E

D

F

K

R

A

H

H

R

A

Q

Y

I

P

G

D

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

Q

Q

R

R

V

V

F

A

L

I

A

A

R

R

A

A

L

L

A

A

Q

M

K

E

P

P

D

K

M

I

Y

M

F

L

L

F

D

D

E

E

P

P

F

T

V

S

G

A

V

L

D

D

V

P

T

E

S

M

E

V

E

G

T

E

I

V

I

L

T

S

I

V

L

M

K

K

E

Q

L

L

R

A

D

N

I

E

G

G

K

M

T

T

V

M

V

V

V

V

V

V

H

T

H

H

D

E

L

M

S

G

K

F

A

A

S

R

D

E

Y

V

F

G

N

D

E

R

L

V

I

L

L

F

L

M

N

D

K

G

E

G

-

Y

L

I

I

I

E

E

Y

E

G

G

A

K

V

P

E

E

K

D

V

L

F

F

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

3c41J Abc protein artp in complex with amp-pnp/mg2+
34% identity, 89% coverage: 5:224/247 of query aligns to 4:226/242 of 3c41J

query
sites
3c41J

I

I

S

D

V

V

K

H

D

Q

L

L

F

K

V

K

S

S

Y
x
F

H

G

G

S

S

L

E

E

A
x
V

L

L

N

K

N

G

V

I

S

N

F

V

T

H

V

I

N

R

E

E

G

G

N

E

L

V

V

V

G

V

I

V

I

I

G

G

P

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

K

R

S

C

L

L

L

N

N

L

L

L

I

E

S

D

I

F

D

D

K

E

G

G

E

E

V

I

Q

I

I

I

L

D

G

G

K

I

S

N

I

L

K

K

-

A

-

K

-

D

-

T

-

N

-

L

-

N

E

K

M

V

R

R

T

E

K

E

V

V

A

G

Y

M

V

V

P

F

Q

Q

R

R

S

F

N

N

I

L

D

-

W

-

D

-

F

F

P

P

-

H

I

M

T

T

V

V

I

L

D

N

T

N

V

I

L

T

L

L

G

A

T

P

Y

-

P

-

N

-

L

M

G

K

I

V

F

R

K

K

R

W

P

P

K

R

K

E

S

K

D

A

K

E

A

A

W

K

A

A

L

M

E

E

C

L

L

L

E

D

K

K

V

V

G

G

I

L

A

K

E

D

F

K

R

A

H

H

R

A

Q

Y

I

P

G

D

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

Q

Q

R

R

V

V

F

A

L

I

A

A

R

R

A

A

L

L

A

A

Q

M

K

E

P

P

D

K

M

I

Y

M

F

L

L

F

D
|
D

E

E

P

P

F

T

V

S

G

A

V

L

D

D

V

P

T

E

S

M

E

V

E

G

T

E

I

V

I

L

T

S

I

V

L

M

K

K

E

Q

L

L

R

A

D

N

I

E

G

G

K

M

T

T

V

M

V

V

V

V

V

V

H

T

H

H

D

E

L

M

S

G

K

F

A

A

S

R

D

E

Y

V

F

G

N

D

E

R

L

V

I

L

L

F

L

M

N

D

K

G

E

G

-

Y

L

I

I

I

E

E

Y

E

G

G

A

K

V

P

E

E

K

D

V

L

F

F

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)
binding magnesium ion: S43 (= S44), D163 (= D162)

2olkA Abc protein artp in complex with adp-beta-s
34% identity, 89% coverage: 5:224/247 of query aligns to 4:226/242 of 2olkA

query
sites
2olkA

I

I

S

D

V

V

K

H

D

Q

L

L

F

K

V

K

S

S

Y
x
F

H

G

G

S

S

L

E

E

A
x
V

L

L

N

K

N

G

V

I

S

N

F

V

T

H

V

I

N

R

E

E

G

G

N

E

L

V

V

V

G

V

I

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

K

R

S

C

L

L

L

N

N

L

L

L

I

E

S

D

I

F

D

D

K

E

G

G

E

E

V

I

Q

I

I

I

L

D

G

G

K

I

S

N

I

L

K

K

-

A

-

K

-

D

-

T

-

N

-

L

-

N

E

K

M

V

R

R

T

E

K

E

V

V

A

G

Y

M

V

V

P

F

Q

Q

R

R

S

F

N

N

I

L

D

-

W

-

D

-

F

F

P

P

-

H

I

M

T

T

V

V

I

L

D

N

T

N

V

I

L

T

L

L

G

A

T

P

Y

-

P

-

N

-

L

M

G

K

I

V

F

R

K

K

R

W

P

P

K

R

K

E

S

K

D

A

K

E

A

A

W

K

A

A

L

M

E

E

C

L

L

L

E

D

K

K

V

V

G

G

I

L

A

K

E

D

F

K

R

A

H

H

R

A

Q

Y

I

P

G

D

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

Q

Q

R

R

V

V

F

A

L

I

A

A

R

R

A

A

L

L

A

A

Q

M

K

E

P

P

D

K

M

I

Y

M

F

L

L

F

D

D

E

E

P

P

F

T

V

S

G

A

V

L

D

D

V

P

T

E

S

M

E

V

E

G

T

E

I

V

I

L

T

S

I

V

L

M

K

K

E

Q

L

L

R

A

D

N

I

E

G

G

K

M

T

T

V

M

V

V

V

V

V

V

H

T

H

H

D

E

L

M

S

G

K

F

A

A

S

R

D

E

Y

V

F

G

N

D

E

R

L

V

I

L

L

F

L

M

N

D

K

G

E

G

-

Y

L

I

I

I

E

E

Y

E

G

G

A

K

V

P

E

E

K

D

V

L

F

F

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

2oljA Abc protein artp in complex with adp/mg2+
34% identity, 89% coverage: 5:224/247 of query aligns to 4:226/242 of 2oljA

query
sites
2oljA

I

I

S

D

V

V

K

H

D

Q

L

L

F

K

V

K

S

S

Y
x
F

H

G

G

S

S

L

E

E

A
x
V

L

L

N

K

N

G

V

I

S

N

F

V

T

H

V

I

N

R

E

E

G

G

N

E

L

V

V

V

G

V

I

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

K

R

S

C

L

L

L

N

N

L

L

L

I

E

S

D

I

F

D

D

K

E

G

G

E

E

V

I

Q

I

I

I

L

D

G

G

K

I

S

N

I

L

K

K

-

A

-

K

-

D

-

T

-

N

-

L

-

N

E

K

M

V

R

R

T

E

K

E

V

V

A

G

Y

M

V

V

P

F

Q

Q

R

R

S

F

N

N

I

L

D

-

W

-

D

-

F

F

P

P

-

H

I

M

T

T

V

V

I

L

D

N

T

N

V

I

L

T

L

L

G

A

T

P

Y

-

P

-

N

-

L

M

G

K

I

V

F

R

K

K

R

W

P

P

K

R

K

E

S

K

D

A

K

E

A

A

W

K

A

A

L

M

E

E

C

L

L

L

E

D

K

K

V

V

G

G

I

L

A

K

E

D

F

K

R

A

H

H

R

A

Q

Y

I

P

G

D

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

Q

Q

R

R

V

V

F

A

L

I

A

A

R

R

A

A

L

L

A

A

Q

M

K

E

P

P

D

K

M

I

Y

M

F

L

L

F

D

D

E

E

P

P

F

T

V

S

G

A

V

L

D

D

V

P

T

E

S

M

E

V

E

G

T

E

I

V

I

L

T

S

I

V

L

M

K

K

E

Q

L

L

R

A

D

N

I

E

G

G

K

M

T

T

V

M

V

V

V

V

V

V

H

T

H

H

D

E

L

M

S

G

K

F

A

A

S

R

D

E

Y

V

F

G

N

D

E

R

L

V

I

L

L

F

L

M

N

D

K

G

E

G

-

Y

L

I

I

I

E

E

Y

E

G

G

A

K

V

P

E

E

K

D

V

L

F

F

binding adenosine-5'-diphosphate: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
33% identity, 89% coverage: 5:225/247 of query aligns to 3:225/241 of 4u00A

query
sites
4u00A

I

I

S

R

V

I

K

R

D

N

L

L

F

H

V

K

S

W

Y
x
F

H

G

G

P

S

L

E

H

A
x
V

L

L

N

K

N

G

V

I

S

H

F

L

T

E

V

V

N

A

E

P

G

G

N

E

L

K

V

L

G

V

I

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

K

R

S

T

L

I

L

N

N

R

L

L

I

E

S

D

I

F

D

Q

K

E

G

G

E

E

V

V

Q

V

I

V

L

D

G

G

K

L

S

S

I

V

K

K

-

D

-

D

-

R

-

A

-

L

-

R

E

E

M

I

R

R

T

R

K

E

V

V

A

G

Y

M

V

V

P

F

Q

Q

R

Q

S

F

N

N

I

L

D

-

W

-

D

-

F

F

P

P

-

H

I

M

T

T

V

V

I

L

D

E

T

N

V

V

L

T

L

L

G

A

T

P

Y

-

P

-

N

-

L

M

G

R

I

V

F

R

K

R

R

W

P

P

K

R

K

E

S

K

D

A

K

E

A

K

W

K

A

A

L

L

E

E

C

L

L

L

E

E

K

R

V

V

G

G

I

I

A

L

E

D

F

Q

R

A

H

R

R

K

Q

Y

I

P

G

A

E

Q

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

V

F

A

L

I

A

A

R

R

A

A

L

L

A

A

Q

M

K

E

P

P

D

K

M

I

Y

M

F

L

L

F

D

D

E

E

P

P

F

T

V

S

G

A

V

L

D

D

V

P

T

E

S

M

E

V

E

G

T

E

I

V

I

L

T

D

I

V

L

M

K

R

E

D

L

L

R

A

D

Q

I

G

G

G

K

M

T

T

V

M

V

V

V

V

V

V

H

T

H

H

D

E

L

M

S

G

K

F

A

A

S

R

D

E

Y

V

F

A

N

D

E

R

L

V

I

V

L

F

L

M

N

D

-

G

K

G

E

Q

L

I

I

V

E

E

Y

E

G

G

A

R

V

P

E

E

K

E

V

I

F

F

T

T

binding adenosine-5'-diphosphate: F12 (≠ Y14), V17 (≠ A19), S37 (≠ N39), G38 (= G40), S39 (≠ A41), G40 (= G42), K41 (= K43), S42 (= S44), T43 (= T45)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
35% identity, 89% coverage: 5:224/247 of query aligns to 2:224/240 of 4ymuJ

query
sites
4ymuJ

I

I

S

F

V

V

K

N

D

D

L

V

F

Y

V

K

S

N

Y
x
F

H

G

G

S

S

L

E

E

A
x
V

L

L

N

K

N

G

V

V

S

T

F

L

T

K

V

V

N

N

E

K

G

G

N

E

L

V

V

V

G

V

I

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

K

R

S

C

L

I

L

N

N

L

L

L

I

E

S

E

I

P

D

T

K

K

G

G

E

E

V

V

Q

F

I

I

L

D

G

G

K

V

-

K

-

I

-

N

-

N

-

G

-

K

-

V

S

N

I

I

K

N

E

K

M

V

R

R

T

Q

K

K

V

V

A

G

Y

M

V

V

P

F

Q

Q

R

H

S

F

N

N

I

L

D

-

W

-

D

-

F

F

P

P

-

H

I

L

T

T

V

A

I

I

D

E

T

N

V

I

L

T

L

L

G

A

T

P

Y

-

P

-

N

-

L

V

G

K

I

V

F

K

K

K

R

M

P

N

K

K

K

K

S

E

D

A

K

E

A

E

W

L

A

A

L

V

E

D

C

L

L

L

E

A

K

K

V

V

G

G

I

L

A

L

E

D

F

K

R

K

H

D

R

Q

Q

Y

I

P

G

I

E

K

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

L

F

A

L

I

A

A

R

R

A

A

L

L

A

A

Q

M

K

Q

P

P

D

E

M

V

Y

M

F

L

L

F

D

D

E
|
E

P

P

F

T

V

S

G

A

V

L

D

D

V

P

T

E

S

M

E

V

E

K

T

E

I

V

I

L

T

N

I

V

L

M

K

K

E

Q

L

L

R

A

D

N

I

E

G

G

K

M

T

T

V

M

V

V

V

V

V

V

H

T

H
|
H

D

E

L

M

S

G

K

F

A

A

S

R

D

E

Y

V

F

G

N

D

E

R

L

V

I

I

L

F

L

M

N

D

K

D

E

G

L

V

I

I

-

V

E

E

Y

E

G

G

A

T

V

P

E

E

K

E

V

I

F

F

binding adenosine-5'-triphosphate: F11 (≠ Y14), V16 (≠ A19), S36 (≠ N39), G37 (= G40), S38 (≠ A41), G39 (= G42), K40 (= K43), S41 (= S44), T42 (= T45), E162 (= E163), H194 (= H195)
binding magnesium ion: S41 (= S44), E162 (= E163)

5x40A Structure of a cbio dimer bound with amppcp (see paper)
34% identity, 85% coverage: 16:225/247 of query aligns to 17:229/280 of 5x40A

query
sites
5x40A

G

G

S
x
V

E

K

A
|
A

L

L

N

D

N

D

V

L

S

S

F

L

T

A

V

V

N

P

E

K

G

G

N

E

L

S

V

L

G

A

I

I

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

K

L

S

H

L

L

L

N

N

G

L

T

I

L

S

R

I

P

D

Q

K

S

G

G

E

R

V

V

Q

L

I

L

L

G

G

G

-

T

-

A

-

T

-

G

-

H

-

S

-

R

K

K

S

D

I

L

K

T

E

G

M

W

R

R

T

R

K

R

V

V

A

G

Y

L

V

V

P

L

Q
|
Q

R

D

S

A

N

D

I

-

D

D

W

Q

D

L

F

F

P

A

I

T

T

T

V

V

I

F

D

E

T

D

V

V

L

S

L

F

G

G

T

P

Y

L

P

-

N

N

L

L

G

G

I

L

F

-

K

-

R

-

P

S

K

E

K

A

S

E

D

A

K

R

A

A

W

R

A

V

L

E

E

E

C

A

L

L

E

A

K

A

V

L

G

S

I

I

A

S

E

D

F

L

R

R

H

D

R

R

Q

P

I

T

G
x
H

E
x
M

L
|
L

S
|
S

G

G

G
|
G

Q
|
Q

Q

K

Q

R

R

R

V

V

F

A

L

I

A

A

R

G

A

A

L

V

A

A

Q

M

K

R

P

P

D

E

M

V

Y

L

F

L

L

L

D

D

E
x
Q

P

P

F

T

V

A

G

G

V

L

D

D

V

L

T

A

S

G

E

T

E

E

T

Q

I

L

I

L

T

T

I

L

L

L

K

R

E

G

L

L

R

R

D

A

I

A

G

G

K

M

T

T

V

L

V

V

V

F

V

S

H

T

H
|
H

D

D

L

V

S

E

K

L

A

A

S

A

D

A

Y

L

F

A

N

D

E

R

L

V

I

A

L

L

L

F

N

R

K

T

-

G

E

R

L

V

I

L

E

A

Y

E

G

G

A

A

V

A

E

E

K

A

V

V

F

L

T

S

binding phosphomethylphosphonic acid adenylate ester: V18 (≠ S17), A20 (= A19), N40 (= N39), G41 (= G40), G43 (= G42), K44 (= K43), S45 (= S44), T46 (= T45), Q88 (= Q80), H139 (≠ G136), M140 (≠ E137), L141 (= L138), S142 (= S139), G144 (= G141), Q145 (= Q142), Q166 (≠ E163), H198 (= H195)
binding magnesium ion: S45 (= S44), Q88 (= Q80)

Sites not aligning to the query:

binding phosphomethylphosphonic acid adenylate ester: 14

P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 2 papers)
31% identity, 94% coverage: 3:233/247 of query aligns to 10:245/265 of P07821

query
sites
P07821

T

T

A

T

I

F

S

A

V

L

K

R

D

N

L

I

F

S

V

F

S

R

Y

V

H

P

G

G

S

R

E

T

A

L

L

L

N

H

N

P

V

L

S

S

F

L

T

T

V

F

N

P

E

A

G

G

N

K

L

V

V

T

G

G

I

L

I

I

G

G

P

H

N

N

G

G

A

S

G

G

K
|
K

S

S

T

T

L

L

L

L

K

K

S

M

L

L

L

G

N

R

L

H

I

Q

S

P

I

P

D

S

K

E

G

G

E

E

V

I

Q

L

I

L

L

D

G

A

K

Q

-

P

-

L

-

E

-

S

-

W

S

S

I

S

K

K

E

A

M

F

R

A

T

R

K

K

V

V

A

A

Y

Y

V

L

P

P

Q

Q

R

Q

S

-

N

-

I

L

D

P

W

P

D

A

F

E

P

G

I

M

T

T

V

V

I

R

D

E

T

L

V

V

L

A

L

I

G

G

T

R

Y

Y

P

P

N

W

L

H

G

G

I

A

F

L

K

G

R

R

P

F

K

G

K

A

S

A

D

D

K

R

A

E

W

K

A

V

L

E

E

E

C

A

L

I

E

S

K

L

V

V

G

G

I

L

A

K

E

P

F

L

R

A

H

H

R

R

Q

L

I

V

G

D

E

S

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

Q

R

R

V

A

F

W

L

I

A

A

R

M

A

L

L

V

A

A

Q

Q

K

D

P

S

D

R

M

C

Y

L

F

L

L

L

D
|
D

E
|
E

P

P

F

T

V

S

G

A

V

L

D

D

V

I

T

A

S

H

E

Q

E

V

T

D

I

V

I

L

T

S

I

L

L

V

K

H

E

R

L

L

-

S

R

Q

D

E

I

R

G

G

K

L

T

T

V

V

V

I

V

A

V

V

H

L

H

H

D

D

L

I

S

N

K

M

A

A

S

A

D

R

Y

Y

F

C

N

D

E

Y

L

L

I

V

L

A

L

L

-

R

N

G

K

G

E

E

L

M

I

I

E

A

Y

Q

G

G

A

T

V

P

E

A

K

E

V

I

F

M

T

R

P

G

E

E

V

T

L

L

G

E

K

M

A

I

Y

Y

K50 (= K43) mutation to Q: Lack of activity.
D172 (= D162) mutation to E: Lack of activity.
E173 (= E163) mutation to A: Lack of activity.

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
30% identity, 93% coverage: 5:233/247 of query aligns to 3:233/238 of 6s8nB

query
sites
6s8nB

I

L

S

T

V

A

K

K

D

N

L

L

F

A

V

K

S

A

Y

Y

H

K

G

G

S

R

E

R

A

V

L

V

N

E

N

D

V

V

S

S

F

L

T

T

V

V

N

N

E

S

G

G

N

E

L

I

V

V

G

G

I

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

L

T

L

F

K

Y

S

M

L

V

L

V

N

G

L

I

I

V

S

P

I

R

D

D

K

A

G

G

E

N

V

I

Q

I

I

I

L

D

G

D

K

D

S

D

I

I

K

S

-

L

-

L

-

P

-

L

-

H

-

A

E

R

M

A

R

R

T

R

K

G

V

I

A

G

Y

Y

V

L

P

P

Q

Q

R

E

S

A

N

S

I

I

D

F

W
x
R

D

R

F

L

P

S

I

V

T

Y

V

D

I

N

D

L

T

M

V

A

L

V

L

L

G

Q

T

I

Y

R

P

D

N

D

L

L

G

S

I

A

F

E

K

Q

R

R

P

E

K

D

K

R

S

A

D

N

K

-

A

-

W

-

A

-

L

-

E

E

C

L

L

M

E

E

K

E

V

F

G

H

I

I

A

E

E

H

F

L

R

R

H

D

R

S

Q
x
M

I
x
G

G
x
Q

E

S

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

R

R

R

V

V

F

E

L

I

A

A

R

R

A

A

L

L

A

A

Q

A

K

N

P

P

D

K

M

F

Y

I

F

L

L

L

D

D

E

E

P

P

F

F

V

A

G

G

V

V

D

D

V

P

T

I

S

S

E

V

E

I

T

D

I

I

I

K

T

R

I

I

L

I

K

E

E

H

L

L

R

R

D

D

I

S

G

G

K

L

T

G

V

V

V

L

V

I

V

T

H

D

H

H

D

N

L

V

S

R

K

E

A

T

S

L

D

A

Y

V

F

C

N

E

E

R

L

A

I

Y

L

I

L

V

N

S

K

Q

-

G

E

H

L

L

I

I

E

A

Y

H

G

G

A

T

V

P

E

T

K

E

V

I

F

L

T

Q

P

D

E

E

V

H

L

V

G

K

K

R

A

V

Y

Y

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ W86), M133 (≠ Q134), G134 (≠ I135), Q135 (≠ G136)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
30% identity, 93% coverage: 5:233/247 of query aligns to 3:233/238 of 6s8gA

query
sites
6s8gA

I

L

S

T

V

A

K

K

D

N

L

L

F

A

V

K

S

A

Y
|
Y

H

K

G

G

S
x
R

E

R

A

V

L

V

N

E

N

D

V

V

S

S

F

L

T

T

V

V

N

N

E

S

G

G

N

E

L

I

V

V

G

G

I

L

I

L

G

G

P

P

N
|
N

G

G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

L

F

K

Y

S

M

L

V

L

V

N

G

L

I

I

V

S

P

I

R

D

D

K

A

G

G

E

N

V

I

Q

I

I

I

L

D

G

D

K

D

S

D

I

I

K

S

-

L

-

L

-

P

-

L

-

H

-

A

E

R

M

A

R

R

T

R

K

G

V

I

A

G

Y

Y

V

L

P

P

Q
|
Q

R

E

S

A

N

S

I

I

D

F

W

R

D

R

F

L

P

S

I

V

T

Y

V

D

I

N

D

L

T

M

V

A

L

V

L

L

G

Q

T

I

Y

R

P

D

N

D

L

L

G

S

I

A

F

E

K

Q

R

R

P

E

K

D

K

R

S

A

D

N

K

-

A

-

W

-

A

-

L

-

E

E

C

L

L

M

E

E

K

E

V

F

G

H

I

I

A

E

E

H

F

L

R

R

H

D

R

S

Q

M

I

G

G

Q

E
x
S

L

L

S
|
S

G

G

G

G

Q
x
E

Q

R

Q

R

R

R

V

V

F

E

L

I

A

A

R

R

A

A

L

L

A

A

Q

A

K

N

P

P

D

K

M

F

Y

I

F

L

L

L

D

D

E

E

P

P

F

F

V

A

G

G

V

V

D

D

V

P

T

I

S

S

E

V

E

I

T

D

I

I

I

K

T

R

I

I

L

I

K

E

E

H

L

L

R

R

D

D

I

S

G

G

K

L

T

G

V

V

V

L

V

I

V

T

H

D

H

H

D

N

L

V

S

R

K

E

A

T

S

L

D

A

Y

V

F

C

N

E

E

R

L

A

I

Y

L

I

L

V

N

S

K

Q

-

G

E

H

L

L

I

I

E

A

Y

H

G

G

A

T

V

P

E

T

K

E

V

I

F

L

T

Q

P

D

E

E

V

H

L

V

G

K

K

R

A

V

Y

Y

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y14), R15 (≠ S17), N37 (= N39), G40 (= G42), K41 (= K43), T42 (≠ S44), T43 (= T45), Q84 (= Q80), S136 (≠ E137), S138 (= S139), E141 (≠ Q142)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
30% identity, 93% coverage: 5:233/247 of query aligns to 3:233/234 of 6b89A

query
sites
6b89A

I

L

S

T

V

A

K

K

D

N

L

L

F

A

V

K

S

A

Y
|
Y

H

K

G

G

S
x
R

E

R

A
x
V

L

V

N

E

N

D

V

V

S

S

F

L

T

T

V

V

N

N

E

S

G

G

N

E

L

I

V

V

G

G

I

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

L

F

K

Y

S

M

L

V

L

V

N

G

L

I

I

V

S

P

I

R

D

D

K

A

G

G

E

N

V

I

Q

I

I

I

L

D

G

D

K

D

S

D

I

I

K

S

-

L

-

L

-

P

-
x
L

-
x
H

-

A

E

R

M

A

R

R

T

R

K

G

V

I

A

G

Y

Y

V

L

P
|
P

Q
|
Q

R

E

S
x
A

N
x
S

I

I

D
x
F

W
x
R

D
x
R

F
x
L

P

S

I

V

T

Y

V

D

I

N

D

L

T

M

V

A

L
x
V

L

L

G

Q

T

I

Y

R

P

D

N

D

L

L

G

S

I

A

F

E

K

Q

R

R

P

E

K

D

K

R

S

A

D

N

K

-

A

-

W

-

A

-

L

-

E

E

C

L

L

M

E

E

K

E

V

F

G

H

I

I

A

E

E

H

F

L

R

R

H

D

R

S

Q

M

I

G

G
x
Q

E

S

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

R

R

R

V

V

F

E

L

I

A

A

R
|
R

A

A

L

L

A

A

Q

A

K

N

P

P

D

K

M

F

Y

I

F

L

L

L

D

D

E

E

P

P

F

F

V

A

G

G

V

V

D

D

V

P

T

I

S

S

E

V

E

I

T

D

I

I

I

K

T

R

I

I

L

I

K

E

E

H

L

L

R

R

D

D

I

S

G

G

K

L

T

G

V

V

V

L

V

I

V

T

H

D

H

H

D

N

L

V

S

R

K

E

A

T

S

L

D

A

Y

V

F

C

N

E

E

R

L

A

I

Y

L

I

L

V

N

S

K

Q

-

G

E

H

L

L

I

I

E

A

Y

H

G

G

A

T

V

P

E

T

K

E

V

I

F

L

T

Q

P

D

E

E

V

H

L

V

G

K

K

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y14), R15 (≠ S17), V17 (≠ A19), N37 (= N39), G38 (= G40), G40 (= G42), K41 (= K43), T42 (≠ S44), T43 (= T45)
binding magnesium ion: T42 (≠ S44), Q84 (= Q80)
binding novobiocin: L71 (vs. gap), H72 (vs. gap), P83 (= P79), A86 (≠ S82), S87 (≠ N83), F89 (≠ D85), R90 (≠ W86), R91 (≠ D87), L92 (≠ F88), V101 (≠ L97), Q135 (≠ G136), R149 (= R150)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
30% identity, 93% coverage: 5:233/247 of query aligns to 3:233/234 of 4p31A

query
sites
4p31A

I

L

S

T

V

A

K

K

D

N

L

L

F

A

V

K

S

A

Y
|
Y

H

K

G

G

S
x
R

E

R

A
x
V

L

V

N

E

N

D

V

V

S

S

F

L

T

T

V

V

N

N

E

S

G

G

N

E

L

I

V

V

G

G

I

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

L

F

K

Y

S

M

L

V

L

V

N

G

L

I

I

V

S

P

I

R

D

D

K

A

G

G

E

N

V

I

Q

I

I

I

L

D

G

D

K

D

S

D

I

I

K

S

-

L

-

L

-

P

-

L

-

H

-

A

E

R

M

A

R

R

T

R

K

G

V

I

A

G

Y

Y

V

L

P

P

Q
|
Q

R

E

S

A

N

S

I

I

D

F

W

R

D

R

F

L

P

S

I

V

T

Y

V

D

I

N

D

L

T

M

V

A

L

V

L

L

G

Q

T

I

Y

R

P

D

N

D

L

L

G

S

I

A

F

E

K

Q

R

R

P

E

K

D

K

R

S

A

D

N

K

-

A

-

W

-

A

-

L

-

E

E

C

L

L

M

E

E

K

E

V

F

G

H

I

I

A

E

E

H

F

L

R

R

H

D

R

S

Q

M

I

G

G

Q

E

S

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

R

R

R

V

V

F

E

L

I

A

A

R

R

A

A

L

L

A

A

Q

A

K

N

P

P

D

K

M

F

Y

I

F

L

L

L

D

D

E

E

P

P

F

F

V

A

G

G

V

V

D

D

V

P

T

I

S

S

E

V

E

I

T

D

I

I

I

K

T

R

I

I

L

I

K

E

E

H

L

L

R

R

D

D

I

S

G

G

K

L

T

G

V

V

V

L

V

I

V

T

H

D

H

H

D

N

L

V

S

R

K

E

A

T

S

L

D

A

Y

V

F

C

N

E

E

R

L

A

I

Y

L

I

L

V

N

S

K

Q

-

G

E

H

L

L

I

I

E

A

Y

H

G

G

A

T

V

P

E

T

K

E

V

I

F

L

T

Q

P

D

E

E

V

H

L

V

G

K

K

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y14), R15 (≠ S17), V17 (≠ A19), G38 (= G40), G40 (= G42), K41 (= K43), T42 (≠ S44), T43 (= T45)
binding magnesium ion: T42 (≠ S44), Q84 (= Q80)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
30% identity, 93% coverage: 5:233/247 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

I

L

S

T

V

A

K

K

D

N

L

L

F

A

V

K

S

A

Y
|
Y

H

K

G

G

S
x
R

E

R

A
x
V

L

V

N

E

N

D

V

V

S

S

F

L

T

T

V

V

N

N

E

S

G

G

N

E

L

I

V

V

G

G

I

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

L

F

K

Y

S

M

L

V

L

V

N

G

L

I

I

V

S

P

I

R

D

D

K

A

G

G

E

N

V

I

Q

I

I

I

L

D

G

D

K

D

S

D

I

I

K

S

-

L

-

L

-

P

-

L

-

H

-

A

E

R

M

A

R

R

T

R

K

G

V

I

A

G

Y

Y

V

L

P

P

Q

Q

R

E

S

A

N

S

I

I

D
x
F

W
x
R

D
x
R

F

L

P

S

I

V

T

Y

V

D

I

N

D

L

T

M

V

A

L

V

L

L

G

Q

T

I

Y

R

P

D

N

D

L

L

G

S

I

A

F

E

K

Q

R

R

P

E

K

D

K

R

S

A

D

N

K

-

A

-

W

-

A

-

L

-

E

E

C

L

L

M

E

E

K

E

V

F

G

H

I

I

A

E

E

H

F

L

R

R

H

D

R

S

Q

M

I

G

G

Q

E

S

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

R

R

R

V

V

F

E

L

I

A

A

R

R

A

A

L

L

A

A

Q

A

K

N

P

P

D

K

M

F

Y

I

F

L

L

L

D

D

E

E

P

P

F

F

V

A

G

G

V

V

D

D

V

P

T

I

S

S

E

V

E

I

T

D

I

I

I

K

T

R

I

I

L

I

K

E

E

H

L

L

R

R

D

D

I

S

G

G

K

L

T

G

V

V

V

L

V

I

V

T

H

D

H

H

D

N

L

V

S

R

K

E

A

T

S

L

D

A

Y

V

F

C

N

E

E

R

L

A

I

Y

L

I

L

V

N

S

K

Q

-

G

E

H

L

L

I

I

E

A

Y

H

G

G

A

T

V

P

E

T

K

E

V

I

F

L

T

Q

P

D

E

E

V

H

L

V

G

K

K

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y14), R15 (≠ S17), V17 (≠ A19), G38 (= G40), G40 (= G42), K41 (= K43), T42 (≠ S44), T43 (= T45)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (≠ D85), R90 (≠ W86), R91 (≠ D87)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
30% identity, 93% coverage: 5:233/247 of query aligns to 3:233/235 of 6mhzA

query
sites
6mhzA

I

L

S

T

V

A

K

K

D

N

L

L

F

A

V

K

S

A

Y
|
Y

H

K

G

G

S

R

E

R

A

V

L

V

N

E

N

D

V

V

S

S

F

L

T

T

V

V

N

N

E

S

G

G

N

E

L

I

V

V

G

G

I

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

L

F

K

Y

S

M

L

V

L

V

N

G

L

I

I

V

S

P

I

R

D

D

K

A

G

G

E

N

V

I

Q

I

I

I

L

D

G

D

K

D

S

D

I

I

K

S

-

L

-

L

-

P

-

L

-

H

-

A

E

R

M

A

R

R

T

R

K

G

V

I

A

G

Y

Y

V

L

P

P

Q
|
Q

R

E

S

A

N

S

I

I

D

F

W

R

D

R

F

L

P

S

I

V

T

Y

V

D

I

N

D

L

T

M

V

A

L

V

L

L

G

Q

T

I

Y

R

P

D

N

D

L

L

G

S

I

A

F

E

K

Q

R

R

P

E

K

D

K

R

S

A

D

N

K

-

A

-

W

-

A

-

L

-

E

E

C

L

L

M

E

E

K

E

V

F

G

H

I

I

A

E

E

H

F

L

R

R

H

D

R

S

Q

M

I

G

G

Q

E
x
S

L

L

S
|
S

G
|
G

G
|
G

Q

E

Q

R

Q

R

R

R

V

V

F

E

L

I

A

A

R

R

A

A

L

L

A

A

Q

A

K

N

P

P

D

K

M

F

Y

I

F

L

L

L

D

D

E
|
E

P

P

F

F

V

A

G
|
G

V

V

D

D

V

P

T

I

S

S

E

V

E

I

T

D

I

I

I

K

T

R

I

I

L

I

K

E

E

H

L

L

R

R

D

D

I

S

G

G

K

L

T

G

V

V

V

L

V

I

V

T

H

D

H
|
H

D

N

L

V

S

R

K

E

A

T

S

L

D

A

Y

V

F

C

N

E

E

R

L

A

I

Y

L

I

L

V

N

S

K

Q

-

G

E

H

L

L

I

I

E

A

Y

H

G

G

A

T

V

P

E

T

K

E

V

I

F

L

T

Q

P

D

E

E

V

H

L

V

G

K

K

R

A

V

Y

Y

binding adp orthovanadate: Y12 (= Y14), N37 (= N39), G38 (= G40), G40 (= G42), K41 (= K43), T42 (≠ S44), T43 (= T45), Q84 (= Q80), S136 (≠ E137), S138 (= S139), G139 (= G140), G140 (= G141), E162 (= E163), G166 (= G167), H194 (= H195)

6mbnA Lptb e163q in complex with atp (see paper)
29% identity, 93% coverage: 5:233/247 of query aligns to 4:234/241 of 6mbnA

query
sites
6mbnA

I

L

S

T

V

A

K

K

D

N

L

L

F

A

V

K

S

A

Y
|
Y

H

K

G

G

S
x
R

E

R

A
x
V

L

V

N

E

N

D

V

V

S

S

F

L

T

T

V

V

N

N

E

S

G

G

N

E

L

I

V

V

G

G

I

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

L

F

K

Y

S

M

L

V

L

V

N

G

L

I

I

V

S

P

I

R

D

D

K

A

G

G

E

N

V

I

Q

I

I

I

L

D

G

D

K

D

S

D

I

I

K

S

-

L

-

L

-

P

-

L

-

H

-

A

E

R

M

A

R

R

T

R

K

G

V

I

A

G

Y

Y

V

L

P

P

Q

Q

R

E

S

A

N

S

I

I

D

F

W

R

D

R

F

L

P

S

I

V

T

Y

V

D

I

N

D

L

T

M

V

A

L

V

L

L

G

Q

T

I

Y

R

P

D

N

D

L

L

G

S

I

A

F

E

K

Q

R

R

P

E

K

D

K

R

S

A

D

N

K

-

A

-

W

-

A

-

L

-

E

E

C

L

L

M

E

E

K

E

V

F

G

H

I

I

A

E

E

H

F

L

R

R

H

D

R

S

Q

M

I

G

G

Q

E

S

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

R

R

R

V

V

F

E

L

I

A

A

R

R

A

A

L

L

A

A

Q

A

K

N

P

P

D

K

M

F

Y

I

F

L

L

L

D

D

E

Q

P

P

F

F

V

A

G

G

V

V

D

D

V

P

T

I

S

S

E

V

E

I

T

D

I

I

I

K

T

R

I

I

L

I

K

E

E

H

L

L

R

R

D

D

I

S

G

G

K

L

T

G

V

V

V

L

V

I

V

T

H

D

H
|
H

D

N

L

V

S

R

K

E

A

T

S

L

D

A

Y

V

F

C

N

E

E

R

L

A

I

Y

L

I

L

V

N

S

K

Q

-

G

E

H

L

L

I

I

E

A

Y

H

G

G

A

T

V

P

E

T

K

E

V

I

F

L

T

Q

P

D

E

E

V

H

L

V

G

K

K

R

A

V

Y

Y

binding adenosine-5'-triphosphate: Y13 (= Y14), R16 (≠ S17), V18 (≠ A19), N38 (= N39), G39 (= G40), G41 (= G42), K42 (= K43), T43 (≠ S44), T44 (= T45), H195 (= H195)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
30% identity, 93% coverage: 5:233/247 of query aligns to 3:233/240 of 6mjpA

query
sites
6mjpA

I

L

S

K

V

A

K

Q

D

H

L

L

F

A

V

K

S

S

Y

Y

H

K

G

K

S

R

E

K

A

V

L

V

N

S

N

D

V

V

S

S

F

L

T

Q

V

V

N

E

E

S

G

G

N

Q

L

I

V

V

G

G

I

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

L

S

L

F

K

Y

S

M

L

I

L

V

N

G

L

L

I

V

S

A

I

R

D

D

K

E

G

G

E

T

V

I

Q

T

I

I

L

D

G

D

K

N

S

D

I

I

K

S

-

I

-

L

-

P

-

M

-

H

-

S

E

R

M

S

R

R

T

M

K

G

V

I

A

G

Y

Y

V

L

P

P

Q

Q

R

E

S

A

N

S

I

I

D

F

W

R

D

K

F

L

P

S

I

V

T

E

V

D

I

N

D

I

T

M

V

A

L

V

L

L

G

Q

T

T

Y

R

P

E

N

E

L

L

G

T

I

H

F
x
E

K

E

R

R

P

Q

K
x
D

K

K

S

L

D

E

K

-

A

-

W

-

A

-

L

-

E

D

C

L

L

L

E

E

K

E

V

F

G

H

I

I

A

Q

E

H

F

I

R

R

H

K

R

S

Q

A

I

G

G

M

E

A

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

R

R

R

V

V

F

E

L

I

A

A

R

R

A

A

L

L

A

A

Q

A

K

N

P

P

D

Q

M

F

Y

I

F

L

L

L

D

D

E

Q

P

P

F

F

V

A

G

G

V

V

D

D

V

P

T

I

S

S

E

V

E

I

T

D

I

I

I

K

T

K

I

I

L

I

K

E

E

H

L

L

R

R

D

D

I

R

G

G

K

L

T

G

V

V

V

L

V

I

V

T

H

D

H

H

D

N

L

V

S

R

K

E

A

T

S

L

D

D

Y

V

F

C

N

E

E

K

L

A

I

Y

L

I

L

V

N

S

K

Q

-

G

E

R

L

L

I

I

E

A

Y

E

G

G

A

T

V

P

E

Q

K

D

V

V

F

L

T

N

P

N

E

E

V

Q

L

V

G

K

K

Q

A

V

Y

Y

binding calcium ion: E111 (≠ F107), D115 (≠ K111)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
36% identity, 88% coverage: 5:222/247 of query aligns to 2:225/232 of 1f3oA

query
sites
1f3oA

I

I

S

K

V

L

K

K

D

N

L

V

F

T

V

K

S

T

Y
|
Y

H

K

G

M

S

G

E

E

-

E

-

I

-

I

-

Y

A

A

L

L

N

K

N

N

V

V

S

N

F

L

T

N

V

I

N

K

E

E

G

G

N

E

L

F

V

V

G

S

I

I

I

M

G

G

P

P

N

S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

K

N

S

I

L

I

L

G

N

C

L

L

I

D

S

K

I

P

D

T

K

E

G

G

E

E

V

V

Q

Y

I

I

L

D

G

N

K

I

S

K

I

T

K

N

E

D

M

L

-

D

-

D

-

D

-

E

-

L

-

T

-

K

-

I

-

R

R

R

T

D

K

K

V

I

A

G

Y

F

V

V

P

F

Q

Q

R

Q

S

F

N

N

I

L

D

-

W

-

D

-

F

I

P

P

I

L

-

L

T

T

V

A

I

L

D

E

T

N

V

V

L

E

L

L

G

P

T

L

Y

-

P

-

N

-

L

-

G

-

I

I

F

F

K

K

-

Y

-

R

-

G

-

A

R

M

P

S

K

G

K

E

S

E

D

R

K

R

A

K

W

R

A

A

L

L

E

E

C

C

L

L

E

K

K

M

V

A

G

E

I

L

A

E

E

E

-

R

F

F

R

A

H

N

R

H

Q

K

I

P

G

N

E

Q

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

V

F

A

L

I

A

A

R

R

A

A

L

L

A

A

Q

N

K

N

P

P

D

P

M

I

Y

I

F

L

L

A

D

D

E

E

P

P

F

T

V

G

G

A

V

L

D

D

V

S

T

K

S

T

E

G

E

E

T

K

I

I

I

M

T

Q

I

L

L

L

K

K

E

K

L

L

-

N

R

E

D

E

I

D

G

G

K

K

T

T

V

V

V

V

V

V

V

V

H

T

H

H

D

D

L

I

S

N

K

V

A

A

S

R

D

-

Y

-

F

F

N

G

E

E

L

R

I

I

L

I

L

Y

N

L

K

K

E

D

L

-

I

-

E

-

Y

-

G

G

A

E

V

V

E

E

K

R

binding adenosine-5'-diphosphate: Y11 (= Y14), G41 (= G40), G43 (= G42), K44 (= K43), S45 (= S44), T46 (= T45)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
33% identity, 79% coverage: 2:196/247 of query aligns to 1:202/226 of 5xu1B

query
sites
5xu1B

K

K

T

Q

A

L

I

I

S

S

V

L

K

K

D

N

L

I

F

F

V

R

S

S

Y

Y

H

R

G

N

S

G

-

D

-

Q

-

E

-

L

E

Q

A

V

L

L

N

K

N

N

V

I

S

N

F

L

T

E

V

V

N

N

E

E

G

G

N

E

L

F

V

V

G

A

I

I

I

M

G

G

P

P

N

S

G

G

A

S

G
|
G

K
|
K

S
|
S

T

T

L

L

L

M

K

N

S

T

L

I

L

G

N

M

L

L

I

D

S

T

I

P

D

T

K

S

G

G

E

E

V

Y

Q

Y

I

L

L

E

G

G

K

Q

S

E

I

V

K

A

E

G

M

L

R

G

T

E

K

K

V

Q

A

L

Y

A

V

K

P

V

Q

R

R

N

S

Q

N

Q

I

I

D

G

W

F

D

V

F

F

P

Q

-

Q

-

F

-

F

-

L

-

L

-

S

-

K

I

L

T

N

V

A

I

L

D

Q

T

N

V

V

L

E

L

L

G

P

-

L

T

I

Y

Y

P

A

N

G

L

V

G

S

I

S

F

S

K

K

R

R

P

R

K

K

K

-

S

-

D

-

K

-

A

-

W

L

A

A

L

E

E

E

C

Y

L

L

E

D

K

K

V

V

G

E

I

L

A

T

E

E

F

R

R

S

H

H

R

H

Q

L

I

P

G

S

E

E

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

F

A

L

I

A

A

R

R

A

A

L

L

A

V

Q

N

K

N

P

P

D

S

M

I

Y

I

F

L

L

A

D

D

E

E

P

P

F

T

V

G

G

A

V

L

D

D

V

T

T

K

S

T

E

G

E

N

T

Q

I

I

I

M

T

Q

I

L

L

L

K

V

E

D

L

L

R

N

D

K

I

E

G

G

K

K

T

T

V

I

V

I

V

M

V

V

H

T

H

H

D

E

binding magnesium ion: G45 (= G42), K46 (= K43), S47 (= S44)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
35% identity, 88% coverage: 5:222/247 of query aligns to 2:225/230 of 1l2tA

query
sites
1l2tA

I

I

S

K

V

L

K

K

D

N

L

V

F

T

V

K

S

T

Y
|
Y

H

K

G

M

S

G

E

E

-

E

-

I

-

I

-

Y

A

A

L

L

N

K

N

N

V

V

S

N

F

L

T

N

V

I

N

K

E

E

G

G

N

E

L

F

V

V

G

S

I

I

I

M

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

K

N

S

I

L

I

L

G

N

C

L

L

I

D

S

K

I

P

D

T

K

E

G

G

E

E

V

V

Q

Y

I

I

L

D

G

N

K

I

S

K

I

T

K

N

E

D

M

L

-

D

-

D

-

D

-

E

-

L

-

T

-

K

-

I

-

R

R

R

T

D

K

K

V

I

A

G

Y

F

V

V

P

F

Q

Q

R

Q

S

F

N

N

I

L

D

-

W

-

D

-

F

I

P

P

I

L

-

L

T

T

V

A

I

L

D

E

T

N

V

V

L

E

L

L

G

P

T

L

Y

-

P

-

N

-

L

-

G

-

I

I

F

F

K

K

-

Y

-

R

-

G

-

A

R

M

P

S

K

G

K

E

S

E

D

R

K

R

A

K

W

R

A

A

L

L

E

E

C

C

L

L

E

K

K

M

V

A

G

E

I

L

A

E

E

E

-

R

F
|
F

R

A

H

N

R

H

Q

K

I

P

G

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

Q

Q

R

R

V

V

F

A

L

I

A

A

R

R

A

A

L

L

A

A

Q

N

K

N

P

P

D

P

M

I

Y

I

F

L

L

A

D

D

E

Q

P

P

F

T

V

G

G

A

V

L

D

D

V

S

T

K

S

T

E

G

E

E

T

K

I

I

I

M

T

Q

I

L

L

L

K

K

E

K

L

L

-

N

R

E

D

E

I

D

G

G

K

K

T

T

V

V

V

V

V

V

V

V

H

T

H
|
H

D

D

L

I

S

N

K

V

A

A

S

R

D

-

Y

-

F

F

N

G

E

E

L

R

I

I

L

I

L

Y

N

L

K

K

E

D

L

-

I

-

E

-

Y

-

G

G

A

E

V

V

E

E

K

R

binding adenosine-5'-triphosphate: Y11 (= Y14), S40 (≠ N39), G41 (= G40), S42 (≠ A41), G43 (= G42), K44 (= K43), S45 (= S44), T46 (= T45), F138 (= F130), Q145 (≠ E137), S147 (= S139), G149 (= G141), Q150 (= Q142), H204 (= H195)

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
30% identity, 91% coverage: 13:237/247 of query aligns to 26:243/378 of P69874

query
sites
P69874

S
x
C

Y
x
F

H

D

G

G

S

K

E

E

A

V

L

I

N

P

N

Q

V

L

S

D

F

L

T

T

V

I

N

N

E

N

G

G

N

E

L
x
F

V

L

G

T

I

L

I

L

G

G

P

P

N

S

G

G

A
x
C