SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_085771168.1 NCBI__GCF_002117405.1:WP_085771168.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 12 hits to proteins with known functional sites (download)

P9WQ73 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
26% identity, 95% coverage: 12:383/390 of query aligns to 17:375/376 of P9WQ73

query
sites
P9WQ73

P

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D

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A

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T154 (= T148) binding
D176 (= D171) binding
Q199 (= Q194) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

2fyfA Structure of a putative phosphoserine aminotransferase from mycobacterium tuberculosis (see paper)
26% identity, 95% coverage: 12:383/390 of query aligns to 10:367/368 of 2fyfA

query
sites
2fyfA

P

P

K

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x
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active site: F101 (= F102), D168 (= D171), K192 (= K195)
binding tetrachloroplatinate(ii): I321 (≠ V338), A324 (≠ E341)
binding pyridoxal-5'-phosphate: A77 (≠ D77), T78 (= T78), W81 (≠ V81), F101 (= F102), T147 (= T148), D168 (= D171), T170 (= T173), Q191 (= Q194), K192 (= K195), N243 (= N248), T244 (= T249)

Sites not aligning to the query:

binding tetrachloroplatinate(ii): 1, 2

8a5wC Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
21% identity, 80% coverage: 6:318/390 of query aligns to 7:306/365 of 8a5wC

query
sites
8a5wC

P

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binding (2S)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-phosphonooxy-propanoic acid: H39 (= H42), R40 (= R43), N236 (= N248), T237 (= T249)
binding phosphoserine: T151 (= T148), K195 (= K195)

Sites not aligning to the query:

binding phosphoserine: 330, 331, 337

8a5wA Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
21% identity, 80% coverage: 6:318/390 of query aligns to 7:306/365 of 8a5wA

query
sites
8a5wA

P

P

K

G

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P

A

A

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L

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N

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H

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R

A

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K

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A

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K

K

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N

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x
G

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x
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x
C

G

G

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Q

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F

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S

A

A

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E

P

M

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W

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W

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Y

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D

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W

N

N

G

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H

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D

D

L

A

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F

Y

A

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Y

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Y

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T
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I

A

P

A

D

D

V

R

K

K

G

G

A

L

V

T

L

I

V

C

C

D
|
D

A

M

T
x
S

S

S

G

N

A

F

F

L

A

S

Q

K

P

P

L

V

D

D

F

V

A

S

K

K

L

F

D

G

V

V

T

I

T

F

F

A

S

G

W

A

Q
|
Q

K
|
K

C

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

E

G

S

F

Y

A

V

L

P

R

P

E

W

C

P

P

L

S

P

V

K

L

I

E

F

Y

R

K

L

V

T

Q

K

A

G

G

S

N

K

S

L

-

I

-

E

-

G

-

V

-

F

-

A

-

G

-

E

S

T

L

I

Y

N

N

T

T

P

P

S

P

L

C

L

F

C

S

V

I

E

Y

D

V

Y

M

L

G

D

L

A

V

L

L

Q

E

W

W

A

I

R

K

S

N

I

N

G

G

L

A

D

A

A

A

L

M

C

E

A

K

R

L

A

S

D

S

A

I

N

K

A

S

A

Q

V

T

V

I

A

Y

E

E

W

I

T

I

L

D

R

N

Q

S

P

Q

A

G

F

F

A

Y

F

V

L

C

A

P

K

V

Q

E

P

P

Q

Q

T

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

E

R

F

I

A

G

D

N

P

A

R

K

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G73 (≠ S76), G74 (≠ D77), C75 (≠ T78), W102 (≠ F102), T151 (= T148), D171 (= D171), S173 (≠ T173), Q194 (= Q194), K195 (= K195)
binding phosphoserine: H39 (= H42), R40 (= R43)

Sites not aligning to the query:

binding phosphoserine: 330, 337

8a5vA Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
21% identity, 80% coverage: 6:318/390 of query aligns to 7:306/365 of 8a5vA

query
sites
8a5vA

P

P

K

G

P

P

A

A

G

K

L

L

P

P

K

H

N

S

P

V

S

L

F

L

S

E

S

-

G

-

P

-

C

-

A

I

K

Q

R

K

P

E

G

L

W

L

S

D

P

Y

Q

K

N

G

L

V

S

G

A

I

A

S

A

V

L

L

G

E

R

M

S

S

H

H

R

R

A

S

K

S

A

D

G

F

K

A

E

K

K

I

L

I

E

N

R

N

A

T

I

E

A

N

L

L

T

V

R

R

E

E

V

L

L

L

R

A

V

V

P

P

D

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

A

G

S

G

D

G

T

C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

S

G

M

L

L

K

G

A

P

G

R

R

P

C

V

A

D

D

V

Y

L

V

A

V

F

T

E

G

S

A

F

W

S

S

S

A

G

K

W

A

A

A

T

E

D

E

V

A

Q

K

K

K

Q

F

L

G

K

T

L

I

P

N

Q

I

A

V

R

H

V

P

L

K

T

L

A

G

P

S

Y

Y

G

T

E

K

L

I

P

P

D

D

L

P

A

S

Q

T

V

W

N

N

G

L

D

N

H

P

D

D

L

A

V

S

F

Y

A

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T

T

T

V

S

H

G

G

V

V

R

E

V

F

P

D

N

-

A

-

F

F

I

I

A

P

A

D

D

V

R

K

K

G

G

A

L

V

T

L

I

V

C

C

D

D

A

M

T

S

S

S

G

N

A

F

F

L

A

S

Q

K

P

P

L

V

D

D

F

V

A

S

K

K

L

F

D

G

V

V

T

I

T

F

F

A

S

G

W

A

Q

Q

K

K

C

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

E

G

S

F

Y

A

V

L

P

R

P

E

W

C

P

P

L

S

P

V

K

L

I

E

F

Y

R

K

L

V

T

Q

K

A

G

G

S

N

K

S

L

-

I

-

E

-

G

-

V

-

F

-

A

-

G

-

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

L

C

L

F

C

S

V

I

E

Y

D

V

Y

M

L

G

D

L

A

V

L

L

Q

E

W

W

A

I

R

K

S

N

I

N

G

G

L

A

D

A

A

A

L

M

C

E

A

K

R

L

A

S

D

S

A

I

N

K

A

S

A

Q

V

T

V

I

A

Y

E

E

W

I

T

I

L

D

R

N

Q

S

P

Q

A

G

F

F

A

Y

F

V

L

C

A

P

K

V

Q

E

P

P

Q

Q

T

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

E

R

F

I

A

G

D

N

P

A

R

K

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: N236 (= N248), T237 (= T249)

Q9Y617 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Homo sapiens (Human) (see 6 papers)
21% identity, 80% coverage: 6:318/390 of query aligns to 12:311/370 of Q9Y617

query
sites
Q9Y617

P

P

K

G

P

P

A

A

G

K

L

L

P

P

K

H

N

S

P

V

S

L

F

L

S

E

S

-

G

-

P

-

C

-

A

I

K

Q

R

K

P

E

G

L

W

L

S

D

P

Y

Q

K

N

G

L

V

S

G

A

I

A

S

A

V

L

L

G

E

R

M

S
|
S

H
|
H

R
|
R

A

S

K

S

A

D

G

F

K

A

E

K

K

I

L

I

E

N

R

N

A

T

I

E

A

N

L

L

T

V

R

R

E

E

V

L

L

L

R

A

V

V

P

P

D

D

D

N

Y
|
Y

R

K

I

V

G

I

I

F

V

L

P

Q

A

G

S

G

D
x
G

T
x
C

G

G

-

Q

-

F

-

S

A

A

V

V

E
x
P

M

L

A

N

L

L

W

I

S

G

M

L

L

K

G

A

P

G

R

R

P

C

V
x
A

D
|
D

V

Y

L

V

A

V

F

T

E

G

S

A

F
x
W

S

S

S

A

G

K

W

A

A

A

T

E

D

E

V

A

Q

K

K

K

Q

F

L

G

K

T

L

I

P

N

Q

I

A

V

R

H

V

P

L

K

T

L

A

G

P

S

Y

Y

G

T

E

K

L

I

P

P

D

D

L

P

A

S

Q

T

V

W

N

N

G

L

D

N

H

P

D

D

L

A

V

S

F

Y

A

V

W

Y

-

Y

-

C

-

A

N

N

G
x
E

T
|
T

T

V

S

H

G

G

V

V

R

E

V

F

P

D

N

-

A

-

F

F

I

I

A

P

A

D

D

V

R

K

K

G

G

A

L

V

T

L

I

V

C

C

D
|
D

A

M

T

S

S
|
S

G

N

A

F

F

L

A

S

Q

K

P

P

L

V

D

D

F

V

A

S

K

K

L

F

D

G

V

V

T

I

T

F

F

A

S

G

W

A

Q
|
Q

K
|
K

C

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

E

G

S

F

Y

A

V

L

P

R

P

E

W

C

P

P

L

S

P

V

K

L

I

E

F

Y

R

K

L

V

T

Q

K

A

G

G

S

N

K

S

L

-

I

-

E

-

G

-

V

-

F

-

A

-

G

-

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

L
x
C

L

F

C

S

V

I

E

Y

D

V

Y

M

L

G

D

L

A

V

L

L

Q

E

W

W

A

I

R

K

S

N

I

N

G

G

L

A

D

A

A

A

L

M

C

E

A

K

R

L

A

S

D

S

A

I

N

K

A

S

A

Q

V

T

V

I

A

Y

E

E

W

I

T

I

L

D

R

N

Q

S

P

Q

A

G

F

F

A

Y

F

V

L

C

A

P

K

V

Q

E

P

P

Q

Q

T

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

E

R

F

I

A

G

D

N

P

A

R

K

S43 (= S41) to R: in PSATD; reduced O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; 3-fold increase of KM for 3-phosphohydroxypyruvate; 5-fold increase of KM for L-glutamate; decreased function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization; does not affect thermal stability
H44 (= H42) binding in other chain
R45 (= R43) binding in other chain
Y70 (= Y68) to N: in NLS2; uncertain significance
G79 (≠ D77) binding ; to W: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway
C80 (≠ T78) binding
P87 (≠ E82) to A: has no effect on O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; does not affect KM for 3-phosphohydroxypyruvate; does not affect KM for L-glutamate; no effect on function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization; does not affect thermal stability; dbSNP:rs11540974
A99 (≠ V94) to V: in NLS2; does not affect secondary structure; does not affect dimerization; increased thermal stability; dbSNP:rs587777778
D100 (= D95) to A: in PSATD; has no effect on O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; does not affect KM for 3-phosphohydroxypyruvate; does not affect KM for L-glutamate; does not affect secondary structure; results in increased protein aggregation as shown by dynamic light scattering; dbSNP:rs118203967
W107 (≠ F102) binding
E155 (≠ G147) to Q: in NLS2; uncertain significance
T156 (= T148) binding
D176 (= D171) binding
S179 (= S174) to L: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; dbSNP:rs587777777
Q199 (= Q194) binding
K200 (= K195) modified: N6-(pyridoxal phosphate)lysine
N241 (= N248) binding in other chain
T242 (= T249) binding in other chain
C245 (≠ L252) to R: in NLS2; reduced O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; 9-fold increase of KM for L-glutamate; does not affect KM for 3-phosphohydroxypyruvate; decreased function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization

Sites not aligning to the query:

335 binding
336 binding
342 binding ; R → W: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; dbSNP:rs202103028

8a5vE Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
21% identity, 80% coverage: 6:318/390 of query aligns to 8:307/366 of 8a5vE

query
sites
8a5vE

P

P

K

G

P

P

A

A

G

K

L

L

P

P

K

H

N

S

P

V

S

L

F

L

S

E

S

-

G

-

P

-

C

-

A

I

K

Q

R

K

P

E

G

L

W

L

S

D

P

Y

Q

K

N

G

L

V

S

G

A

I

A

S

A

V

L

L

G

E

R

M

S

S

H

H

R

R

A

S

K

S

A

D

G

F

K

A

E

K

K

I

L

I

E

N

R

N

A

T

I

E

A

N

L

L

T

V

R

R

E

E

V

L

L

L

R

A

V

V

P

P

D

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

A

G

S

G

D

G

T

C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

S

G

M

L

L

K

G

A

P

G

R

R

P

C

V

A

D

D

V

Y

L

V

A

V

F

T

E

G

S

A

F
x
W

S

S

S

A

G

K

W

A

A

A

T

E

D

E

V

A

Q

K

K

K

Q

F

L

G

K

T

L

I

P

N

Q

I

A

V

R

H

V

P

L

K

T

L

A

G

P

S

Y

Y

G

T

E

K

L

I

P

P

D

D

L

P

A

S

Q

T

V

W

N

N

G

L

D

N

H

P

D

D

L

A

V

S

F

Y

A

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T

T

T

V

S

H

G

G

V

V

R

E

V

F

P

D

N

-

A

-

F

F

I

I

A

P

A

D

D

V

R

K

K

G

G

A

L

V

T

L

I

V

C

C

D

D

A

M

T

S

S

S

G

N

A

F

F

L

A

S

Q

K

P

P

L

V

D

D

F

V

A

S

K

K

L

F

D

G

V

V

T

I

T

F

F

A

S

G

W

A

Q

Q

K

K

C

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

E

G

S

F

Y

A

V

L

P

R

P

E

W

C

P

P

L

S

P

V

K

L

I

E

F

Y

R

K

L

V

T

Q

K

A

G

G

S

N

K

S

L

-

I

-

E

-

G

-

V

-

F

-

A

-

G

-

E

S

T

L

I

Y

N

N

T

T

P

P

S

P

L

C

L

F

C

S

V

I

E

Y

D

V

Y

M

L

G

D

L

A

V

L

L

Q

E

W

W

A

I

R

K

S

N

I

N

G

G

L

A

D

A

A

A

L

M

C

E

A

K

R

L

A

S

D

S

A

I

N

K

A

S

A

Q

V

T

V

I

A

Y

E

E

W

I

T

I

L

D

R

N

Q

S

P

Q

A

G

F

F

A

Y

F

V

L

C

A

P

K

V

Q

E

P

P

Q

Q

T

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

E

R

F

I

A

G

D

N

P

A

R

K

binding sulfate ion: W103 (≠ F102)

Sites not aligning to the query:

binding sulfate ion: 332

3e77A Human phosphoserine aminotransferase in complex with plp
22% identity, 71% coverage: 36:310/390 of query aligns to 31:296/363 of 3e77A

query
sites
3e77A

A

S

A

V

L

L

G

E

R

M

S

S

H

H

R

R

A

S

K

S

A

D

G

F

K

A

E

K

K

I

L

I

E

N

R

N

A

T

I

E

A

N

L

L

T

V

R

R

E

E

V

L

L

L

R

A

V

V

P

P

D

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

A

G

S
x
G

D
x
G

T
x
C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

S

G

M

L

L

K

G

A

P

G

R

R

P

C

V

A

D

D

V

Y

L

V

A

V

F

T

E

G

S

A

F
x
W

S

S

S

A

G

K

W

A

A

A

T

E

D

E

V

A

Q

K

K

K

Q

F

L

G

K

T

L

I

P

N

Q

I

A

V

R

H

V

P

L

K

T

L

A

G

P

S

Y

Y

G

T

E

K

L

I

P

P

D

D

L

P

A

S

Q

T

V

W

N

N

G

L

D

N

H

P

D

D

L

A

V

S

F

Y

A

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

R

E

V

F

P

D

N

-

A

-

F

F

I

I

A

P

A

D

D

V

R

K

K

G

G

A

L

V

T

L

I

V

C

C

D
|
D

A

M

T
x
S

S

S

G

N

A

F

F

L

A

S

Q

K

P

P

L

V

D

D

F

V

A

S

K

K

L

F

D

G

V

V

T

I

T

F

F

A

S

G

W

A

Q
|
Q

K
|
K

C

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

E

G

S

F

Y

A

V

L

P

R

P

E

W

C

P

P

L

S

P

V

K

L

I

E

F

Y

R

K

L

V

T

Q

K

A

G

G

S

N

K

S

L

-

I

-

E

-

G

-

V

-

F

-

A

-

G

-

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

L

C

L

F

C

S

V

I

E

Y

D

V

Y

M

L

G

D

L

A

V

L

L

Q

E

W

W

A

I

R

K

S

N

I

N

G

G

L

A

D

A

A

A

L

M

C

E

A

K

R

L

A

S

D

S

A

I

N

K

A

S

A

Q

V

T

V

I

A

Y

E

E

W

I

T

I

L

D

R

N

Q

S

P

Q

A

G

F

F

A

Y

F

V

L

C

A

P

K

V

Q

E

P

P

Q

Q

T

N

R

R

S

S

N

K

T

M

S

N

V

I

active site: W100 (≠ F102), D169 (= D171), K193 (= K195)
binding pyridoxal-5'-phosphate: G71 (≠ S76), G72 (≠ D77), C73 (≠ T78), W100 (≠ F102), T149 (= T148), D169 (= D171), S171 (≠ T173), Q192 (= Q194), K193 (= K195), N234 (= N248), T235 (= T249)

8a5wE Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
20% identity, 80% coverage: 6:318/390 of query aligns to 8:306/365 of 8a5wE

query
sites
8a5wE

P

P

K

G

P

P

A

A

G

K

L

L

P

P

K

H

N

S

P

V

S

L

F

L

S

E

S

-

G

-

P

-

C

-

A

I

K

Q

R

K

P

E

G

L

W

L

S

D

P

Y

Q

K

N

G

L

V

S

G

A

I

A

S

A

V

L

L

G

E

R

M

S

S

H
|
H

R
|
R

A

S

K

S

A

D

G

F

K

A

E

K

K

I

L

I

E

N

R

N

A

T

I

E

A

N

L

L

T

V

R

R

E

E

V

L

L

L

R

A

V

V

P

P

D

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

A

G

S
x
G

D
x
G

T
x
C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

S

G

M

L

L

K

G

A

P

G

R

R

P

C

V

A

D

D

V

Y

L

V

A

V

F

T

E

G

S

A

F
x
W

S

S

S

A

G

K

W

A

A

A

T

E

D

E

V

A

Q

K

K

K

Q

F

L

G

K

T

L

I

P

N

Q

I

A

V

R

H

V

P

L

K

T

L

A

G

P

S

Y

Y

G

T

E

K

L

I

P

P

D

D

L

P

A

S

Q

T

V

W

N

N

G

L

D

N

H

P

D

D

L

A

V

S

F

Y

A

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

R

E

V

F

P

D

N

-

A

-

F

F

I

I

A

P

A

D

D

V

R

K

K

G

G

A

L

V

T

L

I

V

C

C

D

D

A

M

T
x
S

S

S

G

N

A

F

F

L

A

S

Q

K

P

P

L

V

D

D

F

V

A

S

K

K

L

F

D

G

V

V

T

I

T

F

F

A

S

G

W
x
A

Q
|
Q

K
x
N

C

V

L

-

G

-

G

G

E

S

A

A

A

G

H

V

G

T

M

V

L

V

I

I

L

V

S

R

P

D

R

-

A

-

V

-

E

D

R

L

L

L

E

G

S

F

Y

A

V

L

P

R

P

E

W

C

P

P

L

S

P

V

K

L

I

E

F

Y

R

K

L

V

T

Q

K

A

G

G

S

N

K

S

L

-

I

-

E

-

G

-

V

-

F

-

A

-

G

-

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

L

C

L

F

C

S

V

I

E

Y

D

V

Y

M

L

G

D

L

A

V

L

L

Q

E

W

W

A

I

R

K

S

N

I

N

G

G

L

A

D

A

A

A

L

M

C

E

A

K

R

L

A

S

D

S

A

I

N

K

A

S

A

Q

V

T

V

I

A

Y

E

E

W

I

T

I

L

D

R

N

Q

S

P

Q

A

G

F

F

A

Y

F

V

L

C

A

P

K

V

Q

E

P

P

Q

Q

T

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

E

R

F

I

A

G

D

N

P

A

R

K

binding (2S)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-phosphonooxy-propanoic acid: H40 (= H42), R41 (= R43), N236 (= N248), T237 (= T249)
binding (2~{S})-2-[[(~{R})-[[(5~{S})-5-azanyl-6-oxidanylidene-hexyl]amino]-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]-3-phosphonooxy-propanoic acid: G74 (≠ S76), G75 (≠ D77), C76 (≠ T78), W103 (≠ F102), T152 (= T148), S174 (≠ T173), A194 (≠ W193), Q195 (= Q194), N196 (≠ K195)

Sites not aligning to the query:

binding (2~{S})-2-[[(~{R})-[[(5~{S})-5-azanyl-6-oxidanylidene-hexyl]amino]-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]-3-phosphonooxy-propanoic acid: 330, 331, 337, 341

1w23B Crystal structure of phosphoserine aminotransferase from bacillus alcalophilus (see paper)
21% identity, 80% coverage: 8:319/390 of query aligns to 11:305/357 of 1w23B

query
sites
1w23B

P

P

A

S

G

A

L

L

P

P

K

K

N

-

P

P

S

A

F

L

S

E

S

R

G

-

P

-

C

-

A

A

K

Q

R

K

P

E

G

L

W

L

S

N

P

F

Q

N

N

D

L

T

S

Q

A

M

A

S

A

V

L

M

G

E

R

L

S

S

H

H

R

R

A

S

K

Q

A

S

G

Y

K

E

E

E

K

V

L

H

E

E

R

Q

A

A

I

Q

A

N

L

L

T

L

R

R

E

E

V

L

L

L

R

Q

V

I

P

P

D

N

D

D

Y

Y

R

Q

I

I

G

L

I

F

V

L

P

Q

A

G

S

G

D
x
A

T
x
S

G

L

A

Q

V

F

E

T

M

M

A

L

L

P

W

M

S

N

M

L

L

L

G

T

P

K

R

G

P

T

V

I

D

G

V

N

L

Y

A

V

F

-

E

-

S

-

F

L

S

T

S

G

G

S

W
|
W

A

S

T

E

D

K

V

A

Q

L

K

K

Q

E

L

A

K

K

L

L

P

L

Q

G

A

E

R

T

V

H

L

I

T

A

A

A

-

S

-

T

-

K

-

A

-

N

P

S

Y
|
Y

G

Q

E

S

L

I

P

P

D

D

L

F

A

S

-

E

-

F

Q

Q

V

L

N

N

-

E

G

N

D

D

H

A

D

Y

L

L

V

H

F

I

A

T

W

S

N

N

G

N

T
|
T

T

I

S
x
Y

G

G

V

T

R

Q

V

Y

P

Q

N

N

A

-

F

F

I

P

A

E

A

I

D

N

R

H

K

A

G

P

L

L

T

-

I

I

C

A

D
|
D

A

M

T
x
S

S

S

G

D

A

I

F

L

A

S

Q

R

P

P

L

L

D

K

F

V

A

N

K

Q

L

F

D

G

V

M

T

I

T

Y

F

A

S

G

W

A

Q
|
Q

K
|
K

C

N

L

L

G

G

G

P

E

S

A

G

A

V

H

T

G

V

M

V

L

I

I

V

L

K

S

K

P

D

R

L

A

L

V

V

E

E

R

Q

L

-

E

-

S

-

Y

-

V

-

P

-

W

-

P

-

L

V

P

P

K

T

I

M

F

L

R

Q

L

Y

T

A

K

T

G

H

S

I

K

K

L

-

I

-

E

-

G

-

V

-

F

-

A

S

G

D

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

L

T

L

F

C

S

V

I

E

Y

D

M

Y

L

L

R

D

N

A

V

L

L

Q

D

W

W

A

I

R

K

S

D

I

L

G

G

L

A

D

E

A

A

L

I

C

A

A

K

R

Q

A

N

D

E

A

E

N

K

A

A

A

K

V

I

A

Y

E

D

W

T

T

I

L

D

R

E

Q

S

P

N

A

G

F

F

A

Y

F

V

L

G

A
x
H

K
x
A

Q

E

P

K

Q

G

T

S

R

R

S

S

N

L

T

M

S

N

V

V

C

T

L

F

E

N

F

L

A

R

D

N

P

E

R

E

V

L

active site: W102 (= W106), D172 (= D171), K196 (= K195)
binding magnesium ion: Y127 (= Y126), Y154 (≠ S150), H285 (≠ A299), A286 (≠ K300)
binding pyridoxal-5'-phosphate: A76 (≠ D77), S77 (≠ T78), W102 (= W106), T152 (= T148), D172 (= D171), S174 (≠ T173), Q195 (= Q194), K196 (= K195), N234 (= N248), T235 (= T249)

4azjA Structural basis of l-phosphoserine binding to bacillus alcalophilus phosphoserine aminotransferase (see paper)
20% identity, 80% coverage: 8:319/390 of query aligns to 11:308/360 of 4azjA

query
sites
4azjA

P

P

A

S

G

A

L

L

P

P

K

K

N

-

P

P

S

A

F

L

S

E

S

R

G

-

P

-

C

-

A

A

K

Q

R

K

P

E

G

L

W

L

S

N

P

F

Q

N

N

D

L

T

S

Q

A

M

A

S

A

V

L

M

G

E

R

L

S

S

H
|
H

R
|
R

A

S

K

Q

A

S

G

Y

K

E

E

E

K

V

L

H

E

E

R

Q

A

A

I

Q

A

N

L

L

T

L

R

R

E

E

V

L

L

L

R

Q

V

I

P

P

D

N

D

D

Y

Y

R

Q

I

I

G

L

I

F

V

L

P

Q

A

G

S

G

D
x
A

T
x
S

G

L

A

Q

V

F

E

T

M

M

A

L

L

P

W

M

S

N

M

L

L

L

G

T

P

K

R

G

P

T

V

I

D

G

V

N

L

Y

A

V

F

-

E

-

S

-

F

L

S

T

S

G

G

S

W
|
W

A

S

T

E

D

K

V

A

Q

L

K

K

Q

E

L

A

K

K

L

L

P

L

Q

G

A

E

R

T

V

H

L

I

T

A

A

A

-

S

-

T

-

K

-

A

-

N

P

S

Y

Y

G

Q

E

S

L

I

P

P

D

D

L

F

A

S

-

E

-

F

Q

Q

V

L

N

N

-

E

G

N

D

D

H

A

D

Y

L

L

V

H

F

I

A

T

W

S

N

N

G

N

T
|
T

T

I

S

Y

G

G

V

T

R

Q

V

Y

P

Q

N

N

A

-

F

F

I

P

A

E

A

I

D

N

R

H

K

A

G

P

L

L

T

-

I

I

C

A

D
|
D

A

M

T
x
S

S

S

G

D

A

I

F

L

A

S

Q

R

P

P

L

L

D

K

F

V

A

N

K

Q

L

F

D

G

V

M

T

I

T

Y

F

A

S

G

W

A

Q
|
Q

K
|
K

C

N

L

L

G

G

G

P

E

S

A

G

A

V

H

T

G

V

M

V

L

I

I

V

L

K

S

K

P

D

R

L

A

L

V

N

E

T

R

K

L

V

E

E

S

Q

Y

-

V

-

P

-

W

-

P

-

L

V

P

P

K

T

I

M

F

L

R

Q

L

Y

T

A

K

T

G

H

S

I

K

K

L

-

I

-

E

-

G

-

V

-

F

-

A

S

G

D

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

L

T

L

F

C

S

V

I

E

Y

D

M

Y

L

L

R

D

N

A

V

L

L

Q

D

W

W

A

I

R

K

S

D

I

L

G

G

L

A

D

E

A

A

L

I

C

A

A

K

R

Q

A

N

D

E

A

E

N

K

A

A

A

K

V

I

A

Y

E

D

W

T

T

I

L

D

R

E

Q

S

P

N

A

G

F

F

A

Y

F

V

L

G

A

H

K

A

Q

E

P

K

Q

G

T

S

R

R

S

S

N

L

T

M

S

N

V

V

C

T

L

F

E

N

F

L

A

R

D

N

P

E

R

E

V

L

active site: W102 (= W106), D172 (= D171), K196 (= K195)
binding pyridoxal-5'-phosphate: A76 (≠ D77), S77 (≠ T78), W102 (= W106), T152 (= T148), D172 (= D171), S174 (≠ T173), Q195 (= Q194), K196 (= K195), N237 (= N248), T238 (= T249)
binding phosphoserine: H41 (= H42), R42 (= R43), W102 (= W106), T152 (= T148), K196 (= K195)

Sites not aligning to the query:

binding phosphoserine: 327, 328, 334

3ffrA Crystal structure of a phosphoserine aminotransferase serc (chu_0995) from cytophaga hutchinsonii atcc 33406 at 1.75 a resolution
23% identity, 76% coverage: 17:311/390 of query aligns to 7:303/361 of 3ffrA

query
sites
3ffrA

F

F

S

T

S

P

G

G

P

P

C

S

A

E

K

L

R

Y

P

P

G

T

W

V

S

R

P

Q

Q

H

N

M

L

I

S

T

A

A

-

L

-

D

A

E

A

K

L

I

G

G

R

V

-

I

S

S

H

H

R

R

A

S

K

K

A

K

G

F

K

E

E

E

K

V

L

Y

E

K

R

T

A

A

I

S

A

D

L

N

T

L

R

K

E

T

V

L

L

L

R

E

V

L

P

P

D

S

D

N

Y

Y

R

E

I

V

G

-

I

L

V

F

P

L

A

A

S

S

D

A

T

T

G

-

A

-

V

-

E

-

M

-

A

E

L

I

W

W

S

E

M

R

L

I

G

I

P

Q

R

N

P

C

V

V

D

E

V

K

L

K

A

S

F

F

E

H

-

C

-

V

-

N

-

G

S

S

F
|
F

S

S

S

K

-

R

-

F

-

Y

G

E

W

F

A

A

T

G

D

E

V

L

Q

G

K

R

Q

E

L

A

K

Y

L

K

P

E

Q

E

A

A

R

A

V

F

L

G

T

K

A

G

P

F

Y

Y

G

-

E

-

L

-

P

P

D

A

L

D

A

I

Q

T

V

V

N

P

G

A

D

D

H

A

D

E

L

I

V

I

-

C

F

L

A

T

W

H

N

N

G

E

T

T

T

S

S

S

G

G

V

V

R

S

V

M

P

P

N

V

A

E

-

D

-

I

-

N

A

T

F

F

I

R

A

D

A

K

D

N

R

K

K

D

G

A

L

L

T

I

I

F

C

V

D

D

A

A

T

V

S

S

G

S

A

L

F

P

A

Y

Q

P

P

K

L

F

D

D

F

W

A

T

K

K

L

I

D

D

V

S

T

V

T

F

F

F

S

S

W

V

Q

Q

K

K

C

C

L

F

G

G

G

L

E

P

A

A

A

G

H

L

G

G

M

V

L

W

I

I

L

L

S

N

P

D

R

R

A

V

V

I

E

E

R

K

L

S

E

K

S

A

Y

L

V

L

P

A

P

K

W

R

P

K

L

S

P

I

K

G

I

T

F

Y

R

H

L

T

T

I

K

P

G

S

S

-

K

-

L

M

I

L

E

E

G

K

V

A

F

R

A

V

G

N

E

Q

T

T

I

P

N

E

T

T

P

P

S

N

L

A

L

M

C

N

V

I

E

-

D

-

Y

F

L

L

-

L

-

G

-

K

-

V

-

T

-

G

D

D

A

M

L

L

Q

Q

W

I

A

S

R

A

S

-

I

-

G

-

L

-

D

D

A

G

L

I

C

R

A

K

R

Q

A

T

D

E

A

E

N

K

A

A

V

L

V

I

A

N

E

T

W

Y

T

I

L

E

R

S

Q

S

P

K

A

V

F

F

A

S

F

F

L

G

A

V

K

E

Q

D

P

A

Q

K

T

L

R

R

S

S

N

M

T

T

S

T

V

I

C

V

binding serine: F93 (= F102)

Sites not aligning to the query:

binding serine: 328

Query Sequence

>WP_085771168.1 NCBI__GCF_002117405.1:WP_085771168.1
MSFSHPKPAGLPKNPSFSSGPCAKRPGWSPQNLSAAALGRSHRAKAGKEKLERAIALTRE
VLRVPDDYRIGIVPASDTGAVEMALWSMLGPRPVDVLAFESFSSGWATDVQKQLKLPQAR
VLTAPYGELPDLAQVNGDHDLVFAWNGTTSGVRVPNAAFIAADRKGLTICDATSGAFAQP
LDFAKLDVTTFSWQKCLGGEAAHGMLILSPRAVERLESYVPPWPLPKIFRLTKGSKLIEG
VFAGETINTPSLLCVEDYLDALQWARSIGGLDALCARADANAAVVAEWTLRQPAFAFLAK
QPQTRSNTSVCLEFADPRVIAMDPKARSGLAKALVSLVEKEGAGFDFGAYRDAPPGLRIW
CGPTVEPADVSLLTDWIDWAFEQALAILPA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory