SitesBLAST
Comparing WP_085640679.1 NCBI__GCF_002115805.1:WP_085640679.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6wsbA Crystal structure of a betaine aldehyde dehydrogenase from burkholderia pseudomallei bound to cofactor NAD (see paper)
57% identity, 98% coverage: 12:485/485 of query aligns to 9:488/489 of 6wsbA
- active site: N152 (= N154), E250 (= E251), C284 (= C285), E462 (= E459)
- binding nicotinamide-adenine-dinucleotide: I148 (= I150), G149 (= G151), A150 (= A152), W151 (= W153), N152 (= N154), K175 (= K177), E178 (= E180), G208 (= G210), G211 (= G213), A212 (= A214), F225 (≠ L227), T226 (= T228), G227 (= G229), G228 (≠ S230), T231 (= T233), V235 (= V237), E250 (= E251), L251 (= L252), G252 (= G253), C284 (= C285), E385 (= E382), F387 (= F384)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
55% identity, 98% coverage: 12:485/485 of query aligns to 10:490/490 of Q9HTJ1
- GAWN 150:153 (= GAWN 151:154) binding NADPH
- K162 (= K163) active site, Charge relay system
- KPSE 176:179 (= KPSE 177:180) binding NADPH
- G209 (= G210) binding NADPH
- GTST 230:233 (≠ SVPT 230:233) binding NADPH
- E252 (= E251) active site, Proton acceptor
- C286 (= C285) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E382) binding NADPH
- E464 (= E459) active site, Charge relay system
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
55% identity, 98% coverage: 12:485/485 of query aligns to 9:489/489 of 4cazA
- active site: N152 (= N154), K175 (= K177), E251 (= E251), C285 (= C285), E386 (= E382), E463 (= E459)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I150), G149 (= G151), W151 (= W153), N152 (= N154), K175 (= K177), E178 (= E180), G208 (= G210), G212 (= G213), F226 (≠ L227), T227 (= T228), G228 (= G229), G229 (≠ S230), T232 (= T233), V236 (= V237), E251 (= E251), L252 (= L252), C285 (= C285), E386 (= E382), F388 (= F384)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
55% identity, 98% coverage: 12:485/485 of query aligns to 9:489/489 of 2woxA
- active site: N152 (= N154), K175 (= K177), E251 (= E251), C285 (= C285), E386 (= E382), E463 (= E459)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I150), G149 (= G151), W151 (= W153), N152 (= N154), K175 (= K177), S177 (= S179), E178 (= E180), G208 (= G210), G212 (= G213), F226 (≠ L227), T227 (= T228), G228 (= G229), G229 (≠ S230), T232 (= T233), V236 (= V237), E251 (= E251), L252 (= L252), C285 (= C285), E386 (= E382), F388 (= F384)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
55% identity, 98% coverage: 12:485/485 of query aligns to 9:489/489 of 2wmeA
- active site: N152 (= N154), K175 (= K177), E251 (= E251), C285 (= C285), E386 (= E382), E463 (= E459)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (= G151), W151 (= W153), K175 (= K177), S177 (= S179), E178 (= E180), G208 (= G210), G212 (= G213), F226 (≠ L227), G228 (= G229), G229 (≠ S230), T232 (= T233), V236 (= V237)
8skfA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (lattice translocation disorder)
56% identity, 98% coverage: 12:485/485 of query aligns to 17:497/497 of 8skfA
- binding calcium ion: T33 (≠ V28), I34 (= I29), D100 (= D95), V187 (≠ T181)
- binding nicotinamide-adenine-dinucleotide: I156 (= I150), G157 (= G151), A158 (= A152), W159 (= W153), K183 (= K177), E186 (= E180), G216 (= G210), G220 (= G213), T235 (= T228), G236 (= G229), G237 (≠ S230), S240 (≠ T233), K243 (= K236), E259 (= E251), C293 (= C285), F396 (= F384)
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
56% identity, 98% coverage: 12:485/485 of query aligns to 8:488/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
56% identity, 98% coverage: 12:485/485 of query aligns to 8:488/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
56% identity, 98% coverage: 12:485/485 of query aligns to 8:488/488 of 8vqzA
8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
56% identity, 98% coverage: 12:485/485 of query aligns to 8:488/488 of 8vqwC