SitesBLAST
Comparing WP_076476002.1 NCBI__GCF_900156495.1:WP_076476002.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P07872 Peroxisomal acyl-coenzyme A oxidase 1; ACO; AOX; Palmitoyl-CoA oxidase; Peroxisomal fatty acyl-CoA oxidase; Straight-chain acyl-CoA oxidase; EC 1.3.3.6 from Rattus norvegicus (Rat) (see 3 papers)
32% identity, 78% coverage: 134:688/710 of query aligns to 84:610/661 of P07872
- T139 (= T186) binding FAD
- G178 (= G225) binding FAD
- E421 (= E487) active site, Proton acceptor
- VA 468:469 (≠ AA 534:535) Cleavage
Q63448 Peroxisomal acyl-coenzyme A oxidase 3; Branched-chain acyl-CoA oxidase; BRCACox; Pristanoyl-CoA oxidase; EC 1.3.3.6 from Rattus norvegicus (Rat) (see paper)
33% identity, 87% coverage: 70:687/710 of query aligns to 46:643/700 of Q63448
Sites not aligning to the query:
- 698:700 Microbody targeting signal
5y9dA Crystal structure of acyl-coa oxidase1 from yarrowia lipolytica (see paper)
32% identity, 79% coverage: 134:695/710 of query aligns to 94:633/687 of 5y9dA
- binding flavin-adenine dinucleotide: F145 (= F183), M147 (= M185), T148 (= T186), G153 (= G191), S154 (= S192), W185 (≠ Y223), R316 (= R363), F319 (= F366), I330 (= I377), Y333 (= Y380), R339 (= R386), A417 (= A461), G420 (= G464), Y423 (= Y467), V438 (= V482), T441 (= T485), W442 (≠ F486), D445 (= D489)
2fonB X-ray crystal structure of leacx1, an acyl-coa oxidase from lycopersicon esculentum (tomato) (see paper)
31% identity, 77% coverage: 149:695/710 of query aligns to 99:612/656 of 2fonB
- binding flavin-adenine dinucleotide: Y133 (≠ F183), Q135 (≠ M185), T136 (= T186), G141 (= G191), S142 (= S192), W173 (≠ Y223), P174 (≠ I224), G175 (= G225), R308 (= R363), F311 (= F366), V322 (≠ I377), Y325 (= Y380), Q328 (≠ H383), R331 (= R386), L396 (≠ A461), G399 (= G464), P417 (≠ V482), T420 (= T485), Y421 (≠ F486), D424 (= D489), V427 (= V492)
5ys9A Crystal structure of acyl-coa oxidase3 from yarrowia lipolytica (see paper)
31% identity, 79% coverage: 134:695/710 of query aligns to 102:637/692 of 5ys9A
- binding flavin-adenine dinucleotide: F153 (= F183), M155 (= M185), T156 (= T186), G161 (= G191), S162 (= S192), W193 (≠ Y223), R324 (= R363), Q326 (= Q365), F327 (= F366), Y341 (= Y380), R347 (= R386), Q421 (≠ E460), A422 (= A461), G425 (= G464), Y428 (= Y467), V443 (= V482), T446 (= T485), W447 (≠ F486), D450 (= D489), V453 (= V492)
O65202 Peroxisomal acyl-coenzyme A oxidase 1; AOX 1; Long-chain acyl-CoA oxidase; AtCX1; EC 1.3.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
32% identity, 77% coverage: 149:695/710 of query aligns to 101:614/664 of O65202
- Y135 (≠ F183) binding FAD
- Q137 (≠ M185) binding FAD
- T138 (= T186) binding FAD
- S144 (= S192) binding FAD
- G177 (= G225) binding FAD
- R310 (= R363) binding FAD
- Q330 (≠ H383) binding FAD
- R333 (= R386) binding FAD
- G401 (= G464) binding FAD
- T422 (= T485) binding FAD
- D426 (= D489) binding FAD
- C467 (≠ A535) modified: Disulfide link with 576
- C576 (≠ H657) modified: Disulfide link with 467
1is2A Crystal structure of peroxisomal acyl-coa oxidase-ii from rat liver (see paper)
32% identity, 76% coverage: 152:688/710 of query aligns to 105:592/637 of 1is2A
- binding flavin-adenine dinucleotide: T139 (= T186), G144 (= G191), T145 (≠ S192), W176 (≠ Y223), P177 (≠ I224), R303 (= R363), S306 (≠ F366), F320 (≠ Y380), Q323 (≠ H383), K326 (≠ R386), A391 (= A461), G393 (= G463), G394 (= G464), Y397 (= Y467), T415 (= T485), F416 (= F486), E419 (≠ D489), V422 (= V492)
1w07B Arabidopsis thaliana acyl-coa oxidase 1 (see paper)
32% identity, 77% coverage: 149:695/710 of query aligns to 100:613/658 of 1w07B
- binding flavin-adenine dinucleotide: Y134 (≠ F183), Q136 (≠ M185), T137 (= T186), G142 (= G191), S143 (= S192), W174 (≠ Y223), P175 (≠ I224), R309 (= R363), F312 (= F366), V323 (≠ I377), Y326 (= Y380), Q329 (≠ H383), R332 (= R386), L397 (≠ A461), G400 (= G464), P418 (≠ V482), T421 (= T485), Y422 (≠ F486), D425 (= D489), V428 (= V492), L431 (≠ Q495)
7q86A Crystal structure of human peroxisomal acyl-co-a oxidase 1a, fad- bound-form (see paper)
31% identity, 76% coverage: 152:688/710 of query aligns to 105:575/612 of 7q86A