SitesBLAST
Comparing WP_076583085.1 NCBI__GCF_001971705.1:WP_076583085.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
O28608 Alanine dehydrogenase; AlaDH; EC 1.4.1.1 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
48% identity, 95% coverage: 1:314/332 of query aligns to 1:308/322 of O28608
1omoA Alanine dehydrogenase dimer w/bound NAD (archaeal) (see paper)
48% identity, 95% coverage: 1:314/332 of query aligns to 1:308/320 of 1omoA
- active site: R52 (= R54), D219 (= D225)
- binding nicotinamide-adenine-dinucleotide: T109 (= T116), G134 (= G141), T135 (≠ V142), Q136 (= Q143), Y156 (≠ S163), D157 (= D164), V158 (≠ P165), R159 (≠ D166), T195 (= T201), P196 (= P202), G217 (= G223), D219 (= D225), K223 (= K229), S290 (= S296), T291 (= T297), G292 (= G298)
6t3eB Structure of thermococcus litoralis delta(1)-pyrroline-2-carboxylate reductase in complex with nadh and l-proline (see paper)
35% identity, 97% coverage: 4:325/332 of query aligns to 2:325/325 of 6t3eB
- binding 1,4-dihydronicotinamide adenine dinucleotide: S82 (≠ T87), T111 (= T116), G136 (= G141), V137 (= V142), Q138 (= Q143), D159 (= D164), I160 (≠ P165), A199 (≠ V200), T200 (= T201), T201 (≠ P202), A202 (≠ V203), V206 (≠ I207), V221 (≠ I222), G222 (= G223), W223 (≠ A224), S296 (= S296), V297 (≠ T297), G298 (= G298)
- binding proline: R39 (≠ K41), M54 (= M56), K67 (= K71), R110 (= R115)
Q14894 Ketimine reductase mu-crystallin; NADP-regulated thyroid-hormone-binding protein; EC 1.5.1.25 from Homo sapiens (Human) (see paper)
31% identity, 94% coverage: 5:315/332 of query aligns to 7:311/314 of Q14894
2i99A Crystal structure of human mu_crystallin at 2.6 angstrom (see paper)
31% identity, 94% coverage: 5:315/332 of query aligns to 6:310/312 of 2i99A
- active site: G59 (≠ R54), S228 (≠ D225)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: D81 (= D78), S90 (≠ T87), H91 (≠ V88), R118 (= R115), T119 (= T116), G142 (= G139), A143 (= A140), G144 (= G141), V145 (= V142), Q146 (= Q143), N167 (≠ D164), R168 (≠ P165), T169 (≠ D166), V203 (= V200), T204 (= T201), L205 (≠ P202), A206 (≠ V203), V225 (≠ I222), G226 (= G223), S291 (= S296), L292 (≠ T297), G293 (= G298)
4bv9A Crystal structure of the NADPH form of mouse mu-crystallin. (see paper)
32% identity, 94% coverage: 5:315/332 of query aligns to 5:302/303 of 4bv9A
- active site: G58 (≠ R54), S220 (≠ D225)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: S82 (≠ T87), H83 (≠ V88), T111 (= T116), G134 (= G139), G136 (= G141), V137 (= V142), Q138 (= Q143), N159 (≠ D164), R160 (≠ P165), T161 (≠ D166), V195 (= V200), T196 (= T201), M197 (≠ P202), A198 (≠ V203), V217 (≠ I222), G218 (= G223), S283 (= S296), L284 (≠ T297), G285 (= G298)
- binding pyruvic acid: R45 (≠ K41), M60 (= M56), K73 (= K71), R110 (= R115)
4bvaA Crystal structure of the NADPH-t3 form of mouse mu-crystallin. (see paper)
31% identity, 94% coverage: 5:315/332 of query aligns to 6:301/303 of 4bvaA
- active site: G59 (≠ R54), S219 (≠ D225)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: T106 (= T112), R109 (= R115), T110 (= T116), G135 (= G141), V136 (= V142), Q137 (= Q143), N158 (≠ D164), R159 (≠ P165), T160 (≠ D166), N163 (≠ R169), V194 (= V200), T195 (= T201), M196 (≠ P202), A197 (≠ V203), V216 (≠ I222), S282 (= S296), L283 (≠ T297), G284 (= G298)
- binding 3,5,3'triiodothyronine: R46 (≠ K41), F57 (≠ D52), G59 (≠ R54), V76 (= V73), F78 (≠ V75), S219 (≠ D225), R220 (≠ A226), W223 (≠ K229), E247 (≠ H252)
5gziA Cyclodeaminase_pa
33% identity, 95% coverage: 1:316/332 of query aligns to 5:325/354 of 5gziA
- binding nicotinamide-adenine-dinucleotide: Y85 (≠ V75), T97 (= T87), R125 (= R115), T126 (= T116), G151 (= G141), A152 (≠ V142), Q153 (= Q143), D174 (= D164), T175 (≠ P165), H179 (≠ R169), A212 (≠ V200), T213 (= T201), S214 (≠ P202), V215 (= V203), V237 (≠ I222), G238 (= G223), A239 (= A224), S305 (= S296), T306 (= T297), G307 (= G298)
- binding (2S)-piperidine-2-carboxylic acid: R53 (≠ K41), K81 (= K71), R125 (= R115), A239 (= A224), T306 (= T297), G307 (= G298)
5gzlA Cyclodeaminase_pa
33% identity, 95% coverage: 1:316/332 of query aligns to 5:325/357 of 5gzlA
- binding lysine: G55 (≠ Y43), E57 (≠ D45), I65 (≠ D52), E67 (≠ R54), D240 (= D225), R267 (≠ H252), E268 (≠ S253)
- binding nicotinamide-adenine-dinucleotide: Y85 (≠ V75), T97 (= T87), I98 (≠ V88), T126 (= T116), G151 (= G141), A152 (≠ V142), Q153 (= Q143), D174 (= D164), T175 (≠ P165), H179 (≠ R169), A212 (≠ V200), T213 (= T201), S214 (≠ P202), V222 (≠ I207), V237 (≠ I222), G238 (= G223), A239 (= A224), D240 (= D225), K244 (= K229), S305 (= S296), T306 (= T297), G307 (= G298)
5yu4A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
33% identity, 95% coverage: 1:316/332 of query aligns to 1:321/344 of 5yu4A
- binding 2,4-diaminobutyric acid: E63 (≠ R54), K77 (= K71), R121 (= R115), T302 (= T297), G303 (= G298)
- binding nicotinamide-adenine-dinucleotide: Y81 (≠ V75), T93 (= T87), I94 (≠ V88), R121 (= R115), T122 (= T116), G147 (= G141), A148 (≠ V142), Q149 (= Q143), D170 (= D164), T171 (≠ P165), H175 (≠ R169), A208 (≠ V200), T209 (= T201), S210 (≠ P202), V211 (= V203), V218 (≠ I207), V233 (≠ I222), A235 (= A224), S301 (= S296), T302 (= T297), G303 (= G298)
5yu3A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
33% identity, 95% coverage: 1:316/332 of query aligns to 1:321/344 of 5yu3A
- binding nicotinamide-adenine-dinucleotide: Y81 (≠ V75), T93 (= T87), I94 (≠ V88), T122 (= T116), G147 (= G141), A148 (≠ V142), Q149 (= Q143), D170 (= D164), T171 (≠ P165), A208 (≠ V200), T209 (= T201), S210 (≠ P202), V211 (= V203), V233 (≠ I222), A235 (= A224), S301 (= S296), T302 (= T297), G303 (= G298)
- binding proline: M65 (= M56), K77 (= K71), R121 (= R115)
4mp6A Staphyloferrin b precursor biosynthetic enzyme sbnb bound to citrate and NAD+ (see paper)
26% identity, 97% coverage: 4:325/332 of query aligns to 4:333/334 of 4mp6A
- active site: I60 (vs. gap), M236 (≠ H230)
- binding nicotinamide-adenine-dinucleotide: R92 (≠ T87), R120 (= R115), T121 (= T116), G146 (= G141), L147 (≠ V142), I148 (≠ Q143), D170 (= D164), Q171 (≠ P165), C211 (≠ V200), T212 (= T201), V213 (≠ P202), I233 (= I222), G306 (= G298)
4mpdA Staphyloferrin b precursor biosynthetic enzyme sbnb bound a- ketoglutarate and NAD+ (see paper)
26% identity, 97% coverage: 4:325/332 of query aligns to 4:317/318 of 4mpdA
- active site: I53 (≠ R54), M224 (≠ H230)
- binding 2-oxoglutaric acid: K43 (= K41), R51 (≠ D52), M55 (= M56), K64 (= K71), I66 (≠ V73), R80 (≠ T87), M289 (≠ T297)
- binding nicotinamide-adenine-dinucleotide (acidic form): R80 (≠ T87), R108 (= R115), T109 (= T116), G134 (= G141), I136 (≠ Q143), D158 (= D164), Q159 (≠ P165), F160 (≠ D166), T200 (= T201), V201 (≠ P202), I221 (= I222)
A1B8Z0 Iminosuccinate reductase; EC 1.4.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
33% identity, 88% coverage: 25:315/332 of query aligns to 16:310/320 of A1B8Z0