SitesBLAST

4ea8A X-ray crystal structure of perb from caulobacter crescentus in complex with coenzyme a and gdp-n-acetylperosamine at 1 angstrom resolution (see paper)
41% identity, 77% coverage: 45:231/243 of query aligns to 28:205/207 of 4ea8A

query
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4ea8A

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binding coenzyme a: H145 (≠ E171), F163 (≠ W189), G165 (= G191), V166 (≠ A192), A184 (= A210)
binding GDP-N-acetylperosamine: V35 (= V52), D36 (= D53), A37 (≠ D54), D50 (= D72), I68 (= I92), G69 (= G93)

Sites not aligning to the query:

4eaaA X-ray crystal structure of the h141n mutant of perosamine n- acetyltransferase from caulobacter crescentus in complex with coa and gdp-perosamine (see paper)
41% identity, 77% coverage: 45:231/243 of query aligns to 28:207/210 of 4eaaA

query
sites
4eaaA

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binding coenzyme a: P150 (= P174), F165 (≠ W189), V168 (≠ A192), A186 (= A210), I201 (≠ A225)
binding GDP-perosamine: V35 (= V52), D36 (= D53), A37 (≠ D54), D52 (= D72), I70 (= I92), G71 (= G93)

Sites not aligning to the query:

7txsA X-ray structure of the viob n-aetyltransferase from acinetobacter baumannii in the presence of a reaction intermediate (see paper)
33% identity, 87% coverage: 22:233/243 of query aligns to 1:206/209 of 7txsA

query
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7txsA

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binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-4-({3-[(2-{[(1S)-1-{[(2R,3S,4S,5R,6R)-4,5-dihydroxy-6-{[(R)-hydroxy{[(R)-hydroxy{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)oxolan-2-yl]methoxy}phosphoryl]oxy}phosphoryl]oxy}-2-methyloxan-3-yl]amino}ethyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate (non-preferred name): G10 (= G31), G11 (≠ D32), H12 (≠ Q33), D32 (= D53), N33 (≠ D54), T34 (= T55), K37 (≠ L58), I66 (= I92), G67 (= G93), K74 (≠ H102), I75 (≠ L103), P147 (= P174), G164 (= G191), A165 (= A192), M180 (≠ I207), G182 (= G209), M183 (≠ A210), V198 (≠ A225), L205 (= L232)

7txqA X-ray structure of the viob n-acetyltransferase from acinetobacter baumannii in the present of tdp and acetyl-coenzymea (see paper)
33% identity, 87% coverage: 22:233/243 of query aligns to 1:206/209 of 7txqA

query
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7txqA

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binding acetyl coenzyme *a: P147 (= P174), G164 (= G191), A165 (= A192), G182 (= G209), M183 (≠ A210), V198 (≠ A225), L205 (= L232)
binding thymidine-5'-diphosphate: G10 (= G31), G11 (≠ D32), H12 (≠ Q33), D32 (= D53), N33 (≠ D54), T34 (= T55), K37 (≠ L58), I66 (= I92), G67 (= G93)

7txpA X-ray structure of the viob n-acetyltransferase from acinetobacter baumannii in complex with tdp-4-amino-4,6-dideoxy-d-glucose (see paper)
33% identity, 87% coverage: 22:233/243 of query aligns to 1:206/209 of 7txpA

query
sites
7txpA

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binding dTDP-4-amino-4,6-dideoxyglucose: G10 (= G31), G11 (≠ D32), H12 (≠ Q33), D32 (= D53), N33 (≠ D54), T34 (= T55), K37 (≠ L58), I66 (= I92), G67 (= G93), I75 (≠ L103)

5t2yA Crystal structure of c. Jejuni pgld in complex with 5-methyl-4- (methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid (see paper)
27% identity, 86% coverage: 23:230/243 of query aligns to 4:190/192 of 5t2yA

query
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5t2yA

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G

G

L

I

Q

L

M

I

M

M

P

P

F

Y

A

V

L

V

V

I

H

N

V

A

D

K

A

A

V

K

V

I

G

E

D

K

Q

G

C

V

I

I

V

L

N

N

T

T

R

S

A

S

T

V

V

I

E

E

H

H

D

E

C

C

V

V

L

I

A

G

D

E

G

F

V

S

E

H

I

V

G
x
S

P

V

G

G

A

A

T

K

L

C

C

A

G

G

R

N

V

V

H

K

V

I

G

G

R

K

D

N

T

C

W
x
F

I

L

G
|
G

A
x
I

G

N

A

S

T

C

V

V

L

L

P

P

R

N

L

L

A

S

I

L

G

A

A

D

N

D

S

S

I

I

V

L

G

G

A
x
G

G

G

A

A

V

T

V

L

T

V

R

K

D

N

I

Q

P

D

D

E

N

K

V

G

V

V

V

F

A
x
V

G

G

N

V

P

P

A

A

K

K

binding 5-methyl-4-(methylamino)-2-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxylic acid: S133 (≠ G173), F149 (≠ W189), G151 (= G191), I152 (≠ A192), G170 (≠ A210), V185 (≠ A225)

Q0P9D1 UDP-N-acetylbacillosamine N-acetyltransferase; Protein glycosylation D; UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase; EC 2.3.1.203 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 2 papers)
27% identity, 86% coverage: 23:230/243 of query aligns to 5:193/195 of Q0P9D1

query
sites
Q0P9D1

H

E

R

K

I

I

V

Y

I

I

W

Y

G

G

A

A

G

S

D

G

Q
x
H

G

G

R

L

V

V

D

C

K

E

P

D

I

V

V

A

D

K

R

N

L

M

G

G

L

Y

G

K

L

E

A

C

A

I

M

F

V

L

D

D

T

F

P

K

G

G

L

M

A

K

P

-

F

-

P

-

G

-

V

-

P

-

L

-

Q

-

G

-

F

-

D

-

A

-

F

-

L

-

A

-

W

F

L

E

A

S

T

T

Q

L

Q

P

A

K

H

Y

D

D

L

-

S

-

F

F

V

F

I

I

A

A

I

I

G

G

N

N

P

-

Y

-

G

N

H

E

V

I

R

R

R

K

H

K

L

I

A

Y

Q

Q

K

K

L

I

A

S

A

E

L

N

G

G

L

F

S

K

P

I

F

V

S

N

L

L

I

I

D

H

P

K

T

S

A

A

M

L

V

I

S

S

A

P

G

S

V

A

V

I

L

V

-

E

G

N

T

A

G

G

L

I

Q

L

M

I

M

M

P

P

F

Y

A

V

L

V

V

I

H

N

V

A

D

K

A

A

V

K

V

I

G

E

D

K

Q

G

C

V

I

I

V

L

N
|
N

T

T

R

S

A

S

T

V

V

I

E
|
E

H
|
H

D

E

C

C

V

V

L

I

A

G

D

E

G

F

V

S

E
x
H

I

V

G

S

P

V

G

G

A

A

T

K

L

C

C

A

G

G

R

N

V

V

H

K

V

I

G

G

R

K

D

N

T

C

W

F

I

L

G

G

A
x
I

G

N

A

S

T

C

V

V

L

L

P

P

R

N

L

L

A

S

I

L

G

A

A

D

N

D

S

S

I

I

V

L

G

G

A
x
G

G

G

A

A

V

T

V

L

T

V

R

K

D

N

I

Q

P

D

D

E

N

K

V

G

V

V

V

F

A

V

G

G

N

V

P

P

A

A

K

K

H15 (≠ Q33) mutation to A: Induces a higher KM and approximate 3-fold decrease in the turnover number.
N118 (= N155) mutation to A: Reduction in catalytic activity.
E124 (= E161) mutation to A: Reduction in catalytic activity.
H125 (= H162) active site, Proton acceptor; mutation to A: Strong reduction in catalytic activity.
H134 (≠ E171) binding ; mutation to A: Slight reduction in catalytic activity.
I155 (≠ A192) binding
G173 (≠ A210) binding

3bssA Pgld from campylobacter jejuni, nctc 11168, with native substrate (see paper)
27% identity, 86% coverage: 23:230/243 of query aligns to 4:192/194 of 3bssA

query
sites
3bssA

H

E

R

K

I

I

V

Y

I

I

W

Y

G

G

A

A

G
x
S

D

G

Q
x
H

G

G

R

L

V

V

D

C

K

E

P

D

I

V

V

A

D

K

R

N

L

M

G

G

L

Y

G

K

L

E

A

C

A

I

M

F

V

L

D
|
D

T
x
F

P

K

G

G

L

M

A

K

P

-

F

-

P

-

G

-

V

-

P

-

L

-

Q

-

G

-

F

-

D

-

A

-

F

-

L

-

A

-

W

F

L

E

A

S

T

T

Q

L

Q

P

A

K

H

Y

D

D

L

-

S

-

F

F

V

F

I

I

A

A

I
|
I

G
|
G

N

N

P

-

Y

-

G

N

H

E

V
x
I

R

R

R

K

H

K

L

I

A

Y

Q

Q

K

K

L

I

A

S

A

E

L

N

G

G

L

F

S

K

P

I

F

V

S

N

L

L

I

I

D

H

P

K

T

S

A

A

M

L

V

I

S

S

A

P

G

S

V

A

V

I

L

V

-

E

G

N

T

A

G

G

L

I

Q

L

M

I

M

M

P

P

F

Y

A

V

L

V

V

I

H

N

V

A

D

K

A

A

V

K

V

I

G

E

D

K

Q

G

C

V

I

I

V

L

N

N

T

T

R

S

A

S

T

V

V

I

E

E

H

H

D

E

C

C

V

V

L

I

A

G

D

E

G

F

V

S

E

H

I

V

G

S

P

V

G

G

A

A

T

K

L

C

C

A

G

G

R

N

V

V

H

K

V

I

G

G

R

K

D

N

T

C

W

F

I

L

G

G

A

I

G

N

A

S

T

C

V

V

L

L

P

P

R

N

L

L

A

S

I

L

G

A

A

D

N

D

S

S

I

I

V

L

G

G

A

G

G

G

A

A

V

T

V

L

T

V

R

K

D

N

I

Q

P

D

D

E

N

K

V

G

V

V

V

F

A

V

G

G

N

V

P

P

A

A

K

K

binding UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose: S12 (≠ G31), H14 (≠ Q33), D34 (= D53), D35 (= D54), F36 (≠ T55), I54 (= I92), G55 (= G93), I59 (≠ V99)

2vheA Pgld-coa complex: an acetyl transferase from campylobacter jejuni (see paper)
27% identity, 86% coverage: 23:230/243 of query aligns to 4:192/194 of 2vheA

query
sites
2vheA

H

E

R

K

I

I

V

Y

I

I

W

Y

G

G

A

A

G

S

D

G

Q

H

G

G

R

L

V

V

D

C

K

E

P

D

I

V

V

A

D

K

R

N

L

M

G

G

L

Y

G

K

L

E

A

C

A

I

M

F

V

L

D

D

T

F

P

K

G

G

L

M

A

K

P

-

F

-

P

-

G

-

V

-

P

-

L

-

Q

-

G

-

F

-

D

-

A

-

F

-

L

-

A

-

W

F

L

E

A

S

T

T

Q

L

Q

P

A

K

H

Y

D

D

L

-

S

-

F

F

V

F

I

I

A

A

I

I

G

G

N

N

P

-

Y

-

G

N

H

E

V

I

R

R

R

K

H

K

L

I

A

Y

Q

Q

K

K

L

I

A

S

A

E

L

N

G

G

L

F

S

K

P

I

F

V

S

N

L

L

I

I

D

H

P

K

T

S

A

A

M

L

V

I

S

S

A

P

G

S

V

A

V

I

L

V

-

E

G

N

T

A

G

G

L

I

Q

L

M

I

M

M

P

P

F

Y

A

V

L

V

V

I

H

N

V

A

D

K

A

A

V

K

V

I

G

E

D

K

Q

G

C

V

I

I

V

L

N

N

T

T

R

S

A

S

T

V

V

I

E

E

H

H

D

E

C

C

V

V

L

I

A

G

D

E

G

F

V

S

E

H

I

V

G
x
S

P
x
V

G

G

A

A

T

K

L

C

C

A

G

G

R

N

V

V

H

K

V

I

G

G

R

K

D

N

T

C

W
x
F

I

L

G
|
G

A
x
I

G

N

A

S

T

C

V

V

L

L

P

P

R

N

L

L

A

S

I

L

G

A

A

D

N

D

S

S

I

I

V

L

G
|
G

A
x
G

G

G

A

A

V

T

V

L

T

V

R

K

D

N

I

Q

P

D

D

E

N

K

V

G

V

V

V

F

A
x
V

G

G

N

V

P

P

A

A

K

K

binding coenzyme a: S135 (≠ G173), V136 (≠ P174), F151 (≠ W189), G153 (= G191), I154 (≠ A192), G171 (= G209), G172 (≠ A210), V187 (≠ A225)

Sites not aligning to the query:

binding coenzyme a: 194

3bsyA Pgld from campylobacter jejuni, nctc 11168, in complex with acetyl coenzyme a (see paper)
27% identity, 86% coverage: 23:230/243 of query aligns to 3:191/193 of 3bsyA

query
sites
3bsyA

H

E

R

K

I

I

V

Y

I

I

W

Y

G

G

A

A

G

S

D

G

Q

H

G

G

R

L

V

V

D

C

K

E

P

D

I

V

V

A

D

K

R

N

L

M

G

G

L

Y

G

K

L

E

A

C

A

I

M

F

V

L

D

D

T

F

P

K

G

G

L

M

A

K

P

-

F

-

P

-

G

-

V

-

P

-

L

-

Q

-

G

-

F

-

D

-

A

-

F

-

L

-

A

-

W

F

L

E

A

S

T

T

Q

L

Q

P

A

K

H

Y

D

D

L

-

S

-

F

F

V

F

I

I

A

A

I

I

G

G

N

N

P

-

Y

-

G

N

H

E

V

I

R

R

R

K

H

K

L

I

A

Y

Q

Q

K

K

L

I

A

S

A

E

L

N

G

G

L

F

S

K

P

I

F

V

S

N

L

L

I

I

D

H

P

K

T

S

A

A

M

L

V

I

S

S

A

P

G

S

V

A

V

I

L

V

-

E

G

N

T

A

G

G

L

I

Q

L

M

I

M

M

P

P

F

Y

A

V

L

V

V

I

H

N

V

A

D

K

A

A

V

K

V

I

G

E

D

K

Q

G

C

V

I

I

V

L

N

N

T

T

R

S

A

S

T

V

V

I

E

E

H

H

D

E

C

C

V

V

L

I

A

G

D

E

G

F

V

S

E
x
H

I

V

G
x
S

P
x
V

G

G

A

A

T

K

L

C

C
x
A

G

G

R

N

V

V

H

K

V

I

G

G

R

K

D

N

T

C

W
x
F

I

L

G
|
G

A
x
I

G

N

A

S

T

C

V

V

L
|
L

P

P

R

N

L

L

A

S

I

L

G

A

A

D

N

D

S

S

I

I

V

L

G
|
G

A
x
G

G

G

A

A

V

T

V

L

T
x
V

R

K

D

N

I

Q

P

D

D

E

N

K

V

G

V

V

V

F

A
x
V

G

G

N

V

P
|
P

A

A

K

K

binding acetyl coenzyme *a: H132 (≠ E171), S134 (≠ G173), V135 (≠ P174), A140 (≠ C179), F150 (≠ W189), G152 (= G191), I153 (≠ A192), L158 (= L197), G170 (= G209), G171 (≠ A210), V176 (≠ T215), V186 (≠ A225), P189 (= P228)

5tyhA Pgld from campylobacter jejuni nctc 11168 in complex with 5-(2- furanyl)-1h-pyrazole-3-carboxylic acid (see paper)
31% identity, 65% coverage: 74:230/243 of query aligns to 29:183/185 of 5tyhA

query
sites
5tyhA

F

F

L

L

A

D

W

F

L

E

A

S

T

T

Q

L

Q

P

A

K

H

Y

D

D

L

-

S

-

F

F

V

F

I

I

A

A

I

I

G

G

N

N

P

-

Y

-

G

N

H

E

V

I

R

R

R

K

H

K

L

I

A

Y

Q

Q

K

K

L

I

A

S

A

E

L

N

G

G

L

F

S

K

P

I

F

V

S

N

L

L

I

I

D

H

P

K

T

S

A

A

M

L

V
x
I

S
|
S

A

P

G

S

V

A

V

I

L

V

-

E

G

N

T

A

G

G

L

I

Q

L

M

I

M

M

P

P

F

Y

A

V

L

V

V

I

H
x
N

V

A

D

K

A

A

V

K

V

I

G

E

D

K

Q

G

C

V

I

I

V

L

N
|
N

T

T

R

S

A

S

T

V

V

I

E

E

H

H

D

E

C

C

V

V

L

I

A

G

D

E

G

F

V

S

E

H

I

V

G
x
S

P
x
V

G

G

A

A

T

K

L

C

C

A

G

G

R

N

V

V

H

K

V

I

G

G

R

K

D

N

T

C

W
x
F

I

L

G
|
G

A
x
I

G

N

A

S

T

C

V

V

L

L

P

P

R

N

L

L

A

S

I

L

G

A

A

D

N

D

S

S

I

I

V

L

G

G

A
x
G

G

G

A

A

V

T

V

L

T

V

R

K

D

N

I

Q

P

D

D

E

N

K

V

G

V

V

V

F

A

V

G

G

N

V

P

P

A

A

K

K

binding 3-(furan-2-yl)-1H-pyrazole-5-carboxylic acid: I75 (≠ V124), S76 (= S125), N96 (≠ H143), N108 (= N155), S126 (≠ G173), V127 (≠ P174), F142 (≠ W189), G144 (= G191), I145 (≠ A192), G163 (≠ A210)

7l7yAAA Putative acetyl transferase protein (see paper)
32% identity, 68% coverage: 68:233/243 of query aligns to 48:217/217 of 7l7yAAA

query
sites
7l7yAAA

L

V

Q

N

G

G

F

Y

D

T

A

A

F

M

L

N

A

Y

W

T

L

K

A

F

T

K

Q

S

Q

I

A

K

H

N

D

D

L

D

S

K

F

F

V

V

-

L

I

I

A

A

I
|
I

G
x
A

N

N

P

S

Y

-

G

-

H

S

V

I

R

R

R

Q

H

K

L

I

A

A

Q

D

K

K

L

L

A

V

A

K

L

D

G

G

L

I

S

S

P

L

F

W

S

T

L

V

I

Q

D

G

P

M

T

T

A

T

M

L

V

I

S

M

A

D

G

E

V

V

V

S

L

I

G

D

T

A

G

G

L

A

Q

A

M

L

M

S

P

P

F

F

A

V

L

T

V

I

H

A

V

A

D

N

A

V

V

T

V

I

G

G

D

K

Q

C

C

F

I

H

V

A

N

N

T

L

R

Y

A

S

T

Y

V

V

E

E

H

H

D

D

C

C

V

I

L

I

A

G

D

D

G

Y

V

V

E

T

I

F

G

A

P

P

G

R

A

V

T

S

L

C

C

N

G

G

R

N

V

I

H

H

V

I

G

H

R

D

D

H

T

A

W
x
Y

I

I

G
|
G

A
x
T

G

G

A

A

T

V

V

I

L

K

P

Q

R

G

-

T

-

P

-

D

-

K

-

P

L

L

A

I

I

I

G

G

A

K

N

G

S

A

I

I

V

V

G
|
G

A
x
M

G

G

A

A

V

V

T

T

R

K

D

E

I

V

P

P

D

A

N

G

V

A

V

V

A
x
I

G

G

N

N

P

P

A

A

K

R

V

L

L

L

R

N

binding acetyl coenzyme *a: Y168 (≠ W189), G170 (= G191), T171 (≠ A192), G193 (= G209), M194 (≠ A210), I209 (≠ A225)
binding uridine-5'-diphosphate: I73 (= I92), A74 (≠ G93)

Sites not aligning to the query:

binding uridine-5'-diphosphate: 10, 12, 39, 40

7l82AAA Putative acetyl transferase protein (see paper)
32% identity, 68% coverage: 68:232/243 of query aligns to 48:216/216 of 7l82AAA

query
sites
7l82AAA

L

V

Q

N

G

G

F

Y

D

T

A

A

F

M

L

N

A

Y

W

T

L

K

A

F

T

K

Q

S

Q

I

A

K

H

N

D

D

L

D

S

K

F

F

V

V

-

L

I

I

A

A

I
|
I

G
x
A

N

N

P

S

Y

-

G

-

H

S

V

I

R

R

R

Q

H

K

L

I

A

A

Q

D

K

K

L

L

A

V

A

K

L

D

G

G

L

I

S

S

P

L

F

W

S

T

L

V

I

Q

D

G

P

M

T

T

A

T

M

L

V

I

S

M

A

D

G

E

V

V

V

S

L

I

G

D

T

A

G

G

L

A

Q

A

M

L

M

S

P

P

F

F

A

V

L

T

V

I

H

A

V

A

D

N

A

V

V

T

V

I

G

G

D

K

Q

C

C

F

I

H

V

A

N

N

T

L

R

Y

A

S

T

Y

V

V

E

E

H

H

D

D

C

C

V

I

L

I

A

G

D

D

G

Y

V

V

E

T

I

F

G

A

P

P

G

R

A

V

T

S

L

C

C

N

G

G

R

N

V

I

H

H

V

I

G

H

R

D

D

H

T

A

W
x
Y

I

I

G

G

A
x
T

G

G

A

A

T

V

V

I

L

K

P

Q

R

G

-

T

-

P

-

D

-

K

-

P

L

L

A

I

I

I

G

G

A

K

N

G

S

A

I

I

V

V

G
|
G

A
x
M

G

G

A

A

V

V

T

T

R

K

D

E

I

V

P

P

D

A

N

G

V

A

V

V

A
x
I

G

G

N

N

P

P

A

A

K

R

V

L

L

L

binding [(2~{R},3~{R},4~{S},5~{S},6~{R})-3-acetamido-5-[[(1~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanyl-ethyl]amino]-6-methyl-4-oxidanyl-oxan-2-yl] [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: I73 (= I92), A74 (≠ G93), Y168 (≠ W189), T171 (≠ A192), G193 (= G209), M194 (≠ A210), I209 (≠ A225)

Sites not aligning to the query:

binding [(2~{R},3~{R},4~{S},5~{S},6~{R})-3-acetamido-5-[[(1~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanyl-ethyl]amino]-6-methyl-4-oxidanyl-oxan-2-yl] [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: 10, 12, 39, 40

7l81AAA Putative acetyl transferase protein (see paper)
32% identity, 68% coverage: 68:232/243 of query aligns to 48:216/216 of 7l81AAA

query
sites
7l81AAA

L

V

Q

N

G

G

F

Y

D

T

A

A

F

M

L

N

A

Y

W

T

L

K

A

F

T

K

Q

S

Q

I

A

K

H

N

D

D

L

D

S

K

F

F

V

V

-

L

I

I

A

A

I
|
I

G
x
A

N

N

P

S

Y

-

G

-

H

S

V

I

R

R

R

Q

H

K

L

I

A

A

Q

D

K

K

L

L

A

V

A

K

L

D

G

G

L

I

S

S

P

L

F

W

S

T

L

V

I

Q

D

G

P

M

T

T

A

T

M

L

V

I

S

M

A

D

G

E

V

V

V

S

L

I

G

D

T

A

G

G

L

A

Q

A

M

L

M

S

P

P

F

F

A

V

L

T

V

I

H

A

V

A

D

N

A

V

V

T

V

I

G

G

D

K

Q

C

C

F

I

H

V

A

N

N

T

L

R

Y

A

S

T

Y

V

V

E

E

H

H

D

D

C

C

V

I

L

I

A

G

D

D

G

Y

V

V

E

T

I

F

G
x
A

P

P

G

R

A

V

T

S

L

C

C

N

G

G

R

N

V

I

H

H

V

I

G

H

R

D

D

H

T

A

W
x
Y

I

I

G

G

A
x
T

G

G

A

A

T

V

V

I

L

K

P

Q

R

G

-

T

-

P

-

D

-

K

-

P

L

L

A

I

I

I

G

G

A

K

N

G

S

A

I

I

V

V

G
|
G

A
x
M

G

G

A

A

V

V

T

T

R

K

D

E

I

V

P

P

D

A

N

G

V

A

V

V

A
x
I

G

G

N

N

P

P

A

A

K

R

V

L

L

L

binding coenzyme a: A152 (≠ G173), Y168 (≠ W189), T171 (≠ A192), G193 (= G209), M194 (≠ A210), I209 (≠ A225)
binding UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose: I73 (= I92), A74 (≠ G93)

Sites not aligning to the query:

binding UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose: 10, 12, 39, 40

7l7zAAA Putative acetyl transferase protein (see paper)
32% identity, 68% coverage: 68:232/243 of query aligns to 48:216/216 of 7l7zAAA

query
sites
7l7zAAA

L

V

Q

N

G

G

F

Y

D

T

A

A

F

M

L

N

A

Y

W

T

L

K

A

F

T

K

Q

S

Q

I

A

K

H

N

D

D

L

D

S

K

F

F

V

V

-

L

I

I

A

A

I
|
I

G
x
A

N

N

P

S

Y

-

G

-

H

S

V

I

R

R

R

Q

H

K

L

I

A

A

Q

D

K

K

L

L

A

V

A

K

L

D

G

G

L

I

S

S

P

L

F

W

S

T

L

V

I

Q

D

G

P

M

T

T

A

T

M

L

V

I

S

M

A

D

G

E

V

V

V

S

L

I

G

D

T

A

G

G

L

A

Q

A

M

L

M

S

P

P

F

F

A

V

L

T

V

I

H

A

V

A

D

N

A

V

V

T

V

I

G

G

D

K

Q

C

C

F

I

H

V

A

N

N

T

L

R

Y

A

S

T

Y

V

V

E

E

H

H

D

D

C

C

V

I

L

I

A

G

D

D

G

Y

V

V

E

T

I

F

G

A

P

P

G

R

A

V

T

S

L

C

C

N

G

G

R

N

V

I

H

H

V

I

G

H

R

D

D

H

T

A

W
x
Y

I

I

G

G

A
x
T

G

G

A

A

T

V

V

I

L

K

P

Q

R

G

-

T

-

P

-

D

-

K

-

P

L

L

A

I

I

I

G

G

A

K

N

G

S

A

I

I

V

V

G
|
G

A
x
M

G

G

A

A

V

V

T

T

R

K

D

E

I

V

P

P

D

A

N

G

V

A

V

V

A
x
I

G

G

N

N

P

P

A

A

K

R

V

L

L

L

binding coenzyme a: Y168 (≠ W189), T171 (≠ A192), G193 (= G209), M194 (≠ A210), I209 (≠ A225)
binding UDP-di-N-acetyl-alpha-bacillosamine: I73 (= I92), A74 (≠ G93)

Sites not aligning to the query:

binding UDP-di-N-acetyl-alpha-bacillosamine: 10, 12, 39, 40

4mzuB Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
33% identity, 45% coverage: 122:231/243 of query aligns to 23:139/290 of 4mzuB

query
sites
4mzuB

A

C

M

V

V

I

S

L

A

A

G

G

V

A

V

V

L

I

G

G

T

R

G

N

L

C

Q

N

M

I

M
x
C

P
x
A

F

N

A

S

L

L

V

I

H

E

V

N

D

D

A

V

V

V

V

I

G

G

D

D

Q

N

C

V

I

T

V

I

N

K

T

S

R
x
G

A

V

T

Q

V

I

E

W

H

D

D

G

C

I

V

H

L

I

A

Q

D

D

G

D

V

V

E
x
F

I

I

G

G

P

P

G
x
N

A

V

T

T

L

F

C
x
T

G
x
N

-
x
D

-
x
K

-

Q

-
x
P

-

R

-

S

-

L

R

K

V

T

H

I

V

V

G

K

R

K

D

G

T

A

W

S

I

I

G
|
G

A
|
A

G

N

A

S

T

T

V

I

L

L

P

P

R

G

L

I

A

L

I

I

G

G

A

E

N

N

S

A

I

M

V

V

G
|
G

A
|
A

G

G

A

A

V

V

V

I

T
|
T

R
x
K

D

N

I

V

P

P

D

D

N

N

V

A

V

I

V

V

A
x
I

G

G

N

N

P

P

A

G

K
x
R

V

I

binding coenzyme a: F72 (≠ E171), T80 (≠ C179), N81 (≠ G180), D82 (vs. gap), K83 (vs. gap), P85 (vs. gap), G99 (= G191), A100 (= A192), G117 (= G209), A118 (= A210), T123 (= T215), K124 (≠ R216), I133 (≠ A225), R138 (≠ K230)
binding magnesium ion: G58 (≠ R157), N76 (≠ G175)
binding thymine: C38 (≠ M137), A39 (≠ P138)

Sites not aligning to the query:

binding coenzyme a: 199
binding thymine: 20, 21
binding thymidine-5'-diphosphate: 171, 176, 189, 191, 202, 203, 270

4mzuF Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
33% identity, 45% coverage: 122:231/243 of query aligns to 23:140/294 of 4mzuF

query
sites
4mzuF

A

C

M

V

V

I

S

L

A

A

G

G

V

A

V

V

L

I

G

G

T

R

G

N

L

C

Q

N

M

I

M
x
C

P

A

F

N

A

S

L

L

V

I

H

E

V

N

D

D

A

V

V

V

V

I

G

G

D

D

Q

N

C

V

I

T

V

I

N

K

T

S

R

G

A

V

T

Q

V

I

E

W

H

D

D

G

C

I

V

H

L

I

A

Q

D

D

G

D

V

V

E

F

I

I

G

G

P

P

G

N

A

V

T

T

L

F

C

T

G
x
N

-
x
D

-
x
K

-

Q

-

P

-

R

-

S

-

K

-

I

R

K

V

T

H

I

V

V

G

K

R

K

D

G

T

A

W

S

I

I

G
|
G

A
|
A

G

N

A

S

T

T

V

I

L
|
L

P

P

R

G

L

I

A

L

I

I

G

G

A

E

N

N

S

A

I

M

V

V

G
|
G

A
|
A

G

G

A

A

V

V

V

I

T
|
T

R
x
K

D

N

I

V

P

P

D

D

N

N

V

A

V

I

V

V

A
x
I

G

G

N
|
N

P

P

A

G

K
x
R

V

I

binding coenzyme a: N81 (≠ G180), D82 (vs. gap), K83 (vs. gap), G100 (= G191), A101 (= A192), L106 (= L197), G118 (= G209), A119 (= A210), T124 (= T215), K125 (≠ R216), I134 (≠ A225), N136 (= N227), R139 (≠ K230)
binding thymine: C38 (≠ M137)

Sites not aligning to the query:

Query Sequence

>WP_083763388.1 NCBI__GCF_000009985.1:WP_083763388.1
MPNCPTKRLEPSFPPSARNWPVHRIVIWGAGDQGRVDKPIVDRLGLGLAAMVDDTPGLAP
PFPGVPLLQGFDAFLAWLATQQAHDLSFVIAIGNPYGHVRRHLAQKLAALGLSPFSLIDP
TAMVSAGVVLGTGLQMMPFALVHVDAVVGDQCIVNTRATVEHDCVLADGVEIGPGATLCG
RVHVGRDTWIGAGATVLPRLAIGANSIVGAGAVVTRDIPDNVVVAGNPAKVLRPNLVRAS
KHV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory