SitesBLAST
Comparing WP_084056338.1 NCBI__GCF_900176285.1:WP_084056338.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6jhbB Crystal structure of NADPH and 4-hydroxyphenylpyruvic acid bound aerf from microcystis aeruginosa (see paper)
41% identity, 98% coverage: 1:257/263 of query aligns to 1:260/264 of 6jhbB
- active site: G18 (= G18), S160 (= S157)
- binding 3-(4-hydroxy-phenyl)pyruvic acid: G147 (≠ S144), S149 (= S146), L157 (= L154), S160 (= S157), N164 (≠ R161)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G14 (= G14), S16 (= S16), A17 (≠ Q17), G18 (= G18), I19 (≠ L19), G38 (= G38), R39 (≠ L39), N40 (≠ D40), A65 (= A64), D66 (= D65), V67 (= V66), H68 (≠ T67), N93 (= N92), S94 (≠ A93), E95 (vs. gap), K119 (≠ N116), I145 (≠ M142), I146 (≠ T143), P190 (= P187), I193 (≠ T190), T195 (= T192), P196 (≠ E193), R197 (= R194)
5vpsA Crystal structure of an sdr from burkholderia ambifaria in complex with NADPH with a tcep adduct (see paper)
40% identity, 100% coverage: 1:263/263 of query aligns to 2:260/260 of 5vpsA
- active site: N138 (= N141), S154 (= S157), R158 (= R161), A198 (≠ V201)
- binding [(4~{S})-3-aminocarbonyl-1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]piperidin-4-yl]-tris(3-hydroxy-3-oxopropyl)phosphanium: A15 (≠ G14), S17 (= S16), G19 (= G18), L20 (= L19), A39 (≠ G38), R40 (≠ L39), T41 (≠ D40), D66 (= D65), I67 (≠ V66), N89 (= N92), A90 (= A93), G91 (= G94), G92 (= G95), S141 (= S144), S142 (≠ I145), L151 (= L154), S154 (= S157), R158 (= R161), P184 (= P187), G185 (= G188), L186 (≠ Y189), F187 (≠ T190), T189 (= T192), R191 (= R194), I192 (≠ V195), T195 (≠ L198)
5idyB Crystal structure of an oxidoreductase from burkholderia vietnamiensis in complex with NADP
39% identity, 100% coverage: 1:263/263 of query aligns to 6:264/264 of 5idyB
- active site: N142 (= N141), S158 (= S157), R162 (= R161), A202 (≠ V201)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: A19 (≠ G14), S21 (= S16), G23 (= G18), L24 (= L19), A43 (≠ G38), R44 (≠ L39), T45 (≠ D40), D70 (= D65), I71 (≠ V66), N93 (= N92), A94 (= A93), G95 (= G94), G96 (= G95), S145 (= S144), R162 (= R161), P188 (= P187), G189 (= G188), L190 (≠ Y189), F191 (≠ T190), T193 (= T192), R195 (= R194), I196 (≠ V195)
6jhaA Crystal structure of NADPH bound aerf from microcystis aeruginosa (see paper)
37% identity, 98% coverage: 1:257/263 of query aligns to 1:237/242 of 6jhaA
- active site: G18 (= G18), S145 (= S157)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G14 (= G14), S16 (= S16), I19 (≠ L19), G38 (= G38), R39 (≠ L39), N40 (≠ D40), D66 (= D65), V67 (= V66), N93 (= N92), S94 (≠ A93), E95 (≠ G94), K114 (≠ N116), I140 (≠ M142), L142 (= L154), P175 (= P187), T180 (= T192), R182 (= R194)
1o5iB Crystal structure of 3-oxoacyl-(acyl carrier protein) reductase (tm1169) from thermotoga maritima at 2.50 a resolution
41% identity, 98% coverage: 4:260/263 of query aligns to 1:231/234 of 1o5iB
- active site: G15 (= G18), S125 (= S144), L135 (= L154), Y136 (≠ I155), S138 (= S157), R142 (= R161)
- binding nicotinamide-adenine-dinucleotide: A11 (≠ G14), S13 (= S16), R14 (≠ Q17), G15 (= G18), I16 (≠ L19), R36 (≠ L39), D52 (≠ P63), L53 (≠ I76), G76 (= G95), R142 (= R161), R175 (= R194)
5va8A Crystal structure of short-chain dehydrogenase/reductase sdr from burkholderia phymatum in complex with NADP
38% identity, 99% coverage: 1:261/263 of query aligns to 3:259/261 of 5va8A
- active site: S142 (= S144), R159 (= R161)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: A16 (≠ G14), S18 (= S16), K19 (≠ Q17), G20 (= G18), L21 (= L19), A40 (≠ G38), R41 (≠ L39), T42 (≠ D40), D67 (= D65), I68 (≠ V66), N90 (= N92), A91 (= A93), G92 (= G94), G93 (= G95), R159 (= R161), P185 (= P187), G186 (= G188), I187 (≠ Y189), F188 (≠ T190), T190 (= T192)
- binding 3,3',3''-phosphanetriyltripropanoic acid: S142 (= S144), S143 (≠ I145), I149 (= I151), L152 (= L154), S155 (= S157), R159 (= R161), G186 (= G188), T196 (≠ L198)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
37% identity, 96% coverage: 5:257/263 of query aligns to 3:244/247 of 4jroC
- active site: G16 (= G18), S142 (= S144), Q152 (≠ L156), Y155 (≠ T159), K159 (≠ R161)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G14), S14 (= S16), R15 (≠ Q17), G16 (= G18), I17 (≠ L19), N35 (≠ C37), Y36 (≠ G38), N37 (≠ L39), G38 (≠ D40), S39 (≠ D41), N63 (≠ D65), V64 (= V66), N90 (= N92), A91 (= A93), I93 (≠ G95), I113 (≠ L115), S142 (= S144), Y155 (≠ T159), K159 (≠ R161), P185 (= P187), I188 (≠ T190), T190 (= T192)
3sjuA Hedamycin polyketide ketoreductase bound to NADPH (see paper)
38% identity, 95% coverage: 8:257/263 of query aligns to 1:251/255 of 3sjuA
- active site: G11 (= G18), S138 (= S144), Y151 (≠ S157), K155 (≠ R161), Y196 (≠ T202)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G7 (= G14), S10 (≠ Q17), A31 (≠ G38), R32 (≠ L39), D33 (= D40), C56 (≠ A64), D57 (= D65), V58 (= V66), S84 (≠ N92), A85 (= A93), G86 (= G94), I136 (≠ M142), Y151 (≠ S157), K155 (≠ R161), P181 (= P187), G182 (= G188), Y183 (= Y189), V184 (≠ T190), T186 (vs. gap), M188 (≠ L191)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
34% identity, 96% coverage: 8:259/263 of query aligns to 5:245/246 of 3osuA
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
33% identity, 96% coverage: 8:259/263 of query aligns to 2:238/239 of 3sj7A
- active site: G12 (= G18), S138 (= S144), Q148 (≠ L154), Y151 (≠ S157), K155 (≠ R161)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G14), S10 (= S16), R11 (≠ Q17), I13 (≠ L19), N31 (≠ C37), Y32 (≠ G38), A33 (≠ L39), G34 (≠ D40), S35 (≠ D41), A58 (= A64), N59 (≠ D65), V60 (= V66), N86 (= N92), A87 (= A93), T109 (≠ L115), S138 (= S144), Y151 (≠ S157), K155 (≠ R161), P181 (= P187), G182 (= G188)
3ai2A The crystal structure of l-sorbose reductase from gluconobacter frateurii complexed with NADPH (see paper)
33% identity, 99% coverage: 1:260/263 of query aligns to 1:261/263 of 3ai2A
- active site: G18 (= G18), S144 (= S144), Y157 (≠ S157), K161 (≠ R161)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G14 (= G14), S16 (= S16), S17 (≠ Q17), G18 (= G18), I19 (≠ L19), A38 (≠ G38), R39 (≠ L39), Q40 (≠ D40), V64 (≠ A64), D65 (= D65), V66 (= V66), N92 (= N92), G94 (= G94), N142 (≠ M142), Y157 (≠ S157), K161 (≠ R161), P187 (= P187), I190 (≠ T190), T192 (= T192), W195 (≠ R194)
4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution (see paper)
35% identity, 98% coverage: 3:259/263 of query aligns to 8:252/254 of 4ag3A
- active site: G23 (= G18), S148 (= S144), Y161 (≠ S157), K165 (≠ R161)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G14), S21 (= S16), R22 (≠ Q17), G23 (= G18), I24 (≠ L19), T44 (≠ D40), L68 (≠ A64), D69 (= D65), V70 (= V66), N96 (= N92), A97 (= A93), I146 (≠ M142), S148 (= S144), Y161 (≠ S157), K165 (≠ R161), P191 (= P187), G192 (= G188), F193 (≠ Y189), I194 (≠ T190), T196 (= T192), M198 (≠ R194), T199 (≠ V195)
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
35% identity, 98% coverage: 3:259/263 of query aligns to 1:242/244 of 6t77A
- active site: G16 (= G18), S138 (= S144), Y151 (≠ S157)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G14), S14 (= S16), R15 (≠ Q17), T37 (≠ D41), L58 (≠ A64), N59 (≠ D65), V60 (= V66), A87 (= A93), G88 (= G94), I89 (≠ G95)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
35% identity, 98% coverage: 3:259/263 of query aligns to 4:245/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G14), S17 (= S16), R18 (≠ Q17), I20 (≠ L19), T40 (≠ D41), N62 (≠ D65), V63 (= V66), N89 (= N92), A90 (= A93), I92 (≠ G95), V139 (≠ M142), S141 (= S144), Y154 (≠ S157), K158 (≠ R161), P184 (= P187), G185 (= G188), I187 (≠ T190), T189 (= T192), M191 (≠ R194)
3ai3C The crystal structure of l-sorbose reductase from gluconobacter frateurii complexed with NADPH and l-sorbose (see paper)
33% identity, 99% coverage: 1:260/263 of query aligns to 1:261/263 of 3ai3C
- active site: G18 (= G18), S144 (= S144), Y157 (≠ S157), K161 (≠ R161)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G14 (= G14), S16 (= S16), S17 (≠ Q17), G18 (= G18), I19 (≠ L19), A38 (≠ G38), R39 (≠ L39), Q40 (≠ D40), R43 (≠ E43), D65 (= D65), V66 (= V66), N92 (= N92), G94 (= G94), N142 (≠ M142), Y157 (≠ S157), K161 (≠ R161), P187 (= P187), G188 (= G188), I190 (≠ T190), T192 (= T192), W195 (≠ R194)
- binding alpha-L-sorbopyranose: A252 (≠ S251), F254 (≠ Q253)
- binding L-sorbose: G96 (≠ P96), E154 (≠ L154), Y157 (≠ S157), W195 (≠ R194)
Sites not aligning to the query:
3ai3A The crystal structure of l-sorbose reductase from gluconobacter frateurii complexed with NADPH and l-sorbose (see paper)
33% identity, 99% coverage: 1:260/263 of query aligns to 1:261/263 of 3ai3A
- active site: G18 (= G18), S144 (= S144), Y157 (≠ S157), K161 (≠ R161)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G14 (= G14), S16 (= S16), S17 (≠ Q17), G18 (= G18), I19 (≠ L19), A38 (≠ G38), R39 (≠ L39), Q40 (≠ D40), R43 (≠ E43), V64 (≠ A64), D65 (= D65), V66 (= V66), N92 (= N92), G94 (= G94), N142 (≠ M142), S144 (= S144), Y157 (≠ S157), K161 (≠ R161), P187 (= P187), G188 (= G188), I190 (≠ T190), T192 (= T192), W195 (≠ R194)
- binding L-sorbose: G96 (≠ P96), S144 (= S144), L151 (≠ I151), E154 (≠ L154), Y157 (≠ S157), G188 (= G188)
4k6fB X-ray crystal structure of a putative acetoacetyl-coa reductase from burkholderia cenocepacia bound to the co-factor NADP
36% identity, 96% coverage: 8:259/263 of query aligns to 2:243/245 of 4k6fB
- active site: G12 (= G18), N102 (≠ M108), S138 (= S144), Y151 (≠ S157), K155 (≠ R161)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G14), Y32 (≠ D40), S33 (≠ D41), N36 (≠ L44), V58 (≠ A64), D59 (= D65), V60 (= V66), A87 (= A93), G88 (= G94), I89 (≠ G95)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
35% identity, 98% coverage: 3:259/263 of query aligns to 1:242/244 of P0AEK2
- GASR 12:15 (≠ GASQ 14:17) binding NADP(+)
- T37 (≠ D41) binding NADP(+)
- NV 59:60 (≠ DV 65:66) binding NADP(+)
- N86 (= N92) binding NADP(+)
- Y151 (≠ S157) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ SNTVR 157:161) binding NADP(+)
- A154 (≠ V160) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (≠ R161) mutation to A: Defect in the affinity for NADPH.
- I184 (≠ T190) binding NADP(+)
- E233 (≠ A250) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
35% identity, 97% coverage: 5:259/263 of query aligns to 2:241/243 of 1q7bA
- active site: G15 (= G18), E101 (≠ M108), S137 (= S144), Q147 (≠ L154), Y150 (≠ S157), K154 (≠ R161)
- binding calcium ion: E232 (≠ A250), T233 (≠ S251)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G14), S13 (= S16), R14 (≠ Q17), T36 (≠ D41), N58 (≠ D65), V59 (= V66), N85 (= N92), A86 (= A93), G87 (= G94), I88 (≠ G95), S137 (= S144), Y150 (≠ S157), K154 (≠ R161), P180 (= P187), G181 (= G188), I183 (≠ T190)
P16544 Putative ketoacyl reductase; EC 1.3.1.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
35% identity, 95% coverage: 8:257/263 of query aligns to 7:257/261 of P16544
- 11:39 (vs. 12:40, 41% identical) binding NADP(+)
- D63 (= D65) binding NADP(+)
- K161 (≠ R161) binding NADP(+)
Query Sequence
>WP_084056338.1 NCBI__GCF_900176285.1:WP_084056338.1
MDLGLRGKVAFVAGASQGLGKAVAMELCREGARVAICGLDDPELPKAVEEIREATGAEII
GVPADVTQAEEAKGFIRKGLEHFGTVDILVNNAGGPPSRTFLEVDDEMWFQGIRLNLMST
IRMTREAVPVMMEKKWGRIINMTSISVKQPIDGLILSNTVRSGVVGLAKTLSNELAPYNI
TVNNVCPGYTLTERVRSLAAVTAEKEGTTPEEVIARWQSTIPMGRLGTPEEFAALVTFLA
SERAGYITGASIQIDGGWYKGVM
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory