SitesBLAST
Comparing WP_085772269.1 NCBI__GCF_002117405.1:WP_085772269.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6es9A Methylsuccinyl-coa dehydrogenase of paracoccus denitrificans with bound flavin adenine dinucleotide (see paper)
65% identity, 96% coverage: 25:556/557 of query aligns to 20:545/545 of 6es9A
- active site: F281 (= F292), T282 (= T293), A408 (= A419), R541 (= R552)
- binding coenzyme a: R75 (= R80), F467 (= F478), W470 (≠ R481)
- binding flavin-adenine dinucleotide: Q50 (= Q55), A279 (= A290), F281 (= F292), T282 (= T293), G287 (= G298), S288 (= S299), W312 (= W323), I313 (= I324), T314 (= T325), E374 (= E385), R434 (= R445), Q436 (= Q447), F437 (= F448), L441 (= L452), F444 (= F455), Q502 (= Q513), I503 (= I514), G505 (= G516), G506 (= G517), F528 (= F539), A531 (= A542), E533 (= E544), I534 (= I545)
4iv6B X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
39% identity, 68% coverage: 177:555/557 of query aligns to 7:376/383 of 4iv6B
- active site: L121 (≠ F292), T122 (= T293), G240 (≠ A419), E361 (= E540), K373 (≠ R552)
- binding dihydroflavine-adenine dinucleotide: L121 (≠ F292), T122 (= T293), G126 (≠ N297), G127 (= G298), S128 (= S299), W152 (= W323), I153 (= I324), S154 (≠ T325), R266 (= R445), S268 (≠ Q447), F269 (= F448), I273 (≠ L452), H276 (≠ F455), V279 (≠ I458), R334 (≠ Q513), V335 (≠ I514), G338 (= G517), L356 (≠ I535), G360 (≠ F539), T363 (≠ A542), E365 (= E544), I366 (= I545)
8ciwA Methylsuccinyl-coa dehydrogenase from pseudomonas migulae with bound fad and (2s)-methylsuccinyl-coa (see paper)
36% identity, 95% coverage: 30:556/557 of query aligns to 22:548/555 of 8ciwA
- binding flavin-adenine dinucleotide: Q47 (= Q55), I275 (≠ A290), I277 (≠ F292), T278 (= T293), G283 (= G298), S284 (= S299), W308 (= W323), T310 (= T325), R437 (= R445), V439 (≠ Q447), F440 (= F448), L444 (= L452), Q504 (= Q513), I505 (= I514), G508 (= G517), F530 (= F539), E535 (= E544), T536 (≠ I545)
- binding (2S)-Methylsuccinyl-CoA: R242 (= R257), S284 (= S299), V286 (≠ L301), H332 (≠ Y346), Y370 (= Y380), F401 (= F409), Y402 (≠ K410), M405 (= M413), M408 (≠ F416), R412 (= R420), R418 (= R426), F530 (= F539), E531 (= E540), G532 (= G541), R544 (= R552)
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
38% identity, 69% coverage: 172:555/557 of query aligns to 5:377/379 of 1ukwB
- active site: L124 (≠ F292), S125 (≠ T293), T241 (≠ A419), E362 (= E540), R374 (= R552)
- binding cobalt (ii) ion: D145 (= D313), H146 (≠ V314)
- binding flavin-adenine dinucleotide: F122 (≠ A290), L124 (≠ F292), S125 (≠ T293), G130 (= G298), S131 (= S299), W155 (= W323), S157 (≠ T325), K200 (≠ G373), L357 (≠ I535), Y361 (≠ F539), E362 (= E540), T364 (≠ A542), E366 (= E544), L370 (≠ Q548)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
38% identity, 69% coverage: 172:555/557 of query aligns to 5:377/379 of 1ukwA
- active site: L124 (≠ F292), S125 (≠ T293), T241 (≠ A419), E362 (= E540), R374 (= R552)
- binding flavin-adenine dinucleotide: F122 (≠ A290), L124 (≠ F292), S125 (≠ T293), G130 (= G298), S131 (= S299), W155 (= W323), S157 (≠ T325), L357 (≠ I535), Y361 (≠ F539), E362 (= E540), T364 (≠ A542), E366 (= E544), L370 (≠ Q548)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
39% identity, 67% coverage: 186:556/557 of query aligns to 18:378/378 of 5ol2F
- active site: L124 (≠ F292), T125 (= T293), G241 (≠ A419), G374 (≠ R552)
- binding calcium ion: E29 (= E197), E33 (≠ N202), R35 (≠ Y204)
- binding coenzyme a persulfide: L238 (≠ F416), R242 (= R420), E362 (= E540), G363 (= G541)
- binding flavin-adenine dinucleotide: F122 (≠ A290), L124 (≠ F292), T125 (= T293), P127 (= P295), T131 (≠ S299), F155 (≠ W323), I156 (= I324), T157 (= T325), E198 (≠ G369), R267 (= R445), F270 (= F448), L274 (= L452), F277 (= F455), Q335 (= Q513), L336 (≠ I514), G338 (= G516), G339 (= G517), Y361 (≠ F539), T364 (≠ A542), E366 (= E544)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
36% identity, 68% coverage: 174:554/557 of query aligns to 8:378/378 of 4n5fA
- active site: L126 (≠ F292), T127 (= T293), G243 (≠ A419), E364 (= E540), R376 (= R552)
- binding dihydroflavine-adenine dinucleotide: L126 (≠ F292), T127 (= T293), G132 (= G298), S133 (= S299), F157 (≠ W323), T159 (= T325), T210 (≠ E385), Y363 (≠ F539), T366 (≠ A542), E368 (= E544), M372 (≠ Q548)
P41367 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; MCAD; EC 1.3.8.7 from Sus scrofa (Pig) (see 2 papers)
36% identity, 68% coverage: 172:552/557 of query aligns to 41:413/421 of P41367
- 158:167 (vs. 290:299, 50% identical) binding in other chain
- S167 (= S299) binding octanoyl-CoA
- WIT 191:193 (= WIT 323:325) binding in other chain
- S216 (≠ Y346) binding octanoyl-CoA
- D278 (≠ E417) binding octanoyl-CoA
- R281 (= R420) binding octanoyl-CoA
- RKT 306:308 (≠ RIQ 445:447) binding FAD
- HQ 316:317 (≠ FP 455:456) binding in other chain
- R349 (= R488) binding octanoyl-CoA
- T351 (≠ D490) binding octanoyl-CoA
- QVFGG 374:378 (≠ QIHGG 513:517) binding FAD
- E401 (= E540) active site, Proton acceptor; binding octanoyl-CoA
- GTAQ 402:405 (≠ GAAE 541:544) binding in other chain
3mdeA Crystal structures of medium chain acyl-coa dehydrogenase from pig liver mitochondria with and without substrate (see paper)
36% identity, 68% coverage: 172:552/557 of query aligns to 6:378/385 of 3mdeA
- active site: V125 (≠ F292), T126 (= T293), T245 (≠ A419), E366 (= E540), R378 (= R552)
- binding octanoyl-coenzyme a: T86 (≠ S253), E89 (≠ T256), L93 (≠ I260), S132 (= S299), V134 (≠ L301), S181 (≠ Y346), F235 (= F409), M239 (= M413), F242 (= F416), R314 (= R488), Y365 (≠ F539), E366 (= E540), G367 (= G541)
- binding flavin-adenine dinucleotide: Y123 (≠ A290), V125 (≠ F292), T126 (= T293), G131 (= G298), S132 (= S299), W156 (= W323), I157 (= I324), T158 (= T325), R271 (= R445), T273 (≠ Q447), F274 (= F448), L278 (= L452), H281 (≠ F455), Q339 (= Q513), V340 (≠ I514), G343 (= G517), I361 (= I535), T368 (≠ A542), Q370 (≠ E544)
3mddA Crystal structures of medium chain acyl-coa dehydrogenase from pig liver mitochondria with and without substrate (see paper)
36% identity, 68% coverage: 172:552/557 of query aligns to 6:378/385 of 3mddA
- active site: V125 (≠ F292), T126 (= T293), T245 (≠ A419), E366 (= E540), R378 (= R552)
- binding flavin-adenine dinucleotide: Y123 (≠ A290), T126 (= T293), G131 (= G298), S132 (= S299), W156 (= W323), T158 (= T325), R271 (= R445), T273 (≠ Q447), F274 (= F448), H281 (≠ F455), Q339 (= Q513), V340 (≠ I514), G343 (= G517), I361 (= I535), T368 (≠ A542), Q370 (≠ E544)
1udyA Medium-chain acyl-coa dehydrogenase with 3-thiaoctanoyl-coa (see paper)
36% identity, 68% coverage: 172:552/557 of query aligns to 6:378/385 of 1udyA