SitesBLAST
Comparing WP_084703970.1 NCBI__GCF_000744815.1:WP_084703970.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2dcnA Crystal structure of 2-keto-3-deoxygluconate kinase from sulfolobus tokodaii complexed with 2-keto-6-phosphogluconate (alpha-furanose form)
27% identity, 85% coverage: 22:347/385 of query aligns to 3:307/308 of 2dcnA
- active site: G252 (= G292), A253 (= A293), G254 (= G294), D255 (= D295)
- binding adenosine-5'-diphosphate: D193 (≠ N231), K223 (= K262), G225 (= G264), P226 (= P265), G228 (= G267), V247 (= V287), G254 (= G294), I279 (≠ N319), S282 (≠ G322), V286 (≠ A326)
- binding 6-O-phosphono-beta-D-psicofuranosonic acid: G33 (= G53), F89 (≠ T109), Y105 (≠ F123), R107 (= R125), I136 (≠ T155), R165 (= R189), T251 (≠ L291), G252 (= G292), D255 (= D295), D291 (≠ C331)
Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
30% identity, 78% coverage: 50:350/385 of query aligns to 31:306/309 of Q53W83
- GAEVN 34:38 (≠ GSATN 53:57) binding substrate
- YYR 103:105 (≠ FYR 123:125) binding substrate
- R167 (= R189) binding substrate
- S193 (≠ N231) binding ATP
- 219:225 (vs. 262:268, 57% identical) binding ATP
- GAGD 248:251 (= GAGD 292:295) binding ATP
- D251 (= D295) binding substrate
- N275 (= N319) binding ATP
- D287 (≠ C331) binding substrate
1v1aA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
30% identity, 77% coverage: 50:345/385 of query aligns to 31:301/301 of 1v1aA
- active site: G248 (= G292), A249 (= A293), G250 (= G294), D251 (= D295)
- binding adenosine-5'-diphosphate: K219 (= K262), G221 (= G264), A222 (≠ P265), A249 (= A293), G250 (= G294), N275 (= N319), A279 (= A323)
- binding 2-keto-3-deoxygluconate: G34 (= G53), A35 (≠ S54), N38 (= N57), Y89 (≠ T109), R105 (= R125), R167 (= R189), G248 (= G292), D251 (= D295), D287 (≠ C331)
Sites not aligning to the query:
1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp (see paper)
30% identity, 76% coverage: 50:342/385 of query aligns to 31:298/300 of 1v1bA
- active site: G248 (= G292), A249 (= A293), G250 (= G294), D251 (= D295)
- binding adenosine-5'-triphosphate: K219 (= K262), G221 (= G264), A238 (≠ P282), F239 (≠ V283), V241 (= V285), G248 (= G292), A249 (= A293), G250 (= G294), N275 (= N319), A279 (= A323)
Q97U29 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase; 2-dehydro-3-deoxyglucono/galactono-kinase; 2-keto-3-deoxy-galactonokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; KDGal kinase; EC 2.7.1.178 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
24% identity, 81% coverage: 40:350/385 of query aligns to 21:313/313 of Q97U29
2varA Crystal structure of sulfolobus solfataricus 2-keto-3-deoxygluconate kinase complexed with 2-keto-3-deoxygluconate (see paper)
24% identity, 80% coverage: 40:347/385 of query aligns to 20:309/311 of 2varA
- active site: G254 (= G292), A255 (= A293), G256 (= G294), D257 (= D295)
- binding adenosine monophosphate: G227 (= G264), G230 (= G267), M259 (≠ F297), S284 (≠ G322), I288 (≠ A326)
- binding phosphoaminophosphonic acid-adenylate ester: K225 (= K262), G227 (= G264), S228 (≠ P265), G230 (= G267), G254 (= G292), A255 (= A293), G256 (= G294), D257 (= D295), M259 (≠ F297), I281 (≠ N319), S284 (≠ G322), I288 (≠ A326)
- binding 3-deoxy-alpha-D-erythro-hex-2-ulofuranosonic acid: G33 (= G53), S34 (= S54), Y89 (≠ T109), Y105 (≠ F123), R107 (= R125), I136 (≠ T155), R165 (= R189), G254 (= G292), D257 (= D295)
- binding 2-keto-3-deoxygluconate: G33 (= G53), S34 (= S54), Y89 (≠ T109), L103 (≠ I121), Y105 (≠ F123), R107 (= R125), I136 (≠ T155), R165 (= R189), T253 (≠ L291), G254 (= G292), D257 (= D295), D293 (≠ C331)
Sites not aligning to the query:
5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
28% identity, 74% coverage: 52:337/385 of query aligns to 27:297/306 of 5eynA
- active site: G246 (= G292), A247 (= A293), G248 (= G294), D249 (= D295)
- binding adenosine-5'-diphosphate: H91 (≠ F114), T217 (≠ K262), G219 (= G264), A220 (≠ P265), A238 (≠ P284), V239 (= V285), T244 (≠ G290), G246 (= G292), A247 (= A293), G248 (= G294), F251 (= F297), N279 (= N319), G282 (= G322), A283 (= A323)
- binding beryllium trifluoride ion: G246 (= G292), G248 (= G294), D249 (= D295)
- binding beta-D-fructofuranose: G28 (= G53), A29 (≠ S54), N32 (= N57), F96 (= F119), F98 (= F123), R159 (= R189), D249 (= D295)
Sites not aligning to the query:
3gbuA Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with atp
25% identity, 73% coverage: 24:305/385 of query aligns to 4:255/302 of 3gbuA
Sites not aligning to the query:
3ih0A Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with amp-pnp
25% identity, 73% coverage: 24:305/385 of query aligns to 5:256/304 of 3ih0A
Sites not aligning to the query:
5yggA Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
28% identity, 74% coverage: 52:337/385 of query aligns to 31:301/310 of 5yggA
- binding adenosine-5'-diphosphate: K188 (≠ V229), T221 (≠ K262), G223 (= G264), A242 (≠ P284), V243 (= V285), F255 (= F297), N283 (= N319), G286 (= G322), A287 (= A323)
- binding beta-D-fructofuranose: G32 (= G53), A33 (≠ S54), F100 (= F119), F102 (= F123), R163 (= R189), D253 (= D295)
Sites not aligning to the query:
Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
25% identity, 84% coverage: 24:347/385 of query aligns to 9:309/319 of Q8ZKR2
- D16 (= D31) binding 5-amino-1-(beta-D-ribosyl)imidazole
- G31 (= G53) binding 5-amino-1-(beta-D-ribosyl)imidazole
- Y101 (≠ F123) binding 5-amino-1-(beta-D-ribosyl)imidazole
- R162 (= R189) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A180 (≠ L222) binding K(+)
- A181 (= A223) binding K(+)
- A183 (= A225) binding K(+)
- G213 (= G255) binding K(+)
- D246 (≠ N289) binding K(+)
- T248 (≠ L291) binding K(+)
- D252 (= D295) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A287 (≠ V325) binding K(+)
- A290 (≠ R328) binding K(+)
- G292 (≠ A330) binding K(+)
4xckA Vibrio cholerae o395 ribokinase complexed with adp, ribose and cesium ion. (see paper)
28% identity, 77% coverage: 52:347/385 of query aligns to 38:304/306 of 4xckA
- active site: A249 (≠ G292), A250 (= A293), G251 (= G294), D252 (= D295)
- binding adenosine-5'-diphosphate: T220 (≠ K262), G222 (= G264), S223 (≠ P265), V242 (= V285), T247 (≠ G290), A250 (= A293), F254 (= F297), H276 (≠ N319), A279 (≠ G322), V283 (≠ A326)
- binding alpha-D-ribofuranose: G39 (= G53), K40 (≠ S54), N43 (= N57), A95 (≠ T109), I107 (= I121), I109 (≠ F123), E140 (= E159), T248 (≠ L291), D252 (= D295)
Sites not aligning to the query:
1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog (see paper)
25% identity, 84% coverage: 24:346/385 of query aligns to 5:297/297 of 1tz6A
- active site: C24 (≠ F50), F88 (= F114), G238 (= G292), A239 (= A293), G240 (= G294), D241 (= D295)
- binding phosphomethylphosphonic acid adenylate ester: N149 (≠ D187), K176 (≠ V229), E181 (= E234), S209 (≠ K262), G211 (= G264), A212 (≠ P265), G214 (= G267), A239 (= A293), G240 (= G294), F243 (= F297), N270 (= N319), G273 (= G322), A274 (= A323)
- binding 5-aminoimidazole ribonucleoside: D8 (≠ R27), D12 (= D31), G27 (= G53), F88 (= F114), Y90 (= Y124), R151 (= R189), M154 (≠ F192), D241 (= D295)
1tz3A Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
25% identity, 84% coverage: 24:347/385 of query aligns to 5:298/299 of 1tz3A