SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_076477985.1 NCBI__GCF_900156495.1:WP_076477985.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

8rdhA Crystal structure of udp-galactose 4-epimerase from pyrococcus horikoshii with bound NAD and gdp-l-fucose
23% identity, 83% coverage: 1:243/293 of query aligns to 1:261/319 of 8rdhA

query
sites
8rdhA
M
 
M
H
 
R
V
 
V
F
 
L
V
 
V
T
 
T
G
|
G
G
 
G
T
 
A
G
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G
T
x
F
I
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I
G
 
G
S
 
S
A
 
H
V
 
L
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V
D
 
D
E
 
R
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L
L
 
M
A
 
E
N
 
E
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G
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Y
T
 
K
V
 
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R
A
 
V
L
 
L
A
 
-
R
 
-
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x
D
D
|
D
A
 
L
S
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S
A
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A
D
x
G
A
 
S
L
 
L
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K
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N
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I
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E
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G
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W
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L
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G
R
 
N
A
 
E
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N
A
 
F
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E
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I
R
 
K
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D
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x
M
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D
L
 
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D
 
E
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S
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K
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A
A
 
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K
R
 
D
A
 
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D
G
 
A
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F
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H
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A
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A
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A
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N
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D
 
E
Y
 
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I
P
 
G
D
 
S
G
 
Q
L
 
S
A
 
P
A
 
E
A
 
L
V
 
L
V
 
Y
E
 
E
E
 
T
G
 
N
A
 
V
A
 
L
L
 
I
A
 
T
-
 
Y
S
 
N
L
 
L
G
 
L
E
 
N
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A
L
 
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L
 
R
G
 
N
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S
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Y
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T
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D
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A
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E
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D
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A
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P
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E
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P
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I
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S
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G
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A
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A
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x
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L
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A
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A
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E
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A
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L
L
 
I
E
 
S
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G
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Y
L
 
A
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S
 
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F
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D
V
 
F
R
 
R
A
 
A
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L
A
 
I
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I
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R
M
x
L
P
x
A
R
x
N
T
x
I
V
 
I
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G
N
 
K
R
 
R
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S
T
 
N
G
x
H
G
|
G
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x
V
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I
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Y
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x
D
F
|
F
A
 
I
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N
L
x
K
L
 
L
T
 
K
E
 
A
Q
 
N
A
 
P
R
 
N
R
 
E
T
 
L
G
 
E
V
 
I
A
x
L
G
 
-
Y
 
-
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-
G
 
G
D
 
D
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G
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T
Q
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R
W
x
K
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S
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Y
V
 
L
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H
A
 
I
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D
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T
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I
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D
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G
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I
A
 
M
V
 
K
L
 
L
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F
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E
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H
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F
L
 
L
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N
S
 
G
A
 
E
P
 
E
A
 
R
G
 
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D
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F
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Y
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N
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N
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E
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I
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K
D
 
E
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I
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E
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I
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V
G
 
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E
R
 
E
L
 
M
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N
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L

Sites not aligning to the query:

H1ZZB0 4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide ketoreductase; Aurachin B dehydrogenase; EC 1.1.1.394 from Stigmatella aurantiaca (see paper)
27% identity, 56% coverage: 1:163/293 of query aligns to 1:168/334 of H1ZZB0

query
sites
H1ZZB0
M
 
M
H
 
R
V
 
T
F
 
F
V
 
V
T
 
T
G
 
G
G
 
G
T
 
S
G
 
G
T
 
Y
I
 
L
G
 
G
S
 
R
A
 
N
V
 
L
V
 
L
D
 
S
E
 
A
L
 
L
L
 
V
A
 
A
N
 
R
D
 
G
H
 
I
T
 
S
V
 
V
L
 
R
A
 
A
L
 
L
A
 
V
R
 
R
S
 
S
D
 
E
A
 
E
S
 
A
A
 
A
D
 
Q
A
 
K
L
 
V
A
 
Q
R
 
A
A
 
L
G
 
G
A
 
A
E
 
Q
V
 
P
V
 
I
R
 
L
G
 
G
T
 
T
I
 
L
A
 
E
D
 
H
L
 
R
D
 
E
T
 
T
L
 
L
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K
T
 
E
S
 
G
A
 
M
G
 
A
R
 
G
A
 
C
D
 
D
G
 
V
V
 
L
I
 
F
-
 
H
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A
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A
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A
-
 
L
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T
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S
 
A
L
 
R
A
 
A
F
 
T
T
 
D
P
 
A
D
 
E
Y
 
F
D
 
H
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P
 
A
D
 
N
G
 
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L
 
L
A
 
G
A
 
T
A
 
E
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T
V
 
V
E
 
L
E
 
A
G
 
A
A
 
A
A
 
R
L
 
D
A
 
A
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R
L
 
I
G
 
Q
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R
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M
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V
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H
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S
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T
E
 
E
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A
L
 
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L
 
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A
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G
 
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G
 
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P
 
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W
 
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I
 
L
P
 
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L
 
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D
 
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E
 
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E
 
A
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Y
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P
G
 
A
G
 
T
R
 
K
A
 
A
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Q
S
 
A
V
 
E
N
 
Q
R
 
L
L
 
V
L
 
L
E
 
Q
L
 
A
S
 
N
S
 
G
R
 
P
G
 
G
V
 
F
R
 
T
A
 
T
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V
A
 
V
V
 
V
R
 
R
M
 
-
P
 
P
R
 
R
T
 
F
V
 
I

Query Sequence

>WP_076477985.1 NCBI__GCF_900156495.1:WP_076477985.1
MHVFVTGGTGTIGSAVVDELLANDHTVLALARSDASADALARAGAEVVRGTIADLDTLST
SAGRADGVISLAFTPDYDTPDGLAAAVVEEGAALASLGEALLGSGRPIVTVSGTPWIPGR
LSTERDPLPEEGPVGGRAVSVNRLLELSSRGVRAVAVRMPRTVHNRGTGGFAGLLTEQAR
RTGVAGYPGDGAQRWPAVHALDAAVLFRLALESAPAGTAWHAVADEGDAVRDIASVIGRR
LDLPVESVSEQSLGPFGPVFALDQPASSAHTRETLGWEPVHLGLLEDLENIEP

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory