SitesBLAST
Comparing WP_085772038.1 NCBI__GCF_002117405.1:WP_085772038.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P37685 Aldehyde dehydrogenase B; Acetaldehyde dehydrogenase; EC 1.2.1.4 from Escherichia coli (strain K12) (see paper)
71% identity, 98% coverage: 13:506/506 of query aligns to 19:512/512 of P37685
- R197 (≠ E191) mutation to E: Less than 10% of wild-type acetaldehyde dehydrogenase activity.
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
45% identity, 94% coverage: 22:497/506 of query aligns to 7:478/489 of 4o6rA
- active site: N150 (= N165), K173 (= K188), E248 (= E262), C282 (= C301), E383 (= E402), E460 (= E479)
- binding adenosine monophosphate: I146 (= I161), V147 (≠ I162), K173 (= K188), G206 (= G220), G210 (= G224), Q211 (≠ K225), F224 (= F238), G226 (= G240), S227 (≠ E241), T230 (= T244), R233 (≠ L247)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 5l13A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F166), M168 (= M170), W171 (= W173), F290 (vs. gap), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 4kwgA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F166), M168 (= M170), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 4kwfA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F166), M168 (= M170), W171 (= W173), E262 (= E262), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462), F459 (= F468)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 3sz9A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F166), C295 (≠ V300), C296 (= C301), D451 (≠ H460), F453 (≠ Y462), F459 (= F468)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 3injA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ L120), F164 (= F166), L167 (= L169), F286 (= F293), F290 (vs. gap), D451 (≠ H460), F453 (≠ Y462)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 2vleA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding daidzin: M118 (≠ L120), F164 (= F166), M168 (= M170), W171 (= W173), F286 (= F293), F290 (vs. gap), C295 (≠ V300), C296 (= C301), D451 (≠ H460), V452 (≠ A461), F453 (≠ Y462)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 1o01B
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding (2e)-but-2-enal: C296 (= C301), C297 (≠ T302), F453 (≠ Y462)
- binding nicotinamide-adenine-dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), W162 (= W164), K186 (= K188), E189 (= E191), G219 (= G220), G223 (= G224), A224 (≠ K225), F237 (= F238), G239 (= G240), S240 (≠ E241), I243 (≠ T244), L263 (= L263), G264 (= G264), C296 (= C301), Q343 (= Q348), E393 (= E402), F395 (= F404)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 1cw3A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding magnesium ion: V34 (≠ I39), D103 (= D105), Q190 (= Q192)
- binding nicotinamide-adenine-dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), W162 (= W164), K186 (= K188), G219 (= G220), G223 (= G224), A224 (≠ K225), F237 (= F238), G239 (= G240), S240 (≠ E241), I243 (≠ T244), L263 (= L263), G264 (= G264), C296 (= C301), Q343 (= Q348), K346 (= K351), E393 (= E402), F395 (= F404)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 19:494/496 of 4fr8C
- active site: N165 (= N165), K188 (= K188), Q264 (≠ E262), C298 (= C301), E395 (= E402), E472 (= E479)
- binding nicotinamide-adenine-dinucleotide: I161 (= I161), I162 (= I162), W164 (= W164), K188 (= K188), G221 (= G220), G225 (= G224), A226 (≠ K225), F239 (= F238), G241 (= G240), S242 (≠ E241), I245 (≠ T244), Q345 (= Q348), E395 (= E402), F397 (= F404)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 16:491/493 of 4fr8A
- active site: N162 (= N165), K185 (= K188), Q261 (≠ E262), C295 (= C301), E392 (= E402), E469 (= E479)
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), W161 (= W164), K185 (= K188), G218 (= G220), G222 (= G224), A223 (≠ K225), F236 (= F238), G238 (= G240), S239 (≠ E241), I242 (≠ T244), Q342 (= Q348), K345 (= K351), E392 (= E402), F394 (= F404)
- binding propane-1,2,3-triyl trinitrate: F163 (= F166), L166 (= L169), W170 (= W173), F289 (vs. gap), S294 (≠ V300), C295 (= C301), D450 (≠ H460), F452 (≠ Y462)
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 1nzwA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), S296 (≠ T302), E393 (= E402), E470 (= E479)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), K186 (= K188), E189 (= E191), G219 (= G220), P220 (≠ V221), G223 (= G224), A224 (≠ K225), F237 (= F238), G239 (= G240), S240 (≠ E241), I243 (≠ T244), E262 (= E262), G264 (= G264), S296 (≠ T302), Q343 (= Q348), E393 (= E402), F395 (= F404)
2onmA Human mitochondrial aldehyde dehydrogenase asian variant, aldh2 2, Complexed with NAD+ (see paper)
44% identity, 92% coverage: 22:488/506 of query aligns to 17:479/494 of 2onmA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding adenosine-5'-diphosphate: E189 (= E191), G219 (= G220), G223 (= G224), A224 (≠ K225), F237 (= F238), G239 (= G240), S240 (≠ E241), I243 (≠ T244)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
43% identity, 95% coverage: 22:501/506 of query aligns to 43:518/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
44% identity, 94% coverage: 22:495/506 of query aligns to 9:477/486 of 4pxlA
- active site: N154 (= N165), K177 (= K188), E253 (= E262), C287 (= C301), E384 (= E402), D461 (≠ E479)
- binding nicotinamide-adenine-dinucleotide: I150 (= I161), V151 (≠ I162), P152 (= P163), W153 (= W164), K177 (= K188), E180 (= E191), G210 (= G220), G214 (= G224), A215 (≠ K225), F228 (= F238), G230 (= G240), S231 (≠ E241), V234 (≠ T244), E253 (= E262), G255 (= G264), C287 (= C301), Q334 (= Q348), K337 (= K351), E384 (= E402), F386 (= F404)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
43% identity, 94% coverage: 22:496/506 of query aligns to 21:493/495 of 5iuwA
- active site: N166 (= N165), K189 (= K188), E265 (= E262), C300 (= C301), E399 (= E402), D476 (≠ E479)
- binding 1h-indol-3-ylacetic acid: F167 (= F166), M170 (≠ L169), C300 (= C301), D457 (≠ H460), F465 (= F468)
- binding nicotinamide-adenine-dinucleotide: I162 (= I161), V163 (≠ I162), P164 (= P163), W165 (= W164), N166 (= N165), K189 (= K188), G222 (= G220), G226 (= G224), K227 (= K225), F240 (= F238), T241 (= T239), G242 (= G240), S243 (≠ E241), I246 (≠ T244), Y253 (= Y251), E265 (= E262), A266 (≠ L263), C300 (= C301), E399 (= E402), F401 (= F404)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
43% identity, 94% coverage: 22:496/506 of query aligns to 21:493/495 of 5iuvA
- active site: N166 (= N165), K189 (= K188), E265 (= E262), C300 (= C301), E399 (= E402), D476 (≠ E479)
- binding nicotinamide-adenine-dinucleotide: I162 (= I161), V163 (≠ I162), P164 (= P163), W165 (= W164), N166 (= N165), K189 (= K188), S191 (≠ A190), G222 (= G220), G226 (= G224), K227 (= K225), F240 (= F238), T241 (= T239), G242 (= G240), S243 (≠ E241), I246 (≠ T244), Y253 (= Y251), E265 (= E262), A266 (≠ L263), C300 (= C301), E399 (= E402), F401 (= F404)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 94% coverage: 22:497/506 of query aligns to 20:489/491 of 5gtlA
- active site: N165 (= N165), K188 (= K188), E263 (= E262), C297 (= C301), E394 (= E402), E471 (= E479)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I161), P163 (= P163), K188 (= K188), A190 (= A190), E191 (= E191), Q192 (= Q192), G221 (= G220), G225 (= G224), G241 (= G240), S242 (≠ E241), T245 (= T244), L264 (= L263), C297 (= C301), E394 (= E402), F396 (= F404)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 94% coverage: 22:497/506 of query aligns to 20:489/491 of 5gtkA
- active site: N165 (= N165), K188 (= K188), E263 (= E262), C297 (= C301), E394 (= E402), E471 (= E479)
- binding nicotinamide-adenine-dinucleotide: I161 (= I161), I162 (= I162), P163 (= P163), W164 (= W164), K188 (= K188), E191 (= E191), G221 (= G220), G225 (= G224), A226 (≠ K225), F239 (= F238), G241 (= G240), S242 (≠ E241), T245 (= T244), Y248 (≠ L247), L264 (= L263), C297 (= C301), Q344 (= Q348), R347 (≠ K351), E394 (= E402), F396 (= F404)
Query Sequence
>WP_085772038.1 NCBI__GCF_002117405.1:WP_085772038.1
MLHQEIEKLKGSVAIKKRYDNFIGGQWVAPLGGEYFDNISPITGHPICQVARGRAADVEL
ALDAAHKAKDAWGKTPAAERANMLNKIAQRLDDNLSALALVETIDNGKPIRETTAADIPL
AIDHFRYFAGCLRAQEGSLSEIDHDTVAYHFHEPLGVVGQIIPWNFPILMAAWKLSPALA
AGNCVVLKPAEQTPMSILAVAELIADLLPPGVLNIVNGFGVEAGKPLASNKRIAKIAFTG
ETTTGRLIMQYAAENLIPVTLELGGKSPNIFFADVMAEDDAFLDKALEGFASFALNQGEV
CTCPSRALVQRSIYDKFMEKALARVAKIRQGHPLDPATMIGAQASNDQLEKILSYVDIGR
KEGAKVLIGGERSVLEGELKEGYYMQPTALEGHNRMRVFQEEIFGPVVSVTTFETEEEAL
QIANDTLYGLGAGLWTRDGSRAYRCGRAIRAGRVWTNCYHAYPAHAAFGGYKQSGIGREN
HKMMLDHYQQTKNLLVSYSPKALGLF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory