SitesBLAST
Comparing WP_078429240.1 NCBI__GCF_002019605.1:WP_078429240.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
1v1aA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
36% identity, 92% coverage: 21:330/338 of query aligns to 3:301/301 of 1v1aA
- active site: G248 (= G277), A249 (= A278), G250 (= G279), D251 (= D280)
- binding adenosine-5'-diphosphate: K219 (= K243), G221 (= G245), A222 (≠ P246), A249 (= A278), G250 (= G279), N275 (= N304), A279 (= A308)
- binding 2-keto-3-deoxygluconate: L11 (≠ M29), G34 (= G52), A35 (= A53), N38 (= N56), Y89 (≠ M108), R105 (= R124), R167 (= R186), G248 (= G277), D251 (= D280), D287 (= D316)
Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
36% identity, 92% coverage: 21:330/338 of query aligns to 3:301/309 of Q53W83
- GAEVN 34:38 (≠ GAESN 52:56) binding substrate
- YYR 103:105 (= YYR 122:124) binding substrate
- R167 (= R186) binding substrate
- S193 (≠ G212) binding ATP
- 219:225 (vs. 243:249, 43% identical) binding ATP
- GAGD 248:251 (= GAGD 277:280) binding ATP
- D251 (= D280) binding substrate
- N275 (= N304) binding ATP
- D287 (= D316) binding substrate
1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp (see paper)
37% identity, 91% coverage: 21:327/338 of query aligns to 3:298/300 of 1v1bA
- active site: G248 (= G277), A249 (= A278), G250 (= G279), D251 (= D280)
- binding adenosine-5'-triphosphate: K219 (= K243), G221 (= G245), A238 (≠ L259), F239 (≠ Y260), V241 (= V262), G248 (= G277), A249 (= A278), G250 (= G279), N275 (= N304), A279 (= A308)
2dcnA Crystal structure of 2-keto-3-deoxygluconate kinase from sulfolobus tokodaii complexed with 2-keto-6-phosphogluconate (alpha-furanose form)
32% identity, 92% coverage: 21:330/338 of query aligns to 2:305/308 of 2dcnA
- active site: G252 (= G277), A253 (= A278), G254 (= G279), D255 (= D280)
- binding adenosine-5'-diphosphate: D193 (≠ G212), K223 (= K243), G225 (= G245), P226 (= P246), G228 (= G248), V247 (= V269), G254 (= G279), I279 (≠ N304), S282 (≠ G307), V286 (≠ T311)
- binding 6-O-phosphono-beta-D-psicofuranosonic acid: G33 (= G52), F89 (≠ M108), Y105 (= Y122), R107 (= R124), I136 (= I153), R165 (= R186), T251 (≠ V276), G252 (= G277), D255 (= D280), D291 (= D316)
Q97U29 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase; 2-dehydro-3-deoxyglucono/galactono-kinase; 2-keto-3-deoxy-galactonokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; KDGal kinase; EC 2.7.1.178 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
33% identity, 92% coverage: 21:331/338 of query aligns to 3:309/313 of Q97U29
2varA Crystal structure of sulfolobus solfataricus 2-keto-3-deoxygluconate kinase complexed with 2-keto-3-deoxygluconate (see paper)
33% identity, 92% coverage: 21:331/338 of query aligns to 2:308/311 of 2varA
- active site: G254 (= G277), A255 (= A278), G256 (= G279), D257 (= D280)
- binding adenosine monophosphate: G227 (= G245), G230 (= G248), M259 (≠ F282), S284 (≠ G307), I288 (≠ T311)
- binding phosphoaminophosphonic acid-adenylate ester: K225 (= K243), G227 (= G245), S228 (≠ P246), G230 (= G248), G254 (= G277), A255 (= A278), G256 (= G279), D257 (= D280), M259 (≠ F282), I281 (≠ N304), S284 (≠ G307), I288 (≠ T311)
- binding 3-deoxy-alpha-D-erythro-hex-2-ulofuranosonic acid: L10 (≠ M29), G33 (= G52), S34 (≠ A53), Y89 (≠ M108), Y105 (= Y122), R107 (= R124), I136 (= I153), R165 (= R186), G254 (= G277), D257 (= D280)
- binding 2-keto-3-deoxygluconate: G33 (= G52), S34 (≠ A53), Y89 (≠ M108), L103 (≠ V120), Y105 (= Y122), R107 (= R124), I136 (= I153), R165 (= R186), T253 (≠ V276), G254 (= G277), D257 (= D280), D293 (= D316)
5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
27% identity, 84% coverage: 48:330/338 of query aligns to 24:305/306 of 5eynA
- active site: G246 (= G277), A247 (= A278), G248 (= G279), D249 (= D280)
- binding adenosine-5'-diphosphate: H91 (≠ A115), T217 (≠ K243), G219 (= G245), A220 (≠ P246), A238 (= A264), V239 (≠ P265), T244 (= T275), G246 (= G277), A247 (= A278), G248 (= G279), F251 (= F282), N279 (= N304), G282 (= G307), A283 (= A308)
- binding beryllium trifluoride ion: G246 (= G277), G248 (= G279), D249 (= D280)
- binding beta-D-fructofuranose: G28 (= G52), A29 (= A53), N32 (= N56), F96 (≠ V120), F98 (≠ Y122), R159 (= R186), D249 (= D280)
Sites not aligning to the query:
5yggA Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
27% identity, 84% coverage: 48:330/338 of query aligns to 28:309/310 of 5yggA
- binding adenosine-5'-diphosphate: K188 (≠ L210), T221 (≠ K243), G223 (= G245), A242 (= A264), V243 (≠ P265), F255 (= F282), N283 (= N304), G286 (= G307), A287 (= A308)
- binding beta-D-fructofuranose: G32 (= G52), A33 (= A53), F100 (≠ V120), F102 (≠ Y122), R163 (= R186), D253 (= D280)
Sites not aligning to the query:
3iq0B Crystal structure of a putative ribokinase ii in complex with atp and mg+2 from e.Coli
29% identity, 80% coverage: 61:330/338 of query aligns to 45:305/308 of 3iq0B
- active site: G252 (= G277), A253 (= A278), G254 (= G279), D255 (= D280)
- binding adenosine-5'-triphosphate: S192 (≠ G212), K223 (= K243), G225 (= G245), E247 (≠ Q271), A253 (= A278), G254 (= G279), F257 (= F282), N279 (= N304), G282 (= G307)
3gbuA Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with atp
28% identity, 88% coverage: 22:317/338 of query aligns to 2:284/302 of 3gbuA
- active site: G242 (= G277), A243 (= A278), G244 (= G279), D245 (= D280)
- binding adenosine-5'-triphosphate: K188 (≠ L210), T213 (≠ K243), G215 (= G245), V235 (= V269), P237 (≠ Q271), A243 (= A278), G244 (= G279), A274 (≠ G307)
3ih0A Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with amp-pnp
28% identity, 88% coverage: 22:317/338 of query aligns to 3:285/304 of 3ih0A
3in1A Crystal structure of a putative ribokinase in complex with adp from e.Coli
28% identity, 84% coverage: 46:330/338 of query aligns to 34:308/312 of 3in1A
- active site: R106 (≠ Y121), G255 (= G277), A256 (= A278), G257 (= G279), D258 (= D280)
- binding adenosine-5'-diphosphate: N194 (≠ G212), K225 (= K243), G227 (= G245), G230 (= G248), A244 (≠ G266), T253 (= T275), N282 (= N304), A285 (≠ G307)
2afbA Crystal structure of 2-dehydro-3- deoxygluconokinase (ec 2.7.1.45) (tm0067) from thermotoga maritima at 2.05 a resolution (see paper)
27% identity, 94% coverage: 15:332/338 of query aligns to 1:329/329 of 2afbA
Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
26% identity, 85% coverage: 44:331/338 of query aligns to 23:308/319 of Q8ZKR2
- G31 (= G52) binding 5-amino-1-(beta-D-ribosyl)imidazole
- Y101 (= Y122) binding 5-amino-1-(beta-D-ribosyl)imidazole
- R162 (= R186) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A180 (≠ I203) binding K(+)
- A181 (≠ K204) binding K(+)
- A183 (≠ S206) binding K(+)
- G213 (= G236) binding K(+)
- D246 (= D274) binding K(+)
- T248 (≠ V276) binding K(+)
- D252 (= D280) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A287 (≠ V310) binding K(+)
- A290 (≠ Y313) binding K(+)
- G292 (= G315) binding K(+)
Sites not aligning to the query:
- 16 binding 5-amino-1-(beta-D-ribosyl)imidazole
1tz3A Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
27% identity, 85% coverage: 44:331/338 of query aligns to 19:297/299 of 1tz3A
- active site: C24 (≠ S49), F88 (≠ I112), G238 (= G277), A239 (= A278), G240 (= G279), D241 (= D280)
- binding 5-aminoimidazole ribonucleoside: G27 (= G52), L83 (≠ M108), F88 (≠ I112), Y90 (≠ G114), R151 (= R186), M154 (≠ L189), D241 (= D280)
Sites not aligning to the query:
1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog (see paper)
27% identity, 85% coverage: 44:331/338 of query aligns to 19:297/297 of 1tz6A
- active site: C24 (≠ S49), F88 (≠ I112), G238 (= G277), A239 (= A278), G240 (= G279), D241 (= D280)
- binding phosphomethylphosphonic acid adenylate ester: N149 (= N184), K176 (≠ L210), E181 (= E215), S209 (≠ K243), G211 (= G245), A212 (≠ P246), G214 (= G248), A239 (= A278), G240 (= G279), F243 (= F282), N270 (= N304), G273 (= G307), A274 (= A308)
- binding 5-aminoimidazole ribonucleoside: G27 (= G52), F88 (≠ I112), Y90 (≠ G114), R151 (= R186), M154 (≠ L189), D241 (= D280)
Sites not aligning to the query:
8cqxA Ribokinase from t.Sp mutant a92g
30% identity, 83% coverage: 52:332/338 of query aligns to 37:300/300 of 8cqxA
- binding adenosine-5'-diphosphate: N179 (≠ G212), T217 (≠ K243), G219 (= G245), A220 (≠ P246), G222 (= G248), F250 (= F282), N272 (= N304), G275 (= G307), A276 (= A308), T279 (= T311)
- binding magnesium ion: D242 (= D274), T244 (≠ V276), A278 (≠ V310), S287 (≠ G319)
6znxC Ribokinase from thermus species
31% identity, 83% coverage: 52:332/338 of query aligns to 24:265/265 of 6znxC
3lkiB Crystal structure of fructokinase with bound atp from xylella fastidiosa
27% identity, 91% coverage: 22:330/338 of query aligns to 5:317/322 of 3lkiB
4wjmA Crystal structure of fructokinase from brucella abortus 2308 with bound amppnp
32% identity, 72% coverage: 52:293/338 of query aligns to 36:268/312 of 4wjmA
- active site: G252 (= G277), A253 (= A278), G254 (= G279), D255 (= D280)
- binding phosphoaminophosphonic acid-adenylate ester: T223 (≠ K243), G225 (= G245), A226 (≠ P246), G228 (= G248), G252 (= G277), A253 (= A278), G254 (= G279), V257 (≠ F282)
Sites not aligning to the query:
Query Sequence
>WP_078429240.1 NCBI__GCF_002019605.1:WP_078429240.1
MRLCKQLKVVTAVTHKGINPEILTLGETMVLFQTVQDSRLQYASSLAKSLAGAESNVSIG
LTRLGKRVGWLSRLGNDPFGDYIYSTLLGEGVDLSYVRRDKQYPTGVMFKEIKGAIDPGV
YYYRKSSAASVWKSKELSQEMFEGVKTLHLTGITPALSSECKETSFEAIRLAKQAGAMIS
FDPNMRYKLWSAAEARQTFIELIKLSDIILPGIDEGELITGKQDPDSIAIDILALGAKIV
VIKVGPEGSIAYTKEEGNLYKVKAPGFPVHQVVDTVGAGDGFAAGFLSAYLDQENMFDCL
QRANAIGAMVTQYRGDWEGLPTLEEVESFISGRVAVSR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory