SitesBLAST
Comparing WP_085636384.1 NCBI__GCF_002115805.1:WP_085636384.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7omlA Bacillus subtilis phosphoglucomutase glmm (metal bound) (see paper)
48% identity, 99% coverage: 4:447/447 of query aligns to 2:444/445 of 7omlA
7ojrA Bacillus subtilis phosphoglucomutase glmm (phosphate bound) (see paper)
48% identity, 99% coverage: 4:447/447 of query aligns to 2:444/445 of 7ojrA
P31120 Phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli (strain K12) (see 3 papers)
51% identity, 99% coverage: 3:445/447 of query aligns to 4:444/445 of P31120
- S100 (= S101) mutation to A: 2% of wild-type activity.; mutation to T: 20-fold increase in the non-specific phosphoglucomutase activity towards glucose-phosphate substrates (non aminated).
- S102 (= S103) active site, Phosphoserine intermediate; modified: Phosphoserine; by autocatalysis; mutation to A: Loss of activity in the absence or presence of glucosamine-1,6-diP.
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
3i3wA Structure of a phosphoglucosamine mutase from francisella tularensis
39% identity, 98% coverage: 4:443/447 of query aligns to 1:436/441 of 3i3wA
- active site: R9 (= R12), S99 (= S103), H100 (= H104), K109 (= K113), D237 (= D242), D239 (= D244), D241 (= D246), R242 (= R247), H324 (= H331)
- binding zinc ion: S99 (= S103), D237 (= D242), D239 (= D244), D241 (= D246)
1wqaA Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
33% identity, 95% coverage: 4:429/447 of query aligns to 3:436/455 of 1wqaA
- active site: R11 (= R12), S101 (= S103), H102 (= H104), K111 (= K113), D243 (= D242), D245 (= D244), D247 (= D246), R248 (= R247), G330 (≠ H331), R340 (≠ G341)
- binding magnesium ion: S101 (= S103), D243 (= D242), D245 (= D244), D247 (= D246)
1pcjX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
27% identity, 93% coverage: 20:436/447 of query aligns to 22:442/458 of 1pcjX
- active site: S103 (= S103), H104 (= H104), K113 (= K121), D237 (= D242), D239 (= D244), D241 (= D246), R242 (= R247), H324 (= H331), D335 (≠ G341)
- binding 1-O-phosphono-alpha-D-mannopyranose: S103 (= S103), T301 (≠ V308), G302 (= G309), E320 (= E327), S322 (= S329), H324 (= H331), R416 (= R412), S418 (= S414), N419 (≠ G415), T420 (= T416)
- binding zinc ion: S103 (= S103), D237 (= D242), D239 (= D244), D241 (= D246)
Sites not aligning to the query:
2h5aX Complex of the enzyme pmm/pgm with xylose 1-phosphate (see paper)
27% identity, 93% coverage: 20:436/447 of query aligns to 19:439/455 of 2h5aX
- active site: H101 (= H104), D234 (= D242), D236 (= D244), D238 (= D246), R239 (= R247), D332 (≠ G341)
- binding 1-O-phosphono-alpha-D-xylopyranose: T298 (≠ V308), G299 (= G309), H300 (≠ D310), E317 (= E327), S319 (= S329), H321 (= H331), R413 (= R412), S415 (= S414), N416 (≠ G415), T417 (= T416)
- binding zinc ion: S100 (= S103), D234 (= D242), D236 (= D244), D238 (= D246)
Sites not aligning to the query:
2h4lX Complex of pmm/pgm with ribose 1-phosphate (see paper)
27% identity, 93% coverage: 20:436/447 of query aligns to 19:439/455 of 2h4lX
- active site: H101 (= H104), D234 (= D242), D236 (= D244), D238 (= D246), R239 (= R247), D332 (≠ G341)
- binding 1-O-phosphono-alpha-D-ribofuranose: S100 (= S103), T298 (≠ V308), E317 (= E327), R413 (= R412), S415 (= S414), N416 (≠ G415), T417 (= T416)
- binding zinc ion: S100 (= S103), D234 (= D242), D236 (= D244), D238 (= D246)
Sites not aligning to the query:
2fkfA Phosphomannomutase/phosphoglucomutase from pseudomonas aeruginosa with alpha-d-glucose 1,6-bisphosphate bound (see paper)
27% identity, 93% coverage: 20:436/447 of query aligns to 19:439/455 of 2fkfA
- active site: S100 (= S103), H101 (= H104), K110 (= K121), D234 (= D242), D236 (= D244), D238 (= D246), R239 (= R247), H321 (= H331), D332 (≠ G341)
- binding 1,6-di-O-phosphono-alpha-D-glucopyranose: H101 (= H104), S319 (= S329), R413 (= R412), S415 (= S414), N416 (≠ G415), T417 (= T416)
- binding zinc ion: S100 (= S103), D234 (= D242), D236 (= D244), D238 (= D246)
Sites not aligning to the query:
1pcmX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
27% identity, 93% coverage: 20:436/447 of query aligns to 19:439/455 of 1pcmX
- active site: S100 (= S103), H101 (= H104), K110 (= K121), D234 (= D242), D236 (= D244), D238 (= D246), R239 (= R247), H321 (= H331), D332 (≠ G341)
- binding 6-O-phosphono-alpha-D-mannopyranose: S100 (= S103), T298 (≠ V308), G299 (= G309), H300 (≠ D310), E317 (= E327), S319 (= S329), H321 (= H331), R413 (= R412), S415 (= S414)
- binding zinc ion: S100 (= S103), D234 (= D242), D236 (= D244), D238 (= D246)
Sites not aligning to the query:
1p5gX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
27% identity, 93% coverage: 20:436/447 of query aligns to 19:439/455 of 1p5gX