SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_085126016.1 NCBI__GCF_900177295.1:WP_085126016.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
28% identity, 94% coverage: 12:541/561 of query aligns to 11:552/593 of 6deoA

query
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active site: Y31 (≠ V32), G33 (= G34), G34 (≠ E35), A35 (≠ S36), I36 (≠ Y37), E57 (= E58), T80 (= T81), F119 (= F120), Q120 (= Q121), E121 (= E122), K169 (≠ E170), K224 (≠ E225), M260 (≠ I261), V287 (≠ T288), V403 (≠ A393), L428 (vs. gap), G429 (= G418), M431 (= M420), D456 (= D445), N483 (= N472), E485 (≠ M474), Q486 (≠ Y475), M488 (≠ T477), V489 (≠ I478), W492 (≠ H481), L514 (= L503), N519 (≠ G508), V520 (≠ G509)
binding flavin-adenine dinucleotide: R159 (= R160), G213 (= G216), A214 (= A217), G215 (= G218), N218 (vs. gap), T240 (≠ A241), L241 (≠ F242), Q242 (≠ R243), L258 (≠ V259), G280 (= G281), A281 (≠ P282), R282 (= R283), D284 (≠ G285), R286 (≠ M287), V287 (≠ T288), E313 (≠ H308), I314 (≠ P309), N318 (≠ E313), D332 (= D327), V333 (≠ F331), M408 (≠ T398), G426 (≠ T416)
binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ I261), D285 (≠ E286), R286 (≠ M287), M488 (≠ T477), W492 (≠ H481)
binding magnesium ion: D456 (= D445), N483 (= N472), E485 (≠ M474)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (≠ A393), G404 (= G394), Q405 (≠ N395), H406 (≠ Y396), G429 (= G418), M431 (= M420), G455 (= G444), D456 (= D445), A457 (≠ G446), S458 (≠ C447), M461 (= M450), N483 (= N472), E485 (≠ M474), Q486 (≠ Y475), G487 (= G476), M488 (≠ T477), V489 (≠ I478)

1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
27% identity, 94% coverage: 12:541/561 of query aligns to 10:556/597 of 1t9aA

query
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active site: Y30 (≠ V32), G32 (= G34), G33 (≠ E35), A34 (≠ S36), I35 (≠ Y37), E56 (= E58), T79 (= T81), F118 (= F120), Q119 (= Q121), E120 (= E122), K168 (≠ E170), R228 (= R226), M264 (≠ T251), V291 (≠ T288), V407 (≠ A393), L432 (vs. gap), G433 (= G418), M435 (= M420), D460 (= D445), N487 (= N472), E489 (≠ M474), Q490 (≠ Y475), M492 (≠ T477), V493 (≠ I478), W496 (≠ H481), L518 (= L503), G523 (= G508), L524 (≠ G509)
binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ E35), V108 (= V110), P109 (≠ A111), F118 (= F120), K168 (≠ E170), M264 (≠ T251), D289 (≠ E286), R290 (≠ M287), M492 (≠ T477), V493 (≠ I478), W496 (≠ H481)
binding flavin-adenine dinucleotide: R158 (= R160), G217 (= G215), A218 (≠ G216), G219 (≠ A217), N222 (≠ D220), T244 (≠ A241), L245 (≠ F242), Q246 (≠ R243), L262 (vs. gap), M264 (≠ T251), H265 (= H252), G284 (= G281), A285 (≠ P282), R286 (= R283), D288 (≠ G285), R290 (≠ M287), V291 (≠ T288), E317 (≠ H308), V318 (≠ P309), N322 (≠ E313), G335 (≠ A326), D336 (= D327), A337 (≠ P328), Q411 (≠ A397), M412 (≠ T398), G430 (≠ T416), G431 (≠ S417)
binding magnesium ion: D460 (= D445), N487 (= N472), E489 (≠ M474)
binding propyl trihydrogen diphosphate: V407 (≠ A393), G408 (= G394), Q409 (≠ N395), H410 (≠ Y396), M435 (= M420), G459 (= G444), D460 (= D445), A461 (≠ G446), S462 (≠ C447), N487 (= N472), E489 (≠ M474), Q490 (≠ Y475), G491 (= G476), M492 (≠ T477)
binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G418), M435 (= M420), M465 (= M450)

Sites not aligning to the query:

active site: 557

1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
27% identity, 94% coverage: 12:541/561 of query aligns to 9:555/596 of 1t9dA

query
sites
1t9dA

T

T

G

G

E

Q

I

I

L

F

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N

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E

C

M

L

M

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R

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x
Y

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E
x
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x
A

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x
I

L

L

A

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V

V

L

Y

D

D

A

A

L

I

Y

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N

A

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D

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I

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E
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E

G

Q

G

G

A

A

A

G

M

H

M

M

A

A

D

E

A

G

Y

Y

G

A

K

R

L

A

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S

G

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P

G

G

I

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C

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F

L

V

V

T
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T

R

S

G

G

P
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P

G

G

A

A

T

T

N

N

A

V

S

V

A

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M

H

A

I

D

A

A

F

F

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A

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D

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G

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I

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P

M

M

I

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F

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G

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x
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A

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F

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E
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E

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M

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K

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A

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N

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A

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S

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R

P

P

G

G

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P

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L

L

V

A

D

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L

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x
K

D

D

-

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-

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-

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I

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L

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A

T

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K

A

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C

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A

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D

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M

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A

G

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A

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A

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I

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G

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x
A

A
x
G

G

I

W

L

D
x
N

A

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A

A

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R

-

L

F

L

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A

K

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A
x
T

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x
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x
Q

R

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Q

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F

F

D

D

N

Q

-

E

-

D

-

P

-

K

-

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-

L

-

D

-
x
M

-
x
L

-

G

T
x
M

H
|
H

G

G

C

C

Y

A

A

T

G

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D

N

V

L

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A

I

-

G

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I

-

N

-

P

-

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-

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G

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x
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x
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x
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x
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T

T

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-

A

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I

V

I

H

H

V

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H
x
E

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x
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x
N

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I

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A

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x
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D

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x
A

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-

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x
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x
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x
M

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I

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x
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x
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x
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M

G

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D

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M
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M

H

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E

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L

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A

A

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Q

H

A

G

G

A

T

A

P

V

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I

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F

I

V

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V

I

V

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D

N

N
|
N

G

E

M
x
E

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x
Q

G

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T
x
M

I
x
V

R

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x
W

Q

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N

F

Y

Y

P

E

G

H

R

R

I

Y

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A

H

T

T

S

H

L

Q

S

L

N

N

P

P

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D

F

F

V

I

K

K

L
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L

A

A

E

E

A

A

Y

M

G
|
G

G
x
L

Y

K

G

G

E

L

R

R

V

V

E

K

R

K

T

Q

E

E

D

E

F

L

A

D

G

A

A

K

F

L

A

K

R

E

A

F

Q

V

A

S

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A

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L

L

H

E

L

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E

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D

D

active site: Y29 (≠ V32), G31 (= G34), G32 (≠ E35), A33 (≠ S36), I34 (≠ Y37), E55 (= E58), T78 (= T81), F117 (= F120), Q118 (= Q121), E119 (= E122), K167 (≠ E170), R227 (= R226), M263 (≠ T251), V290 (≠ T288), V406 (≠ A393), L431 (vs. gap), G432 (= G418), M434 (= M420), D459 (= D445), N486 (= N472), E488 (≠ M474), Q489 (≠ Y475), M491 (≠ T477), V492 (≠ I478), W495 (≠ H481), L517 (= L503), G522 (= G508), L523 (≠ G509)
binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ E35), A33 (≠ S36), V107 (= V110), P108 (≠ A111), F117 (= F120), K167 (≠ E170), M263 (≠ T251), D288 (≠ E286), R289 (≠ M287), W495 (≠ H481)
binding flavin-adenine dinucleotide: R157 (= R160), G216 (= G215), A217 (≠ G216), G218 (≠ A217), N221 (≠ D220), T243 (≠ A241), L244 (≠ F242), Q245 (≠ R243), M260 (vs. gap), L261 (vs. gap), H264 (= H252), G283 (= G281), A284 (≠ P282), R285 (= R283), D287 (≠ G285), R289 (≠ M287), V290 (≠ T288), E316 (≠ H308), V317 (≠ P309), N321 (≠ E313), G334 (≠ A326), D335 (= D327), A336 (≠ P328), Q410 (≠ A397), M411 (≠ T398), G429 (≠ T416), G430 (≠ S417)
binding magnesium ion: D459 (= D445), N486 (= N472), E488 (≠ M474)
binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E58), P81 (= P84), Q118 (= Q121), G432 (= G418), M434 (= M420), M464 (= M450)

Sites not aligning to the query:

active site: 556

1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
27% identity, 94% coverage: 12:541/561 of query aligns to 9:555/596 of 1t9cA

query
sites
1t9cA

T

T

G

G

E

Q

I

I

L

F

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R

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C

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L

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V

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G

E
x
G

S
x
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Y
x
I

L

L

A

P

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L

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D

D

A

A

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E

G

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A

A

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M

H

M

M

A

A

D

E

A

G

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Y

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A

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A

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G

G

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K

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P

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G

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C

V

F

L

V

V

T
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T

R

S

G

G

P

P

G

G

A

A

T

T

N

N

A

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S

V

A

T

G

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A

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A

A

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M

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x
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R

P

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G

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I

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x
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x
A

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M

G

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F

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N

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x
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x
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G

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x
M

I
x
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x
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Q

Q

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N

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A

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T

S

H

L

Q

S

L

N

N

P

P

D

D

F

F

V

I

K

K

L
|
L

A

A

E

E

A

A

Y

M

G
|
G

G
x
L

Y

K

G

G

E

L

R

R

V

V

E

K

R

K

T

Q

E

E

D

E

F

L

A

D

G

A

A

K

F

L

A

K

R

E

A

F

Q

V

A

S

A

T

G

K

T

G

P

P

A

V

L

L

H

E

L

V

I

E

L

V

D

D

active site: Y29 (≠ V32), G31 (= G34), G32 (≠ E35), A33 (≠ S36), I34 (≠ Y37), E55 (= E58), T78 (= T81), F117 (= F120), Q118 (= Q121), E119 (= E122), K167 (≠ E170), R227 (= R226), M263 (≠ T251), V290 (≠ T288), V406 (≠ A393), L431 (vs. gap), G432 (= G418), M434 (= M420), D459 (= D445), N486 (= N472), E488 (≠ M474), Q489 (≠ Y475), M491 (≠ T477), V492 (≠ I478), W495 (≠ H481), L517 (= L503), G522 (= G508), L523 (≠ G509)
binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ E35), V107 (= V110), P108 (≠ A111), F117 (= F120), K167 (≠ E170), D288 (≠ E286), R289 (≠ M287), W495 (≠ H481)
binding flavin-adenine dinucleotide: R157 (= R160), G216 (= G215), A217 (≠ G216), G218 (≠ A217), N221 (≠ D220), T243 (≠ A241), L244 (≠ F242), Q245 (≠ R243), L261 (vs. gap), M263 (≠ T251), H264 (= H252), G283 (= G281), A284 (≠ P282), R285 (= R283), D287 (≠ G285), R289 (≠ M287), V290 (≠ T288), E316 (≠ H308), V317 (≠ P309), N321 (≠ E313), G334 (≠ A326), D335 (= D327), A336 (≠ P328), M411 (≠ T398), G429 (≠ T416), G430 (≠ S417)
binding magnesium ion: D459 (= D445), N486 (= N472), E488 (≠ M474)

Sites not aligning to the query:

active site: 556

6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
28% identity, 94% coverage: 12:541/561 of query aligns to 13:556/597 of 6demA

query
sites
6demA

T

T

G

G

E

E

I

I

L

F

V

H

R

E

C

M

L

M

K

L

T

R

H

H

G

K

V

V

D

D

T

T

L

V

Y

F

C

G

V
x
Y

P

A

G
|
G

E
x
G

S
x
A

Y
x
I

L

L

A

P

V

V

L

F

D

D

A

A

L

I

Y

Y

D

N

A

S

P

D

E

K

I

F

R

K

P

F

I

V

V

L

C

P

R

R

Q

H

E
|
E

G

Q

G

G

A

A

A

G

M

H

M

M

A

A

D

E

A

G

Y

Y

G

A

K

R

L

A

T

S

G

G

R

K

P

P

G

G

I

V

C

V

F

L

V

V

T
|
T

R

S

G

G

P

P

G

G

A

A

T

T

N

N

A

V

S

I

A

T

G

P

V

M

H

A

I

D

A

A

F

L

Q

M

D

D

S

G

T

V

P

P

M

L

I

V

L

V

F

F

V

S

G

G

Q

Q

V

V

A

P

R

T

E

T

D

A

Q

I

E

G

R

T

E

D

A

A

F
|
F

Q
|
Q

E
|
E

I

A

D

D

Y

I

R

V

R

G

M

I

Y

S

G

R

Q

S

L

C

A

T

K

K

W

W

V

N

A

V

E

M

I

V

D

K

D

N

A

V

R

A

R

E

I

L

P

P

E

R

F

R

L

I

S

N

R

E

A

A

F

F

H

E

T

I

A

A

T

T

S

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

L

V

A

D

L

L

P

P

E
x
K

D

D

-

V

-

T

-

A

-

S

M

I

L

L

R

R

D

E

R

S

V

I

T

P

A

I

P

N

A

T

C

T

L

L

A

-

Y

-

E

-

P

P

T

S

E

V

S

S

A

E

M

F

G

T

L

S

G

E

Q

A

V

I

E

K

R

R

L

A

G

A

A

N

L

I

L

L

E

N

A

K

A

A

E

K

R

K

P

P

F

I

A

-

L

I

I

Y

G

A

G
|
G

A
|
A

G
|
G

W

I

-

L

-
x
N

D

N

A

E

T

Q

A

G

C

P

E
x
K

R

L

F

L

R

K

R

E

F

L

A

A

E

D

A

K

W

A

K

N

L

I

P

P

V

V

G

T

A

T

A
x
T

F
x
L

R
x
Q

R

G

Q

L

D

G

H

A

F

F

D

D

N

Q

T

R

H

D

G

P

C

K

Y

S

A

L

G

D

D

M

V
x
L

G

G

I
x
M

G

H

I

G

N

S

P

A

K

A

L

A

A

N

K

T

R

A

V

I

K

Q

E

N

A

A

D

D

L

C

L

I

V

A

V

L

G
|
G

P
x
A

R
|
R

L

F

G
x
D

E
x
D

M
x
R

T
x
V

T

T

G

G

G

N

Y

I

S

S

-

K

-

F

-

A

-

P

-

E

-

A

L

K

I

L

S

A

I

A

P

S

E

E

P

G

Q

R

G

G

R

G

L

I

V

L

H

H

V

F

H
x
E

P
x
I

D

S

P

P

E

K

E
x
N

L

I

G

N

R

K

V

V

Y

V

R

E

P

A

T

T

M

E

A

A

V

I

A

E

A

G

D
|
D

P

-

R

-

S

-

F
x
V

A

T

A

A

A

N

V

L

Q

Q

S

S

L

F

L

I

P

P

P

L

A

V

E

D

-

S

-

I

-

E

-

N

-

R

P

P

A

E

W

W

A

F

A

N

G

K

T

I

E

N

Q

E

A

W

H

K

R

K

D

K

Y

Y

-

P

-

Y

-

S

L

Y

D

Q

W

L

N

E

A

T

P

P

V

G

E

S

I

L

V

I

G

K

R

P

L

Q

Q

T

M

L

A

I

K

K

L

E

M

I

D

S

W

D

L

Q

A

A

E

Q

T

T

L

Y

P

N

A

K

D

E

A

V

I

I

L

V

C

T

N

T

G

G

A
x
V

G
|
G

N
x
Q

Y
x
H

A

Q

T
x
M

W

W

I

A

H

A

R

Q

F

H

Y

F

R

T

F

W

R

T

R

Q

F

P

G

R

S

T

Q

M

L

I

A

T

P

S

T
x
G

S

G

-
x
L

G
|
G

S

T

M
|
M

G

G

Y

Y

G

G

V

L

P

P

A

A

V

I

A

G

A

A

K

Q

L

V

R

A

H

K

P

P

E

D

R

A

T

I

V

V

L

I

A

D

F

I

A

D

G
|
G

D
|
D

G
x
A

C
x
S

F

F

M

N

M
|
M

H

T

G

L

Q

T

E

E

F

L

A

S

T

S

A

A

A

V

Q

Q

H

A

G

G

A

A

A

P

V

I

I

K

F

V

V

C

V

V

V

L

D

N

N
|
N

G

E

M
x
E

Y
x
Q

G
|
G

T
x
M

I
x
V

R

T

M

Q

H
x
W

Q

Q

E

S

R

L

N

F

Y

Y

P

E

G

H

R

R

I

Y

S

S

A

H

T

T

S

H

L

Q

S

S

N

N

P

P

D

D

F

F

V

M

K

K

L
|
L

A

A

E

E

A

S

Y

M

G
x
N

G
x
V

Y

K

G

G

E

I

R

R

V

I

E

T

R

N

T

Q

E

Q

D

E

F

L

A

K

G

S

A

G

F

V

A

K

R

E

A

F

Q

L

A

D

A

A

G

T

T

E

P

P

A

V

L

L

H

E

L

V

I

I

L

V

D

E

active site: Y33 (≠ V32), G35 (= G34), G36 (≠ E35), A37 (≠ S36), I38 (≠ Y37), E59 (= E58), T82 (= T81), F121 (= F120), Q122 (= Q121), E123 (= E122), K171 (≠ E170), K228 (≠ E225), M264 (≠ I261), V291 (≠ T288), V407 (≠ A393), L432 (vs. gap), G433 (= G418), M435 (= M420), D460 (= D445), N487 (= N472), E489 (≠ M474), Q490 (≠ Y475), M492 (≠ T477), V493 (≠ I478), W496 (≠ H481), L518 (= L503), N523 (≠ G508), V524 (≠ G509)
binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ I261), D289 (≠ E286), R290 (≠ M287), M492 (≠ T477), W496 (≠ H481)
binding flavin-adenine dinucleotide: R161 (= R160), G217 (= G216), A218 (= A217), G219 (= G218), N222 (vs. gap), T244 (≠ A241), L245 (≠ F242), Q246 (≠ R243), L262 (≠ V259), G284 (= G281), A285 (≠ P282), R286 (= R283), D288 (≠ G285), R290 (≠ M287), V291 (≠ T288), E317 (≠ H308), I318 (≠ P309), N322 (≠ E313), D336 (= D327), V337 (≠ F331), M412 (≠ T398), G430 (≠ T416)
binding magnesium ion: D460 (= D445), N487 (= N472), E489 (≠ M474)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A393), G408 (= G394), Q409 (≠ N395), H410 (≠ Y396), M435 (= M420), G459 (= G444), D460 (= D445), A461 (≠ G446), S462 (≠ C447), M465 (= M450), N487 (= N472), E489 (≠ M474), Q490 (≠ Y475), G491 (= G476), M492 (≠ T477), V493 (≠ I478)

Sites not aligning to the query:

binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: 567

6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
28% identity, 94% coverage: 12:541/561 of query aligns to 13:556/597 of 6delA

query
sites
6delA

T

T

G

G

E

E

I

I

L

F

V

H

R

E

C

M

L

M

K

L

T

R

H

H

G

K

V

V

D

D

T

T

L

V

Y

F

C

G

V
x
Y

P

A

G
|
G

E
x
G

S
x
A

Y
x
I

L

L

A

P

V

V

L

F

D

D

A

A

L

I

Y

Y

D

N

A

S

P

D

E

K

I

F

R

K

P

F

I

V

V

L

C

P

R

R

Q

H

E
|
E

G

Q

G

G

A

A

A

G

M

H

M

M

A

A

D

E

A

G

Y

Y

G

A

K

R

L

A

T

S

G

G

R

K

P

P

G

G

I

V

C

V

F

L

V

V

T
|
T

R

S

G

G

P

P

G

G

A

A

T

T

N

N

A

V

S

I

A

T

G

P

V

M

H

A

I

D

A

A

F

L

Q

M

D

D

S

G

T

V

P

P

M

L

I

V

L

V

F

F

V

S

G

G

Q

Q

V

V

A

P

R

T

E

T

D

A

Q

I

E

G

R

T

E

D

A

A

F
|
F

Q
|
Q

E
|
E

I

A

D

D

Y

I

R

V

R

G

M

I

Y

S

G

R

Q

S

L

C

A

T

K

K

W

W

V

N

A

V

E

M

I

V

D

K

D

N

A

V

R

A

R

E

I

L

P

P

E

R

F

R

L

I

S

N

R

E

A

A

F

F

H

E

T

I

A

A

T

T

S

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

L

V

A

D

L

L

P

P

E
x
K

D

D

-

V

-

T

-

A

-

S

M

I

L

L

R

R

D

E

R

S

V

I

T

P

A

I

P

N

A

T

C

T

L

L

A

-

Y

-

E

-

P

P

T

S

E

V

S

S

A

E

M

F

G

T

L

S

G

E

Q

A

V

I

E

K

R

R

L

A

G

A

A

N

L

I

L

L

E

N

A

K

A

A

E

K

R

K

P

P

F

I

A

-

L

I

I

Y

G

A

G
|
G

A
|
A

G
|
G

W

I

-

L

-
x
N

D

N

A

E

T

Q

A

G

C

P

E
x
K

R

L

F

L

R

K

R

E

F

L

A

A

E

D

A

K

W

A

K

N

L

I

P

P

V

V

G

T

A

T

A
x
T

F
x
L

R
x
Q

R

G

Q

L

D

G

H

A

F

F

D

D

N

Q

T

R

H

D

G

P

C

K

Y

S

A

L

G

D

D

M

V
x
L

G

G

I
x
M

G

H

I

G

N

S

P

A

K

A

L

A

A

N

K

T

R

A

V

I

K

Q

E

N

A

A

D

D

L

C

L

I

V

A

V

L

G
|
G

P
x
A

R
|
R

L

F

G
x
D

E
x
D

M
x
R

T
x
V

T

T

G

G

G

N

Y

I

S

S

-

K

-

F

-

A

-

P

-

E

-

A

L

K

I

L

S

A

I

A

P

S

E

E

P

G

Q

R

G

G

R

G

L

I

V

L

H

H

V

F

H
x
E

P
x
I

D

S

P

P

E

K

E
x
N

L

I

G

N

R

K

V

V

Y

V

R

E

P

A

T

T

M

E

A

A

V

I

A

E

A

G

D
|
D

P

-

R

-

S

-

F
x
V

A

T

A

A

A

N

V

L

Q

Q

S

S

L

F

L

I

P

P

P

L

A

V

E

D

-

S

-

I

-

E

-

N

-

R

P

P

A

E

W

W

A

F

A

N

G

K

T

I

E

N

Q

E

A

W

H

K

R

K

D

K

Y

Y

-

P

-

Y

-

S

L

Y

D

Q

W

L

N

E

A

T

P

P

V

G

E

S

I

L

V

I

G

K

R

P

L

Q

Q

T

M

L

A

I

K

K

L

E

M

I

D

S

W

D

L

Q

A

A

E

Q

T

T

L

Y

P

N

A

K

D

E

A

V

I

I

L

V

C

T

N

T

G

G

A
x
V

G
|
G

N
x
Q

Y
x
H

A

Q

T
x
M

W

W

I

A

H

A

R

Q

F

H

Y

F

R

T

F

W

R

T

R

Q

F

P

G

R

S

T

Q

M

L

I

A

T

P

S

T
x
G

S

G

-
x
L

G
|
G

S

T

M
|
M

G

G

Y

Y

G

G

V

L

P

P

A

A

V

I

A

G

A

A

K

Q

L

V

R

A

H

K

P

P

E

D

R

A

T

I

V

V

L

I

A

D

F

I

A

D

G
|
G

D
|
D

G
x
A

C
x
S

F

F

M

N

M
|
M

H

T

G

L

Q

T

E

E

F

L

A

S

T

S

A

A

A

V

Q

Q

H

A

G

G

A

A

A

P

V

I

I

K

F

V

V

C

V

V

V

L

D

N

N
|
N

G

E

M
x
E

Y
x
Q

G
|
G

T
x
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active site: Y33 (≠ V32), G35 (= G34), G36 (≠ E35), A37 (≠ S36), I38 (≠ Y37), E59 (= E58), T82 (= T81), F121 (= F120), Q122 (= Q121), E123 (= E122), K171 (≠ E170), K228 (≠ E225), M264 (≠ I261), V291 (≠ T288), V407 (≠ A393), L432 (vs. gap), G433 (= G418), M435 (= M420), D460 (= D445), N487 (= N472), E489 (≠ M474), Q490 (≠ Y475), M492 (≠ T477), V493 (≠ I478), W496 (≠ H481), L518 (= L503), N523 (≠ G508), V524 (≠ G509)
binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (≠ E286), R290 (≠ M287), W496 (≠ H481)
binding flavin-adenine dinucleotide: R161 (= R160), G217 (= G216), A218 (= A217), G219 (= G218), N222 (vs. gap), T244 (≠ A241), L245 (≠ F242), Q246 (≠ R243), L262 (≠ V259), G284 (= G281), A285 (≠ P282), R286 (= R283), D288 (≠ G285), R290 (≠ M287), V291 (≠ T288), E317 (≠ H308), I318 (≠ P309), N322 (≠ E313), D336 (= D327), V337 (≠ F331), M412 (≠ T398), G430 (≠ T416)
binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A393), G408 (= G394), Q409 (≠ N395), H410 (≠ Y396), G433 (= G418), M435 (= M420), G459 (= G444), D460 (= D445), A461 (≠ G446), S462 (≠ C447), M465 (= M450), N487 (= N472), E489 (≠ M474), Q490 (≠ Y475), G491 (= G476), M492 (≠ T477), V493 (≠ I478)
binding magnesium ion: D460 (= D445), N487 (= N472), E489 (≠ M474)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A393), G408 (= G394), Q409 (≠ N395), H410 (≠ Y396), G433 (= G418), M435 (= M420), G459 (= G444), D460 (= D445), A461 (≠ G446), S462 (≠ C447), M465 (= M450), N487 (= N472), E489 (≠ M474), Q490 (≠ Y475), G491 (= G476), M492 (≠ T477), V493 (≠ I478)

6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
28% identity, 94% coverage: 12:541/561 of query aligns to 15:558/599 of 6denA

query
sites
6denA

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