SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_078212710.1 NCBI__GCF_002017945.1:WP_078212710.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12) (see paper)
56% identity, 98% coverage: 5:252/252 of query aligns to 10:257/257 of P0AAH0

query
sites
P0AAH0

K

K

I

I

D

Q

V

V

T

R

D

N

L

L

S

N

L

F

F

Y

Y

Y

G

G

E

K

K

F

K

H

A

A

L

L

S

K

S

N

V

I

S

N

M

L

Q

D

I

I

Q

A

A

K

N

N

K

Q

V

V

T

T

A

A

L

F

I

I

G

G

P

P

S

S

G

G

C

C

G
|
G

K
|
K

S

S

T

T

F

L

L

L

R

R

C

T

I

F

N

N

R

K

M

M

N

F

D

E

L

L

I

Y

P

P

G

E

V

Q

K

R

I

A

S

E

G

G

R

E

M

I

L

L

V

L

E

D

G

G

I

D

D

N

I

I

Y

L

D

T

K

N

E

S

V

Q

D

D

V

I

V

A

N

L

I

L

R

R

K

A

K

K

I

V

G

G

M

M

V

V

F

F

Q

Q

K

K

S

P

N

T

P

P

F

F

P

P

K

M

S

S

I

I

F

Y

E

D

N

N

V

I

A

A

Y

F

G

G

P

V

R

R

I

L

N

F

G

E

I

K

K

L

N

S

K

R

T

A

Q

D

L

M

D

D

E

E

I

R

V

V

E

Q

V

W

S

A

L

L

R

T

Q

K

A

A

I

L

W

W

E

N

E

E

L

T

K

K

D

D

R

K

L

L

D

H

D

Q

S

S

A

G

M

Y

G

S

L

L

S

S

G

G

Q

Q

R

R

L

L

C

C

I

I

A

A

R

R

T

G

L

I

A

A

V

I

N

R

P

P

D

E

I

V

I

L

L

L

M

L

D

D

E

E

P

P

A

C

S

S

A

A

L

L

D

D

P

P

L

I

S

S

T

T

S

G

K

R

I

I

E

E

L

L

V

I

H

T

E

E

L

L

K

K

E

Q

Q

D

Y

Y

T

T

I

V

V

V

I

I

V

V

T

T

H

H

N

N

M

M

Q

Q

A

A

R

R

T

C

S

S

D

D

H

H

T

T

A

A

F

F

F

M

Y

Y

M

L

G

G

E

E

L

L

I

I

E

E

M

F

G

S

K

N

T

T

K

D

D

D

I

L

F

F

T

T

K

K

P

P

E

A

K

K

Q

Q

T

T

E

E

D

D

Y

Y

I

I

T

T

G

G

R

R

F

Y

G

G

G48 (= G43) mutation to I: Loss of phosphate transport.
K49 (= K44) mutation to Q: Loss of phosphate transport.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

3c4jA Abc protein artp in complex with atp-gamma-s
35% identity, 98% coverage: 6:251/252 of query aligns to 4:242/242 of 3c4jA

query
sites
3c4jA

I

I

D

D

V

V

T

H

D

Q

L

L

S

K

L

K

F

S

Y
x
F

G

G

E

S

K

L

K

E

A
x
V

L

L

S

K

S

G

V

I

S

N

M

V

Q

H

I

I

Q

R

A

E

N

G

K

E

V

V

T

V

A

V

L

V

I

I

G

G

P

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

L

L

R

R

C

C

I

L

N

N

R

L

M

L

N

E

D

D

L

F

I

D

P

-

G

-

V

-

K

-

I

-

S

E

G

G

R

E

M

I

L

I

V

I

E

D

G

G

I

I

D

N

I

L

Y

K

D

A

K

K

E

D

V

T

D

N

V

L

V

N

N

K

I

V

R

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

K

R

S

F

N

N

P

L

F

F

P

P

K

H

-

M

S

T

I

V

F

L

E

N

N

N

V

I

A

T

Y

L

G

A

P

P

R

-

I

-

N

-

G

-

I

M

K

K

N

V

K

R

T

K

Q

W

L

P

D

R

E

E

I

K

V

A

E

E

V

A

S

K

L

A

R

M

Q

E

A

L

I

D

W

K

E

V

E

G

L

L

K

K

D

D

R

K

L

A

D

H

D

A

S

Y

A

P

M

D

G

S

L

L

S

S

G

G

Q

Q

Q

A

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

M

N

E

P

P

D

K

I

I

I

M

L

L

M

F

D

D

E

E

P

P

A

T

S

S

A

A

L

L

D

D

P

P

L

E

S

M

T

V

S

G

K

E

I

V

E

L

E

S

L

V

V

M

H

K

E

Q

L

L

-

A

K

N

E

E

Q

G

Y

M

T

T

I

M

V

V

I

V

V

V

T

T

H

H

N

E

M

M

Q

G

Q

F

A

A

A

R

R

E

T

V

S

G

D

D

H

R

T

V

A

L

F

F

F

M

Y

D

M

G

G

G

E

Y

L

I

I

I

E

E

M

E

G

G

K

K

T

P

K

E

D

D

I

L

F

F

T

D

K

R

P

P

E

Q

K

H

K

E

Q

R

T

T

E

K

D

A

Y

F

I

L

T

S

G

K

R

V

F

F

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y15), V18 (≠ A20), S38 (= S40), G39 (= G41), S40 (≠ C42), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)

3c41J Abc protein artp in complex with amp-pnp/mg2+
35% identity, 98% coverage: 6:251/252 of query aligns to 4:242/242 of 3c41J

query
sites
3c41J

I

I

D

D

V

V

T

H

D

Q

L

L

S

K

L

K

F

S

Y
x
F

G

G

E

S

K

L

K

E

A
x
V

L

L

S

K

S

G

V

I

S

N

M

V

Q

H

I

I

Q

R

A

E

N

G

K

E

V

V

T

V

A

V

L

V

I

I

G

G

P

P

S
|
S

G
|
G

C

S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

L

L

R

R

C

C

I

L

N

N

R

L

M

L

N

E

D

D

L

F

I

D

P

-

G

-

V

-

K

-

I

-

S

E

G

G

R

E

M

I

L

I

V

I

E

D

G

G

I

I

D

N

I

L

Y

K

D

A

K

K

E

D

V

T

D

N

V

L

V

N

N

K

I

V

R

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

K

R

S

F

N

N

P

L

F

F

P

P

K

H

-

M

S

T

I

V

F

L

E

N

N

N

V

I

A

T

Y

L

G

A

P

P

R

-

I

-

N

-

G

-

I

M

K

K

N

V

K

R

T

K

Q

W

L

P

D

R

E

E

I

K

V

A

E

E

V

A

S

K

L

A

R

M

Q

E

A

L

I

D

W

K

E

V

E

G

L

L

K

K

D

D

R

K

L

A

D

H

D

A

S

Y

A

P

M

D

G

S

L

L

S

S

G

G

Q

Q

Q

A

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

M

N

E

P

P

D

K

I

I

I

M

L

L

M

F

D
|
D

E

E

P

P

A

T

S

S

A

A

L

L

D

D

P

P

L

E

S

M

T

V

S

G

K

E

I

V

E

L

E

S

L

V

V

M

H

K

E

Q

L

L

-

A

K

N

E

E

Q

G

Y

M

T

T

I

M

V

V

I

V

V

V

T

T

H

H

N

E

M

M

Q

G

Q

F

A

A

A

R

R

E

T

V

S

G

D

D

H

R

T

V

A

L

F

F

F

M

Y

D

M

G

G

G

E

Y

L

I

I

I

E

E

M

E

G

G

K

K

T

P

K

E

D

D

I

L

F

F

T

D

K

R

P

P

E

Q

K

H

K

E

Q

R

T

T

E

K

D

A

Y

F

I

L

T

S

G

K

R

V

F

F

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y15), V18 (≠ A20), S38 (= S40), G39 (= G41), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)
binding magnesium ion: S43 (= S45), D163 (= D173)

2olkA Abc protein artp in complex with adp-beta-s
35% identity, 98% coverage: 6:251/252 of query aligns to 4:242/242 of 2olkA

query
sites
2olkA

I

I

D

D

V

V

T

H

D

Q

L

L

S

K

L

K

F

S

Y
x
F

G

G

E

S

K

L

K

E

A
x
V

L

L

S

K

S

G

V

I

S

N

M

V

Q

H

I

I

Q

R

A

E

N

G

K

E

V

V

T

V

A

V

L

V

I

I

G

G

P

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

L

L

R

R

C

C

I

L

N

N

R

L

M

L

N

E

D

D

L

F

I

D

P

-

G

-

V

-

K

-

I

-

S

E

G

G

R

E

M

I

L

I

V

I

E

D

G

G

I

I

D

N

I

L

Y

K

D

A

K

K

E

D

V

T

D

N

V

L

V

N

N

K

I

V

R

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

K

R

S

F

N

N

P

L

F

F

P

P

K

H

-

M

S

T

I

V

F

L

E

N

N

N

V

I

A

T

Y

L

G

A

P

P

R

-

I

-

N

-

G

-

I

M

K

K

N

V

K

R

T

K

Q

W

L

P

D

R

E

E

I

K

V

A

E

E

V

A

S

K

L

A

R

M

Q

E

A

L

I

D

W

K

E

V

E

G

L

L

K

K

D

D

R

K

L

A

D

H

D

A

S

Y

A

P

M

D

G

S

L

L

S

S

G

G

Q

Q

Q

A

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

M

N

E

P

P

D

K

I

I

I

M

L

L

M

F

D

D

E

E

P

P

A

T

S

S

A

A

L

L

D

D

P

P

L

E

S

M

T

V

S

G

K

E

I

V

E

L

E

S

L

V

V

M

H

K

E

Q

L

L

-

A

K

N

E

E

Q

G

Y

M

T

T

I

M

V

V

I

V

V

V

T

T

H

H

N

E

M

M

Q

G

Q

F

A

A

A

R

R

E

T

V

S

G

D

D

H

R

T

V

A

L

F

F

F

M

Y

D

M

G

G

G

E

Y

L

I

I

I

E

E

M

E

G

G

K

K

T

P

K

E

D

D

I

L

F

F

T

D

K

R

P

P

E

Q

K

H

K

E

Q

R

T

T

E

K

D

A

Y

F

I

L

T

S

G

K

R

V

F

F

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y15), V18 (≠ A20), S38 (= S40), G39 (= G41), S40 (≠ C42), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)

2oljA Abc protein artp in complex with adp/mg2+
35% identity, 98% coverage: 6:251/252 of query aligns to 4:242/242 of 2oljA

query
sites
2oljA

I

I

D

D

V

V

T

H

D

Q

L

L

S

K

L

K

F

S

Y
x
F

G

G

E

S

K

L

K

E

A
x
V

L

L

S

K

S

G

V

I

S

N

M

V

Q

H

I

I

Q

R

A

E

N

G

K

E

V

V

T

V

A

V

L

V

I

I

G

G

P

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

L

L

R

R

C

C

I

L

N

N

R

L

M

L

N

E

D

D

L

F

I

D

P

-

G

-

V

-

K

-

I

-

S

E

G

G

R

E

M

I

L

I

V

I

E

D

G

G

I

I

D

N

I

L

Y

K

D

A

K

K

E

D

V

T

D

N

V

L

V

N

N

K

I

V

R

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

K

R

S

F

N

N

P

L

F

F

P

P

K

H

-

M

S

T

I

V

F

L

E

N

N

N

V

I

A

T

Y

L

G

A

P

P

R

-

I

-

N

-

G

-

I

M

K

K

N

V

K

R

T

K

Q

W

L

P

D

R

E

E

I

K

V

A

E

E

V

A

S

K

L

A

R

M

Q

E

A

L

I

D

W

K

E

V

E

G

L

L

K

K

D

D

R

K

L

A

D

H

D

A

S

Y

A

P

M

D

G

S

L

L

S

S

G

G

Q

Q

Q

A

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

M

N

E

P

P

D

K

I

I

I

M

L

L

M

F

D

D

E

E

P

P

A

T

S

S

A

A

L

L

D

D

P

P

L

E

S

M

T

V

S

G

K

E

I

V

E

L

E

S

L

V

V

M

H

K

E

Q

L

L

-

A

K

N

E

E

Q

G

Y

M

T

T

I

M

V

V

I

V

V

V

T

T

H

H

N

E

M

M

Q

G

Q

F

A

A

A

R

R

E

T

V

S

G

D

D

H

R

T

V

A

L

F

F

F

M

Y

D

M

G

G

G

E

Y

L

I

I

I

E

E

M

E

G

G

K

K

T

P

K

E

D

D

I

L

F

F

T

D

K

R

P

P

E

Q

K

H

K

E

Q

R

T

T

E

K

D

A

Y

F

I

L

T

S

G

K

R

V

F

F

binding adenosine-5'-diphosphate: F13 (≠ Y15), V18 (≠ A20), S38 (= S40), G39 (= G41), S40 (≠ C42), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
34% identity, 96% coverage: 6:248/252 of query aligns to 2:237/240 of 4ymuJ

query
sites
4ymuJ

I

I

D

F

V

V

T

N

D

D

L

V

S

Y

L

K

F

N

Y
x
F

G

G

E

S

K

L

K

E

A
x
V

L

L

S

K

S

G

V

V

S

T

M

L

Q

K

I

V

Q

N

A

K

N

G

K

E

V

V

T

V

A

V

L

I

I

I

G

G

P

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

F

L

L

L

R

R

C

C

I

I

N

N

R

L

M

L

N

E

D

E

L

-

I

-

P

-

G

-

V

-

K

P

I

T

S

K

G

G

R

E

M

V

L

F

V

I

E

D

G

G

I

V

D

K

I

I

Y

N

D

N

K

G

E

K

V

V

D

N

V

I

V

N

N

K

I

V

R

R

K

Q

K

K

I

V

G

G

M

M

V

V

F

F

Q

Q

K

H

S

F

N

N

P

L

F

F

P

P

K

H

-

L

S

T

I

A

F

I

E

E

N

N

V

I

A

T

Y

L

G

A

P

P

R

V

I

K

N

V

G

K

I

K

K

M

N

N

K

K

T

K

Q

E

L

A

D

E

E

E

I

L

V

A

E

V

V

D

S

L

L

L

R

A

Q

K

A

V

A

G

I

L

W

L

E

-

L

-

K

-

D

D

R

K

L

K

D

D

D

Q

S

Y

A

P

M

I

G

K

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

L

L

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

M

N

Q

P

P

D

E

I

V

I

M

L

L

M

F

D

D

E
|
E

P

P

A

T

S

S

A

A

L

L

D

D

P

P

L

E

S

M

T

V

S

K

K

E

I

V

E

L

E

N

L

V

V

M

H

K

E

Q

L

L

-

A

K

N

E

E

Q

G

Y

M

T

T

I

M

V

V

I

V

V

V

T

T

H
|
H

N

E

M

M

Q

G

Q

F

A

A

A

R

R

E

T

V

S

G

D

D

H

R

T

V

A

I

F

F

F

M

Y

D

M

D

G

G

E

V

L

I

I

V

E

E

M

E

G

G

K

T

T

P

K

E

D

E

I

I

F

F

T

Y

K

R

P

A

E

K

K

N

K

E

Q

R

T

T

E

R

D

E

Y

F

I

L

T

S

binding adenosine-5'-triphosphate: F11 (≠ Y15), V16 (≠ A20), S36 (= S40), G37 (= G41), S38 (≠ C42), G39 (= G43), K40 (= K44), S41 (= S45), T42 (= T46), E162 (= E174), H194 (= H205)
binding magnesium ion: S41 (= S45), E162 (= E174)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
33% identity, 96% coverage: 6:247/252 of query aligns to 3:236/241 of 4u00A

query
sites
4u00A

I

I

D

R

V

I

T

R

D

N

L

L

S

H

L

K

F

W

Y
x
F

G

G

E

P

K

L

K

H

A
x
V

L

L

S

K

S

G

V

I

S

H

M

L

Q

E

I

V

Q

A

A

P

N

G

K

E

V

K

T

L

A

V

L

I

I

I

G

G

P

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

F

L

L

I

R

R

C

T

I

I

N

N

R

R

M

L

N

E

D

D

L

F

I

Q

P

-

G

-

V

-

K

-

I

-

S

E

G

G

R

E

M

V

L

V

V

V

E

D

G

G

I

L

D

S

I

V

Y

K

D

D

K

D

E

R

V

A

D

-

V

L

V

R

N

E

I

I

R

R

K

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

K

Q

S

F

N

N

P

L

F

F

P

P

K

H

-

M

S

T

I

V

F

L

E

E

N

N

V

V

A

T

Y

L

G

A

P

P

-

M

R

R

I

V

N

R

G

R

I

W

K

P

N

R

K

E

T

K

Q

A

L

E

D

K

E

K

I

A

V

L

E

E

V

L

S

L

L

E

R

R

Q

V

A

G

A

I

I

L

W

-

E

-

L

-

K

-

D

D

R

Q

L

A

D

R

D

K

S

Y

A

P

M

A

G

Q

L

L

S

S

G

G

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

M

N

E

P

P

D

K

I

I

I

M

L

L

M

F

D

D

E

E

P

P

A

T

S

S

A

A

L

L

D

D

P

P

L

E

S

M

T

V

S

G

K

E

I

V

E

L

E

D

L

V

V

M

H

R

E

D

L

L

K

A

E

Q

-

G

Q

G

Y

M

T

T

I

M

V

V

I

V

V

V

T

T

H

H

N

E

M

M

Q

G

Q

F

A

A

A

R

R

E

T

V

S

A

D

D

H

R

T

V

A

V

F

F

F

M

Y

D

M

G

G

G

E

Q

L

I

I

V

E

E

M

E

G

G

K

R

T

P

K

E

D

E

I

I

F

F

T

T

K

R

P

P

E

K

K

E

Q

R

T

T

E

R

D

S

Y

F

I

L

binding adenosine-5'-diphosphate: F12 (≠ Y15), V17 (≠ A20), S37 (= S40), G38 (= G41), S39 (≠ C42), G40 (= G43), K41 (= K44), S42 (= S45), T43 (= T46)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
35% identity, 91% coverage: 19:247/252 of query aligns to 19:241/343 of P30750

query
sites
P30750

K

Q

A

A

L

L

S

N

V

V

S

S

M

L

Q

H

I

V

Q

P

A

A

N

G

K

Q

V

I

T

Y

A

G

L

V

I

I

G

G

P

A

S
|
S

G
|
G

C
x
A

G
|
G

K
|
K

S
|
S

T
|
T

F

L

L

I

R

R

C

C

I

V

N

N

R

L

M

L

N

E

D

R

L

-

I

-

P

-

G

-

V

-

K

P

I

T

S

E

G

G

R

S

M

V

L

L

V

V

E

D

G

G

I

Q

D

E

I

L

Y

T

D

T

-

L

K

S

E

E

V

S

D

E

V

L

V

T

N

K

I

A

R

R

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q

Q

K

H

S

F

N

N

P

L

F

L

P

S

-

S

K

R

S

T

I

V

F

F

E

G

N

N

V

V

A

A

Y

L

G

P

P

L

R

E

I

L

N

D

G

-

I

-

K

-

N

-

K

N

T

T

Q

P

L

K

D

D

E

E

I

-

V

V

E

K

V

R

S

R

L

V

R

T

Q

E

A

L

I

S

W

L

E

V

E

G

L

L

K

G

D

D

R

K

L

H

D

D

D

S

S

Y

A

P

M

S

G

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

S

N

N

P

P

D

K

I

V

I

L

L

L

M

C

D

D

E
|
E

P

A

A

T

S

S

A

A

L

L

D

D

P

P

L

A

S

T

T

T

S

R

K

S

I

I

E

L

E

E

L

L

V

L

H

K

E

D

L

I

K

N

E

R

Q

R

-

L

-

G

Y

L

T

T

I

I

V

L

I

L

V

I

T

T

H

H

N

E

M

M

Q

D

Q

V

A

V

A

K

R

R

T

I

S

C

D

D

H

C

T

V

A

A

F

V

F

I

Y

S

M

N

G

G

E

E

L

L

I

I

E

E

M

Q

G

D

K

T

T

V

K

S

D

E

I

V

F

F

T

S

K

H

P

P

E

K

K

T

K

P

Q

L

T

A

E

Q

D

K

Y

F

I

I

40:46 (vs. 40:46, 86% identical) binding ATP
E166 (= E174) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
34% identity, 91% coverage: 19:247/252 of query aligns to 20:242/344 of 3tuzC

query
sites
3tuzC

K

Q

A

A

L

L

S

N

V

V

S

S

M

L

Q

H

I

V

Q

P

A

A

N

G

K

Q

V

I

T

Y

A

G

L

V

I

I

G

G

P

A

S

S

G
|
G

C

A

G
|
G

K
|
K

S
|
S

T
|
T

F

L

L

I

R

R

C

C

I

V

N

N

R

L

M

L

N

E

D

R

L

-

I

-

P

-

G

-

V

-

K

P

I

T

S

E

G

G

R

S

M

V

L

L

V

V

E

D

G

G

I

Q

D

E

I

L

Y

T

D

T

-

L

K

S

E

E

V

S

D

E

V

L

V

T

N

K

I

A

R

R

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q

Q

K

H

S

F

N

N

P

L

F

L

P

S

-

S

K

R

S

T

I

V

F

F

E

G

N

N

V

V

A

A

Y

L

G

P

P

L

R

E

I

L

N

D

G

-

I

-

K

-

N

-

K

N

T

T

Q

P

L

K

D

D

E

E

I

-

V

V

E

K

V

R

S

R

L

V

R

T

Q

E

A

L

I

S

W

L

E

V

E

G

L

L

K

G

D

D

R

K

L

H

D

D

D

S

S

Y

A

P

M

S

G

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

S

N

N

P

P

D

K

I

V

I

L

L

L

M

C

D

D

E

Q

P

A

A

T

S

S

A

A

L

L

D

D

P

P

L

A

S

T

T

T

S

R

K

S

I

I

E

L

E

E

L

L

V

L

H

K

E

D

L

I

K

N

E

R

Q

R

-

L

-

G

Y

L

T

T

I

I

V

L

I

L

V

I

T

T

H

H

N

E

M

M

Q

D

Q

V

A

V

A

K

R

R

T

I

S

C

D

D

H

C

T

V

A

A

F

V

F

I

Y

S

M

N

G

G

E

E

L

L

I

I

E

E

M

Q

G

D

K

T

T

V

K

S

D

E

I

V

F

F

T

S

K

H

P

P

E

K

K

T

K

P

Q

L

T

A

E

Q

D

K

Y

F

I

I

binding adenosine-5'-diphosphate: G42 (= G41), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 14
binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
34% identity, 91% coverage: 19:247/252 of query aligns to 20:242/344 of 3tuiC

query
sites
3tuiC

K

Q

A

A

L

L

S

N

V

V

S

S

M

L

Q

H

I

V

Q

P

A

A

N

G

K

Q

V

I

T

Y

A

G

L

V

I

I

G

G

P

A

S

S

G
|
G

C
x
A

G
|
G

K
|
K

S
|
S

T
|
T

F

L

L

I

R

R

C

C

I

V

N

N

R

L

M

L

N

E

D

R

L

-

I

-

P

-

G

-

V

-

K

P

I

T

S

E

G

G

R

S

M

V

L

L

V

V

E

D

G

G

I

Q

D

E

I

L

Y

T

D

T

-

L

K

S

E

E

V

S

D

E

V

L

V

T

N

K

I

A

R

R

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q

Q

K

H

S

F

N

N

P

L

F

L

P

S

-

S

K

R

S

T

I

V

F

F

E

G

N

N

V

V

A

A

Y

L

G

P

P

L

R

E

I

L

N

D

G

-

I

-

K

-

N

-

K

N

T

T

Q

P

L

K

D

D

E

E

I

-

V

V

E

K

V

R

S

R

L

V

R

T

Q

E

A

L

I

S

W

L

E

V

E

G

L

L

K

G

D

D

R

K

L

H

D

D

D

S

S

Y

A

P

M

S

G

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

S

N

N

P

P

D

K

I

V

I

L

L

L

M

C

D

D

E

Q

P

A

A

T

S

S

A

A

L

L

D

D

P

P

L

A

S

T

T

T

S

R

K

S

I

I

E

L

E

E

L

L

V

L

H

K

E

D

L

I

K

N

E

R

Q

R

-

L

-

G

Y

L

T

T

I

I

V

L

I

L

V

I

T

T

H

H

N

E

M

M

Q

D

Q

V

A

V

A

K

R

R

T

I

S

C

D

D

H

C

T

V

A

A

F

V

F

I

Y

S

M

N

G

G

E

E

L

L

I

I

E

E

M

Q

G

D

K

T

T

V

K

S

D

E

I

V

F

F

T

S

K

H

P

P

E

K

K

T

K

P

Q

L

T

A

E

Q

D

K

Y

F

I

I

binding adenosine-5'-diphosphate: G42 (= G41), A43 (≠ C42), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
34% identity, 91% coverage: 19:247/252 of query aligns to 20:242/344 of 6cvlD

query
sites
6cvlD

K

Q

A

A

L

L

S

N

V

V

S

S

M

L

Q

H

I

V

Q

P

A

A

N

G

K

Q

V

I

T

Y

A

G

L

V

I

I

G

G

P

A

S
|
S

G
|
G

C
x
A

G
|
G

K
|
K

S
|
S

T
|
T

F

L

L

I

R

R

C

C

I

V

N

N

R

L

M

L

N

E

D

R

L

-

I

-

P

-

G

-

V

-

K

P

I

T

S

E

G

G

R

S

M

V

L

L

V

V

E

D

G

G

I

Q

D

E

I

L

Y

T

D

T

-

L

K

S

E

E

V

S

D

E

V

L

V

T

N

K

I

A

R

R

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q

Q

K

H

S

F

N

N

P

L

F

L

P

S

-

S

K

R

S

T

I

V

F

F

E

G

N

N

V

V

A

A

Y

L

G

P

P

L

R

E

I

L

N

D

G

-

I

-

K

-

N

-

K

N

T

T

Q

P

L

K

D

D

E

E

I

-

V

V

E

K

V

R

S

R

L

V

R

T

Q

E

A

L

I

S

W

L

E

V

E

G

L

L

K

G

D

D

R

K

L

H

D

D

D

S

S

Y

A

P

M

S

G
x
N

L

L

S
|
S

G

G

Q
|
Q

Q

K

Q

Q

R

R

L

V

C

A

I

I

A

A

R

R

T

A

L

L

A

A

V

S

N

N

P

P

D

K

I

V

I

L

L

L

M

C

D

D

E

Q

P

A

A

T

S

S

A

A

L

L

D

D

P

P

L

A

S

T

T

T

S

R

K

S

I

I

E

L

E

E

L

L

V

L

H

K

E

D

L

I

K

N

E

R

Q

R

-

L

-

G

Y

L

T

T

I

I

V

L

I

L

V

I

T

T

H
|
H

N

E

M

M

Q

D

Q

V

A

V

A

K

R

R

T

I

S

C

D

D

H

C

T

V

A

A

F

V

F

I

Y

S

M

N

G

G

E

E

L

L

I

I

E

E

M

Q

G

D

K

T

T

V

K

S

D

E

I

V

F

F

T

S

K

H

P

P

E

K

K

T

K

P

Q

L

T

A

E

Q

D

K

Y

F

I

I

binding phosphothiophosphoric acid-adenylate ester: S41 (= S40), G42 (= G41), A43 (≠ C42), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46), N141 (≠ G148), S143 (= S150), Q146 (= Q153), H200 (= H205)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 12, 14, 19

P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
34% identity, 99% coverage: 1:249/252 of query aligns to 2:255/258 of P02915

query
sites
P02915

M

M

K

S

D

E

V

N

K

K

I

L

D

H

V

V

T

I

D

D

L

L

S

H

L

K

F

R

Y

Y

G

G

E

G

K

H

K

E

A

V

L

L

S

K

S

G

V

V

S

S

M

L

Q

Q

I

A

Q

R

A

A

N

G

K

D

V

V

T

I

A

S

L

I

I

I

G

G

P

S

S
|
S

G
|
G

C

S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

L

L

R

R

C

C

I

I

N

N

R

F

M

L

N

E

D

K

L

P

I

S

P

E

G

G

V

A

K

I

I

I

S

V

G

N

R

G

M

Q

L

N

V

I

E

N

G

L

I

V

D

R

I

D

Y

K

D

D

K

G

E

Q

V

L

D

K

V

V

V

A

N

D

-

K

-

N

-

Q

-

L

-

R

-

L

I

L

R

R

K

T

K

R

I

L

G

T

M

M

V

V

F

F

Q

Q

K

H

S

F

N

N

P

L

F

W

P

S

K

H

-

M

S

T

I

V

F

L

E

E

N

N

V

V

A

M

Y

E

G

A

P

P

R

-

I

-

N

-

G

-

I

-

K

-

N

-

K

-

T

I

Q

Q

L

V

D

L

E

G

I

L

V

S

E

K

V

H

S

D

L

A

R

R

Q

E

A

R

A

A

I

L

W

K

E

Y

E

L

L

A

K

K

D

V

R

G

L

I

D

D

D

E

S

R

A

A

M

Q

G

G

-

K

-

Y

-

P

-

V

-

H

L

L

S

S

G

G

Q

Q

R

R

L

V

C

S

I

I

A

A

R

R

T

A

L

L

A

A

V

M

N

E

P

P

D

D

I

V

I

L

L

L

M

F

D

D

E

E

P

P

A

T

S

S

A

A

L

L

D

D

P

P

L

E

S

L

T

V

S

G

K

E

I

V

E

L

E

R

L

I

V

M

H

Q

E

Q

L

L

K

A

E

E

Q

E

-

G

Y

K

T

T

I

M

V

V

I

V

V

V

T

T

H

H

N

E

M

M

Q

G

Q

F

A

A

A

R

R

H

T

V

S

S

D

S

H

H

T

V

A

I

F

F

F

L

Y

H

M

Q

G

G

E

K

L

I

I

E

E

E

M

E

G

G

K

D

T

P

K

E

D

Q

I

V

F

F

T

G

K

N

P

P

E

Q

K

S

K

P

Q

R

T

L

E

Q

D

Q

Y

F

I

L

T

K

G

G

S41 (= S40) binding ATP
G42 (= G41) binding ATP
G44 (= G43) binding ATP
K45 (= K44) binding ATP
S46 (= S45) binding ATP
T47 (= T46) binding ATP

1b0uA Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
34% identity, 97% coverage: 5:249/252 of query aligns to 2:251/258 of 1b0uA

query
sites
1b0uA

K

K

I

L

D

H

V

V

T

I

D

D

L

L

S

H

L

K

F

R

Y
|
Y

G

G

E

G

K
x
H

K

E

A

V

L

L

S

K

S

G

V

V

S

S

M

L

Q

Q

I

A

Q

R

A

A

N

G

K

D

V

V

T

I

A

S

L

I

I

I

G

G

P

S

S
|
S

G
|
G

C

S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

L

L

R

R

C

C

I

I

N

N

R

F

M

L

N

E

D

K

L

P

I

S

P

E

G

G

V

A

K

I

I

I

S

V

G

N

R

G

M

Q

L

N

V

I

E

N

G

L

I

V

D

R

I

D

Y

K

D

D

K

G

E

Q

V

L

D

K

V

V

V

A

N

D

-

K

-

N

-

Q

-

L

-

R

-

L

I

L

R

R

K

T

K

R

I

L

G

T

M

M

V

V

F

F

Q

Q

K

H

S

F

N

N

P

L

F

W

P

S

K

H

-

M

S

T

I

V

F

L

E

E

N

N

V

V

A

M

Y

E

G

A

P

P

R

-

I

-

N

-

G

-

I

-

K

-

N

-

K

-

T

I

Q

Q

L

V

D

L

E

G

I

L

V

S

E

K

V

H

S

D

L

A

R

R

Q

E

A

R

A

A

I

L

W

K

E

Y

E

L

L

A

K

K

D

V

R

G

L

I

D

D

D

E

S

R

A

A

M

Q

G

G

-

K

-

Y

-

P

-

V

-

H

L

L

S

S

G

G

Q

Q

R

R

L

V

C

S

I

I

A

A

R

R

T

A

L

L

A

A

V

M

N

E

P

P

D

D

I

V

I

L

L

L

M

F

D

D

E

E

P

P

A

T

S

S

A

A

L

L

D

D

P

P

L

E

S

L

T

V

S

G

K

E

I

V

E

L

E

R

L

I

V

M

H

Q

E

Q

L

L

K

A

E

E

Q

E

-

G

Y

K

T

T

I

M

V

V

I

V

V

V

T

T

H

H

N

E

M

M

Q

G

Q

F

A

A

A

R

R

H

T

V

S

S

D

S

H

H

T

V

A

I

F

F

F

L

Y

H

M

Q

G

G

E

K

L

I

I

E

E

E

M

E

G

G

K

D

T

P

K

E

D

Q

I

V

F

F

T

G

K

N

P

P

E

Q

K

S

K

P

Q

R

T

L

E

Q

D

Q

Y

F

I

L

T

K

G

G

binding adenosine-5'-triphosphate: Y12 (= Y15), H15 (≠ K18), S37 (= S40), G38 (= G41), G40 (= G43), K41 (= K44), S42 (= S45), T43 (= T46)

3d31A Modbc from methanosarcina acetivorans (see paper)
32% identity, 90% coverage: 20:247/252 of query aligns to 15:228/348 of 3d31A

query
sites
3d31A

A

S

L

L

S

D

S

N

V

L

S

S

M

L

Q

K

I

V

Q

E

A

S

N

G

K

E

V

Y

T

F

A

V

L

I

I

L

G

G

P

P

S

T

G

G

C

A

G

G

K

K

S

T

T

L

F

F

L

L

R

-

C

-

I

-

N

-

R

-

M

-

N

-

D

E

L

L

I

I

P

A

G

G

V

F

K

H

I

V

-

P

-

D

S

S

G

G

R

R

M

I

L

L

V

L

E

D

G

G

I

K

D

D

I

V

Y

T

D

D

K

L

E

S

V

P

D

E

V

-

N

-

I

-

R

K

K

H

K

D

I

I

G

A

M

F

V

V

F

Y

Q

Q

K

N

S

Y

N

S

P

L

F

F

P

P

K

H

-

M

S

N

I

V

F

K

E

K

N

N

V

L

A

E

Y

F

G

G

P

M

R

R

I

M

N

K

G

K

I

I

K

K

N

D

-

P

K

K

T

R

Q

V

L

L

D

D

E

T

I

A

V

R

E

D

V

L

S

K

L

I

R

E

Q

H

A

L

A

-

I

-

W

-

E

-

L

-

K

-

D

-

R

-

L

L

D

D

D

R

S

N

A

P

M

L

G

T

L

L

S

S

G

G

Q

E

Q

Q

R

R

L

V

C

A

I

L

A

A

R

R

T

A

L

L

A

V

V

T

N

N

P

P

D

K

I

I

I

L

L

L

M

L

D

D

E

E

P

P

A

L

S

S

A

A

L

L

D

D

P

P

L

R

S

T

T

Q

S

E

K

N

I

A

E

R

E

E

L

M

V

L

H

S

E

V

L

L

-

H

-

K

K

K

E

N

Q

K

Y

L

T

T

I

V

V

L

I

H

V

I

T

T

H

H

N

D

M

Q

Q

T

Q

E

A

A

A

R

R

I

T

M

S

A

D

D

H

R

T

I

A

A

F

V

Y

M

M

D

G

G

E

K

L

L

I

I

E

Q

M

V

G

G

K

K

T

P

K

E

D

E

I

I

F

F

T

E

K

K

P

P

E

V

K

E

K

G

Q

R

T

V

E

A

D

S

Y

F

I

V

Sites not aligning to the query:

binding tungstate(vi)ion: 286, 320, 323, 340, 341, 342

Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
34% identity, 88% coverage: 17:237/252 of query aligns to 19:235/280 of Q5M244

query
sites
Q5M244

E

E

K

R

A

A

L

L

S

F

S

D

V

M

S

T

M

V

Q

T

I

I

Q

K

A

D

N

G

K

S

V

Y

T

T

A

A

L

F

I

I

G

G

P

H

S

T

G

G

C

S

G

G

K

K

S

S

T

T

F

I

L

M

R

Q

C

L

I

L

N

N

R

G

M

L

N

Y

D

-

L

-

I

-

P

-

G

-

V

L

K

P

I

T

S

S

G

G

R

Q

M

V

L

K

V

V

E

D

G

D

-

T

-

I

I

I

D

N

I

S

Y

Q

D

S

K

K

E

N

V

K

D

E

V

I

V

K

N

P

I

I

R

R

K

K

I

V

G

G

M

L

V

V

F

F

Q

Q

-

F

-

P

K

E

S

S

N
x
Q

P

L

F

F

P

A

K

E

S

T

I

V

F

L

E

E

N

D

V

I

A

A

Y

F

G

G

P

P

R

Q

I

N

N

F

G

G

I

V

K

S

N

K

K

E

T

E

Q

A

L

E

D

Q

E

R

I

A

V

L

E

E

V

-

S

S

L

L

R

R

Q

L

A

V

A

G

I

L

W

S

E

D

E

E

L

L

K

R

D

D

R

Q

L

-

D

-

S

N

A

P

M

F

G

D

L

L

S

S

G

G

Q

Q

Q

M

Q

R

R

R

L

V

C

A

I

I

A

A

R

G

T

I

L

L

A

A

V

M

N

Q

P

P

D

D

I

I

I

L

L

V

M

L

D

D

E
|
E

P

P

A

T

S

A

A

G

L

L

D

D

P

P

L

Q

S

G

T

R

S

K

K

E

I

L

E

M

E

S

L

L

V

F

H

K

E

Q

L

L

K

H

-

L

E

S

Q

G

Y

I

T

T

I

I

V

V

I

L

V

V

T

T

H

H

N

L

M

M

Q

D

A

V

A

A

R

D

T

Y

S

A

D

T

H

A

T

V

A

N

F

V

F

M

Y

E

M

K

G

G

E

R

L

L

I

V

E

L

M

S

G

G

K

T

T

P

K

K

D

D

I

V

F

F

T

Q

K

K

Q97 (≠ N96) mutation to A: No effect on ATPase, 10-fold decrease in riboflavin uptake; when associated with A-90 in EcfA1.
E171 (= E174) mutation to Q: 10-fold decrease in ATPase and riboflavin uptake; when associated with Q-163 in EcfA1.

7ahhC Opua inhibited inward-facing, sbd docked (see paper)
33% identity, 92% coverage: 16:247/252 of query aligns to 37:259/382 of 7ahhC

query
sites
7ahhC

G

G

E

A

K
x
T

K
x
V

A
x
G

L

V

S

Y

S

D

V

T

S

N

M

F

Q

E

I

I

Q

N

A

E

N

G

K

E

V

I

T

F

A

V

L

I

I

M

G

G

P

L

S

S

G
|
G

C

S

G
|
G

K
|
K

S

S

T

T

F

L

L

L

R

R

C

L

I

L

N

N

R

R

M

L

N

I

D

E

L

-

I

-

P

-

G

-

V

-

K

P

I

T

S

S

G

G

R

K

M

I

L

F

V

I

E

D

G

N

I

Q

D

D

I

V

-

A

-

T

Y

L

D

N

K

K

E

E

V

-

D

D

V

L

N

Q

I

V

R

R

K

R

K

K

-

T

I

M

G

S

M

M

V

V

F

F

Q

Q

K

N

S

F

N

G

P

L

F

F

P

P

-

H

K

R

S

T

I

I

F

L

E

E

N

N

V

T

A

E

Y

Y

G

G

P

L

R

E

I

V

N

Q

G

N

I

V

K

P

N

-

K

K

T

E

Q

E

L

R

D

R

E

K

I

R

V

A

E

E

V

K

S

A

L

L

R

D

Q

N

A

A

A

-

I

-

W

-

E

-

E

N

L

L

K

L

D

D

R

F

L

K

D

D

D

Q

S

Y

A

P

M

K

G

Q

L

L

S

S

G

G

Q

M

Q

Q

R

R

L

V

C

G

I

L

A

A

R

R

T

A

L

L

A

A

V

N

N

D

P

P

D

E

I

I

I

L

L

L

M

M

D
|
D

E
|
E

P

A

A

F

S

S

A

A

L

L

D

D

P

P

L

L

S

I

T

R

S

R

K

E

I

M

E

Q

E

D

L

E

V

L

H

L

E

E

L

L

K

Q

E

A

Q

K

Y

F

-

Q

-

K

T

T

I

I

V

I

I

F

V

V

T

S

H

H

N

D

M

L

Q

N

Q

E

A

A

A

L

R

R

T

I

S

G

D

D

H

R

T

I

A

A

F

I

F

M

Y

K

M

D

G

G

E

K

L

I

I

M

E

Q

M

I

G

G

K

T

T

G

K

E

D

E

I

I

F

L

T

T

K

N

P

P

E

-

K

-

Q

-

T

A

E

N

D

D

Y

Y

I

V

binding phosphoaminophosphonic acid-adenylate ester: T39 (≠ K18), V40 (≠ K19), G41 (≠ A20), G62 (= G41), G64 (= G43), K65 (= K44), D187 (= D173), E188 (= E174)

Sites not aligning to the query:

7aheC Opua inhibited inward facing (see paper)
33% identity, 92% coverage: 16:247/252 of query aligns to 37:259/382 of 7aheC

query
sites
7aheC

G

G

E

A

K

T

K

V

A

G

L

V

S

Y

S

D

V

T

S

N

M

F

Q

E

I

I

Q

N

A

E

N

G

K

E

V

I

T

F

A

V

L

I

I

M

G

G

P

L

S

S

G

G

C

S

G

G

K

K

S

S

T

T

F

L

L

L

R

R

C

L

I

L

N

N

R

R

M

L

N

I

D

E

L

-

I

-

P

-

G

-

V

-

K

P

I

T

S

S

G

G

R

K

M

I

L

F

V

I

E

D

G

N

I

Q

D

D

I

V

-

A

-

T

Y

L

D

N

K

K

E

E

V

-

D

D

V

L

N

Q

I

V

R

R

K

R

K

K

-

T

I

M

G

S

M

M

V

V

F

F

Q

Q

K

N

S

F

N

G

P

L

F

F

P

P

-

H

K

R

S

T

I

I

F

L

E

E

N

N

V

T

A

E

Y

Y

G

G

P

L

R

E

I

V

N

Q

G

N

I

V

K

P

N

-

K

K

T

E

Q

E

L

R

D

R

E

K

I

R

V

A

E

E

V

K

S

A

L

L

R

D

Q

N

A

A

A

-

I

-

W

-

E

-

E

N

L

L

K

L

D

D

R

F

L

K

D

D

D

Q

S

Y

A

P

M

K

G

Q

L

L

S

S

G

G

Q

M

Q

Q

R

R

L

V

C

G

I

L

A

A

R

R

T

A

L

L

A

A

V

N

N

D

P

P

D

E

I

I

I

L

L

L

M

M

D

D

E

E

P

A

A

F

S

S

A

A

L

L

D

D

P

P

L

L

S

I

T

R

S

R

K

E

I

M

E

Q

E

D

L

E

V

L

H

L

E

E

L

L

K

Q

E

A

Q

K

Y

F

-

Q

-

K

T

T

I

I

V

I

I

F

V

V

T

S

H

H

N

D

M

L

Q

N

Q

E

A

A

A

L

R

R

T

I

S

G

D

D

H

R

T

I

A

A

F

I

F

M

Y

K

M

D

G

G

E

K

L

I

I

M

E

Q

M

I

G

G

K

T

T

G

K

E

D

E

I

I

F

L

T

T

K

N

P

P

E

-

K

-

Q

-

T

A

E

N

D

D

Y

Y

I

V

Sites not aligning to the query:

binding (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide: 275, 297, 298

7ahdC Opua (e190q) occluded (see paper)
32% identity, 92% coverage: 16:247/252 of query aligns to 37:259/260 of 7ahdC

query
sites
7ahdC

G

G

E

A

K
x
T

K

V

A

G

L

V

S

Y

S

D

V

T

S

N

M

F

Q

E

I

I

Q

N

A

E

N

G

K

E

V

I

T

F

A

V

L

I

I

M

G

G

P

L

S
|
S

G
|
G

C

S

G
|
G

K
|
K

S
|
S

T
|
T

F

L

L

L

R

R

C

L

I

L

N

N

R

R

M

L

N

I

D

E

L

-

I

-

P

-

G

-

V

-

K

P

I

T

S

S

G

G

R

K

M

I

L

F

V

I

E

D

G

N

I

Q

D

D

I

V

-

A

-

T

Y

L

D

N

K

K

E

E

V

-

D

D

V

L

N

Q

I

V

R

R

K

R

K

K

-

T

I

M

G

S

M

M

V

V

F

F

Q
|
Q

K

N

S

F

N

G

P

L

F

F

P

P

-

H

K

R

S

T

I

I

F

L

E

E

N

N

V

T

A

E

Y

Y

G

G

P

L

R

E

I

V

N

Q

G

N

I

V

K

P

N

-

K

K

T

E

Q

E

L

R

D

R

E

K

I

R

V

A

E

E

V

K

S

A

L

L

R

D

Q

N

A

A

A

N

I

L

W

L

E

-

L

-

K

-

D

D

R

F

L

K

D

D

D

Q

S

Y

A

P

M
x
K

G
x
Q

L

L

S
|
S

G

G

G
|
G

Q
x
M

Q

Q

R

R

L

V

C

G

I

L

A

A

R

R

T

A

L

L

A

A

V

N

N

D

P

P

D

E

I

I

I

L

L

L

M

M

D

D

E
x
Q

P

A

A

F

S

S

A

A

L

L

D

D

P

P

L

L

S

I

T

R

S

R

K

E

I

M

E

Q

E

D

L

E

V

L

H

L

E

E

L

L

K

Q

E

A

Q

K

Y

F

-

Q

-

K

T

T

I

I

V

I

I

F

V

V

T

S

H
|
H

N

D

M

L

Q

N

Q

E

A

A

A

L

R

R

T

I

S

G

D

D

H

R

T

I

A

A

F

I

F

M

Y

K

M

D

G

G

E

K

L

I

I

M

E

Q

M

I

G

G

K

T

T

G

K

E

D

E

I

I

F

L

T

T

K

N

P

P

E

-

K

-

Q

-

T

A

E

N

D

D

Y

Y

I

V

binding adenosine-5'-triphosphate: T39 (≠ K18), S61 (= S40), G62 (= G41), G64 (= G43), K65 (= K44), S66 (= S45), T67 (= T46), Q111 (= Q93), K161 (≠ M147), Q162 (≠ G148), S164 (= S150), G166 (= G152), M167 (≠ Q153), Q188 (≠ E174), H221 (= H205)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12

4ayxA Structure of the human mitochondrial abc transporter, abcb10 (rod form b) (see paper)
34% identity, 85% coverage: 25:238/252 of query aligns to 361:569/571 of 4ayxA

query
sites
4ayxA

S

S

M

L

Q

S

I

I

Q

P

A

S

N

G

K

S

V

V

T

T

A

A

L

L

I

V

G

G

P

P

S
|
S

G
|
G

C

S

G
|
G

K
|
K

S
|
S

T
|
T

F

V

L

L

R

S

C

L

I

L

N

L

R

R

M

L

N

Y

D

D

L

-

I

-

P

-

G

-

V

-

K

P

I

A

S

S

G

G

R

T

M

I

L

S

V

L

E

D

G

G

I

H

D

D

I

I

Y

-

D

-

K

R

E

Q

V

L

D

N

V

P

V

V

N

W

I

L

R

R

K

S

K

K

I

I

G

G

M

T

V

V

F

S

Q
|
Q

K

E

S

P

N

I

P

L

F

F

P

S

K

C

S

S

I

I

F

A

E

E

N

N

V

I

A

A

Y

Y

G

G

P

A

R

D

I

D

N

P

G

S

I

S

K

V

N

T

K

A

T

E

Q

E

L

I

D

Q

E

R

I

V

V

A

E

E

V

V

S

A

L

N

R

A

Q

V

A

A

A

F

I

I

W

R

-

N

-

F

-

P

E

Q

E

G

L

F

K

N

D

T

R

V

L

V

D

G

D

E

S

K

A

G

M

V

G

L

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

L

I

C

A

I

I

A

A

R

R

T

A

L

L

A

L

V

K

N

N

P

P

D

K

I

I

I

L

L

L

M

L

D

D

E

E

P

A

A

T

S

S

A

A

L

L

D

D

P

A

L

E

S

N

T

E

S

Y

K

L

I

V

E

Q

E

E

L

A

V

L

H

D

E

R

L

L

K

M

E

D

Q

G

Y

R

T

T

I

V

V

L

I

V

V

I

T

A

H

H

N

R

M

L

Q

-

Q

S

A

T

A

I

R

K

T

N

S

A