SitesBLAST
Comparing WP_085123269.1 NCBI__GCF_900177295.1:WP_085123269.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4wjmA Crystal structure of fructokinase from brucella abortus 2308 with bound amppnp
40% identity, 97% coverage: 1:306/314 of query aligns to 7:312/312 of 4wjmA
- active site: G252 (= G246), A253 (= A247), G254 (= G248), D255 (= D249)
- binding phosphoaminophosphonic acid-adenylate ester: T223 (= T217), G225 (= G219), A226 (= A220), G228 (= G222), G252 (= G246), A253 (= A247), G254 (= G248), V257 (≠ F251), V292 (= V286), A295 (= A289)
7fcaD Pfkb(mycobacterium marinum) (see paper)
37% identity, 94% coverage: 3:298/314 of query aligns to 5:282/282 of 7fcaD
3gbuA Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with atp
30% identity, 98% coverage: 5:311/314 of query aligns to 5:297/302 of 3gbuA
- active site: G242 (= G246), A243 (= A247), G244 (= G248), D245 (= D249)
- binding adenosine-5'-triphosphate: K188 (= K184), T213 (= T217), G215 (= G219), V235 (= V239), P237 (≠ V241), A243 (= A247), G244 (= G248), A274 (= A289)
3ih0A Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with amp-pnp
30% identity, 98% coverage: 5:311/314 of query aligns to 6:298/304 of 3ih0A
5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
31% identity, 98% coverage: 4:311/314 of query aligns to 6:306/306 of 5eynA
- active site: G246 (= G246), A247 (= A247), G248 (= G248), D249 (= D249)
- binding adenosine-5'-diphosphate: H91 (≠ D91), T217 (= T217), G219 (= G219), A220 (= A220), A238 (≠ P238), V239 (= V239), T244 (= T244), G246 (= G246), A247 (= A247), G248 (= G248), F251 (= F251), N279 (≠ V286), G282 (≠ A289), A283 (= A290)
- binding beryllium trifluoride ion: G246 (= G246), G248 (= G248), D249 (= D249)
- binding beta-D-fructofuranose: D9 (≠ E7), D13 (= D11), G28 (= G29), A29 (≠ S30), N32 (= N33), F96 (≠ Y96), F98 (= F98), R159 (= R159), D249 (= D249)
5yggA Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
31% identity, 97% coverage: 6:311/314 of query aligns to 12:310/310 of 5yggA
- binding adenosine-5'-diphosphate: K188 (= K184), T221 (= T217), G223 (= G219), A242 (≠ P238), V243 (= V239), F255 (= F251), N283 (≠ V286), G286 (≠ A289), A287 (= A290)
- binding beta-D-fructofuranose: D13 (≠ E7), D17 (= D11), G32 (= G29), A33 (≠ S30), F100 (≠ Y96), F102 (= F98), R163 (= R159), D253 (= D249)
Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
30% identity, 77% coverage: 28:270/314 of query aligns to 30:273/319 of Q8ZKR2
- G31 (= G29) binding 5-amino-1-(beta-D-ribosyl)imidazole
- Y101 (≠ F98) binding 5-amino-1-(beta-D-ribosyl)imidazole
- R162 (= R159) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A180 (≠ L177) binding K(+)
- A181 (≠ R178) binding K(+)
- A183 (≠ S180) binding K(+)
- G213 (= G210) binding K(+)
- D246 (= D243) binding K(+)
- T248 (≠ V245) binding K(+)
- D252 (= D249) binding 5-amino-1-(beta-D-ribosyl)imidazole
Sites not aligning to the query:
- 16 binding 5-amino-1-(beta-D-ribosyl)imidazole
- 287 binding K(+)
- 290 binding K(+)
- 292 binding K(+)
1v1aA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
34% identity, 82% coverage: 3:258/314 of query aligns to 5:260/301 of 1v1aA
- active site: G248 (= G246), A249 (= A247), G250 (= G248), D251 (= D249)
- binding adenosine-5'-diphosphate: K219 (≠ T217), G221 (= G219), A222 (= A220), A249 (= A247), G250 (= G248)
- binding 2-keto-3-deoxygluconate: L11 (= L9), G34 (= G29), A35 (≠ S30), N38 (= N33), Y89 (≠ S84), R105 (≠ G100), R167 (= R159), G248 (= G246), D251 (= D249)
Sites not aligning to the query:
Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
34% identity, 82% coverage: 3:258/314 of query aligns to 5:260/309 of Q53W83
- GAEVN 34:38 (≠ GSPFN 29:33) binding substrate
- YYR 103:105 (≠ FYG 98:100) binding substrate
- R167 (= R159) binding substrate
- S193 (= S186) binding ATP
- 219:225 (vs. 217:223, 71% identical) binding ATP
- GAGD 248:251 (= GAGD 246:249) binding ATP
- D251 (= D249) binding substrate
Sites not aligning to the query:
- 275 binding ATP
- 287 binding substrate
1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp (see paper)
34% identity, 82% coverage: 3:258/314 of query aligns to 5:260/300 of 1v1bA
- active site: G248 (= G246), A249 (= A247), G250 (= G248), D251 (= D249)
- binding adenosine-5'-triphosphate: K219 (≠ T217), G221 (= G219), A238 (≠ G236), F239 (≠ R237), V241 (= V239), G248 (= G246), A249 (= A247), G250 (= G248)
Sites not aligning to the query:
3lkiB Crystal structure of fructokinase with bound atp from xylella fastidiosa
30% identity, 99% coverage: 3:312/314 of query aligns to 6:319/322 of 3lkiB
1tz3A Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
29% identity, 77% coverage: 28:270/314 of query aligns to 26:262/299 of 1tz3A
- active site: F88 (≠ Y96), G238 (= G246), A239 (= A247), G240 (= G248), D241 (= D249)
- binding 5-aminoimidazole ribonucleoside: G27 (= G29), L83 (= L85), F88 (≠ Y96), Y90 (≠ F98), R151 (= R159), M154 (≠ V162), D241 (= D249)
Sites not aligning to the query:
1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog (see paper)
29% identity, 77% coverage: 28:270/314 of query aligns to 26:262/297 of 1tz6A
- active site: F88 (≠ Y96), G238 (= G246), A239 (= A247), G240 (= G248), D241 (= D249)
- binding phosphomethylphosphonic acid adenylate ester: N149 (= N157), K176 (= K184), E181 (≠ D189), S209 (≠ T217), G211 (= G219), A212 (= A220), G214 (= G222), A239 (= A247), G240 (= G248), F243 (= F251)
- binding 5-aminoimidazole ribonucleoside: G27 (= G29), F88 (≠ Y96), Y90 (≠ F98), R151 (= R159), M154 (≠ V162), D241 (= D249)
Sites not aligning to the query:
3iq0B Crystal structure of a putative ribokinase ii in complex with atp and mg+2 from e.Coli
26% identity, 83% coverage: 38:297/314 of query aligns to 45:290/308 of 3iq0B
- active site: G252 (= G246), A253 (= A247), G254 (= G248), D255 (= D249)
- binding adenosine-5'-triphosphate: S192 (= S186), K223 (≠ T217), G225 (= G219), E247 (≠ V241), A253 (= A247), G254 (= G248), F257 (= F251), N279 (≠ V286), G282 (≠ A289)
6a8cA Ribokinase from leishmania donovani with adp (see paper)
27% identity, 93% coverage: 16:308/314 of query aligns to 38:324/327 of 6a8cA
- binding adenosine-5'-diphosphate: G245 (= G219), A246 (= A220), T271 (= T244), A274 (= A247), G275 (= G248), N300 (≠ V286), A303 (= A289)
- binding glycerol: S42 (= S20), S44 (≠ R22), G50 (= G28), G51 (= G29), N55 (= N33)
Sites not aligning to the query:
6a8bA Ribokinase from leishmania donovani with amppcp (see paper)
27% identity, 93% coverage: 16:308/314 of query aligns to 38:324/327 of 6a8bA