Comparing WP_084058689.1 NCBI__GCF_900176285.1:WP_084058689.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6y88B Igps (indole-3-glycerol phosphate synthase) from pseudomonas aeruginosa in complex with substrate inhibitor rcdrp (see paper)
47% identity, 96% coverage: 3:259/268 of query aligns to 5:263/265 of 6y88B
6y88G Igps (indole-3-glycerol phosphate synthase) from pseudomonas aeruginosa in complex with substrate inhibitor rcdrp (see paper)
46% identity, 88% coverage: 24:259/268 of query aligns to 17:250/253 of 6y88G
1vc4B Crystal structure of indole-3-glycerol phosphate synthase (trpc) from thermus thermophilus at 1.8 a resolution (see paper)
50% identity, 84% coverage: 35:260/268 of query aligns to 31:254/254 of 1vc4B
3t55A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with phenoxymethyl benzoic acid (pmba)
44% identity, 96% coverage: 3:259/268 of query aligns to 2:255/258 of 3t55A
3t44A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with indole glycerol phosphate (igp) amd anthranilate
44% identity, 98% coverage: 3:264/268 of query aligns to 2:259/259 of 3t44A
3t78A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with 5-fluoroanthranilate
44% identity, 98% coverage: 3:264/268 of query aligns to 2:257/257 of 3t78A
1lbfA Crystal structure of indole-3-glycerol phosphate syntase (igps)with reduced 1-(o-caboxyphenylamino)-1-deoxyribulose 5-phosphate (rcdrp) (see paper)
39% identity, 74% coverage: 54:250/268 of query aligns to 47:240/247 of 1lbfA
Sites not aligning to the query:
1jukA Indole-3-glycerolphosphate synthase from sulfolobus solfataricus in a trigonal crystal form (see paper)
39% identity, 74% coverage: 54:250/268 of query aligns to 47:240/247 of 1jukA
1igsA Indole-3-glycerolphosphate synthase from sulfolobus solfataricus at 2.0 a resolution (see paper)
39% identity, 74% coverage: 54:250/268 of query aligns to 47:240/247 of 1igsA
1a53A Complex of indole-3-glycerolphosphate synthase from sulfolobus solfataricus with indole-3-glycerolphosphate at 2.0 a resolution (see paper)
39% identity, 74% coverage: 54:250/268 of query aligns to 47:240/247 of 1a53A
3t40A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) complex with n-2-carboxyphenyl glycine (cpg)
42% identity, 98% coverage: 3:264/268 of query aligns to 2:248/251 of 3t40A
1jcmP Trpc stability mutant containing an engineered disulphide bridge and in complex with a cdrp-related substrate (see paper)
37% identity, 96% coverage: 3:259/268 of query aligns to 4:253/259 of 1jcmP
1piiA Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from escherichia coli refined at 2.0 angstroms resolution (see paper)
37% identity, 96% coverage: 3:259/268 of query aligns to 4:253/452 of 1piiA
Sites not aligning to the query:
4iwwA Computational design of an unnatural amino acid metalloprotein with atomic level accuracy (see paper)
36% identity, 75% coverage: 54:255/268 of query aligns to 47:245/247 of 4iwwA
3uzjA Designed protein ke59 r13 3/11h with benzotriazole (see paper)
34% identity, 74% coverage: 54:250/268 of query aligns to 47:240/247 of 3uzjA
3uz5A Designed protein ke59 r13 3/11h (see paper)
34% identity, 74% coverage: 54:250/268 of query aligns to 47:240/247 of 3uz5A
3uxdA Designed protein ke59 r1 7/10h with dichlorobenzotriazole (dbt) (see paper)
34% identity, 75% coverage: 54:255/268 of query aligns to 47:245/247 of 3uxdA
7etxA Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum (see paper)
35% identity, 96% coverage: 3:259/268 of query aligns to 6:256/472 of 7etxA
Sites not aligning to the query:
7etyA Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum in complex with reduced 1-(o-carboxyphenylamino)-1- deoxyribulose 5-phosphate (rcdrp) (see paper)
35% identity, 96% coverage: 3:259/268 of query aligns to 4:254/470 of 7etyA
Sites not aligning to the query:
4ou1A Crystal structure of a computationally designed retro-aldolase covalently bound to folding probe 1 [(6-methoxynaphthalen-2-yl) (oxiran-2-yl)methanol] (see paper)
34% identity, 75% coverage: 54:255/268 of query aligns to 47:245/247 of 4ou1A
>WP_084058689.1 NCBI__GCF_900176285.1:WP_084058689.1
MGILSKILEVKRREVQEARRREPLSRLQRRAQEAPPARPFVERLSAPGPAGANVIAEIKR
ASPSKGTIRSHLDPPSHAWAYQRAGAAALSVLTDRSFFQGSEQDLQSARTAVSLPVLRKD
FVIDEYQIYEARAMGADAVLLIVRAVSPSFLRDALSLCRELGLGALVEVHDERELETALA
CDAPLVGVNNRDLATFRTDIQTSIRLKTLLPAHTPLVAESGIGSRQDVETLLEAGIFNFL
VGTSLVRAPDPERALQSLLGTAPTRQGI
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory