Comparing WP_077278866.1 NCBI__GCF_002000365.1:WP_077278866.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
69% identity, 99% coverage: 9:1249/1250 of query aligns to 8:1227/1227 of P13009
Sites not aligning to the query:
Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
54% identity, 99% coverage: 13:1249/1250 of query aligns to 26:1265/1265 of Q99707
3bulA E. Coli i690c/g743c meth c-terminal fragment (649-1227) (see paper)
63% identity, 48% coverage: 652:1247/1250 of query aligns to 3:575/577 of 3bulA
3ivaA Structure of the b12-dependent methionine synthase (meth) c-teminal half with adohcy bound (see paper)
63% identity, 48% coverage: 652:1247/1250 of query aligns to 3:575/576 of 3ivaA
4cczA Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
55% identity, 50% coverage: 13:637/1250 of query aligns to 10:611/611 of 4cczA
8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
37% identity, 69% coverage: 13:877/1250 of query aligns to 9:839/841 of 8g3hA
6bdyA Crystal structure of the meth reactivation domain bound to sinefungin (see paper)
58% identity, 28% coverage: 904:1247/1250 of query aligns to 4:325/326 of 6bdyA
1mskA Methionine synthase (activation domain) (see paper)
58% identity, 28% coverage: 904:1247/1250 of query aligns to 4:325/327 of 1mskA
3k13C Structure of the pterin-binding domain metr of 5- methyltetrahydrofolate-homocysteine methyltransferase from bacteroides thetaiotaomicron
67% identity, 23% coverage: 357:640/1250 of query aligns to 4:286/287 of 3k13C
1bmtA How a protein binds b12: a 3.O angstrom x-ray structure of the b12- binding domains of methionine synthase (see paper)
73% identity, 20% coverage: 652:895/1250 of query aligns to 3:245/246 of 1bmtA
3bofA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
30% identity, 47% coverage: 13:599/1250 of query aligns to 11:538/560 of 3bofA
1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex) (see paper)
30% identity, 47% coverage: 13:599/1250 of query aligns to 11:538/559 of 1q8jA
5vooA Methionine synthase folate-binding domain with methyltetrahydrofolate from thermus thermophilus hb8 (see paper)
36% identity, 22% coverage: 355:633/1250 of query aligns to 1:273/282 of 5vooA
8sseA Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8 (see paper)
41% identity, 15% coverage: 657:842/1250 of query aligns to 1:180/507 of 8sseA
Sites not aligning to the query:
7xcnP Crystal structure of the mttb-mttc complex at 2.7 a resolution (see paper)
31% identity, 12% coverage: 688:839/1250 of query aligns to 36:188/215 of 7xcnP
Sites not aligning to the query:
4jgiB 1.5 angstrom crystal structure of a novel cobalamin-binding protein from desulfitobacterium hafniense dcb-2 (see paper)
34% identity, 11% coverage: 699:834/1250 of query aligns to 45:174/206 of 4jgiB
Sites not aligning to the query:
2i2xB Crystal structure of methanol:cobalamin methyltransferase complex mtabc from methanosarcina barkeri (see paper)
31% identity, 14% coverage: 662:839/1250 of query aligns to 43:216/258 of 2i2xB
Sites not aligning to the query:
Q46EH4 Methanol--corrinoid protein; Methanol:corrinoid methyltransferase 1 subunit of 27 kDa; MT1 subunit 27 kDa from Methanosarcina barkeri (strain Fusaro / DSM 804) (see paper)
31% identity, 14% coverage: 662:839/1250 of query aligns to 43:216/258 of Q46EH4
Sites not aligning to the query:
5dmmA Crystal structure of the homocysteine methyltransferase mmum from escherichia coli, metallated form (see paper)
26% identity, 25% coverage: 14:322/1250 of query aligns to 9:284/288 of 5dmmA
3ezxA Structure of methanosarcina barkeri monomethylamine corrinoid protein
34% identity, 12% coverage: 689:838/1250 of query aligns to 36:185/212 of 3ezxA
Sites not aligning to the query:
>WP_077278866.1 NCBI__GCF_002000365.1:WP_077278866.1
MTDDRTRLLETHIKERILVLDGAMGTMIQGYGLDESDYRGERFADWKSDLKGNNDLLVLT
RPDVIGEIHGQYLEAGADILETNTFNATRIAMADYAMEEMVPEINREAARIAREAADAWT
EKNPDKPRFVAGVLGPTNRTASISPDVNDPGFRNVDFDTLVAAYREAAEALIEGGADLLL
IETVFDTLNAKAAVFAVETLFDDTGKRLPVMISGTITDASGRTLSGQVTEAFWNSLRHAQ
PFSFGLNCALGPKELRAYVEELSNIADTNVSAHPNAGLPNEFGEYDLIPEQMAEHIREWA
ESGFLNIVGGCCGTTPDHIRAIAGAVADVAPRKVPEVPAACRLSGLEPCNITEDSLFVNV
GERTNVTGSARFKRLIKDGDYEIALEVAASQVENGAQIIDVNMDEGMLDSQAAMVRFLNL
VAAEPDISRVPVMIDSSKWEVIEAGLKCIQGKGIVNSISLKEGEETFIEHAKLVRRYGAA
VIVMAFDEQGQADTKERKVEICERAYRILTDKVGFPAEDIIFDPNIFAIATGIEEHNNYG
VDFIEATREIKQRLPHALVSGGVSNVSFSFRGNEPVREAIHAVFLYHAIHAGMDMGIVNA
GQLAVYDEVDKELRELVEDVVLNRREDATERLLEVAERYRGEGGEAKKEDLEWRKLPVKK
RLEHALVKGIDTHVVEDTEEVRQQVDHPIQVIEGPLMDGMNVVGDLFGDGKMFLPQVVKS
ARVMKKAVAHLIPFIEALKKEGDRPNGKVLMATVKGDVHDIGKNIVGVVLQCNNFEVIDL
GVMVPAQKILDTAKEQDVDVIGLSGLITPSLEEMAHMAKEMERLGFSIPLLIGGATTSRA
HTAVKIEPHYSGPTVWVKDASRAVGVVQSLISDSTRDDYVAKIRADYEEVRVNHAGRQKT
QKWLTLEQARENRAPIDWQGYQPPRPKALDAPPAEKGITVLHPCGPDSVVIRFDDYPLEE
LKDYIDWTPFFHAWELHAAYPRIFEDEVVGEEAKKLFKDARDMLEKIIGEGWLKARGVIG
FFPANSVDADDIELYRDEDRKQPLMRLHHLRQQTERRGKGPNQCLADFIAPRDTALPDYL
GAFAVTAGIGIDEHVKRFEAAHDDYHAIMLKALADRLAEAFAERMHERVRREFWAYAPEE
HLDNDALIREQYQGIRPAPGYPACPEHTEKGLLWELLDPVENAGMSITESYAMLPTAAVS
GWYFAHPEAKYFNVGKINRDQVASYAKRKGMKPAEAERWLAPNLGYEPED
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory