SitesBLAST
Comparing WP_084057910.1 NCBI__GCF_900176285.1:WP_084057910.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5aovA Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
53% identity, 88% coverage: 35:326/330 of query aligns to 36:330/334 of 5aovA
- active site: L100 (= L99), R241 (= R237), D265 (= D261), E270 (= E266), H288 (= H284)
- binding glyoxylic acid: M52 (≠ T51), L53 (≠ I52), L53 (≠ I52), Y74 (= Y73), A75 (≠ G74), V76 (= V75), G77 (= G76), R241 (= R237), H288 (= H284)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: V76 (= V75), T104 (= T103), F158 (≠ L153), G159 (= G154), R160 (= R155), I161 (= I156), S180 (≠ A175), R181 (= R176), A211 (≠ H207), V212 (= V208), P213 (= P209), T218 (= T214), I239 (≠ T235), A240 (= A236), R241 (= R237), H288 (= H284), G290 (= G286)
6biiA Crystal structure of pyrococcus yayanosii glyoxylate hydroxypyruvate reductase in complex with NADP and malonate (re-refinement of 5aow) (see paper)
52% identity, 98% coverage: 2:326/330 of query aligns to 3:329/332 of 6biiA
- active site: L99 (= L99), R240 (= R237), D264 (= D261), E269 (= E266), H287 (= H284)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: V75 (= V75), T103 (= T103), G156 (= G152), F157 (≠ L153), G158 (= G154), R159 (= R155), I160 (= I156), A179 (= A175), R180 (= R176), S181 (vs. gap), K183 (= K177), V211 (= V208), P212 (= P209), E216 (= E213), T217 (= T214), V238 (≠ T235), A239 (= A236), R240 (= R237), D264 (= D261), H287 (= H284), G289 (= G286)
O58320 Glyoxylate reductase; EC 1.1.1.26 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
51% identity, 98% coverage: 2:326/330 of query aligns to 4:330/334 of O58320
2dbqA Crystal structure of glyoxylate reductase (ph0597) from pyrococcus horikoshii ot3, complexed with NADP (i41) (see paper)
51% identity, 98% coverage: 2:326/330 of query aligns to 4:330/333 of 2dbqA
- active site: L100 (= L99), R241 (= R237), D265 (= D261), E270 (= E266), H288 (= H284)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: V76 (= V75), T104 (= T103), L158 (= L153), G159 (= G154), R160 (= R155), I161 (= I156), S180 (≠ A175), R181 (= R176), T182 (≠ L179), A211 (≠ H207), V212 (= V208), P213 (= P209), T218 (= T214), I239 (≠ T235), A240 (= A236), R241 (= R237), D265 (= D261), H288 (= H284), G290 (= G286)
Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
44% identity, 85% coverage: 32:311/330 of query aligns to 33:306/313 of Q65CJ7
3bazA Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
44% identity, 85% coverage: 32:311/330 of query aligns to 31:304/311 of 3bazA
- active site: L98 (= L99), R230 (= R237), A251 (= A258), D254 (= D261), E259 (= E266), H277 (= H284)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: V74 (= V75), G149 (= G152), L150 (= L153), G151 (= G154), R152 (= R155), I153 (= I156), S172 (≠ A175), R173 (= R176), S174 (≠ K177), C201 (≠ V208), P202 (= P209), T207 (= T214), I228 (≠ T235), G229 (≠ A236), R230 (= R237), D254 (= D261), H277 (= H284), G279 (= G286)
2gcgA Ternary crystal structure of human glyoxylate reductase/hydroxypyruvate reductase (see paper)
41% identity, 96% coverage: 1:318/330 of query aligns to 3:323/324 of 2gcgA
- active site: L103 (= L99), R241 (= R237), D265 (= D261), E270 (= E266), H289 (= H284)
- binding (2r)-2,3-dihydroxypropanoic acid: L55 (≠ I52), S78 (≠ G74), V79 (= V75), G80 (= G76), R241 (= R237), H289 (= H284)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: V79 (= V75), T107 (= T103), G156 (= G152), G158 (= G154), I160 (= I156), G180 (≠ A175), R181 (= R176), R184 (= R181), C212 (≠ V208), S213 (≠ P209), T218 (= T214), I239 (≠ T235), R241 (= R237), D265 (= D261), H289 (= H284), G291 (= G286)
Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase; EC 1.1.1.79; EC 1.1.1.81 from Homo sapiens (Human) (see paper)
41% identity, 96% coverage: 1:318/330 of query aligns to 7:327/328 of Q9UBQ7
- VG 83:84 (= VG 75:76) binding substrate
- GRI 162:164 (= GRI 154:156) binding NADP(+)
- RQP--R 185:188 (≠ RKPLGR 176:181) binding NADP(+)
- S217 (≠ P209) binding NADP(+)
- I243 (≠ T235) binding NADP(+)
- R245 (= R237) binding substrate
- D269 (= D261) binding substrate
- HIGS 293:296 (≠ HVGS 284:287) binding substrate
- G295 (= G286) binding NADP(+)
6ih6A Phosphite dehydrogenase mutant i151r/p176r/m207a from ralstonia sp. 4506 in complex with non-natural cofactor nicotinamide cytosine dinucleotide
39% identity, 87% coverage: 33:318/330 of query aligns to 34:327/330 of 6ih6A
- binding [[(2S,3S,4R,5S)-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4R,5S)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate: T104 (= T103), R151 (≠ V151), G154 (= G154), A155 (≠ R155), V156 (≠ I156), D175 (≠ A175), A207 (≠ H207), V208 (= V208), P209 (= P209), T214 (= T214), A235 (≠ T235), C236 (≠ A236), R237 (= R237)
4e5mA Thermostable phosphite dehydrogenase e175a/a176r in complex with NADP (see paper)
35% identity, 96% coverage: 2:318/330 of query aligns to 4:326/329 of 4e5mA
- active site: L100 (= L99), R237 (= R237), D261 (= D261), E266 (= E266), H292 (= H284)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: K76 (≠ V75), L100 (= L99), T104 (= T103), G154 (= G154), A155 (≠ R155), I156 (= I156), R176 (= R176), L208 (≠ V208), P209 (= P209), T214 (= T214), P235 (≠ T235), C236 (≠ A236), R237 (= R237), H292 (= H284), G294 (= G286)
4e5pA Thermostable phosphite dehydrogenase a176r variant in complex with nad (see paper)
35% identity, 96% coverage: 2:318/330 of query aligns to 4:326/332 of 4e5pA
- active site: L100 (= L99), R237 (= R237), D261 (= D261), E266 (= E266), H292 (= H284)
- binding nicotinamide-adenine-dinucleotide: K76 (≠ V75), L100 (= L99), T104 (= T103), G154 (= G154), A155 (≠ R155), I156 (= I156), A175 (= A175), R176 (= R176), L208 (≠ V208), P209 (= P209), T214 (= T214), P235 (≠ T235), C236 (≠ A236), R237 (= R237), H292 (= H284)
4e5kA Thermostable phosphite dehydrogenase in complex with NAD and sulfite (see paper)
35% identity, 96% coverage: 2:318/330 of query aligns to 4:326/329 of 4e5kA
- active site: L100 (= L99), R237 (= R237), D261 (= D261), E266 (= E266), H292 (= H284)
- binding nicotinamide-adenine-dinucleotide: K76 (≠ V75), G77 (= G76), L100 (= L99), T104 (= T103), G152 (= G152), G154 (= G154), A155 (≠ R155), I156 (= I156), H174 (≠ T174), E175 (≠ A175), A176 (≠ R176), A207 (≠ H207), L208 (≠ V208), P209 (= P209), P235 (≠ T235), C236 (≠ A236), R237 (= R237), D261 (= D261), H292 (= H284), G294 (= G286)
- binding sulfite ion: M53 (≠ I52), L75 (≠ G74), K76 (≠ V75), G77 (= G76), L100 (= L99), R237 (= R237), H292 (= H284)
1wwkA Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
39% identity, 94% coverage: 1:310/330 of query aligns to 1:304/304 of 1wwkA
- active site: S96 (≠ L99), R230 (= R237), D254 (= D261), E259 (= E266), H278 (= H284)
- binding nicotinamide-adenine-dinucleotide: V100 (≠ T103), G146 (= G152), F147 (≠ L153), G148 (= G154), R149 (= R155), I150 (= I156), Y168 (≠ T174), D169 (≠ A175), P170 (≠ R176), V201 (= V208), P202 (= P209), T207 (= T214), T228 (= T235), S229 (≠ A236), D254 (= D261), H278 (= H284), G280 (= G286)
O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 3 papers)
35% identity, 90% coverage: 2:298/330 of query aligns to 8:297/533 of O43175