SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_085771999.1 NCBI__GCF_002117405.1:WP_085771999.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4bmsF Short chain alcohol dehydrogenase from ralstonia sp. Dsm 6428 in complex with NADPH
58% identity, 100% coverage: 1:249/249 of query aligns to 1:249/249 of 4bmsF

query
sites
4bmsF

M

M

G

Y

K

R

L

L

S

L

G

N

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K

V

T

A

A

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G

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S

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D

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x
Q

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P

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A

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V

active site: S137 (= S137), H147 (≠ F147), Y150 (= Y150), K154 (= K154), Q195 (≠ A195)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G13), N15 (= N15), S16 (= S16), I18 (= I18), R38 (= R38), R39 (= R39), A59 (≠ G59), D60 (= D60), V61 (= V61), N87 (= N87), S88 (≠ A88), G89 (= G89), V110 (≠ I110), S137 (= S137), Y150 (= Y150), K154 (= K154), G181 (= G181), I183 (= I183), T185 (= T185), I187 (= I187)

6ihhA Crystal structure of rasadh f12 from ralstonia.Sp in complex with NADPH and a6o
58% identity, 100% coverage: 1:249/249 of query aligns to 1:249/249 of 6ihhA

query
sites
6ihhA

M

M

G

Y

K

R

L

L

S

L

G

N

K

K

V

T

A

A

V

V

V

I

T

T

G
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G

G

G

N
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N

S
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S

G
|
G

I
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I

G

G

L

L

S

A

T

T

A

A

Q

K

L

R

F

F

A

V

A

A

E

E

G

G

A

A

H

Y

L

V

V

F

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I

T

V

G

G

R
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R

R
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R

K

R

A

K

E

E

L

L

D

E

T

Q

A

A

V

A

A

A

E

E

I

I

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G

H

R

G

N

A

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V

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K

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E

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D

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L

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Y

A

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x
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K

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H

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N

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W

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F
x
L

G

E

K

N

V

N

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Q

K

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P

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L

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P

E

E

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I

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A

A

K

A

A

A

A

V

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L

F

F

L

L

A

A

S

S

D

D

D

D

A

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S

S

Y

Y

V

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A

G

G

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I

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E

L

L

Y

F

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V

V

binding (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one: S137 (= S137), H147 (≠ F147), Y150 (= Y150), L188 (≠ F188), L246 (= L246)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G13), N15 (= N15), S16 (= S16), G17 (= G17), I18 (= I18), R38 (= R38), R39 (= R39), D60 (= D60), V61 (= V61), N87 (= N87), S88 (≠ A88), G89 (= G89), V110 (≠ I110), T135 (≠ N135), S137 (= S137), Y150 (= Y150), K154 (= K154), P180 (= P180), G181 (= G181), A182 (≠ P182), I183 (= I183), T185 (= T185), S187 (≠ I187)

8ijgC Crystal structure of alcohol dehydrogenase m5 from burkholderia gladioli with NADP
52% identity, 99% coverage: 3:249/249 of query aligns to 3:250/250 of 8ijgC

query
sites
8ijgC

K

R

L

L

S

E

G

G

K

K

V

V

A

A

V

L

V

V

T

T

G
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G

G

G

N
x
T

S
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S

G

G

I
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I

G

G

L

L

S

A

T

T

A

A

Q

K

L

D

F

L

A

A

A

A

E

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G

G

A

A

H

R

L

V

V

I

V

I

T

T

G

G

R
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R

R
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R

K

Q

A

A

E

E

L

L

D

D

T

Q

A

A

V

V

A

A

E

A

I

L

G

G

H

Q

G

G

A

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G

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D

V
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V

S

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K

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A

A

D

D

L

L

D

D

A

A

L

L

Y

F

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K

T

F

E

G

G

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R

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D

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I

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L

F

F

A

T

N
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A

A

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G

V

G

C

A

E

S

L

M

A

A

P

A

L

L

V

G

G

E

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S

E

E

E

Q

H

H

F

F

D

D

K

D

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F

F

D

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x
R

N

N

V

V

K

K

G

A

L

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L

V

F

F

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T

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V

Q

Q

K

K

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A

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P

L

L

F

M

A

P

D

Q

G

G

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S

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x
A

V

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Q

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A

A

A

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K

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N

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S

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x
T

E

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P

I

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x
G

F

L

G

A

K

E

V

L

G

G

L

G

S

D

A

T

E

Q

Q

E

L

G

Q

Q

E

D

F

G

D

T

-

L

A

A

Q

Y

I

L

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A

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K

L

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V

P

P

L

I

G

G

R

R

F

L

G

A

K

D

P

P

E

S

E

E

I

I

A

A

K

K

A

V

A

V

L

S

F

F

L

L

A

A

S

S

D

D

D

D

A

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S

Y

F

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A

N

G

G

A

A

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E

L

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Y

T

V

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D

D

G

G

G

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L

Q

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Q

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V

binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G13), T15 (≠ N15), S16 (= S16), I18 (= I18), R38 (= R38), R39 (= R39), D60 (= D60), V61 (= V61), N87 (= N87), G89 (= G89), R110 (≠ I110), N135 (= N135), A137 (≠ S137), Y150 (= Y150), K154 (= K154), P180 (= P180), G181 (= G181), T183 (≠ I183), T185 (= T185), G187 (≠ I187)

7v0hG Crystal structure of putative glucose 1-dehydrogenase from burkholderia cenocepacia in complex with NADP and a potential reaction product
45% identity, 99% coverage: 1:246/249 of query aligns to 6:252/253 of 7v0hG

query
sites
7v0hG

M

M

G

S

K

K

L

L

S

A

G

G

K

K

V

V

A

A

V

I

V

V

T

T

G
|
G

G

A

N
x
S

S
x
K

G
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G

I
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I

G

G

L

A

S

A

T

I

A

A

Q

K

L

A

F

L

A

A

A

D

E

E

G

G

A

A

H

A

L

V

V

V

V

V

T

N

-

Y

G
x
A

R
x
S

R
x
S

K

K

A

A

E

G

L

A

D

D

-

A

-

V

-

V

T

S

A

A

V

I

A

T

E

E

I

A

G

G

H

G

G

R

A

A

V

V

G

A

V

V

Q

G

G
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G

D
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D

V
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V

S

S

K

K

L

A

A

A

D

D

L

A

D

Q

A

R

L

I

Y

V

A

D

E

T

V

A

K

I

S

E

K

T

F

Y

G

G

R

R

I

L

D

D

I

V

L

L

F

V

A

N

N
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N

A
x
S

G
|
G

V

V

C
x
Y

E

E

L

F

A

A

P

P

L

I

V

E

G

A

V

I

S

T

E

E

E

E

H

H

F

Y

D

R

K

R

V

Q

F

F

D

D

I

T

N

N

V

V

K

F

G

G

L

V

L

L

F

L

T

T

V

T

Q

Q

K

A

A

A

L

V

P

K

L

H

F

L

A

G

D

E

G

G

G

A

S

S

I

I

I

I

L

N

N
x
I

S

S

S
|
S

V

V

A

V

N

T

T

S

T

I

G

T

I

P

P

P

A

A

F

S

G

A

V

V

Y
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Y

S

S

A

G

T

T

K
|
K

A

G

A

A

V

V

R

D

S

A

F

I

A

T

R

G

T

V

W

L

T

A

S

L

E

E

L

L

K

G

D

P

R

R

N

K

I

I

R

R

V

V

N

N

V

A

I

I

S

N

P
|
P

G
|
G

P
x
M

I
|
I

E

V

T
|
T

P

E

I
x
G

F
x
T

G

H

K

S

V

A

G

G

L
x
I

S

I

A

G

E

S

Q

D

L

L

Q

E

E

-

F

-

D

-

A

A

Q

Q

I

V

S

L

A

G

K

Q

V

T

P

P

L

L

G

G

R

R

F

L

G

G

K

E

P

P

E

N

E

D

I

I

A

A

K

S

A

V

A

A

L

V

F

F

L

L

A

A

S

S

D

D

D

D

A

A

S

R

Y

W

V

M

A

T

G

G

A

E

D

H

L

L

Y

V

V

V

D

S

G

G

G

G

L

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: G18 (= G13), S20 (≠ N15), K21 (≠ S16), G22 (= G17), I23 (= I18), A43 (≠ G37), S44 (≠ R38), S45 (≠ R39), G68 (= G59), D69 (= D60), V70 (= V61), N96 (= N87), S97 (≠ A88), G98 (= G89), Y100 (≠ C91), I144 (≠ N135), S146 (= S137), Y159 (= Y150), K163 (= K154), P189 (= P180), G190 (= G181), M191 (≠ P182), I192 (= I183), T194 (= T185), G196 (≠ I187), T197 (≠ F188)
binding (2R)-2-(hydroxymethyl)pentanedioic acid: S146 (= S137), Y159 (= Y150), M191 (≠ P182), I202 (≠ L193)

5t2uA Short chain dehydrogenase/reductase family protein (see paper)
46% identity, 99% coverage: 3:249/249 of query aligns to 3:241/241 of 5t2uA

query
sites
5t2uA

K

E

L

L

S

E

G

G

K

L

V

T

A

A

V

L

V

V

T

T

G
|
G

G

G

N

T

S

S

G
|
G

I

I

G

G

L

L

S

E

T

S

A

A

Q

R

L

L

F

M

A

A

A

A

E

E

G

G

A

A

H

D

L

V

V

V

V

I

T

T

G

G

R
|
R

R
x
D

K

A

A

Q

E
x
R

L

G

D

E

T

Q

A

A

V

A

A

A

E

D

I

I

G

G

H

H

G

G

A

A

V

R

G

F

V

V

Q

Q

G

A

D
|
D

V

-

S

-

K

-

L
|
L

A

G

D

D

L

L

D

D

A

S

L

V

Y

-

A

A

E

D

V

L

K

A

S

A

K

Q

F

A

G

P

R

D

I

V

D

D

I

I

L

L

F

V

A

N

N
|
N

A
|
A

G

G

V

I

C
x
Y

E

P

L

Q

A

A

P

S

L

T

V

F

G

D

V

Q

S

D

E

V

E

A

H

G

F

F

D

Q

K

Q

V

L

F

F

D

D

I

T

N

N

V

V

K

R

G

G

L

T

L

Y

F

F

T

L

V

V

Q

A

K

A

A

A

L

A

P

K

-

G

L

M

F

V

A

A

D

R

G

G

-

H

G

G

S

S

I

I

I

V

L

N

N
x
I

S

T

S
x
T

V

L

A

A

N

A

T

H

T

K

G

G

I

F

P

P

A

G

F
x
T

G

S

V

V

Y
|
Y

S

G

A

A

T

T

K
|
K

A

A

A

A

V

L

R

E

S

S

F

L

A

T

R

R

T

T

W

W

T

A

S

A

E

E

L

F

K

G

D

A

R

N

N

G

I

V

R

R

V

V

N

N

V

S

I

V

S

S

P
|
P

G

G

P
|
P

I
x
T

E

R

T
|
T

P

P

I
x
T

F

-

G

-

K

-

V

-

G

-

L

-

S
x
T

A

L

E

E

Q

Q

L

L

Q

G

E

D

F

F

D

I

A

D

Q

D

I

V

S

A

A

A

K

G

V

L

P

P

L

L

G

R

R

R

F

T

G

A

K

A

P

P

E

E

E

E

I

I

A

A

K

Q

A

A

A

V

L

L

F

F

L

L

A

A

S

S

D

P

D

R

A

A

S

S

Y

F

V

V

A

T

G

G

A

S

D

T

L

L

Y

Y

V

V

D

D

G

G

G

G

L

G

V

Y

A

A

V

V

active site: G17 (= G17), T135 (≠ S137), T145 (≠ F147), Y148 (= Y150), K152 (= K154)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G13), G17 (= G17), R38 (= R38), D39 (≠ R39), R42 (≠ E42), D60 (= D60), L61 (= L64), N83 (= N87), A84 (= A88), Y87 (≠ C91), I133 (≠ N135), T135 (≠ S137), Y148 (= Y150), K152 (= K154), P178 (= P180), P180 (= P182), T181 (≠ I183), T183 (= T185), T185 (≠ I187), T186 (≠ S194)

4esoB Crystal structure of a putative oxidoreductase protein from sinorhizobium meliloti 1021 in complex with NADP
42% identity, 98% coverage: 2:246/249 of query aligns to 1:244/251 of 4esoB

query
sites
4esoB

G

G

K

N

L

Y

S

Q

G

G

K

K

V

K

A

A

V

I

V

V

T

I

G
|
G

G

G

N
x
T

S
x
H

G
|
G

I
x
M

G

G

L

L

S

A

T

T

A

V

Q

R

L

R

F

L

A

V

A

E

E

G

G

G

A

A

H

E

L

V

V

L

V

L

T

T

G

G

R
|
R

R
x
N

K

E

A

S

E
x
N

L

I

D

A

T

R

A

I

V

R

A

E

E

E

I

F

G

G

H

P

G

R

A

V

V

H

G

A

V

L

Q

R

G
x
S

D
|
D

V
x
I

S

A

K

D

L

L

A

N

D

E

L

I

D

A

A

V

L

L

Y

G

A

A

E

A

V

A

K

G

S

Q

K

T

F

L

G

G

R

A

I

I

D

D

I

L

L

L

F

H

A

I

N
|
N

A
|
A

G
|
G

V

V

C

S

E

E

L

L

A

E

P

P

L

F

V

D

G

Q

V

V

S

S

E

E

E

A

H

S

F

Y

D

D

K

R

V

Q

F

F

D

A

I

V

N

N

V

T

K

K

G

G

L

A

L

F

F

F

T

T

V

V

Q

Q

K

R

A

L

L

T

P

P

L

L

F

I

A

R

D

E

G

G

G

G

S

S

I

I

I

V

L

F

N
x
T

S

S

S
|
S

V

V

A

A

N

D

T

E

T

G

G

G

I

H

P

P

A

G

F
x
M

G

S

V

V

Y
|
Y

S

S

A

A

T

S

K
|
K

A

A

A

A

V

L

R

V

S

S

F

F

A

A

R

S

T

V

W

L

T

A

S

A

E

E

L

L

K

L

D

P

R

R

N

G

I

I

R

R

V

V

N

N

V

S

I

V

S

S

P
|
P

G
|
G

P

F

I
|
I

E

D

T
|
T

P

P

I
x
T

F
x
K

G
|
G

K

V

V

A

G

G

L

I

S

T

A

E

E

A

Q

E

L

R

Q

A

E

E

F

F

D

K

A

T

Q

L

I

G

S

D

A

N

K

I

V

T

P

P

L

M

G

K

R

R

F

N

G

G

K

T

P

A

E

D

E

E

I

V

A

A

K

R

A

A

A

V

L

L

F

F

L

L

A

A

S

F

D

-

D

E

A

A

S

T

Y

F

V

T

A

T

G

G

A

A

D

K

L

L

Y

A

V

V

D

D

G

G

G

G

L

L

active site: G16 (= G17), S136 (= S137), M146 (≠ F147), Y149 (= Y150), K153 (= K154)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G13), T14 (≠ N15), H15 (≠ S16), M17 (≠ I18), R37 (= R38), N38 (≠ R39), N41 (≠ E42), S58 (≠ G59), D59 (= D60), I60 (≠ V61), N86 (= N87), A87 (= A88), G88 (= G89), T134 (≠ N135), S136 (= S137), Y149 (= Y150), P179 (= P180), G180 (= G181), I182 (= I183), T184 (= T185), T186 (≠ I187), K187 (≠ F188), G188 (= G189)

3pk0B Crystal structure of short-chain dehydrogenase/reductase sdr from mycobacterium smegmatis (see paper)
43% identity, 99% coverage: 1:247/249 of query aligns to 5:252/262 of 3pk0B

query
sites
3pk0B

M

M

G

F

K

D

L

L

S

Q

G

G

K

R

V

S

A

V

V

V

V

V

T

T

G

G

G

G

N

T

S

K

G
|
G

I

I

G

G

L

R

S

G

T

I

A

A

Q

T

L

V

F

F

A

A

A

R

E

A

G

G

A

A

H

N

L

V

V

A

V

V

T

A

G

G

R

R

R

S

K

T

A

A

E

D

L

I

D

D

T

A

A

C

V

V

A

A

-

D

-

L

-
x
D

E

Q

I

L

G
|
G

H

S

G
|
G

A

K

V

V

-

I

G

G

V

V

Q

Q

G

T

D

D

V

V

S

S

K

D

L

R

A

A

D

Q

L

C

D

D

A

A

L

L

Y

A

A

G

E

R

V

A

K

V

S

E

K

E

F

F

G

G

R

G

I

I

D

D

I

V

L

V

F

C

A

A

N

N

A

A

G

G

V

V

C

F

E

P

L

D

A

A

P

P

L

L

V

A

G

T

V

M

S

T

E

P

E

E

H

Q

F

L

D

N

K

G

V

I

F

F

D

A

I

V

N

N

V

V

K

N

G

G

L

T

L

F

F

Y

T

A

V

V

Q

Q

K

A

A

C

L

L

-

D

P

A

L

L

F

I

A

A

D

S

G

G

-

S

G

G

S

R

I

V

I

V

L

L

N

T

S

S

S
|
S

V

I

A

T

N

G

-

P

T

I

T

T

G

G

I

Y

P

P

A

G

F
x
W

G

S

V

H

Y
|
Y

S

G

A

A

T

T

K
|
K

A

A

A

A

V

Q

R

L

S

G

F

F

A

M

R

R

T

T

W

A

T

A

S

I

E

E

L

L

K

A

D

P

R

H

N

K

I

I

R

T

V

V

N

N

V

A

I

I

S

M

P

P

G

G

P

N

I

I

E

M

T

T

P

E

I

-

F

-

G

-

K

-

V

-

G

G

L

L

S

-

A

L

E

E

Q

N

L

G

Q

E

E

E

F

Y

D

I

A

A

Q

S

I

M

S

A

A

R

K

S

V

I

P

P

L

A

G

G

R

A

F

L

G

G

K

T

P

P

E

E

E

D

I

I

A

G

K

H

A

L

A

A

L

A

F

F

L

L

A

A

S

T

D

K

D

E

A

A

S

G

Y

Y

V

I

A

T

G

G

A

Q

D

A

L

I

Y

A

V

V

D

D

G

G

G

G

L

Q

V

V

active site: G21 (= G17), S147 (= S137), W158 (≠ F147), Y161 (= Y150), K165 (= K154)
binding calcium ion: D55 (vs. gap), G58 (= G51), G60 (= G53)

4nbuB Crystal structure of fabg from bacillus sp (see paper)
39% identity, 99% coverage: 1:247/249 of query aligns to 2:243/244 of 4nbuB

query
sites
4nbuB

M

M

G

S

K

R

L

L

S

Q

G

D

K

K

V

V

A

A

V

I

V

I

T

T

G
|
G

G

A

N

A

S
x
N

G
|
G

I
|
I

G

G

L

L

S

E

T

A

A

A

Q

R

L

V

F

F

A

M

A

K

E

E

G

G

A

A

H

K

L

V

V

V

V

I

T

A

G
x
D

R
x
F

R

N

K

E

A

A

E

A

L

G

D

K

T

E

A

A

V

V

A

-

E

E

I

A

G

N

H

P

G

G

A

V

V

V

G

F

V

I

Q

R

G
x
V

D
|
D

V
|
V

S

S

K

D

L

R

A

E

D

S

L

V

D

H

A

R

L

L

Y

V

A

E

E

N

V

V

K

A

S

E

K

R

F

F

G

G

R

K

I

I

D

D

I

I

L

L

F

I

A

N

N
|
N

A
|
A

G
|
G

V
x
I

C

T

E

R

L
x
D

A

S

P

M

L

L

V

S

G
x
K

V

M

S

T

E

V

E

D

H

Q

F

F

D

Q

K

Q

V

V

F

I

D

N

I

V

N
|
N

V

L

K

T

G

G

L

V

L

F

F

H

T

C

V

T

Q

Q

K

A

A

V

L

L

P

P

L

Y

F

M

A

A

D

E

-

Q

-

G

G

K

G

G

S

K

I

I

I

I

L

N

N
x
T

S

S

S
|
S

V

V

A

T

N

G

T

T

T

Y

G

G

I
x
N

P
x
V

A

G

F
x
Q

G

T

V

N

Y
|
Y

S

A

A

A

T

A

K
|
K

A

A

A

G

V

V

R

I

S

G

F

M

A

T

R

K

T

T

W

W

T

A

S

K

E

E

L

L

K

A

D

R

R

K

N

G

I

I

R

N

V

V

N

N

V

A

I

V

S

A

P
|
P

G

G

P
x
F

I
x
T

E

E

T
|
T

P

A

I
x
M

F

V

G

A

K

E

V

V

G

-

L

-

S

-

A

P

E

E

Q

K

L

V

Q

I

E

E

F

-

D

-

A

-

Q
x
K

I

M

S

K

A

A

K

Q

V

V

P

P

L

M

G

G

R

R

F

L

G

G

K

K

P

P

E

E

E

D

I

I

A

A

K

N

A

A

A

Y

L

L

F

F

L

L

A

A

S

S

D

H

D

E

A

S

S

D

Y

Y

V

V

A

N

G

G

A

H

D

V

L

L

Y

H

V

V

D

D

G

G

G

G

L

I

V

M

active site: G18 (= G17), N111 (= N111), S139 (= S137), Q149 (≠ F147), Y152 (= Y150), K156 (= K154)
binding acetoacetyl-coenzyme a: D93 (≠ L93), K98 (≠ G98), S139 (= S137), N146 (≠ I144), V147 (≠ P145), Q149 (≠ F147), Y152 (= Y150), F184 (≠ P182), M189 (≠ I187), K200 (≠ Q204)
binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G13), N17 (≠ S16), G18 (= G17), I19 (= I18), D38 (≠ G37), F39 (≠ R38), V59 (≠ G59), D60 (= D60), V61 (= V61), N87 (= N87), A88 (= A88), G89 (= G89), I90 (≠ V90), T137 (≠ N135), S139 (= S137), Y152 (= Y150), K156 (= K154), P182 (= P180), F184 (≠ P182), T185 (≠ I183), T187 (= T185), M189 (≠ I187)

6ci9D Rmm microcompartment-associated aminopropanol dehydrogenase NADP + aminoacetone holo-structure (see paper)
38% identity, 98% coverage: 3:247/249 of query aligns to 6:250/259 of 6ci9D

query
sites
6ci9D

K

S

L

L

S

E

G

G

K

R

V

S

A

A

V

I

V

V

T

T

G
|
G

G

G

N
x
S

S

K

G
|
G

I
|
I

G

G

L

R

S

G

T

I

A

A

Q

E

L

T

F

F

A

A

A

N

E

A

G

G

A

V

H

D

L

V

V

V

V

I

T

T

G
|
G

R
|
R

R
x
N

K

Q

A

D

E

D

L

L

D

D

T

R

A

T

V

V

A

A

E

D

I

L

G

S

-

G

-

T

H

R

G

G

A

K

V

V

-

T

G

A

V

V

Q

R

G

A

D
|
D

V
|
V

S

T

K

D

L

P

A

E

D

D

L

A

D

R

A

R

L

T

Y

V

A

A

E

E

V

T

K

V

S

S

K

R

F

H

G

G

R

G

I

L

D

D

I

I

L

V

F

C

A

A

N
|
N

A

A

G
|
G

V

I

C
x
F

E

P

L

S

A

G

P

R

L

L

V

E

G

D

V

L

S

T

E

P

E

D

H

D

F

I

D

E

K

Q

V

V

F

L

D

G

I

V

N

N

V

F

K

K

G

G

L

T

L

V

F

Y

T

I

V

V

Q

Q

K

A

A

A

L

L

P

Q

-

A

L

L

F

T

A

A

D

S

G

G

-

H

G

G

S

R

I

V

I

V

L

V

N
x
T

S

S

S
|
S

V

I

A
x
T

N

G

-

P

T

I

T

T

G

G

I

Y

P

P

A

G

F
x
W

G

S

V

H

Y
|
Y

S

G

A

A

T

S

K
|
K

A

A

A

A

V

Q

R

L

S

G

F

F

A

L

R

R

T

T

W

A

T

A

S

M

E

E

L

L

K

A

D

P

R

K

N

K

I

I

R

T

V

I

N

N

V

A

I

V

S

L

P
|
P

G
|
G

P
x
N

I
|
I

E

M

T
|
T

P

E

I
x
G

F
x
L

G

D

K

E

V

M

G

G

L

-

S

-

A

-

E

-

Q

-

L

-

Q

Q

E

D

F

Y

D

L

A

D

Q

Q

I

M

S

A

A

S

K

A

V

I

P

P

L

A

G

G

R

R

F

L

G

G

K

S

P

V

E

A

E

D

I

I

A

G

K

N

A

A

A

A

L

L

F

F

L

F

A

A

S

T

D

D

D

E

A

A

S

A

Y

Y

V

V

A

T

G

G

A

Q

D

T

L

L

Y

V

V

V

D

D

G

G

G

G

L

Q

V

V

active site: G20 (= G17), S145 (= S137), Y159 (= Y150)
binding 1-aminopropan-2-one: F97 (≠ C91), S145 (= S137), T147 (≠ A139), W156 (≠ F147), Y159 (= Y150), G190 (= G181)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G16 (= G13), S18 (≠ N15), G20 (= G17), I21 (= I18), G40 (= G37), R41 (= R38), N42 (≠ R39), D66 (= D60), V67 (= V61), N93 (= N87), G95 (= G89), T143 (≠ N135), S145 (= S137), Y159 (= Y150), K163 (= K154), P189 (= P180), N191 (≠ P182), I192 (= I183), T194 (= T185), G196 (≠ I187), L197 (≠ F188)

8hfkA Crystal structure of cbar mutant (h162f) in complex with NADP+ and halogenated aryl ketone (see paper)
34% identity, 98% coverage: 2:245/249 of query aligns to 4:257/259 of 8hfkA

query
sites
8hfkA

G

G

K

R

L

L

S

D

G

G

K

K

V

V

A

A

V

L

V

V

T

T

G
|
G

G

S

N

G

S
x
R

G

G

I
|
I

G

G

L

A

S

A

T

V

A

A

Q

V

L

H

F

L

A

G

A

L

E

L

G

G

A

A

H

K

L

V

V

V

V

V

-

N

-

Y

-
x
A

-
x
N

T
x
S

G

P

R

T

R

H

K

A

A

Q

E

K

L

V

D

V

T

D

A

E

V

I

A

K

E

Q

I

L

G

G

H

S

G

D

A

A

V

I

G

A

V

I

Q

K

G

A

D
|
D

V

V

S

R

K

Q

L

V

A

P

D

E

L

I

D

V

A

R

L

L

Y

F

A

D

E

E

V

A

K

V

S

A

K

H

F

F

G

G

R

Q

I

L

D

D

I

I

L

A

F

V

A

S

N
|
N

A
x
S

G

G

V

V

C

V

E

S

L

F

A

G

P

H

L

L

V

K

G

D

V

V

S

T

E

E

E

E

H

E

F

F

D

D

K

R

V

V

F

F

D

S

I
x
L

N

N

V

T

K

R

G

G

L

Q

L

F

F

F

T

V

V

A

Q

R

K

E

A

A

L

Y

P

K

L

H

F

L

A

N

D

N

G

G

G

G

S

R

I

I

I

I

L

M

N
x
T

S

S

S
|
S

V
x
N

A
x
T

N

S

T

R

T

D

G

S

I

V

P

P

A

K

F
|
F

G

S

V

L

Y
|
Y

S

S

A

G

T

S

K
|
K

A

G

A

A

V

I

R

D

S

S

F

F

A

V

R

R

T

I

W

F

T

S

S

K

E

D

L

C

K

G

D

D

R

K

N

K

I

I

R

T

V

V

N

N

V

A

I

V

S

A

P
|
P

G
|
G

P
x
G

I
x
T

E

V

T
|
T

P

D

I
x
M

F

F

G

H

K

D

V
|
V

G

S

-

Q

-

H

-

Y

-

I

-

P

-

N

-

G

-

E

-

T

L

Y

S

T

A

P

E

E

Q

E

L

R

Q

Q

E

K

F

M

D

A

A

A

Q

H

I

A

S

S

A

-

K

-

V

-

P

P

L

L

G

H

R

R

F

N

G

G

K

F

P

P

E

E

E

D

I

I

A

A

K

R

A

V

A

V

L

G

F

F

L

L

A

V

S

S

D

A

D

E

A

G

S

E

Y

W

V

I

A

N

G

G

A

K

D

V

L

L

Y

T

V

V

D

D

G

G

G

G

binding 2-bromanyl-1-(4-bromanyl-2-oxidanyl-phenyl)ethanone: S143 (= S137), N144 (≠ V138), T145 (≠ A139), F153 (= F147), Y156 (= Y150), G187 (= G181), M193 (≠ I187), V197 (= V191)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G13), R18 (≠ S16), I20 (= I18), A40 (vs. gap), N41 (vs. gap), S42 (≠ T36), D66 (= D60), N93 (= N87), S94 (≠ A88), L116 (≠ I110), T141 (≠ N135), Y156 (= Y150), K160 (= K154), P186 (= P180), G187 (= G181), G188 (≠ P182), T189 (≠ I183), T191 (= T185), M193 (≠ I187)

Sites not aligning to the query:

binding 2-bromanyl-1-(4-bromanyl-2-oxidanyl-phenyl)ethanone: 259

7ejhA Crystal structure of kred mutant-f147l/l153q/y190p/l199a/m205f/m206f and 2-hydroxyisoindoline-1,3-dione complex
36% identity, 99% coverage: 3:248/249 of query aligns to 5:252/253 of 7ejhA

query
sites
7ejhA

K

R

L

L

S

K

G

G

K

K

V

V

A

A

V

I

V

V

T

T

G
|
G

G

G

N
x
T

S

L

G

G

I
|
I

G

G

L

L

S

A

T

I

A

A

Q

D

L

K

F

F

A

V

A

E

E

E

G

G

A

A

H

K

L

V

V

V

V

I

T

T

G

G

R
|
R

R
x
H

K

A

A

D

E

V

L

G

D

E

T

K

A

A

V

A

A

K

E

S

I

I

G

G

H

G

G

T

A

D

V

V

-

I

-

R

G

F

V

V

Q

Q

G

H

D
|
D

V
x
A

S

S

K

D

L

E

A

A

D

G

L

W

D

T

A

K

L

L

Y

F

A

D

E

T

V

T

K

E

S

E

K

A

F

F

G

G

R

P

I

V

D

T

I

T

L

V

F

V

A

N

N
|
N

A
|
A

G

G

V

I

C

A

E

V

L

S

A

K

P

S

L

V

V

E

G

D

V

T

S

T

E

T

E

E

H

E

F

W

D

R

K

K

V

L

F

L

D

S

I
x
V

N

N

V

L

K

D

G

G

L

V

L

F

F

F

T

G

V

T

Q

R

K

L

A

G

L

I

P

Q

L

R

F

M

A

K

D

N

-

K

-

G

-

L

G

G

G

A

S

S

I

I

I

I

L

N

N
x
M

S

S

S
|
S

V
x
I

A
x
E

N

G

T

L

T

V

G

G

I

D

P

P

A

T

F

Q

G

G

V

A

Y
|
Y

S

N

A

A

T

S

K
|
K

A

G

A

A

V

V

R

R

S

I

F

M

A

S

R

K

T

S

-

A

-

A

W

L

T

D

S

C

E

A

L

L

K

K

D

D

R

Y

N

D

I

V

R

R

V

V

N

N

V

T

I

V

S

H

P
|
P

G
|
G

P
|
P

I
|
I

E

K

T
|
T

P
|
P

I
x
L

F
x
V

G

D

K

-

V

-

G

-

L

-

S

D

A

A

E

E

Q

G

L

A

Q

E

E

E

F

F

D
x
F

A

S

Q

Q

I

-

S

R

A

T

K

K

V

T

P

P

L

M

G

G

R

H

F

I

G

G

K

E

P

P

E

N

E

D

I

I

A

A

K

W

A

I

A

C

L

V

F

Y

L

L

A

A

S

S

D

D

D

E

A

S

S

K

Y

F

V

A

A

T

G

G

A

A

D

E

L

F

Y

V

V

V

D

D

G

G

G

G

L

Y

V

T

A

A

binding 2-oxidanylisoindole-1,3-dione: S144 (= S137), I145 (≠ V138), E146 (≠ A139), Y157 (= Y150), V197 (≠ F188), F207 (≠ D202)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G13), T17 (≠ N15), I20 (= I18), R40 (= R38), H41 (≠ R39), D64 (= D60), A65 (≠ V61), N91 (= N87), A92 (= A88), V114 (≠ I110), M142 (≠ N135), S144 (= S137), Y157 (= Y150), K161 (= K154), P189 (= P180), G190 (= G181), P191 (= P182), I192 (= I183), T194 (= T185), P195 (= P186), L196 (≠ I187)

7ejiB Crystal structure of kred f147l/l153q/y190p/l199a/m205f/m206f variant and methyl methacrylate complex
36% identity, 99% coverage: 3:248/249 of query aligns to 3:250/251 of 7ejiB

query
sites
7ejiB

K

R

L

L

S

K

G

G

K

K

V

V

A

A

V

I

V

V

T

T

G
|
G

G

G

N
x
T

S
x
L

G
|
G

I
|
I

G

G

L

L

S

A

T

I

A

A

Q

D

L

K

F

F

A

V

A

E

E

E

G

G

A

A

H

K

L

V

V

V

V

I

T

T

G

G

R
|
R

R
x
H

K

A

A

D

E

V

L

G

D

E

T

K

A

A

V

A

A

K

E

S

I

I

G

G

H

G

G

T

A

D

V

V

-

I

-

R

G

F

V

V

Q

Q

G

H

D
|
D

V
x
A

S

S

K

D

L

E

A

A

D

G

L

W

D

T

A

K

L

L

Y

F

A

D

E

T

V

T

K

E

S

E

K

A

F

F

G

G

R

P

I

V

D

T

I

T

L

V

F

V

A

N

N
|
N

A
|
A

G

G

V

I

C

A

E

V

L

S

A

K

P

S

L

V

V

E

G

D

V

T

S

T

E

T

E

E

H

E

F

W

D

R

K

K

V

L

F

L

D

S

I
x
V

N

N

V

L

K

D

G

G

L

V

L

F

F

F

T

G

V

T

Q

R

K

L

A

G

L

I

P

Q

L

R

F

M

A

K

D

N

-

K

-

G

-

L

G

G

G

A

S

S

I

I

I

I

L

N

N
x
M

S

S

S
|
S

V
x
I

A

E

N

G

T

L

T

V

G

G

I

D

P

P

A

T

F

Q

G

G

V

A

Y
|
Y

S

N

A

A

T

S

K
|
K

A

G

A

A

V

V

R

R

S

I

F

M

A

S

R

K

T

S

-

A

-

A

W

L

T

D

S

C

E

A

L

L

K

K

D

D

R

Y

N

D

I

V

R

R

V

V

N

N

V

T

I

V

S

H

P
|
P

G

G

P
|
P

I
|
I

E

K

T
|
T

P
|
P

I
x
L

F

V

G

D

K

-

V

-

G

-

L

-

S

D

A

A

E

E

Q

G

L

A

Q

E

E

E

F

F

D
x
F

A

S

Q

Q

I

-

S

R

A

T

K

K

V

T

P

P

L

M

G

G

R

H

F

I

G

G

K

E

P

P

E

N

E

D

I

I

A

A

K

W

A

I

A

C

L

V

F

Y

L

L

A

A

S

S

D

D

D

E

A

S

S

K

Y

F

V

A

A

T

G

G

A

A

D

E

L

F

Y

V

V

V

D

D

G

G

G

G

L

Y

V

T

A

A

binding methyl 2-methylprop-2-enoate: S142 (= S137), I143 (≠ V138), Y155 (= Y150), F205 (≠ D202)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G13), T15 (≠ N15), L16 (≠ S16), G17 (= G17), I18 (= I18), R38 (= R38), H39 (≠ R39), D62 (= D60), A63 (≠ V61), N89 (= N87), A90 (= A88), V112 (≠ I110), M140 (≠ N135), S142 (= S137), Y155 (= Y150), K159 (= K154), P187 (= P180), P189 (= P182), I190 (= I183), T192 (= T185), P193 (= P186), L194 (≠ I187)

4nbtA Crystal structure of fabg from acholeplasma laidlawii (see paper)
41% identity, 98% coverage: 3:246/249 of query aligns to 2:237/239 of 4nbtA

query
sites
4nbtA

K

K

L

L

S

E

G

G

K

K

V

V

A

A

V

V

V

I

T

T

G
|
G

G

G

N

A

S
x
K

G
|
G

I
x
L

G

G

L

Q

S

A

T

I

A

A

Q

L

L

A

F

Y

A

A

A

E

E

E

G

G

A

A

H

K

L

-

V

V

V

I

T

A

G

G

R

-

R

-

K

-

A

-

E

-

L

-

D
|
D

T
x
L

A

G

V

D

A

L

E

T

I

Y

G

S

H

H

G

P

A

N

V

V

-

E

G

G

V

M

Q

Y

G
x
L

D
x
N

V
|
V

S

T

K

D

L

V

A

T

D

G

L

V

D

E

A

K

L

F

Y

Y

A

Q

E

S

V

V

K

I

S

D

K

K

F

Y

G

G

R

K

I

I

D

D

I

I

L

L

F

V

A

N

N
|
N

A
|
A

G
|
G

V

I

C

T

E

K

L

D

A

A

P

M

L

T

V

R

G

K

V

M

S

T

E

E

E

A

H

Q

F

W

D

D

K

A

V

V

F

I

D

D

I

V

N

N

V

L

K

K

G

G

L

V

L

F

F

N

T

L

V

T

Q

R

K

L

A

V

L

G

P

P

L

Q

F

M

A

Q

D

T

G

N

G

G

-

Y

-

G

S

S

I

I

I

I

L

N

N
x
I

S

S

S
|
S

V

V

A

V

N

G

T

V

T

F

G

G

I

N

P

I

A

G

F

Q

G

A

V

N

Y
|
Y

S

A

A

A

T

T

K
|
K

A

A

A

G

V

V

R

I

S

G

F

L

A

T

R

M

T

T

W

W

T

A

S

K

E

E

-

F

-

A

L

L

K

K

D

G

R

A

N

N

I

V

R

R

V

V

N

N

V

A

I

I

S

A

P
|
P

G
|
G

P

Y

I
|
I

E

M

T
|
T

P

D

I

I

F

L

G

K

K

T

V

V

G

P

L

-

S

-

A

-

E

-

Q

-

L

-

Q

Q

E

D

F

L

D

L

A

D

Q

K

I

F

S

A

A

A

K

L

V

T

P

M

L

L

G

N

R

R

F

L

G

G

K

Q

P

P

E

E

E

E

I

I

A

A

K

K

A

V

A

A

L

L

F

F

L

L

A

A

S

S

D

D

D

D

A

A

S

S

Y

Y

V

V

A

T

G

G

A

Q

D

T

L

I

Y

N

V

V

D

N

G

G

G

G

L

M

active site: G16 (= G17), S132 (= S137), Y145 (= Y150), K149 (= K154)
binding nicotinamide-adenine-dinucleotide: G12 (= G13), K15 (≠ S16), G16 (= G17), L17 (≠ I18), D36 (= D44), L37 (≠ T45), L52 (≠ G59), N53 (≠ D60), V54 (= V61), N80 (= N87), A81 (= A88), G82 (= G89), I130 (≠ N135), S132 (= S137), Y145 (= Y150), K149 (= K154), P177 (= P180), G178 (= G181), I180 (= I183), T182 (= T185)

4fj0D Crystal structure of the ternary complex between a fungal 17beta- hydroxysteroid dehydrogenase (holo form) and 3,7-dihydroxy flavone (see paper)
35% identity, 98% coverage: 2:245/249 of query aligns to 5:259/261 of 4fj0D

query
sites
4fj0D

G

G

K

R

L

L

S

D

G

G

K

K

V

V

A

A

V

L

V

V

T

T

G
|
G

G

S

N

G

S
x
R

G
|
G

I
|
I

G

G

L

A

S

A

T

V

A

A

Q

V

L

H

F

L

A

G

A

R

E

L

G

G

A

A

H

K

L

V

V

V

V

V

T

N

-

Y

G
x
A

R
x
N

R
x
S

K

T

A

K

E

D

L

A

D

E

T

K

A

V

V

V

A

S

E

E

I

I

-

K

-

A

-

L

G

G

H

S

G

D

A

A

V

I

G

A

V

I

Q

K

G

A

D

D

V
x
I

S

R

K

Q

L

V

A

P

D

E

L

I

D

V

A

K

L

L

Y

F

A

D

E

Q

V

A

K

V

S

A

K

H

F

F

G

G

R

H

I

L

D

D

I

I

L

A

F

V

A

S

N
|
N

A
x
S

G
|
G

V

V

C

V

E

S

L

F

A

G

P

H

L

L

V

K

G

D

V

V

S

T

E

E

E

E

H

E

F

F

D

D

K

R

V

V

F

F

D

S

I
x
L

N

N

V

T

K

R

G

G

L

Q

L

F

F

F

T

V

V

A

Q

R

K

E

A

A

L

Y

P

R

L

H

F

L

A

T

D

E

G

G

G

G

S

R

I

I

I

V

L

L

N
x
T

S

S

S
|
S

V

-

A

-

N
|
N

T

T

T

S

-

K

-

D

-

F

G

S

I

V

P

P

A

K

F
x
H

G

S

V

L

Y
|
Y

S

S

A

G

T

S

K
|
K

A

G

A

A

V

V

R

D

S

S

F

F

A

V

R

R

T

I

W

F

T

S

S

K

E

D

L

C

K

G

D

D

R

K

N

K

I

I

R

T

V

V

N

N

V

A

I

V

S

A

P
|
P

G
|
G

P
x
G

I
x
T

E

V

T
|
T

P

D

I
x
M

F
|
F

G

H

K

E

V

V

-
x
S

-

H

-

H

-
x
Y

-

I

-

P

-

N

-

G

-

T

G

S

L

Y

S

T

A

A

E

E

Q

Q

L

R

Q

Q

E

Q

F

M

D
x
A

A

A

Q

H

I

A

S

S

A

-

K

-

V

-

P

P

L

L

G

H

R

R

F

N

G

G

K

W

P

P

E

Q

E

D

I

V

A

A

K

N

A

V

A

V

L

G

F

F

L

L

A

V

S

S

D

K

D

E

A

G

S

E

Y

W

V

V

A

N

G

G

A

K

D

V

L

L

Y

T

V

L

D

D

G

G

G

G

active site: G20 (= G17), S144 (= S137), N145 (= N140), H155 (≠ F147), Y158 (= Y150), K162 (= K154), Y203 (vs. gap)
binding 3,7-dihydroxy-2-phenyl-4H-chromen-4-one: S144 (= S137), N145 (= N140), G190 (≠ P182), F196 (= F188), S200 (vs. gap), Y203 (vs. gap), A219 (≠ D202)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G16 (= G13), R19 (≠ S16), G20 (= G17), I21 (= I18), A41 (≠ G37), N42 (≠ R38), S43 (≠ R39), I68 (≠ V61), N94 (= N87), S95 (≠ A88), G96 (= G89), L117 (≠ I110), T142 (≠ N135), Y158 (= Y150), K162 (= K154), P188 (= P180), G189 (= G181), G190 (≠ P182), T191 (≠ I183), T193 (= T185), M195 (≠ I187)

4fj1B Crystal structure of the ternary complex between a fungal 17beta- hydroxysteroid dehydrogenase (holo form) and genistein (see paper)
35% identity, 98% coverage: 2:245/249 of query aligns to 3:257/259 of 4fj1B

query
sites
4fj1B

G

G

K

R

L

L

S

D

G

G

K

K

V

V

A

A

V

L

V

V

T

T

G
|
G

G

S

N

G

S
x
R

G
|
G

I
|
I

G

G

L

A

S

A

T

V

A

A

Q

V

L

H

F

L

A

G

A

R

E

L

G

G

A

A

H

K

L

V

V

V

V

V

T

N

-

Y

G
x
A

R
x
N

R
x
S

K

T

A

K

E

D

L

A

D

E

T

K

A

V

V

V

A

S

E

E

I

I

-

K

-

A

-

L

G

G

H

S

G

D

A

A

V

I

G

A

V

I

Q

K

G

A

D

D

V
x
I

S

R

K

Q

L

V

A

P

D

E

L

I

D

V

A

K

L

L

Y

F

A

D

E

Q

V

A

K

V

S

A

K

H

F

F

G

G

R

H

I

L

D

D

I

I

L

A

F

V

A

S

N
|
N

A
x
S

G
|
G

V

V

C

V

E

S

L

F

A

G

P

H

L

L

V

K

G

D

V

V

S

T

E

E

E

E

H

E

F

F

D

D

K

R

V

V

F

F

D

S

I
x
L

N

N

V

T

K

R

G

G

L

Q

L

F

F

F

T

V

V

A

Q

R

K

E

A

A

L

Y

P

R

L

H

F

L

A

T

D

E

G

G

G

G

S

R

I

I

I

V

L

L

N
x
T

S

S

S
|
S

V

-

A

-

N
|
N

T

T

T

S

-

K

-

D

-

F

G

S

I

V

P

P

A

K

F
x
H

G

S

V

L

Y
|
Y

S

S

A

G

T

S

K
|
K

A

G

A

A

V

V

R

D

S

S

F

F

A

V

R

R

T

I

W

F

T

S

S

K

E

D

L

C

K

G

D

D

R

K

N

K

I

I

R

T

V

V

N

N

V

A

I

V

S

A

P

P

G
|
G

P
x
G

I
x
T

E

V

T
|
T

P

D

I
x
M

F
|
F

G

H

K

E

V

V

-
x
S

-

H

-

H

-
x
Y

-
x
I

-

P

-

N

-

G

-

T

G

S

L

Y

S

T

A

A

E

E

Q

Q

L

R

Q

Q

E

Q

F
x
M

D
x
A

A

A

Q

H

I

A

S

S

A

-

K

-

V

-

P

P

L

L

G

H

R

R

F

N

G

G

K

W

P

P

E

Q

E

D

I

V

A

A

K

N

A

V

A

V

L

G

F

F

L

L

A

V

S

S

D

K

D

E

A

G

S

E

Y

W

V

V

A

N

G

G

A

K

D

V

L

L

Y

T

V

L

D

D

G

G

G

G

active site: G18 (= G17), S142 (= S137), N143 (= N140), H153 (≠ F147), Y156 (= Y150), K160 (= K154), Y201 (vs. gap)
binding genistein: G188 (≠ P182), F194 (= F188), S198 (vs. gap), Y201 (vs. gap), I202 (vs. gap), M216 (≠ F201), A217 (≠ D202)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G14 (= G13), R17 (≠ S16), G18 (= G17), I19 (= I18), A39 (≠ G37), N40 (≠ R38), S41 (≠ R39), I66 (≠ V61), N92 (= N87), S93 (≠ A88), G94 (= G89), L115 (≠ I110), T140 (≠ N135), S142 (= S137), Y156 (= Y150), K160 (= K154), G187 (= G181), T189 (≠ I183), T191 (= T185), M193 (≠ I187)

4fj2B Crystal structure of the ternary complex between a fungal 17beta- hydroxysteroid dehydrogenase (holo form) and biochanin a (see paper)
35% identity, 98% coverage: 2:245/249 of query aligns to 4:258/260 of 4fj2B

query
sites
4fj2B

G

G

K

R

L

L

S

D

G

G

K

K

V

V

A

A

V

L

V

V

T

T

G
|
G

G

S

N

G

S
x
R

G
|
G

I
|
I

G

G

L

A

S

A

T

V

A

A

Q

V

L

H

F

L

A

G

A

R

E

L

G

G

A

A

H

K

L

V

V

V

V

V

T

N

-

Y

G
x
A

R
x
N

R
x
S

K

T

A

K

E

D

L

A

D

E

T

K

A

V

V

V

A

S

E

E

I

I

-

K

-

A

-

L

G

G

H

S

G

D

A

A

V

I

G

A

V

I

Q

K

G

A

D

D

V
x
I

S

R

K

Q

L

V

A

P

D

E

L

I

D

V

A

K

L

L

Y

F

A

D

E

Q

V

A

K

V

S

A

K

H

F

F

G

G

R

H

I

L

D

D

I

I

L

A

F

V

A

S

N
|
N

A
x
S

G
|
G

V

V

C

V

E

S

L

F

A

G

P

H

L

L

V

K

G

D

V

V

S

T