SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_083453266.1 NCBI__GCF_001293685.1:WP_083453266.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1jroA Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
35% identity, 96% coverage: 1:455/474 of query aligns to 1:433/450 of 1jroA

query
sites
1jroA

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binding flavin-adenine dinucleotide: G42 (= G42), D43 (≠ E43), L189 (≠ V206), A191 (= A208), G192 (= G209), G193 (= G210), T194 (= T211), D195 (= D212), V196 (≠ L213), F258 (≠ L277), A259 (≠ G278), T268 (= T287), G271 (= G290), N272 (= N291), A274 (= A293), G280 (= G299), D281 (= D300), R318 (≠ L337), V324 (≠ I343)
binding fe2/s2 (inorganic) cluster: E37 (= E37), G38 (= G38), C39 (= C39), N40 (≠ G40), G42 (= G42), C44 (= C44), G45 (= G45), C47 (= C47), C63 (= C59), C103 (= C98), C106 (= C101), C134 (= C133), C136 (= C135)

2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde (see paper)
34% identity, 96% coverage: 1:455/474 of query aligns to 1:433/450 of 2w54A

query
sites
2w54A

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binding flavin-adenine dinucleotide: G42 (= G42), L189 (≠ V206), A191 (= A208), G192 (= G209), G193 (= G210), T194 (= T211), D195 (= D212), V196 (≠ L213), W199 (= W216), L213 (= L230), F258 (≠ L277), A259 (≠ G278), A267 (≠ G286), T268 (= T287), G271 (= G290), N272 (= N291), A274 (= A293), N275 (≠ T294), G280 (= G299), D281 (= D300), R318 (≠ L337), V324 (≠ I343), Q347 (= Q366)
binding fe2/s2 (inorganic) cluster: G38 (= G38), C39 (= C39), N40 (≠ G40), G42 (= G42), C44 (= C44), G45 (= G45), C47 (= C47), C63 (= C59), C103 (= C98), G104 (= G99), C106 (= C101), C134 (= C133), R135 (= R134), C136 (= C135)
binding {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-di(sulfanyl-kappaS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(hydroxy)oxo(thioxo)molybdenum: Q102 (= Q97), C136 (= C135)

4uhxA Human aldehyde oxidase in complex with phthalazine and thioridazine (see paper)
29% identity, 84% coverage: 58:456/474 of query aligns to 70:492/1290 of 4uhxA

query
sites
4uhxA

S

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L

L

N

P

P

P

I

L

L

H

A

V

V

L

G

D

N

A

C

T

T

V

L

T

N

V

L

Q

L

S

S

A

K

E

E

G

G

T

K

R

R

H

Q

L

I

P

P

I

L

A

N

S

E

L

Q

I

F

T

L

G

S

P

K

G

C

Q

P

T

N

A

A

-

D

L

L

M

K

P

P

G

Q

E

E

I

I

I
x
L

S

V

A

S

V

V

I

N

I

I

P

P

K

Y

P

S

A

R

A

K

D

W

A

E

R

F

Q

V

H

S

F

A

E

F

K

R

V

Q

G

A

L

Q

R

R

Q

Q

A

E

M

N

A

A

C
x
L

A

A

V

I

A

V

S

N

L

S

A

G

A

M

V

R

V

V

T

F

F

F

D

G

D

E

T

G

G

D

G

G

I

I

D

I

R

R

A

E

R

L

-

C

L

I

A

S

W

Y

G

G

S

G

V

V

G

G

P

P

T

A

V

T

V

I

R

C

L

A

P

K

E

N

V

S

E

C

A

Q

A

K

L

L

C

I

G

G

G

R

R

H

L

W

D

N

Q

E

K

Q

T

M

L

L

D

D

A

I

L

A

R

C

P

R

L

L

V

I

S

L

R

N

H

E

L

V

S

S

P

L

I

L

S

G

D

S

V

A

R

P

A

G

G

G

-

K

A

V

D

E

Y

F

R

K

R

R

R

T

V

L

A

I

G

I

N

S

L

F

L

L

L

F

R

K

L

F

binding flavin-adenine dinucleotide: P229 (≠ R205), V230 (= V206), I231 (≠ F207), M232 (≠ A208), G233 (= G209), N234 (≠ G210), T235 (= T211), S236 (≠ D212), V237 (≠ L213), L310 (= L277), A311 (≠ G278), A319 (≠ G286), S320 (≠ T287), G323 (= G290), H324 (≠ N291), I326 (≠ A293), H329 (≠ S296), S332 (≠ G299), D333 (= D300), L377 (≠ I343), L404 (≠ C370)
binding fe2/s2 (inorganic) cluster: C71 (= C59), C111 (= C98), G112 (= G99), C114 (= C101), C146 (= C133), C148 (= C135)

Sites not aligning to the query:

active site: 732, 767, 843, 847, 875, 1223, 1224
binding flavin-adenine dinucleotide: 43, 44
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69
binding 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine: 540, 542, 543, 1014, 1015, 1018, 1019, 1020, 1079
binding 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine: 540, 542, 543, 1014, 1015, 1018, 1019, 1020

3zyvB Crystal structure of the mouse liver aldehyde oxidase 3 (maox3) (see paper)
30% identity, 96% coverage: 5:459/474 of query aligns to 6:483/1262 of 3zyvB

query
sites
3zyvB

F

F

E

F

L

V

N

N

G

G

K

K

P

K

I

V

C

T

-

E

L

R

D

N

A

A

P

D

A

P

D

E

R

V

R

N

A

L

V

L

D

F

L

Y

L

L

R

R

E

K

D

V

L

I

G

R

L

L

T

T

G

G

T

T

K

K

E
x
Y

G

G

C
|
C

G
|
G

T

G

G
|
G

E

D

C
|
C

G

G

A

A

C
|
C

T

T

I

V

L

M

V

I

D

S

G

R

R

Y

S

D

R

P

L

I

S

S

-

K

-

R

-

I

-

S

-

H

-

F

-

S

-

A

-
x
T

-

A

C
|
C

L

L

M

V

L

P

V

I

P

C

Q

S

L

L

E

H

G

G

R

A

K

A

I

V

T

T

I

V

E

E

G

G

L

I

A

G

P

S

G

T

E

K

-

T

H

R

L

I

H

H

P

P

V

V

Q

Q

A

E

A

R

F

I

V

A

R

K

H

G

G

H

A

G

V

T

Q

Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

M

M

V

V

L

M

T

S

A

I

V

Y

D

T

L

L

A

R

R

N

H

H

P

P

E

E

P

P

R

S

H

T

D

E

E

Q

V

I

I

M

E

E

A

T

V

L

S

G

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

R

K

P

I

I

V

V

S

E

A

S

V

A

M

-

D

-

A

K

G

S

N

F

T

C

P

P

P

T

M

K

P

L

C

Y

S

E

R

K

Q

K

E

E

P

F

A

Q

P

P

-

L

D

D

P

P

-

T

-

Q

-

E

-

L

-

I

-

F

P

P

N

E

G

L

L

M

R

R

N

M

A

A

G

E

R

Q

P

N

G

T

G

V

T

L

T

T

-

F

-

R

A

G

G

E

S

R

P

T

V

T

W

W

M

I

-

A

P

P

R

G

T

T

L

L

E

N

D

D

L

L

W

L

P

E

L

L

L

K

A

M

Q

K

Y

H

P

P

Q

S

A

A

R

P

V
x
L

F

V

A
x
I

G
|
G

G
x
N

T
|
T

D
x
Y

L
|
L

L

G

V

L

W

-

R

-

N

-

G

H

K

M

I

V

D

S

S

Y

P

P

A

I

L

I

I

I

G

S

L

P

E

A

R

R

I

I

D

L

A

E

L

L

R

F

G

V

I

V

A

T

E

N

T

T

P

K

D

Q

T

G

V

L

R

T

I

L

G

G

-
x
T

-

G

-

L

A

S

A

L

T

T

T

Q

H

V

E

K

A

N

L

V

L

L

A

S

D

D

P

-

L

V

V

V

S

S

R

R

-

L

-

P

-

K

-

E

-

K

-

T

-

Q

-

I

H

Y

F

C

P

A

V

L

L

L

K

K

Q

Q

A

-

L

L

R

K

T

T

L
|
L

G
x
A

S

G

P

Q

H

Q

I

I

R

R

H

N

V

V

G
x
A

T
x
S

I

L

G

G

G
|
G

N
x
H

L

I

A
x
I

T

S

A

R

S

L

P

P

A

T

G
x
S

D
|
D

T

L

L

N

P

P

P

I

L

L

H

G

V

I

L

G

D

N

A

C

T

I

V

L

T

N

V

V

Q

A

S

S

A

T

E

E

G

G

T

I

R

Q

H

Q

L

I

P

P

I

L

A

N

S

D

L

H

I

F

T

L

G

A

P

-

G

-

Q

-

T

A

A

I

L

L

M

K

P

P

G

E

E

Q

I

V

I
x
L

S

I

A

S

V

V

I

F

I

V

P

P

K

R

P

S

A

S

A

K

D

W

A

E

R

F

Q

V

H

S

F

A

E

F

K

R

V

Q

G

A

L

P

R

R

Q

Q

A

Q

M

N

A
|
A

C
x
F

A

A

V

T

A

V

S

N

L

A

A

G

A

M

V

K

V

V

T

V

F

F

-

K

D

E

D

D

T

T

G

N

G

T

I

I

D

T

R

D

A

L

R

G

L

I

A

L

W

Y

G

G

S

G

V

I

G

G

P

A

T

T

V

V

V

I

R

S

L

A

P

D

E

K

V

S

E

C

A

R

A

Q

L

L

C

I

G

G

G

R

R

C

L

W

D

D

Q

E

K

E

T

M

L

L

D

D

A

D

L

A

R

G

P

K

L

M

V

I

S

C

R

E

H

E

L

V

S

S

P

L

I

L

S

M

D

A

V

P

R

G

A

G

G

M

A

E

D

E

Y

Y

R

R

R

K

R

T

V

L

A

A

G

I

N

S

L

F

L

L

L

F

R

M

L

F

A

Y

D

L

D

D

binding flavin-adenine dinucleotide: L227 (≠ V206), I229 (≠ A208), G230 (= G209), N231 (≠ G210), T232 (= T211), Y233 (≠ D212), L234 (= L213), T267 (vs. gap), L303 (= L277), A304 (≠ G278), A312 (≠ G286), S313 (≠ T287), G316 (= G290), H317 (≠ N291), I319 (≠ A293), S325 (≠ G299), D326 (= D300), L366 (≠ I343), A392 (= A369), F393 (≠ C370)
binding fe2/s2 (inorganic) cluster: Y39 (≠ E37), C41 (= C39), G42 (= G40), G44 (= G42), C46 (= C44), C49 (= C47), T69 (vs. gap), C71 (= C59), C111 (= C98), G112 (= G99), C114 (= C101), C146 (= C133), C148 (= C135)

Sites not aligning to the query:

active site: 716, 751, 829, 833, 861, 1207, 1208

1t3qA Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
53% identity, 31% coverage: 1:147/474 of query aligns to 4:150/162 of 1t3qA

query
sites
1t3qA

M

M

K

R

I

I

E

S

F

A

E

T

L

I

N

N

G

G

K

K

P

P

I

R

C

V

L

F

D

Y

A

V

P

E

A

P

D

R

R

M

R

H

A

L

V

A

D

D

L

A

L

L

R

R

E

E

D

V

L

V

G

G

L

L

T

T

G

G

T

T

K

K

E
x
I

G

G

C
|
C

G
x
E

T

Q

G
|
G

E

V

C
|
C

G
|
G

A

S

C
|
C

T

T

I

I

L

L

V

I

D

D

G

G

R

A

S

P

R

M

L
x
R

S

S

C
|
C

L

L

M

T

L

L

V

A

P

V

Q

Q

L

A

E

E

G

G

R

C

K

S

I

I

T

E

T

T

I

V

E

E

G

G

L

L

A

S

P

Q

G

G

E

E

H

K

L

L

H

N

P

A

V

L

Q

Q

A

D

A

S

F

F

V

R

R

R

H

H

G

H

A

A

V

L

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

A

G

G

M

M

V

L

L

A

T

T

A

A

V

R

D

S

L

I

L

L

A

A

R

E

H

N

P

P

E

A

P

P

R

S

H

R

D

D

E

E

V

V

I

R

E

E

A

V

V

M

S

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

E

K

T

I

I

V

I

S

D

A

A

V

I

M

T

D

D

binding fe2/s2 (inorganic) cluster: I40 (≠ E37), C42 (= C39), E43 (≠ G40), G45 (= G42), C47 (= C44), G48 (= G45), C50 (= C47), R60 (≠ L57), C62 (= C59), C101 (= C98), G102 (= G99), C104 (= C101), C136 (= C133), C138 (= C135)
binding pterin cytosine dinucleotide: Q100 (= Q97), C138 (= C135)

7orcB Human aldehyde oxidase in complex with raloxifene (see paper)
29% identity, 84% coverage: 58:456/474 of query aligns to 70:491/1299 of 7orcB

query
sites
7orcB

S

A

C
|
C

L

L

M

I

L

P

V

I

P

C

Q

S

L

L

E

Y

G

G

R

A

K

A

I

V

T

T

I

V

E

E

G

G

L

I

A

G

P

S

G

T

E

H

-

T

H

R

L

I

H

H

P

P

V

V

Q

Q

A

E

A

R

F

I

V

A

R

K

H

C

G

H

A

G

V

T

Q

Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

M

M

V

V

L

M

T

S

A

I

V

Y

D

T

L

L

A

R

R

N

H

H

P

P

E

E

P

P

R

T

H

L

D

D

E

Q

V

L

I

T

E

D

A

A

V

L

S

G

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

R

K

P

I

I

V

I

S

D

A

A

V

C

M

K

D

T

A

F

G

-

N

-

T

C

P

K

P

P

M

K

P

L

C

F

S

A

R

E

Q

E

E

E

P

F

A

L

P

P

-

L

D

D

P

P

-

T

-

Q

-

E

-

L

-

I

-

F

P

P

N

E

G

L

L

M

R

I

N

M

A

A

G

E

R

K

P

Q

G

S

G

Q

T

R

T

T

-

R

-

V

A

F

G

G

S

S

P

E

-

R

-

M

V

M

W

W

M

F

-

S

P

P

R

V

T

T

L

L

E

K

D

E

L

L

W

L

P

E

L

F

L

K

A

F

Q

K

Y

Y

P

P

Q

Q

A

A

R
x
P

V
|
V

F
x
I

A
x
M

G
|
G

G
x
N

T
|
T

D
x
S

L
x
V

L

G

V

P

W

E

R

V

R

K

N

F

G

K

K

G

I

V

D

F

S

H

P

P

A

V

L

I

I

I

G

S

L

P

E

D

R

R

I

I

D

E

A

E

L

L

R

S

G

V

I

V

A

N

E

H

T

A

P

Y

D

N

T

G

V

L

R

T

I

L

G

G

A

A

A

G

T

L

T

S

H

L

-

A

-

Q

-

V

E

K

A

D

L

I

L

L

A

A

D

D

P

V

L

V

-

Q

-

K

-

L

-

P

-

E

V

K

S

T

R

Q

H

M

F

Y

P

H

V

A

L

L

K

L

Q

K

A

H

L

L

R

G

T

T

L
|
L

G
x
A

S

G

P

S

H

Q

I

I

R

R

H

N

V

M

G
x
A

T
x
S

I

L

G

G

G
|
G

N
x
H

L

I

A

I

T
x
S

A

R

S
x
H

P

P

A

D

G
x
S

D
|
D

T

L

L

N

P

P

P

I

L

L

H

A

V

V

L

G

D

N

A

C

T

T

V

L

T

N

V

L

Q

L

S

S

A

K

E

E

G

G

T

K

R

R

H

Q

L

I

P

P

I

L

A

N

S

E

L

Q

I

F

T

L

G

S

P

K

G

C

Q

P

T

N

A

A

-

D

L

L

M

K

P

P

G

Q

E

E

I

I

I
x
L

S

V

A

S

V

V

I

N

I

I

P

P

K

Y

P

S

A

R

A

K

D

W

A

E

R

F

Q

V

H

S

F

A

E

F

K

R

V

Q

G

A

L

Q

R

R

Q

Q

A

E

M

N

A

A

C
x
L

A

A

V

I

A

V

S

N

L

S

A

G

A

M

V

R

V

V

T

F

F

F

D

G

D

E

T
x
G

G
x
D

G
|
G

I

I

D

I

R

R

A

E

R

L

-

C

L

I

A

S

W

Y

G

G

S

G

V

V

G

G

P

P

T

A

V

T

V

I

R

C

L

A

P

K

E

N

V

S

E

C

A

Q

A

K

L

L

C

I

G

G

G

R

R
x
H

L

W

D
x
N

Q

E

K

Q

T

M

L

L

D

D

A

I

L

A

R

C

P

R

L

L

V

I

S

L

R

N

H

E

L

V

S

S

P

L

I

L

S

G

D

S

V

A

R

P

A

G

G

G

-

K

A

V

D

E

Y

F

R

K

R

R

R

T

V

L

A

I

G

I

N

S

L

F

L

L

L

F

R

K

L

F

binding flavin-adenine dinucleotide: P228 (≠ R205), V229 (= V206), I230 (≠ F207), M231 (≠ A208), G232 (= G209), N233 (≠ G210), T234 (= T211), S235 (≠ D212), V236 (≠ L213), L309 (= L277), A310 (≠ G278), A318 (≠ G286), S319 (≠ T287), G322 (= G290), H323 (≠ N291), S326 (≠ T294), H328 (≠ S296), S331 (≠ G299), D332 (= D300), L376 (≠ I343), L403 (≠ C370)
binding fe2/s2 (inorganic) cluster: C71 (= C59), C111 (= C98), G112 (= G99), C114 (= C101), C146 (= C133), C148 (= C135)
binding raloxifene: G417 (≠ T384), D418 (≠ G385), G419 (= G386), H449 (≠ R415), N451 (≠ D417)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 43, 44
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 716
binding raloxifene: 506, 507, 616, 619, 740, 743, 746

8emtA Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
28% identity, 84% coverage: 58:456/474 of query aligns to 70:478/1254 of 8emtA

query
sites
8emtA

S

A

C
|
C

L

L

M

I

L

P

V

I

P

C

Q

S

L

L

E

Y

G

G

R

A

K

A

I

V

T

T

I

V

E

E

G

G

L

I

A

G

P

S

G

T

E

H

-

T

H

R

L

I

H

H

P

P

V

V

Q

Q

A

E

A

R

F

I

V

A

R

K

H

C

G

H

A

G

V

T

Q

Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

M

M

V

V

L

M

T

S

A

I

V

Y

D

T

L

L

A

R

R

N

H

H

P

P

E

E

P

P

R

T

H

L

D

D

E

Q

V

L

I

T

E

D

A

A

V

L

S

G

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

R

K

P

I

I

V

I

S

-

A

-

V

-

M

-

D

D

A

A

G

C

N

K

T

T

P

-

M

-

P

F

C

C

S

K

R

T

Q

T

E

Q

P

E

A

L

P

I

D

F

P

P

P

E

N

L

G

M

L

I

-

M

-

A

-

E

R

K

N

Q

A

S

G

Q

R

R

P

T

G

R

G

V

T

F

T

G

A

S

G

E

S

R

P

M

V

M

W

W

M

F

-

S

P

P

R

V

T

T

L

L

E

K

D

E

L

L

W

L

P

E

L

F

L

K

A

F

Q

K

Y

Y

P

P

Q

Q

A

A

R
x
P

V
|
V

F
x
I

A
x
M

G
|
G

G

N

T
|
T

D
x
S

L
x
V

L

G

V

P

W

E

R

V

R

K

N

F

G

K

K

G

I

V

D

F

S

H

P

P

A

V

L

I

I

I

G

S

L

P

E

D

R

R

I

I

D

E

A

E

L

L

R

S

G

V

I

V

A

N

E

H

T

A

P

Y

D

N

T

G

V

L

R

T

I

L

G

G

A

A

A

G

T

L

T

S

H

L

-

A

-

Q

-

V

E

K

A

D

L

I

L

L

A

A

D

D

P

V

L

V

-

Q

-

K

-

L

-

P

-

E

V

K

S

T

R

Q

H

M

F

Y

P

H

V

A

L

L

K

L

Q

K

A

H

L

L

R

G

T

T

L
|
L

G
x
A

S

G

P

S

H

Q

I

I

R

R

H

N

V

M

G

A

T
x
S

I

L

G

G

G
|
G

N
x
H

L

I

A
x
I

T

S

A

R

S

H

P

P

A

D

G

S

D
|
D

T

L

L

N

P

P

P

I

L

L

H

A

V

V

L

G

D

N

A

C

T

T

V

L

T

N

V

L

Q

L

S

S

A

K

E

E

G

G

T

K

R

R

H

Q

L

I

P

P

I

L

A

N

S

E

L

Q

I

F

T

L

G

S

P

K

G

C

Q

P

T

N

A

A

-

D

L

L

M

K

P

P

G

Q

E

E

I

I

I

L

S

V

A

S

V

V

I

N

I

I

P

P

K

Y

P

S

A

R

A

K

D

W

A

E

R

F

Q

V

H

S

F

A

E

F

K

R

V

Q

G

A

L

Q

R

R

Q

Q

A

E

M

N

A

A

C

L

A

A

V

I

A

V

S

N

L

S

A

G

A

M

V

R

V

V

T

F

F

F

D

G

D

E

T

G

G

D

G

G

I

I

D

I

R

R

A

E

R

L

-

C

L

I

A

S

W

Y

G

G

S

G

V

V

G

G

P

P

T

A

V

T

V

I

R

C

L

A

P

K

E

N

V

S

E

C

A

Q

A

K

L

L

C

I

G

G

G

R

R

H

L

W

D

N

Q

E

K

Q

T

M

L

L

D

D

A

I

L

A

R

C

P

R

L

L

V

I

S

L

R

N

H

E

L

V

S

S

P

L

I

L

S

G

D

S

V

A

R

P

A

G

G

G

-

K

A

V

D

E

Y

F

R

K

R

R

R

T

V

L

A

I

G

I

N

S

L

F

L

L

L

F

R

K

L

F

binding flavin-adenine dinucleotide: P215 (≠ R205), V216 (= V206), I217 (≠ F207), M218 (≠ A208), G219 (= G209), T221 (= T211), S222 (≠ D212), V223 (≠ L213), L296 (= L277), A297 (≠ G278), S306 (≠ T287), G309 (= G290), H310 (≠ N291), I312 (≠ A293), D319 (= D300)
binding fe2/s2 (inorganic) cluster: C71 (= C59), C111 (= C98), G112 (= G99), C114 (= C101), C146 (= C133), C148 (= C135)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 45, 46, 49, 69

8emtB Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
28% identity, 84% coverage: 58:456/474 of query aligns to 68:473/1221 of 8emtB

query
sites
8emtB

S

A

C
|
C

L

L

M

I

L

P

V

I

P

C

Q

S

L

L

E

Y

G

G

R

A

K

A

I

V

T

T

I

V

E

E

G

G

L

I

A

G

P

S

G

T

E

H

-

T

H

R

L

I

H

H

P

P

V

V

Q

Q

A

E

A

R

F

I

V

A

R

K

H

C

G

H

A

G

V

T

Q

Q

C
|
C

G

G

F

F

C
|
C

T

T

P

P

G

G

M

M

V

V

L

M

T

S

A

I

V

Y

D

T

L

L

A

R

R

N

H

H

P

P

E

E

P

P

R

T

H

L

D

D

E

Q

V

L

I

T

E

D

A

A

V

L

S

G

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

R

K

P

I

I

V

I

S

D

A

A

V

C

M

K

D

T

A

F

G

C

N

K

T

E

P

L

P

I

M

F

P

P

C

-

S

-

R

-

Q

-

E

-

P

-

A

-

P

P

D

E

P

L

P

M

P

I

N

M

G

A

L

E

R

K

N

Q

A

S

G

Q

R

R

P

T

G

R

G

V

T

F

T

G

A

S

G

E

S

R

P

M

V

M

W

W

M

F

-

S

P

P

R

V

T

T

L

L

E

K

D

E

L

L

W

L

P

E

L

F

L

K

A

F

Q

K

Y

Y

P

P

Q

Q

A

A

R
x
P

V
|
V

F

I

A
x
M

G
|
G

G

N

T
|
T

D
x
S

L
x
V

L

G

V

P

W

E

R

V

R

K

N

F

G

K

K

G

I

V

D

F

S

H

P

P

A

V

L

I

I

I

G

S

L

P

E

D

R

R

I

I

D

E

A

E

L

L

R

S

G

V

I

V

A

N

E

H

T

A

P

Y

D

N

T

G

V

L

R

T

I

L

G

G

A

A

A

G

T

L

T

S

H

L

-

A

-

Q

-

V

E

K

A

D

L

I

L

L

A

A

D

D

P

V

L

V

-

Q

-

K

-

L

-

P

-

E

V

K

S

T

R

Q

H

M

F

Y

P

H

V

A

L

L

K

L

Q

K

A

H

L

L

R

G

T

T

L
|
L

G
x
A

S

G

P

S

H

Q

I

I

R

R

H

N

V

M

G
x
A

T

S

I

L

G

G

G
|
G

N
x
H

L

I

A
x
I

T

S

A

R

S

H

P

P

A

D

G

S

D
|
D

T

L

L

N

P

P

P

I

L

L

H

A

V

V

L

G

D

N

A

C

T

T

V

L

T

N

V

L

Q

L

S

S

A

K

E

E

G

G

T

K

R

R

H

Q

L

I

P

P

I

L

A

N

S

E

L

Q

I

F

T

L

G

S

P

K

G

C

Q

P

T

N

A

A

-

D

L

L

M

K

P

P

G

Q

E

E

I

I

I

L

S

V

A

S

V

V

I

N

I

I

P

P

K

Y

P

S

A

R

A

K

D

W

A

E

R

F

Q

V

H

S

F

A

E

F

K

R

V

Q

G

A

L

Q

R

R

Q

Q

A

E

M

N

A

A

C

L

A

A

V

I

A

V

S

N

L

S

A

G

A

M

V

R

V

V

T

F

F

F

D

G

D

E

T

G

G

D

G

G

I

I

D

I

R

R

A

E

R

L

-

C

L

I

A

S

W

Y

G

G

S

G

V

V

G

G

P

P

T

A

V

T

V

I

R

C

L

A

P

K

E

N

V

S

E

C

A

Q

A

K

L

L

C

I

G

G

G

R

R

H

L

W

D

N

Q

E

K

Q

T

M

L

L

D

D

A

I

L

A

R

C

P

R

L

L

V

I

S

L

R

N

H

E

L

V

S

S

P

L

I

L

S

G

D

S

V

A

R

P

A

G

G

G

-

K

A

V

D

E

Y

F

R

K

R

R

R

T

V

L

A

I

G

I

N

S

L

F

L

L

L

F

R

K

L

F

binding flavin-adenine dinucleotide: P210 (≠ R205), V211 (= V206), M213 (≠ A208), G214 (= G209), T216 (= T211), S217 (≠ D212), V218 (≠ L213), L291 (= L277), A292 (≠ G278), A300 (≠ G286), G304 (= G290), H305 (≠ N291), I307 (≠ A293), D314 (= D300)
binding fe2/s2 (inorganic) cluster: C69 (= C59), C109 (= C98), C112 (= C101), C144 (= C133), C146 (= C135)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 38, 39, 40, 42, 44, 45, 47

2e3tA Crystal structure of rat xanthine oxidoreductase mutant (w335a and f336l) (see paper)
28% identity, 95% coverage: 5:456/474 of query aligns to 6:491/1291 of 2e3tA

query
sites
2e3tA

F

F

E

F

L

V

N

N

G

G

K

K

P

K

I

V

C

V

-

E

L

K

D

N

A

A

P

D

A

P

D

E

R

T

A

L

V

L

D

V

L

Y

L

L

R

R

E

R

D

K

L

L

G

G

L

L

T

C

G

G

T

T

K

K

E

L

G
|
G

C
|
C

G
|
G

T

E

G
|
G

E

G

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

M

V

I

D

S

G

K

R

Y

S

D

R

R

L

L

-

Q

-

N

-

K

-

I

-

V

-

H

-

F

-

S

-

V

-
x
N

S

A

C
|
C

L

L

M

A

L

P

V

I

P

C

Q

S

L

L

E

H

G

H

R

V

K

A

I

V

T

T

I

V

E

E

G

G

L

I

A

G

P

N

G

T

E

Q

H

K

L

L

H

H

P

P

V

V

Q

Q

A

E

A

R

F

I

V

A

R

R

H

S

G

H

A

G

V

S

Q
|
Q

C
|
C

G

G

F

F

C
|
C

T

T

P

P

G

G

M

I

V

V

L

M

T

S

A

M

V

Y

D

T

L

L

A

R

R

N

H

Q

P

P

E

E

P

P

R

T

H

V

D

E

E

E

V

I

I

E

E

N

A

A

V

F

S

Q

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

R

K

P

I

I

V

L

S

Q

A

G

V

F

M

R

D

T

A

F

G

A

N

K

T

D

P

S

P

P

M

S

P

L

C

F

S

N

R

P

Q

E

E

D

P

F

A

K

P

P

-

L

D

D

P

P

-

T

-

Q

-

E

-

P

-

I

-

F

P

P

N

E

G

L

L

L

R

R

N

L

A

K

G

D

R

T

P

P

G

Q

G

K

T

K

-

L

-

R

T

F

A

E

G

G

S

E

P

R

V

V

-

T

W

W

M

I

P

Q

-

A

R

S

T

T

L

M

E

E

D

E

L

L

W

L

P

D

L

L

L

K

A

A

Q

Q

Y

H

P

P

Q

D

A

A

R
x
K

V
x
L

F
x
V

A
x
V

G
|
G

G
x
N

T
|
T

D
x
E

L
x
I

L

G

V

I

W

E

R

M

R

K

N

F

G

K

K

N

I

M

D

L

S

F

P

P

A

L

L

I

I

V

G

C

L

P

E

A

R

W

I

I

D

P

A

E

L

L

R

N

G

S

I

V

A

V

E

H

T

G

P

P

D

E

T

G

V

I

R

S

I

F

G

G

A

A

A

S

-

C

-

P

-

L

T

S

T

L

H

V

E

E

A

S

L

V

L

L

A

A

D

E

P

E

L

I

V

A

-

K

-

L

-

P

-

E

-

Q

-

K

S

T

R

E

H

V

F

F

P

R

V

G

L

V

K

M

Q

E

A

Q

L

L

R

R

T

A

L
|
L

G

A

S

G

P

K

H

Q

I

V

R

K

H

S

V

V

G
x
A

T
x
S

I

I

G

G

G
|
G

N
|
N

L

I

A
x
I

T
|
T

A

A

S

S

P

P

A

I

G
x
S

D
|
D

T

L

L

N

P

P

P

V

L

F

H

M

V

A

L

S

D

G

A

A

T

K

V

L

T

T

V

L

Q

V

S

S

A

-

E

R

G

G

T

T

R

R

H

R

L

T

P

V

I

R

A

M

S

D

L

H

I

T

T

F

G

F

P

P

G

G

-

Y

-

R

Q

K

T

T

A

L

L

L

M

R

P

P

G

E

E

E

I
|
I

I
x
L

S

L

A

S

V

I

I

E

I

I

P

P

-

Y

K

S

P

K

A

E

A

G

D

E

A

F

R

F

Q

S

H

A

F

F

E

K

K

Q

V

A

G

S

L

R

R

R

Q

E

A

D

M

D

A

I

C

A

A

K

V

V

A

T

S

S

L

G

A

M

A

R

V

V

V

L

T

F

F

K

D

P

D

G

T

T

G

I

G

E

I

V

D

Q

R

E

A

L

R

S

L

L

A

C

W

F

G

G

S

G

V

M

G

A

P

D

T

R

V

T

V

I

R

S

L

A

P

L

E

K

V

T

E

T

A

P

A

K

L

Q

C

L

G

S

G

K

R

S

L

W

D

N

Q

E

K

E

T

L

L

L

D

Q

A

S

L

V

R

C

P

A

L

G

V

L

S

A

R

E

H

E

L

L

S

Q

P

L

I

A

S

P

D

D

V

A

R

P

A

G

G

G

-

M

A

V

D

E

Y

F

R

R

R

T

V

L

A

T

G

L

N

S

L

F

R

K

L

F

binding flavin-adenine dinucleotide: G44 (= G42), K228 (≠ R205), L229 (≠ V206), V230 (≠ F207), V231 (≠ A208), G232 (= G209), N233 (≠ G210), T234 (= T211), E235 (≠ D212), I236 (≠ L213), L309 (= L277), A318 (≠ G286), S319 (≠ T287), G322 (= G290), N323 (= N291), I325 (≠ A293), T326 (= T294), S331 (≠ G299), D332 (= D300), I375 (= I342), L376 (≠ I343)
binding fe2/s2 (inorganic) cluster: G40 (= G38), C41 (= C39), G42 (= G40), G44 (= G42), C46 (= C44), G47 (= G45), C49 (= C47), N69 (vs. gap), C71 (= C59), Q109 (= Q97), C110 (= C98), C113 (= C101), C145 (= C133), C147 (= C135)

Sites not aligning to the query:

active site: 740, 775, 853, 857, 885, 1233, 1234
binding bicarbonate ion: 812, 813, 850, 882, 883, 887, 888, 891
binding calcium ion: 713, 714, 716, 809, 810, 840, 843, 844, 847, 880, 881
binding fe2/s2 (inorganic) cluster: 717
binding uric acid: 775, 853, 887, 982, 983, 1051, 1052, 1234

6a7xA Rat xanthine oxidoreductase, d428a variant, NAD bound form
28% identity, 95% coverage: 5:456/474 of query aligns to 6:491/1295 of 6a7xA

query
sites
6a7xA

F

F

E

F

L

V

N

N

G

G

K

K

P

K

I

V

C

V

-

E

L

K

D

N

A

A

P

D

A

P

D

E

R

T

A

L

V

L

D

V

L

Y

L

L

R

R

E

R

D

K

L

L

G

G

L

L

T

C

G

G

T

T

K

K

E

L

G
|
G

C
|
C

G
|
G

T

E

G
|
G

E

G

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

M

V

I

D

S

G

K

R

Y

S

D

R

R

L

L

-

Q

-

N

-

K

-

I

-

V

-

H

-

F

-

S

-

V

-
x
N

S

A

C
|
C

L

L

M

A

L

P

V

I

P

C

Q

S

L

L

E

H

G

H

R

V

K

A

I

V

T

T

I

V

E

E

G

G

L

I

A

G

P

N

G

T

E

Q

H

K

L

L

H

H

P

P

V

V

Q

Q

A

E

A

R

F

I

V

A

R

R

H

S

G

H

A

G

V

S

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

M

I

V

V

L

M

T

S

A

M

V

Y

D

T

L

L

A

R

R

N

H

Q

P

P

E

E

P

P

R

T

H

V

D

E

E

E

V

I

I

E

E

N

A

A

V

F

S

Q

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

R

K

P

I

I

V

L

S

Q

A

G

V

F

M

R

D

T

A

F

G

A

N

K

T

D

P

G

P

P

M

S

P

L

C

F

S

N

R

P

Q

E

E

D

P

F

A

K

P

P

-

L

D

D

P

P

-

T

-

Q

-

E

-

P

-

I

-

F

P

P

N

E

G

L

L

L

R

R

N

L

A

K

G

D

R

T

P

P

G

Q

G

K

T

K

-

L

-

R

T

F

A

E

G

G

S

E

P

R

V

V

-

T

W

W

M

I

P

Q

-

A

R

S

T

T

L

M

E

E

D

E

L

L

W

L

P

D

L

L

L

K

A

A

Q

Q

Y

H

P

P

Q

D

A

A

R
x
K

V
x
L

F
x
V

A
x
V

G
|
G

G
x
N

T
|
T

D
x
E

L
x
I

L

G

V

I

W

E

R

M

R

K

N

F

G

K

K

N

I

M

D

L

S

F

P

P

A

L

L

I

I

V

G

C

L

P

E

A

R

W

I

I

D

P

A

E

L

L

R

N

G

S

I

V

A

V

E

H

T

G

P

P

D

E

T

G

V

I

R

S

I

F

G

G

A

A

A

S

-

C

-

P

-

L

T

S

T

L

H

V

E

E

A

S

L

V

L

L

A

A

D

E

P

E

L

I

V

A

-

K

-

L

-

P

-

E

-

Q

-

K

S

T

R

E

H

V

F

F

P

R

V

G

L

V

K

M

Q

E

A

Q

L

L

R

R

T

W

L
x
F

G

A

S

G

P

K

H

Q

I
x
V

R

K

H

S

V

V

G

A

T
x
S

I

I

G

G

G
|
G

N
|
N

L

I

A
x
I

T
|
T

A

A

S

S

P
|
P

A

I

G

S

D
|
D

T

L

L

N

P

P

P

V

L

F

H

M

V

A

L

S

D

G

A

A

T

K

V

L

T

T

V

L

Q

V

S

S

A

-

E

R

G

G

T

T

R

R

H

R

L

T

P

V

I

R

A

M

S

D

L

H

I

T

T

F

G

F

P

P

G

G

-
x
Y

-
x
R

Q

K

T

T

A

L

L

L

M

R

P

P

G

E

E

E

I

I

I
x
L

S

L

A

S

V

I

I

E

I

I

P

P

-

Y

K

S

P

K

A

E

A

G

D

E

A

F

R

F

Q

S

H

A

F

F

E

K

K

Q

V

A

G

S

L

R

R

R

Q

E

A

A

M

D

A

I

C

A

A

K

V

V

A

T

S

S

L

G

A

M

A

R

V

V

V

L

T

F

F

K

D

P

D

G

T

T

G

I

G

E

I

V

D

Q

R

E

A

L

R

S

L

L

A

C

W

F

G

G

S

G

V

M

G
x
A

P
x
D

T

R

V

T

V

I

R

S

L

A

P

L

E

K

V

T

E

T

A

P

A

K

L

Q

C

L

G

S

G

K

R

S

L

W

D

N

Q

E

K

E

T

L

L

L

D

Q

A

S

L

V

R

C

P

A

L

G

V

L

S

A

R

E

H

E

L

L

S

Q

P

L

I

A

S

P

D

D

V

A

R
x
P

A

G