SitesBLAST
Comparing WP_084055988.1 NCBI__GCF_900176285.1:WP_084055988.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5exeA Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-tpp adduct (see paper)
36% identity, 97% coverage: 5:380/389 of query aligns to 6:390/394 of 5exeA
5exdD Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-di-oxido-methyl-tpp (coom-tpp) intermediate (see paper)
36% identity, 97% coverage: 5:380/389 of query aligns to 6:390/394 of 5exdD
- active site: R30 (≠ T29), E58 (= E57), R108 (= R107)
- binding [2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-[1,1,2-tris(oxidanyl)-2-oxidanylidene-ethyl]-1,3-thiazol-3-ium-5-yl]ethoxy-oxidanyl-phosphoryl] hydrogen phosphate: Y27 (= Y26), P28 (= P27), I29 (= I28), R30 (≠ T29), E58 (= E57), R108 (= R107), D115 (≠ N114)
5c4iA Structure of an oxalate oxidoreductase (see paper)
36% identity, 97% coverage: 5:380/389 of query aligns to 6:390/394 of 5c4iA
6ciqA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with coenzyme a bound (see paper)
28% identity, 93% coverage: 2:364/389 of query aligns to 2:375/1169 of 6ciqA
Sites not aligning to the query:
- active site: 999
- binding coenzyme a: 423, 424, 427, 428, 553, 586, 999
- binding magnesium ion: 966, 994, 996
- binding iron/sulfur cluster: 678, 680, 685, 686, 688, 689, 691, 695, 696, 700, 734, 741, 742, 743, 744, 745, 747, 751, 757, 807, 808, 811, 813, 836, 998, 1074, 1075
- binding thiamine diphosphate: 813, 835, 836, 865, 965, 966, 967, 996, 997, 998, 999, 1000
6cinB Crystal structure of pyruvate:ferredoxin oxidoreductase from moorella thermoacetica (see paper)
28% identity, 93% coverage: 2:364/389 of query aligns to 2:375/1169 of 6cinB
Sites not aligning to the query:
- active site: 999
- binding magnesium ion: 966, 994, 996
- binding iron/sulfur cluster: 455, 678, 685, 686, 687, 688, 689, 691, 695, 700, 741, 742, 743, 744, 745, 746, 747, 751, 752, 757, 758, 807, 808, 811, 813, 836, 998, 1074, 1075
- binding thiamine diphosphate: 834, 835, 836, 865, 965, 966, 967, 996, 997, 998, 999, 1000
6cioA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with lactyl-tpp bound (see paper)
28% identity, 93% coverage: 2:364/389 of query aligns to 2:375/1164 of 6cioA
Sites not aligning to the query:
- active site: 999
- binding magnesium ion: 966, 994, 996
- binding iron/sulfur cluster: 455, 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836, 1074, 1075
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: 813, 834, 835, 836, 865, 965, 966, 967, 996, 997, 998, 999, 1000
Q2RMD6 Pyruvate:ferredoxin oxidoreductase; PFOR; Pyruvate synthase; EC 1.2.7.1 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see paper)
28% identity, 93% coverage: 2:364/389 of query aligns to 3:376/1171 of Q2RMD6
Sites not aligning to the query:
- 424:428 binding CoA
- 456 binding CoA
- 556 binding CoA
- 598 binding CoA
- 686 binding [4Fe-4S] cluster
- 689 binding [4Fe-4S] cluster
- 692 binding [4Fe-4S] cluster
- 696 binding [4Fe-4S] cluster
- 742 binding [4Fe-4S] cluster
- 745 binding [4Fe-4S] cluster
- 748 binding [4Fe-4S] cluster
- 752 binding [4Fe-4S] cluster
- 809 binding [4Fe-4S] cluster
- 812 binding [4Fe-4S] cluster
- 814 binding thiamine diphosphate
- 837 binding [4Fe-4S] cluster; binding thiamine diphosphate
- 967 binding Mg(2+)
- 967:969 binding thiamine diphosphate
- 995 binding Mg(2+)
- 995:1000 binding thiamine diphosphate
- 997 binding Mg(2+)
- 1075 binding [4Fe-4S] cluster
6cipA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with acetyl-tpp bound (see paper)
28% identity, 93% coverage: 2:364/389 of query aligns to 2:375/1165 of 6cipA
Sites not aligning to the query:
- active site: 999
- binding 2-acetyl-thiamine diphosphate: 813, 834, 835, 836, 865, 965, 966, 967, 996, 998, 999
- binding magnesium ion: 966, 994, 996
- binding iron/sulfur cluster: 455, 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836, 998, 1074
P94692 Pyruvate:ferredoxin oxidoreductase; PFOR; POR; Pyruvate synthase; EC 1.2.7.1 from Desulfocurvibacter africanus (Desulfovibrio africanus) (see 3 papers)
28% identity, 90% coverage: 15:364/389 of query aligns to 17:379/1232 of P94692
- T31 (= T29) binding pyruvate
- E64 (= E57) binding thiamine diphosphate
- R114 (= R107) binding pyruvate
Sites not aligning to the query:
- 689 binding [4Fe-4S] cluster
- 692 binding [4Fe-4S] cluster
- 695 binding [4Fe-4S] cluster
- 699 binding [4Fe-4S] cluster
- 745 binding [4Fe-4S] cluster
- 748 binding [4Fe-4S] cluster
- 751 binding [4Fe-4S] cluster
- 755 binding [4Fe-4S] cluster
- 812 binding [4Fe-4S] cluster
- 815 binding [4Fe-4S] cluster
- 817 binding thiamine diphosphate
- 840 binding [4Fe-4S] cluster; binding thiamine diphosphate
- 962:965 binding thiamine diphosphate
- 963 binding Mg(2+)
- 983 binding Ca(2+)
- 985 binding Ca(2+)
- 991 binding Mg(2+)
- 991:996 binding thiamine diphosphate
- 993 binding Mg(2+)
- 1056 binding Ca(2+)
- 1059 binding Ca(2+)
- 1061 binding Ca(2+)
- 1063 binding Ca(2+)
- 1071 binding [4Fe-4S] cluster
7plmA Cryoem reconstruction of pyruvate ferredoxin oxidoreductase (pfor) in anaerobic conditions (see paper)
28% identity, 90% coverage: 15:364/389 of query aligns to 16:378/1177 of 7plmA
Sites not aligning to the query:
- binding calcium ion: 950, 952, 1026, 1028
- binding magnesium ion: 930, 958, 960, 962
- binding iron/sulfur cluster: 458, 657, 659, 664, 665, 666, 667, 668, 670, 674, 675, 679, 708, 715, 716, 717, 718, 719, 721, 725, 726, 731, 732, 781, 782, 785, 787, 810, 962, 1038, 1039
- binding thiamine diphosphate: 787, 808, 809, 810, 839, 929, 930, 931, 960, 961, 962, 963, 964
2c3uA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus, oxygen inhibited form (see paper)
28% identity, 90% coverage: 15:364/389 of query aligns to 16:378/1231 of 2c3uA
Sites not aligning to the query:
- active site: 995
- binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: 816, 837, 839, 868, 869, 961, 962, 963, 964, 992, 993, 994, 995, 996
- binding calcium ion: 982, 984, 1055, 1056, 1058, 1060, 1062
- binding magnesium ion: 962, 990, 992
- binding pyruvic acid: 995
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 811, 814, 816, 839, 1070, 1071
2c3pA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
28% identity, 90% coverage: 15:364/389 of query aligns to 16:378/1231 of 2c3pA
- active site: T30 (= T29), E63 (= E57), R113 (= R107)
- binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: P28 (= P27), I29 (= I28), T30 (= T29), E63 (= E57), Q87 (= Q81), R113 (= R107)
Sites not aligning to the query:
- active site: 995
- binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: 816, 837, 838, 839, 868, 869, 961, 962, 963, 992, 993, 994, 995, 996
- binding calcium ion: 982, 983, 984, 1055, 1056, 1058, 1060, 1062
- binding magnesium ion: 962, 990, 992
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839, 994, 1070, 1071
2c3oA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
28% identity, 90% coverage: 15:364/389 of query aligns to 16:378/1231 of 2c3oA
Sites not aligning to the query:
- active site: 995
- binding calcium ion: 982, 984, 1056, 1058, 1060
- binding magnesium ion: 962, 990, 992
- binding pyruvic acid: 996
- binding iron/sulfur cluster: 458, 681, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 746, 747, 748, 749, 750, 754, 760, 761, 810, 811, 814, 816, 839, 1070, 1071
- binding thiamine diphosphate: 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996
1kekA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase (see paper)
28% identity, 90% coverage: 15:364/389 of query aligns to 16:378/1231 of 1kekA
Sites not aligning to the query:
- active site: 995
- binding calcium ion: 982, 984, 1055, 1056, 1058, 1062
- binding 2-acetyl-thiamine diphosphate: 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996
- binding magnesium ion: 962, 990, 992
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 703, 737, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839, 1070, 1071
1b0pA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
28% identity, 90% coverage: 15:364/389 of query aligns to 16:378/1231 of 1b0pA
Sites not aligning to the query:
- active site: 995
- binding calcium ion: 982, 984, 1055, 1056, 1058, 1060
- binding magnesium ion: 962, 990, 992
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 737, 744, 745, 747, 748, 750, 754, 755, 760, 811, 814, 816, 839, 994, 1070, 1071
- binding thiamine diphosphate: 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996
6n2oC 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
26% identity, 89% coverage: 4:350/389 of query aligns to 201:556/572 of 6n2oC
Sites not aligning to the query:
- binding succinyl-coenzyme a: 14, 16, 17, 18, 19, 41, 43, 44, 45, 128, 131, 157, 168
6n2oA 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
26% identity, 89% coverage: 4:350/389 of query aligns to 201:556/572 of 6n2oA
Sites not aligning to the query:
6n2nA Crystal structure of 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus (see paper)
26% identity, 89% coverage: 4:350/389 of query aligns to 201:556/572 of 6n2nA
Q96XT2 2-oxoacid:ferredoxin oxidoreductase 2, subunit alpha; OFOR2; EC 1.2.7.11 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
24% identity, 87% coverage: 24:363/389 of query aligns to 252:611/628 of Q96XT2
- T257 (= T29) binding substrate
- R344 (= R107) binding substrate
5b47A 2-oxoacid:ferredoxin oxidoreductase 2 from sulfolobus tokodai - pyruvate complex (see paper)
24% identity, 87% coverage: 24:363/389 of query aligns to 251:610/627 of 5b47A
Query Sequence
>WP_084055988.1 NCBI__GCF_900176285.1:WP_084055988.1
MKKVVEGSHAVSEAVRLARVDVISAYPITPQTHIVELLSEYCSDGTLNARFLRVESEHSA
MAALIGAASAGVRTFTATSSQGLALMHELLHWAAGARLPIVMAEVNRALAPGWNIWTEQT
DSLAQRDTGWIQLYCEDAQEALDTTLQAFRLAETVHLPVMVVLDAFFLSHTYEPVDIPEP
EEADRFLPPFQPAFCLDTENPAAFNQLAPPNAYMEMRRSMQDAMESALDVLDAIEDDYER
LFGRRYGAVEAVHCDDADIILVTSGTITSTSRLVLRQLREKGEKVGLVKMKAFRPFPFEA
LRIHTAHAKKLAVIDRNFSFGAGGIFAQEIRSALCNLARRPLVFGYVAGLGGRDVTTDVI
EDIYWRTKTSAHPEAESIWIGLHQPAPAA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory