SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_084938412.1 NCBI__GCF_002095475.1:WP_084938412.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
75% identity, 99% coverage: 1:718/727 of query aligns to 1:719/719 of 6tnmA

query
sites
6tnmA

M

M

L

L

Y

Y

Q

K

G

G

D

D

T

T

L

L

S

Y

V

L

H

D

W

W

L

L

D

E

D

D

G

G

I

I

A

A

E

E

L

L

V

V

F

F

D

D

A

A

P

P

G

G

S

S

V

V

N

N

K

K

L

L

D

D

T

T

K

A

T

T

V

V

A

A

S

S

L

L

G

G

E

E

A

A

L

I

G

G

I

V

L

L

E

E

Q

Q

Q

Q

P

S

A

D

L

L

R

K

G

G

L

L

L

L

L

L

S

R

S

S

A

N

K

K

P

A

A

A

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F
|
F

L

L

S

S

L

L

F

F

D

L

A

V

P

P

E

E

E

E

K

Q

L

L

S

S

Q

Q

W

W

L

L

A

H

F

F

A

A

N

N

S

S

I

V

F

F

N

N

R

R

L

L

E

E

D

D

L

L

P

P

V

V

P

P

T

T

V

I

A

A

A

A

I

V

D

N

G

G

Y

Y

A

A

L

L

G

G

G
|
G

G

G

C

C

E
|
E

C

C

V

V

L

L

A

A

T

T

D

D

F

Y

R

R

I

L

A

A

T

T

P

P

T

D

A

L

R

R

I

I

G

G

L

L

P
|
P

E
|
E

T

T

K

K

L

L

G

G

I

I

M

M

P

P

G
|
G

F

F

G

G

G

G

S

S

V

V

R

R

L

M

P

P

R

R

L

M

L

L

G

G

A

A

D

D

S

S

A

A

L

L

E

E

I

I

I

I

A

A

A

A

G

G

K

K

D

D

I

V

D

G

G

A

N

D

S

Q

A

A

L

L

K

K

L

I

G

G

L

L

I

V

D

D

A

G

V

V

V

V

S

K

S

A

D

E

K

K

L

L

R

V

A

E

A

G

A

A

L

K

T

A

M

V

L

L

Q

R

D

Q

A

A

I

I

-

N

A

G

Q

D

G

L

S

D

W

W

Q

K

V

A

R

K

R

R

A

Q

P

P

K

K

L

L

N

E

P

P

L

L

K

K

L

L

S

S

P

K

I

I

E

E

A

A

A

T

M

M

S

S

F

F

T

T

I

I

A

A

K

K

S

G

M

M

V

V

M

A

Q

Q

T

T

A

A

G

G

K

K

H

H

Y

Y

P

P

A

A

P

P

I

I

T

T

A

A

V

V

K

K

T

T

I

I

E

E

A

A

A

A

A

A

S

R

L

F

H

G

R

R

D

E

D

E

A

A

L

L

K
x
N

L

L

E

E

T

N

A

K

A

S

F

F

V

V

P

P

L

L

A

A

Q

H

S

T

D

N

V

E

A

A

R

R

A

A

L

L

V

V

G

G

I

I

F

F

L

L

N

N

D

D

Q

Q

Y

Y

V

V

K

K

G

G

L

K

A

A

K

K

K

K

H

L

S

T

S

K

A

D

A

V

G

E

A

T

P

P

Q

K

Q

Q

A

A

A

A

V

V

L

L

G

G

A

A

G

G

I

I

M

M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

W

W

K

K

G

G

V

V

P

P

V

V

K

V

M

M

K

K

D
|
D

I
|
I

N

N

P

D

Q

K

A

S

L

L

T

T

L

L

G

G

M

M

T

T

E

E

A

A

S

A

K

K

L

L

L

L

N

N

K

K

Q

Q

L

L

E

E

R

R

G

G

K

K

I

I

D

D

G

G

A

L

K

K

L

L

A

A

S

G

V

V

L

I

T

S

T

T

I

I

Q

H

P

P

T

T

L

L

D

D

Y

Y

A

A

G

G

F

F

E

D

R

R

T

V

D

D

V

I

V

V

V

V

E

E

A

A

V
|
V

V
|
V

E

E

N

N

P

P

Q

K

I
x
V

K

K

A

K

K

A

V

V

L

L

A

A

E

E

T

T

E

E

Q

Q

H

K

L

V

R

R

E

Q

D

D

A

T

I

V

L

L

A

A

S

S

N

N

T

T

S
|
S

T

T

I

I

P

P

I

I

S

S

L

E

L

L

A

A

Q

N

S

A

L

L

Q

E

R

R

P

P

E

E

N

N

F

F

C

C

G

G

M

M

H
|
H

F

F

F

F

N

N

P

P

V

V

P

H

R

R

M

M

P

P

L

L

V

V

E
|
E

V

I

I

I

R

R

G

G

E

E

K

K

T

S

S

S

E

D

A

E

T

T

I

I

S

A

K

K

V

V

V

V

A

A

W

W

A

A

S

S

K

K

M

M

G

G

K

K

T

T

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

F

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

A

A

G

F

F

S

S

L

Q

L

L

L

L

R

R

D

D

G

G

A

A

D

D

F

F

R

R

Q

K

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

Q

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

W

Y

L

L

L

L

D

D

V

V

V

V

G

G

I

I

D

D

T

T

A

A

H

H

H

H

A

A

Q

Q

K

A

V

V

M

M

A

A

Q

A

G

G

F

F

P

P

T

Q

R

R

M

M

Q

Q

K

K

D

D

Y

Y

R

R

D

D

A

A

I

I

D

D

V

A

L

L

F

F

D

D

A

A

Q

N

R

R

F

F

G

G

Q

Q

K
|
K

N

N

G

G

K

L

G

G

F

F

Y

W

L

R

W

Y

E

K

Q

E

D

D

K

S

K

K

G

G

K

K

A

P

Q

K

K

K

K

E

A

E

D

D

P

A

A

A

V

V

D

E

A

D

L

L

L

L

E

A

P

E

I

V

C

S

E

Q

P

P

K

K

R

R

V

D

F

F

S

S

D

E

E

E

D

E

I

I

A

I

N

A

R

R

M

M

M

M

L

I

P

P

M

M

L

V

N

N

E

E

V

V

V

V

R

R

C

C

L

L

E

E

E

E

N

G

I

I

I

I

A

A

S

T

P

P

A

A

E

E

A

A

D

D

M

M

A

A

L

L

V

V

Y

Y

G

G

L

L

G

G

F

F

P

P

P

P

F

F

R

H

G

G

G

G

A

A

F

F

R

R

Y

W

M

L

D

D

T

T

L

L

G

G

N

S

S

A

N

K

V

Y

V

L

D

D

Q

M

A

A

K

Q

R

Q

Y

Y

I

Q

A

H

L

L

G

G

P

P

L

L

Y

Y

T

E

L

V

P

P

E

E

Q

G

L

L

V

R

Q

N

K

K

A

A

H

R

Q

H

H

N

Q

E

S

P

W

Y

Y

Y

P

P

A

P

V

V

Q

E

P

P

active site: A68 (= A68), F73 (= F73), G116 (= G116), E119 (= E119), P138 (= P138), E139 (= E139), G147 (= G147), N271 (≠ K270), S429 (= S428), H450 (= H449), E462 (= E461), N500 (= N499)
binding adenosine-5'-triphosphate: D343 (= D342), I344 (= I343), V400 (= V399), V401 (= V400), V406 (≠ I405), K584 (= K583)

P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
75% identity, 99% coverage: 1:718/727 of query aligns to 1:719/729 of P21177

query
sites
P21177

M

M

L

L

Y

Y

Q

K

G

G

D

D

T

T

L

L

S

Y

V

L

H

D

W

W

L

L

D

E

D

D

G

G

I

I

A

A

E

E

L

L

V

V

F

F

D

D

A

A

P

P

G

G

S

S

V

V

N

N

K

K

L

L

D

D

T

T

K

A

T

T

V

V

A

A

S

S

L

L

G

G

E

E

A

A

L

I

G

G

I

V

L

L

E

E

Q

Q

Q

Q

P

S

A

D

L

L

R

K

G

G

L

L

L

L

L

L

S

R

S

S

A

N

K

K

P

A

A

A

F

F

I

I

V

V

G

G

A

A

D

D

I

I

T

T

E

E

F

F

L

L

S

S

L

L

F

F

D

L

A

V

P

P

E

E

E

E

K

Q

L

L

S

S

Q

Q

W

W

L

L

A

H

F

F

A

A

N

N

S

S

I

V

F

F

N

N

R

R

L

L

E

E

D

D

L

L

P

P

V

V

P

P

T

T

V

I

A

A

A

A

I

V

D

N

G

G

Y

Y

A

A

L

L

G

G

G
|
G

G

G

C

C

E

E

C

C

V

V

L

L

A

A

T

T

D

D

F

Y

R

R

I

L

A

A

T

T

P

P

T

D

A

L

R

R

I

I

G

G

L

L

P

P

E

E

T

T

K

K

L

L

G

G

I

I

M

M

P

P

G

G

F

F

G

G

G

G

S

S

V

V

R

R

L

M

P

P

R

R

L

M

L

L

G

G

A

A

D

D

S

S

A

A

L

L

E

E

I

I

I

I

A

A

A

A

G

G

K

K

D

D

I

V

D

G

G

A

N

D

S

Q

A

A

L

L

K

K

L

I

G

G

L

L

I

V

D

D

A

G

V

V

V

V

S

K

S

A

D

E

K

K

L

L

R

V

A

E

A

G

A

A

L

K

T

A

M

V

L

L

Q

R

D

Q

A

A

I

I

-

N

A

G

Q

D

G

L

S

D

W

W

Q

K

V

A

R

K

R

R

A

Q

P

P

K

K

L

L

N

E

P

P

L

L

K

K

L

L

S

S

P

K

I

I

E

E

A

A

A

T

M

M

S

S

F

F

T

T

I

I

A

A

K

K

S

G

M

M

V

V

M

A

Q

Q

T

T

A

A

G

G

K

K

H

H

Y

Y

P

P

A

A

P

P

I

I

T

T

A

A

V

V

K

K

T

T

I

I

E

E

A

A

A

A

A

A

S

R

L

F

H

G

R

R

D

E

D

E

A

A

L

L

K

N

L

L

E

E

T

N

A

K

A

S

F

F

V

V

P

P

L

L

A

A

Q

H

S

T

D

N

V

E

A

A

R

R

A

A

L

L

V

V

G

G

I

I

F

F

L

L

N

N

D

D

Q

Q

Y

Y

V

V

K

K

G

G

L

K

A

A

K

K

K

K

H

L

S

T

S

K

A

D

A

V

G

E

A

T

P

P

Q

K

Q

Q

A

A

A

A

V

V

L

L

G

G

A

A

G
|
G

I

I

M

M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

W

W

K

K

G

G

V

V

P

P

V

V

K

V

M

M

K

K

D

D

I

I

N

N

P

D

Q

K

A

S

L

L

T

T

L

L

G

G

M

M

T

T

E

E

A

A

S

A

K

K

L

L

L

L

N

N

K

K

Q

Q

L

L

E

E

R

R

G

G

K

K

I

I

D

D

G

G

A

L

K

K

L

L

A

A

S

G

V

V

L

I

T

S

T

T

I

I

Q

H

P

P

T

T

L

L

D

D

Y

Y

A

A

G

G

F

F

E

D

R

R

T

V

D

D

V

I

V

V

V

V

E

E

A

A

V

V

V

V

E

E

N

N

P

P

Q

K

I

V

K

K

A

K

K

A

V

V

L

L

A

A

E

E

T

T

E

E

Q

Q

H

K

L

V

R

R

E

Q

D

D

A

T

I

V

L

L

A

A

S

S

N

N

T

T

S

S

T

T

I

I

P

P

I

I

S

S

L

E

L

L

A

A

Q

N

S

A

L

L

Q

E

R

R

P

P

E

E

N

N

F

F

C

C

G

G

M

M

H
|
H

F

F

F

F

N

N

P

P

V

V

P

H

R

R

M

M

P

P

L

L

V

V

E

E

V

I

I

I

R

R

G

G

E

E

K

K

T

S

S

S

E

D

A

E

T

T

I

I

S

A

K

K

V

V

V

V

A

A

W

W

A

A

S

S

K

K

M

M

G

G

K

K

T

T

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

F

V

V

N

N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

A

A

G

F

F

S

S

L

Q

L

L

L

L

R

R

D

D

G

G

A

A

D

D

F

F

R

R

Q

K

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

Q

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

W

Y

L

L

L

L

D

D

V

V

V

V

G

G

I

I

D

D

T

T

A

A

H

H

H

H

A

A

Q

Q

K

A

V

V

M

M

A

A

Q

A

G

G

F

F

P

P

T

Q

R

R

M

M

Q

Q

K

K

D

D

Y

Y

R

R

D

D

A

A

I

I

D

D

V

A

L

L

F

F

D

D

A

A

Q

N

R

R

F

F

G

G

Q

Q

K

K

N

N

G

G

K

L

G

G

F

F

Y

W

L

R

W

Y

E

K

Q

E

D

D

K

S

K

K

G

G

K

K

A

P

Q

K

K

K

K

E

A

E

D

D

P

A

A

A

V

V

D

E

A

D

L

L

L

L

E

A

P

E

I

V

C

S

E

Q

P

P

K

K

R

R

V

D

F

F

S

S

D

E

E

E

D

E

I

I

A

I

N

A

R

R

M

M

M

M

L

I

P

P

M

M

L

V

N

N

E

E

V

V

V

V

R

R

C

C

L

L

E

E

E

E

N

G

I

I

I

I

A

A

S

T

P

P

A

A

E

E

A

A

D

D

M

M

A

A

L

L

V

V

Y

Y

G

G

L

L

G

G

F

F

P

P

P

P

F

F

R

H

G

G

G

G

A

A

F

F

R

R

Y

W

M

L

D

D

T

T

L

L

G

G

N

S

S

A

N

K

V

Y

V

L

D

D

Q

M

A

A

K

Q

R

Q

Y

Y

I

Q

A

H

L

L

G

G

P

P

L

L

Y

Y

T

E

L

V

P

P

E

E

Q

G

L

L

V

R

Q

N

K

K

A

A

H

R

Q

H

H

N

Q

E

S

P

W

Y

Y

Y

P

P

A

P

V

V

Q

E

P

P

G116 (= G116) mutation to F: Absence of both enoyl-CoA hydratase and 3-hydroxyacyl-CoA epimerase activities. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase is only slightly affected.
G322 (= G321) mutation to A: 10-fold increase in KM for NADH.
H450 (= H449) active site, For 3-hydroxyacyl-CoA dehydrogenase activity; mutation H->A,Q: Almost complete loss of 3-hydroxyacyl-CoA dehydrogenase activity.

1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
56% identity, 98% coverage: 1:713/727 of query aligns to 1:714/715 of 1wdlA

query
sites
1wdlA

M

M

L

I

Y

Y

Q

E

G

G

D

K

T

A

L

I

S

T

V

V

H

T

W

A

L

L

D

E

D

S

G

G

I

I

A

V

E

E

L

L

V

K

F

F

D

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

L

F

D

N

T

R

K

L

T

T

V

L

A

N

S

E

L

L

G

R

E

Q

A

A

L

V

G

D

I

A

L

I

E

K

Q

A

Q

D

P

A

A

S

L

V

R

K

G

G

L

V

L

I

L

V

S

S

S

S

A

G

K

K

P

D

A

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

L

V

S

E

L

N

F

F

D

K

A

L

P

P

E

D

E

A

K

E

L

L

S

I

Q

A

W

G

L
x
N

A

L

F

E

A

A

N
|
N

S

K

I

I

F

F

N

S

R

D

L

F

E

E

D

D

L

L

P

N

V

V

P

P

T

T

V

V

A

A

A

A

I

I

D

N

G

G

Y

I

A

A

L

L

G

G

G
|
G

G

G

C

L

E
|
E

C

M

V

C

L

L

A

A

T

A

D

D

F

F

R

R

I

V

A

M

T

A

P

D

T

S

A

A

R

K

I

I

G

G

L

L

P
|
P

E
|
E

T

V

K

K

L

L

G

G

I

I

M

Y

P
|
P

G
|
G

F

F

G

G

G

G

S

T

V

V

R

R

L

L

P

P

R

R

L

L

L

I

G

G

A

V

D

D

S

N

A

A

L

V

E

E

I

W

I

I

A

A

A

S

G

G

K

K

D

E

I

N

D

R

G

A

N

E

S

D

A

A

L

L

K

K

L

V

G

S

L

A

I

V

D

D

A

A

V

V

V

V

S

T

S

A

D

D

K

K

L

L

R

G

A

A

A

A

A

A

L

L

T

D

M

L

L

I

Q

K

D

R

A

A

I

I

A

S

-

G

Q

E

G

L

S

D

W

Y

Q

K

V

A

R

K

R

R

A

Q

P

P

K

K

L

L

N

E

P

K

L

L

K

K

L

L

S

N

P

A

I

I

E

E

A

Q

A

M

M

M

S

A

F

F

T

E

I

T

A

A

K

K

S

G

M

F

V

V

M

A

Q

G

T

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

I

V

T

E

A

A

V

I

K

K

T

T

I

I

E

Q

A

K

A

A

A

A

S

N

L

F

H

G

R

R

D

D

D

K

A

A

L

L

K

E

L

V

E

E

T

A

A

A

A

G

F

F

V

A

P

K

L

L

A

A

Q

K

S

T

D

S

V

A

A

S

R

N

A

C

L

L

V

I

G

G

I

L

F

F

L

L

N

N

D

D

Q

Q

Y

E

V

L

K

K

G

K

L

K

A

A

K

K

K

V

H

Y

S

D

S

K

A

I

A

A

G

K

A

D

P

V

Q

K

Q

Q

A

A

A

A

V

V

L

L

G

G

A
|
A

G

G

I
|
I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

W

S

K

K

G

G

V

T

P

P

V

I

K

L

M

M

K

K

D
|
D

I
|
I

N

N

P

E

Q

H

A

G

L

I

T

E

L

Q

G

G

M

L

T

A

E

E

A

A

S

A

K

K

L

L

L

L

N

V

K

G

Q

R

L

V

E

D

R

K

G

G

K

R

I

M

D

T

G

P

A

A

K

K

L

M

A

A

S

E

V

V

L

L

T

N

T

G

I

I

Q

R

P

P

T

T

L

L

D

S

Y

Y

A

G

G

D

F

F

E

G

R

N

T

V

D

D

V

L

V

V

V

V

E

E

A
|
A

V
|
V

V

V

E
|
E

N

N

P

P

Q

K

I

V

K

K

A

Q

K

A

V

V

L

L

A

A

E

E

T

V

E

E

Q

N

H

H

L

V

R

R

E

E

D

D

A

A

I

I

L

L

A

A

S

S

N
|
N

T
|
T

S
|
S

T

T

I

I

P

S

I

I

S

S

L

L

L

L

A

A

Q

K

S

A

L

L

Q

K

R

R

P

P

E

E

N

N

F

F

C

V

G

G

M

M

H
|
H

F

F

F

F

N

N

P

P

V

V

P

H

R

M

M

M

P

P

L

L

V

V

E
|
E

V

V

I

I

R

R

G

G

E

E

K

K

T

S

S

S

E

D

A

L

T

A

I

V

S

A

K

T

V

T

V

V

A

A

W

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

A

G

F

F

S

A

L

K

L

L

L

V

R

S

D

A

G

G

A

V

D

D

F

F

R

V

Q

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

W

Y

L

L

L

M

D

D

V

V

V

V

G

G

I

I

D

D

T

T

A

G

H

H

H

H

A

G

Q

R

K

D

V

V

M

M

A

A

Q

E

G

G

F

F

P

P

T

D

R

R

M

M

Q

K

K

D

D

D

Y

R

R

R

D

S

A

A

I

I

D

D

V

A

L

L

F

Y

D

E

A

A

Q

K

R

R

F

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

L

A

W

Y

E

E

Q

A

D

D

K

K

K

K

G

G

K

K

A

Q

Q

K

K

K

K

L

A

V

D

D

P

S

A

S

V

V

D

L

A

E

L

V

L

L

E

K

P

P

I

I

C

V

E

Y

P

E

K

Q

R

R

V

D

F

V

S

T

D

D

E

E

D

D

I

I

A

I

N

N

R

W

M

M

M

M

L

I

P

P

M

L

L

C

N

L

E

E

V

T

V

V

R

R

C

C

L

L

E

E

E

D

N

G

I

I

I

V

A

E

S

T

P

A

A

A

E

E

A

A

D

D

M

M

A

G

L

L

V

V

Y

Y

G

G

L

I

G

G

F

F

P

P

P

L

F

F

R

R

G

G

G

G

A

A

F

L

R

R

Y

Y

M

I

D

D

T

S

L

I

G

G

N

V

S

A

N

E

V

F

V

V

D

A

Q

L

A

A

K

D

R

Q

Y

Y

I

A

A

E

L

L

G

G

P

A

L

L

Y

Y

T

H

L

P

P

T

E

A

Q

K

L

L

V

R

Q

E

K

M

A

A

H

K

Q

N

H

G

Q

Q

S

S

W

F

Y

F

active site: A69 (= A68), N89 (≠ L88), N93 (= N92), G117 (= G116), E120 (= E119), P139 (= P138), E140 (= E139), P147 (= P146), G148 (= G147), S430 (= S428), H451 (= H449), E463 (= E461), N501 (= N499)
binding nicotinamide-adenine-dinucleotide: A322 (= A320), I324 (= I322), M325 (= M323), D344 (= D342), I345 (= I343), A400 (= A398), V401 (= V399), E403 (= E401), N428 (= N426), T429 (= T427), S430 (= S428)

P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
56% identity, 98% coverage: 1:713/727 of query aligns to 1:714/715 of P28793

query
sites
P28793

M

M

L

I

Y

Y

Q

E

G

G

D

K

T

A

L

I

S

T

V

V

H

T

W

A

L

L

D

E

D

S

G

G

I

I

A

V

E

E

L

L

V

K

F

F

D

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

L

F

D

N

T

R

K

L

T

T

V

L

A

N

S

E

L

L

G

R

E

Q

A

A

L

V

G

D

I

A

L

I

E

K

Q

A

Q

D

P

A

A

S

L

V

R

K

G

G

L

V

L

I

L

V

S

S

S

S

A

G

K

K

P

D

A

V

F

F

I

I

V

V

G

G

A

A

D

D

I

I

T

T

E

E

F

F

L

V

S

E

L

N

F

F

D

K

A

L

P

P

E

D

E

A

K

E

L

L

S

I

Q

A

W

G

L

N

A

L

F

E

A

A

N

N

S

K

I

I

F

F

N

S

R

D

L

F

E

E

D

D

L

L

P

N

V

V

P

P

T

T

V

V

A

A

A

A

I

I

D

N

G

G

Y

I

A

A

L

L

G

G

G

G

G

G

C

L

E

E

C

M

V

C

L

L

A

A

T

A

D

D

F

F

R

R

I

V

A

M

T

A

P

D

T

S

A

A

R

K

I

I

G

G

L

L

P

P

E

E

T

V

K

K

L

L

G

G

I

I

M

Y

P

P

G

G

F

F

G

G

G

G

S

T

V

V

R

R

L

L

P

P

R

R

L

L

L

I

G

G

A

V

D

D

S

N

A

A

L

V

E

E

I

W

I

I

A

A

A

S

G

G

K

K

D

E

I

N

D

R

G

A

N

E

S

D

A

A

L

L

K

K

L

V

G

S

L

A

I

V

D

D

A

A

V

V

V

V

S

T

S

A

D

D

K

K

L

L

R

G

A

A

A

A

A

A

L

L

T

D

M

L

L

I

Q

K

D

R

A

A

I

I

A

S

-

G

Q

E

G

L

S

D

W

Y

Q

K

V

A

R

K

R

R

A

Q

P

P

K

K

L

L

N

E

P

K

L

L

K

K

L

L

S

N

P

A

I

I

E

E

A

Q

A

M

M

M

S

A

F

F

T

E

I

T

A

A

K

K

S

G

M

F

V

V

M

A

Q

G

T

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

I

V

T

E

A

A

V

I

K

K

T

T

I

I

E

Q

A

K

A

A

A

A

S

N

L

F

H

G

R

R

D

D

D

K

A

A

L

L

K

E

L

V

E

E

T

A

A

A

A

G

F

F

V

A

P

K

L

L

A

A

Q

K

S

T

D

S

V

A

A

S

R

N

A

C

L

L

V

I

G

G

I

L

F

F

L

L

N

N

D
|
D

Q

Q

Y

E

V

L

K

K

G

K

L

K

A

A

K

K

K

V

H

Y

S

D

S

K

A

I

A

A

G

K

A

D

P

V

Q

K

Q

Q

A

A

A

A

V

V

L

L

G

G

A

A

G

G

I

I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

W

S

K

K

G

G

V

T

P

P

V

I

K

L

M

M

K

K

D
|
D

I

I

N

N

P

E

Q

H

A

G

L

I

T

E

L

Q

G

G

M

L

T

A

E

E

A

A

S

A

K

K

L

L

L

L

N

V

K

G

Q

R

L

V

E

D

R

K

G

G

K

R

I

M

D

T

G

P

A

A

K

K

L

M

A

A

S

E

V

V

L

L

T

N

T

G

I

I

Q

R

P

P

T

T

L

L

D

S

Y

Y

A

G

G

D

F

F

E

G

R

N

T

V

D

D

V

L

V

V

V

V

E

E

A

A

V
|
V

V
|
V

E
|
E

N

N

P

P

Q

K

I

V

K
|
K

A

Q

K

A

V

V

L

L

A

A

E

E

T

V

E

E

Q

N

H

H

L

V

R

R

E

E

D

D

A

A

I

I

L

L

A

A

S

S

N

N

T

T

S
|
S

T

T

I

I

P

S

I

I

S

S

L

L

L

L

A

A

Q

K

S

A

L

L

Q

K

R

R

P

P

E

E

N

N

F

F

C

V

G

G

M

M

H

H

F

F

F

F

N
|
N

P

P

V

V

P

H

R

M

M

M

P

P

L

L

V

V

E

E

V

V

I

I

R

R

G

G

E

E

K

K

T

S

S

S

E

D

A

L

T

A

I

V

S

A

K

T

V

T

V

V

A

A

W

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

A

G

F

F

S

A

L

K

L

L

L

V

R

S

D

A

G

G

A

V

D

D

F

F

R

V

Q

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

W

Y

L

L

L

M

D

D

V

V

V

V

G

G

I

I

D

D

T

T

A

G

H

H

H

H

A

G

Q

R

K

D

V

V

M

M

A

A

Q

E

G

G

F

F

P

P

T

D

R

R

M

M

Q

K

K

D

D

D

Y

R

R

R

D

S

A

A

I

I

D

D

V

A

L

L

F

Y

D

E

A

A

Q

K

R

R

F

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

L

A

W

Y

E

E

Q

A

D

D

K

K

K

K

G

G

K

K

A

Q

Q

K

K

K

K

L

A

V

D

D

P

S

A

S

V

V

D

L

A

E

L

V

L

L

E

K

P

P

I

I

C

V

E

Y

P

E

K

Q

R

R

V

D

F

V

S

T

D

D

E

E

D

D

I

I

A

I

N

N

R

W

M

M

M

M

L

I

P

P

M

L

L

C

N

L

E

E

V

T

V

V

R

R

C

C

L

L

E

E

E

D

N

G

I

I

I

V

A

E

S

T

P

A

A

A

E

E

A

A

D

D

M

M

A

G

L

L

V

V

Y
|
Y

G

G

L

I

G

G

F

F

P

P

P

L

F

F

R

R

G

G

G

G

A

A

F

L

R

R

Y

Y

M

I

D

D

T

S

L

I

G

G

N

V

S

A

N

E

V

F

V

V

D

A

Q

L

A

A

K

D

R

Q

Y

Y

I

A

A

E

L

L

G

G

P

A

L

L

Y

Y

T

H

L

P

P

T

E

A

Q

K

L

L

V

R

Q

E

K

M

A

A

H

K

Q

N

H

G

Q

Q

S

S

W

F

Y

F

D297 (= D295) binding substrate
M325 (= M323) binding NAD(+)
D344 (= D342) binding NAD(+)
VVE 401:403 (= VVE 399:401) binding NAD(+)
K408 (= K406) binding NAD(+)
S430 (= S428) binding NAD(+)
N454 (= N452) binding NAD(+)
N501 (= N499) binding substrate
Y660 (= Y659) binding substrate

1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
55% identity, 98% coverage: 1:713/727 of query aligns to 1:706/707 of 1wdmA

query
sites
1wdmA

M

M

L

I

Y

Y

Q

E

G

G

D

K

T

A

L

I

S

T

V

V

H

T

W

A

L

L

D

E

D

S

G

G

I

I

A

V

E

E

L

L

V

K

F

F

D

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

L

F

D

N

T

R

K

L

T

T

V

L

A

N

S

E

L

L

G

R

E

Q

A

A

L

V

G

D

I

A

L

I

E

K

Q

A

Q

D

P

A

A

S

L

V

R

K

G

G

L

V

L

I

L

V

S

S

S

S

A

G

K

K

P

D

A

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

L

V

S

E

L

N

F

F

D

K

A

L

P

P

E

D

E

A

K

E

L

L

S

I

Q

A

W

G

L
x
N

A

L

F

E

A

A

N
|
N

S

K

I

I

F

F

N

S

R

D

L

F

E

E

D

D

L

L

P

N

V

V

P

P

T

T

V

V

A

A

A

A

I

I

D

N

G

G

Y

I

A

A

L

L

G

G

G
|
G

G

G

C

L

E
|
E

C

M

V

C

L

L

A

A

T

A

D

D

F

F

R

R

I

V

A

M

T

A

P

D

T

S

A

A

R

K

I

I

G

G

L

L

P
|
P

E
|
E

T

V

K
|
K

L

L

G

G

I

I

M

Y

P
|
P

G
|
G

F

F

G

G

G

G

S

T

V

V

R

R

L

L

P

P

R

R

L

L

L

I

G

G

A

V

D

D

S

N

A

A

L

V

E

E

I

W

I

I

A

A

A

S

G

G

K

K

D

E

I

N

D

R

G

A

N

E

S

D

A

A

L

L

K

K

L

V

G

S

L

A

I

V

D

D

A

A

V

V

V

V

S

T

S

A

D

D

K

K

L

L

R

G

A

A

A

A

A

A

L

L

T

D

M

L

L

I

Q

K

D

R

A

A

I

I

A

S

-

G

Q

E

G

L

S

D

W

Y

Q

K

V

A

R

K

R

R

A

Q

P

P

K

K

L

L

N

E

P

K

L

L

K

K

L

L

S

N

P

A

I

I

E

E

A

Q

A

M

M

M

S

A

F

F

T

E

I

T

A

A

K

K

S

G

M

F

V

V

M

A

Q

G

T

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

I

V

T

E

A

A

V

I

K

K

T

T

I

I

E

Q

A

K

A

A

A

A

S

N

L

F

H

G

R

R

D

D

D

K

A

A

L

L

K

E

L

V

E

E

T

A

A

A

A

G

F

F

V

A

P

K

L

L

A

A

Q

K

S

T

D

S

V

A

A

S

R

N

A

C

L

L

V

I

G

G

I

L

F

F

L

L

N

N

D
|
D

Q

Q

Y

E

V

L

K

K

G

K

L

K

A

A

K

K

K

V

H

Y

S

D

S

K

A

I

A

A

G

K

A

D

P

V

Q

K

Q

Q

A

A

A

A

V

V

L

L

G
|
G

A
|
A

G

G

I
|
I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

W

S

K

K

G

G

V

T

P

P

V

I

K

L

M

M

K

K

D
|
D

I

I

N

N

P

E

Q

H

A

G

L

I

T

E

L

Q

G

G

M

L

T

A

E

E

A

A

S

A

K

K

L

L

L

L

N

V

K

G

Q

R

L

V

E

D

R

K

G

G

K

R

I

M

D

T

G

P

A

A

K

K

L

M

A

A

S

E

V

V

L

L

T

N

T

G

I

I

Q

R

P

P

T

T

L

L

D

S

Y

Y

A

G

G

D

F

F

E

G

R

N

T

V

D

D

V

L

V

V

V

V

E

E

A

A

V
|
V

V

V

E
|
E

N

N

P

P

Q

K

I

V

K

K

A

Q

K

A

V

V

L

L

A

A

E

E

T

V

E

E

Q

N

H

H

L

V

R

R

E

E

D

D

A

A

I

I

L

L

A

A

S

S

N
|
N

T

T

S
|
S

T

T

I

I

P

S

I

I

S

S

L

L

L

L

A

A

Q

K

S

A

L

L

Q

K

R

R

P

P

E

E

N

N

F

F

C

V

G

G

M

M

H
|
H

F

F

F

F

N
|
N

P

P

V

V

P

H

R

M

M
|
M

P

P

L

L

V

V

E
|
E

V

V

I

I

R

R

G

G

E

E

K

K

T

S

S

S

E

D

A

L

T

A

I

V

S

A

K

T

V

T

V

V

A

A

W

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

A

G

F

F

S

A

L

K

L

L

L

V

R

S

D

A

G

G

A

V

D

D

F

F

R

V

Q

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P
|
P

M

M

G

G

P

P

A

A

W

Y

L

L

L

M

D

D

V

V

V

V

G

G

I

I

D

D

T

T

A

G

H

H

H

H

A

G

Q

R

K

D

V

V

M

M

A

A

Q

E

G

G

F

F

P

P

T

D

R

R

M

M

Q

K

K

D

D

D

Y

R

R

R

D

S

A

A

I

I

D

D

V

A

L

L

F

Y

D

E

A

A

Q

K

R

R

F

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

L

A

W

Y

E

-

Q

-

D

-

K

-

K

-

G

-

K

-

A

-

Q

K

K

K

K

L

A

V

D

D

P

S

A

S

V

V

D

L

A

E

L

V

L

L

E

K

P

P

I

I

C

V

E

Y

P

E

K

Q

R

R

V

D

F

V

S

T

D

D

E

E

D

D

I

I

A

I

N

N

R

W

M

M

M

M

L

I

P

P

M

L

L

C

N

L

E

E

V

T

V

V

R

R

C

C

L

L

E

E

E

D

N

G

I

I

I

V

A

E

S

T

P

A

A

A

E

E

A

A

D

D

M

M

A

G

L

L

V

V

Y
|
Y

G

G

L

I

G

G

F

F

P

P

P
x
L

F

F

R

R

G

G

G

G

A

A

F

L

R

R

Y

Y

M

I

D

D

T

S

L

I

G

G

N

V

S

A

N

E

V

F

V

V

D

A

Q

L

A

A

K

D

R

Q

Y

Y

I

A

A

E

L

L

G

G

P

A

L

L

Y

Y

T

H

L

P

P

T

E

A

Q

K

L

L

V

R

Q

E

K

M

A

A

H

K

Q

N

H

G

Q

Q

S

S

W

F

Y

F

active site: A69 (= A68), N89 (≠ L88), N93 (= N92), G117 (= G116), E120 (= E119), P139 (= P138), E140 (= E139), P147 (= P146), G148 (= G147), S430 (= S428), H451 (= H449), E463 (= E461), N501 (= N499)
binding acetyl coenzyme *a: K142 (= K141), D297 (= D295), M459 (= M457), N501 (= N499), P534 (= P533), Y652 (= Y659), L658 (≠ P665)
binding nicotinamide-adenine-dinucleotide: G321 (= G319), A322 (= A320), I324 (= I322), M325 (= M323), D344 (= D342), V401 (= V399), E403 (= E401), N428 (= N426), S430 (= S428), N454 (= N452)

6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
37% identity, 97% coverage: 7:713/727 of query aligns to 5:703/707 of 6yswA

query
sites
6yswA

T

T

L

L

S

N

V

V

H

R

W

L

L

-

D

-

D

D

G

N

I

I

A

A

E

V

L

I

V

T

F

I

D

D

A

V

P

P

G

G

S
x
E

-

K

V
x
M

N

N

K

T

L

L

D

K

T

A

K

E

T

F

V

A

A

S

S

Q

L

V

G

R

E

A

A

I

L

I

G

K

I

Q

L

L

E

R

Q

E

Q

N

P

K

A

E

L

L

R

R

G

G

L

V

L

V

L

F

S

V

S

S

A

A

K

K

P

P

-

D

A

N

F

F

I

I

V

A

G

G

A
|
A

D
|
D

I
|
I

T

N

E

M

F
x
I

L

G

S

N

L

C

F

K

D

T

A

A

P

Q

E

E

-

A

E

E

K

A

L

L

S
x
A

Q

R

W

Q

L

-

A

-

F

-

A

G

N
x
Q

S

Q

I

L

F

M

N

A

R

E

L

I

E

H

D

A

L

L

P

P

V

I

P

Q

T

V

V

I

A

A

A

A

I

I

D

H

G

G

Y

A

A

C

L

L

G

G

G
|
G

G

G

C

L

E
|
E

C

L

V

A

L

L

A

A

T

C

D

H

F

G

R

R

I

V

A

C

T

T

-

D

-

D

P

P

T

K

A

T

R

V

I

L

G

G

L

L

P
|
P

E
|
E

T

V

K

Q

L
|
L

G

G

I

L

M

L

P

P

G
|
G

F

S

G

G

G

G

S

T

V

Q

R

R

L

L

P

P

R

R

L

L

L

I

G

G

A

V

D

S

S

T

A

A

L

L

E

E

I

M

I

I

A

L

A

T

G

G

K

K

D

Q

I

L

D

R

G

A

N

K

S

Q

A

A

L

L

K

K

L

L

G

G

L

L

I

V

D

D

A

D

V

V

V

V

S

P

S

H

D

S

K

I

L

L

R

L

A

E

A

A

A

A

L

V

T

E

M

L

L

A

Q

K

D

-

A

-

I

-

A

-

Q

-

G

-

S

-

W

-

Q

-

V

-

R

K

R

E

A

R

P

P

K

S

L

S

N

R

P

P

L

L

K

P

L

V

-

R

-

E

-

R

-

I

-

L

-

A

S

G

P

P

I

L

E

G

A

R

A

A

M

L

S

L

F

F

T

K

I

M

A

V

K

G

S

K

M

K

V

T

M

E

Q

H

T

K

A

T

G

Q

K

G

H

N

Y

Y

P

P

A

A

P

T

I

E

T

R

A

I

V

L

K

E

T

V

I

V

E

E

A

T

A

G

A

L

S

A

L

Q

H

G

R

T

D

S

D

S

A

G

L

Y

K
x
D

L

A

E

E

T

A

A

R

A

A

F

F

V

G

P

E

L

L

A

A

Q

M

S

T

D

P

V

Q

A

S

R

Q

A

A

L

L

V

R

G

S

I

I

F

F

L

F

N

A

D

S

Q
x
T

Y

D

V

V

K
|
K

G

-

L

-

A

K

K

D

K

P

H

G

S

S

S

D

A

A

A

P

G

P

A

A

P

P

-

L

Q

N

Q

S

A

V

A

G

V

I

L

L

G

G

A

G

G

G

I

L

M

M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

V

S

T

A

A

W

C

K

K

-

A

G

G

V

I

P

P

V

V

K

R

M

I

K

K

D

D

I

I

N

N

P

P

Q

Q

A

G

L

I

T

N

L

H

G

A

M

L

T

K

E

Y

A

S

S

W

K

D

L

Q

L

L

N

E

K

G

Q

K

L

V

E

R

R

R

G

R

K

H

I

L

D

K

G

A

A

S

K

E

L

R

A

D

S

K

V

Q

L

L

T

A

T

L

I

I

Q

S

P

G

T

T

L

T

D

D

Y

Y

A

R

G

G

F

F

E

A

R

H

T

R

D

D

V

L

V

I

V

I

E

E

A

A

V

V

V

F

E

E

N

N

P

L

Q

E

I

L

K

K

A

Q

K

Q

V

M

L

V

A

A

E

E

T

V

E

E

Q

Q

H

N

L

C

R

A

E

A

D

H

A

T

I

I

L

F

A

A

S

S

N

N

T

T

S
|
S

T

S

I

L

P

P

I

I

S

G

L

D

L

I

A

A

Q

A

S

H

L

A

Q

T

R

R

P

P

E

E

N

Q

F

V

C

I

G

G

M

L

H
|
H

F

F

F

F

N

S

P

P

V

V

P

E

R

K

M

M

P

P

L

L

V

V

E
|
E

V

I

I

I

R

P

G

H

E

A

K

G

T

T

S

S

E

A

A

Q

T

T

I

I

S

A

K

T

V

T

V

V

A

K

W

L

A

A

S

K

K

K

M

Q

G

G

K

K

T

T

P

P

I

I

V

V

V

V

N

R

D

D

C

K

P

A

G

G

F

F

F

Y

V

V

N
|
N

R

R

V

I

L

L

F

A

P

P

Y

Y

F

I

A

N

A

E

F

A

S

I

L

R

L

M

L

L

R

T

D

Q

G

G

A

E

D

R

F

V

R

E

Q

H

I

I

D

D

K

A

V

A

M

L

E

V

K

K

Q

-

F

F

G

G

W

F

P

P

M

V

G

G

P

P

A

I

W

Q

L

L

L

L

D

D

V

E

V

V

G

G

I

I

D

D

T

T

A

G

H

T

H

K

A

I

Q

I

K

P

V

V

M

L

A

E

Q

A

G

A

F

Y

P

G

T

E

R

R

M

F

Q

S

K

A

D

P

Y

A

R

-

D

N

A

V

I

V

D

S

V

S

L

I

F

L

D

N

A

D

Q

D

R

R

F

K

G

G

Q

R

K

K

N

N

G

G

K

R

G

G

F

F

Y

Y

L

L

W

Y

E

G

Q

Q

D

-

K

K

K

G

G

R

K

K

A

S

Q

K

K

K

K

Q

A

V

D

D

P

P

A

A

V

I

D

Y

A

P

L

L

L

I

E

G

P

T

I

Q

C

G

E

Q

P

G

K

R

R

-

V

-

F

I

S

S

D

A

E

P

D

Q

I

V

A

A

N

E

R

R

M

C

M

V

L

M

P

L

M

M

L

L

N

N

E

E

V

A

V

V

R

R

C

C

L

V

E

D

E

E

N

Q

I

V

I

I

A

R

S

S

P

V

A

R

E

D

A

G

D

D

M

I

A

G

L

A

V

V

Y

F

G

G

L

I

G

G

F

F

P

P

P

P

F

F

R

L

G

G

G

G

A

P

F

F

R

R

Y

Y

M

I

D

D

T

S

L

L

G

G

N

A

S

G

N

E

V

V

V

V

D

A

Q

I

A

M

K

Q

R

R

Y

L

-

A

I

T

A

Q

L

Y

G

G

P

S

L

R

Y

F

T

T

L

P

P

C

E

E

Q

R

L

L

V

V

Q

E

K

M

A

G

H

A

Q

R

H

G

Q

E

S

S

W

F

Y

W

active site: A66 (= A68), I71 (≠ F73), A84 (≠ S85), Q88 (≠ N92), G112 (= G116), E115 (= E119), P136 (= P138), E137 (= E139), G145 (= G147), D264 (≠ K270), S422 (= S428), H443 (= H449), E455 (= E461), N493 (= N499)
binding coenzyme a: E23 (≠ S27), M25 (≠ V28), A66 (= A68), D67 (= D69), I68 (= I70), P136 (= P138), E137 (= E139), L140 (= L142), T290 (≠ Q296), K293 (= K299)

P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
34% identity, 94% coverage: 17:703/727 of query aligns to 49:750/763 of P40939

query
sites
P40939

I

V

A

A

E

V

L

V

V

R

F

I

D

N

A

S

P

P

G

N

S

S

-

K

V

V

N

N

K

T

L

L

D

S

T

K

K

E

T

L

V

H

A

S

S

E

L

F

G

S

E

E

A

V

L

M

G

N

I

E

L

I

E

W

Q

A

Q

S

P

D

A

Q

L

I

R

R

G

S

L

A

L

V

L

L

S

I

S

S

A

S

K

K

P

P

-

G

A

C

F

F

I

I

V

A

G

G

A

A

D

D

I

I

T

N

E

M

F

L

L

A

S

A

L

C

F

K

D

T

A

L

P

Q

E

E

E

-

K

-

L

V

S

T

Q

Q

W

L

L

S

A

Q

F

E

A

A

N

Q

S

R

I

I

F

V

N

E

R

K

L

L

E

E

D

K

L

S

P

T

V

K

P

P

T

I

V

V

A

A

A

A

I

I

D

N

G

G

Y

S

A

C

L

L

G

G

G

G

G

G

C

L

E

E

C

V

V

A

L

I

A

S

T

C

D

Q

F

Y

R

R

I

I

A

A

T

T

P

K

T

D

A

R

R

K

-

T

-

V

I

L

G

G

L

T

P

P

E

E

T

V

K

L

L

L

G

G

I

A

M

L

P

P

G

G

F

A

G

G

G

G

S

T

V

Q

R

R

L

L

P

P

R

K

L

M

L

V

G

G

A

V

D

P

S

A

A

A

L

L

E

D

I

M

I

M

A

L

A

T

G

G

K

R

D

S

I

I

D

R

G

A

N

D

S

R

A

A

L

K

K

K

L

M

G

G

L

L

I

V

D

D

A

Q

V

L

V

V

-

E

-

P

-

L

-

G

-

P

-

G

-

L

-

K

-

P

-

P

-

E

-

E

-

R

S

T

S

I

D

E

K

Y

L

L

R

E

A

E

A

V

A

A

L

I

T

T

M

F

L

-

Q

-

D

-

A

-

I

-

A

A

Q

K

G

G

S

L

W

A

Q

D

V

K

R

K

R

I

A

S

P

P

K

K

L

R

N

D

P

K

L

G

K

L

L

V

S

E

P

K

I

L

E

T

A

A

-

Y

A

A

M

M

S

T

F

I

T

P

I

F

A

V

K

R

S

Q

M

Q

V
|
V

M

Y

-

K

-

K

-

V

-

E

-

E

-

K

-

V

-

R

-

K

Q

Q

T

T

A

K

G

G

K

-

H

L

Y

Y

P

P

A

A

P

P

I

L

T

K

A

I

V
x
I

K

D

T

V

I

V

E

K

A

T

A

G

A

I

S

E

L

Q

H

G

R

S

D

D

D

A

A

G

L

Y

K

L

L