SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_086508344.1 NCBI__GCF_002151265.1:WP_086508344.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
35% identity, 97% coverage: 7:259/261 of query aligns to 5:257/260 of P02911

query
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P02911

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D33 (= D34) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
Y36 (= Y37) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
D52 (≠ E53) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
C60 (= C61) modified: Disulfide link with 67
C67 (= C68) modified: Disulfide link with 60
F74 (≠ W75) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
S91 (= S92) binding L-arginine; binding L-ornithine; mutation to A: Has no effect on the arginine and histidine binding affinity.
S92 (= S93) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
S94 (≠ A95) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
R99 (= R100) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
L139 (≠ Q141) mutation to K: Changes ligand specificity. Can bind glutamine. Still able to bind basic amino acids, however, with 1000-fold less affinity for arginine.; mutation to Q: Does not affect ligand preference.
T143 (≠ L145) binding L-arginine; binding L-lysine; binding L-ornithine
D183 (= D184) binding L-arginine; binding L-ornithine; mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.

5owfA Structure of a lao-binding protein mutant with glutamine (see paper)
34% identity, 89% coverage: 29:259/261 of query aligns to 3:232/235 of 5owfA

query
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binding glutamine: Y11 (= Y37), F49 (≠ W75), S66 (= S92), S67 (= S93), S69 (≠ A95), R74 (= R100), K114 (≠ Q141), S117 (≠ T144), T118 (≠ L145), D158 (= D184)

P0AEU0 Histidine-binding periplasmic protein; HBP from Escherichia coli (strain K12) (see 3 papers)
35% identity, 89% coverage: 29:259/261 of query aligns to 28:257/260 of P0AEU0

query
sites
P0AEU0

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C60 (= C61) modified: Disulfide link with 67
C67 (= C68) modified: Disulfide link with 60
S91 (= S92) binding L-histidine
S92 (= S93) binding L-histidine
S94 (≠ A95) binding L-histidine
R99 (= R100) binding L-histidine
T143 (≠ L145) binding L-histidine
D183 (= D184) binding L-histidine

Sites not aligning to the query:

1:22 signal peptide

P02910 Histidine-binding periplasmic protein; HBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
35% identity, 89% coverage: 28:259/261 of query aligns to 27:257/260 of P02910

query
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P02910

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E40 (≠ M41) mutation to K: Decrease in ATPase-inducing activity and histidine transport; when associated with K-47.
K42 (≠ R43) mutation to E: Increases ATPase-inducing activity and histidine transport; when associated with K-47.
E47 (= E48) mutation to K: Decrease in ATPase-inducing activity and histidine transport; when associated with K-40. Increases ATPase-inducing activity and histidine transport; when associated with E-42.
D171 (= D172) mutation D->A,N: Strong decrease in ATPase-inducing activity and histidine transport.
R176 (= R177) mutation R->D,S: Strong decrease in ATPase-inducing activity and histidine transport.
D178 (= D179) mutation to A: Slight decrease in ATPase-inducing activity and histidine transport.

Sites not aligning to the query:

1:22 signal peptide

1hslA Refined 1.89 angstroms structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport(slash)chemosensory receptors (see paper)
35% identity, 89% coverage: 28:259/261 of query aligns to 5:235/238 of 1hslA

query
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1hslA

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H

D

F

Y

K

K

R

F

I

G

S

G

G

P

F

A

I

V

K

K

E

D

P

-

E

E

H

K

I

L

F

F

G

G

K

V

G

G

V

T

G

G

V

M

A

G

F

L

R

R

Q

K

R

E

D

D

E

N

A

E

L

L

A

R

E

E

R

A

F

L

N

N

E

K

A

A

L

F

A

A

A

E

L

M

K

R

E

A

D

D

G

G

T

T

Y

Y

D

E

E

K

I

L

M

A

E

K

R

K

Y

Y

F

F

N

D

Y

F

D

D

I

V

binding histidine: Y14 (= Y37), L52 (≠ W75), S69 (= S92), S70 (= S93), L71 (≠ M94), S72 (≠ A95), R77 (= R100), T120 (= T144), T121 (≠ L145), D161 (= D184)

1lstA Three-dimensional structures of the periplasmic lysine-, arginine-, ornithine-binding protein with and without a ligand (see paper)
34% identity, 89% coverage: 29:259/261 of query aligns to 6:235/238 of 1lstA

query
sites
1lstA

I

V

R

R

L

I

G

G

V

T

D

D

I

T

P

T

Y
|
Y

E

A

P

P

F

F

M

S

Y

S

R

K

Q

D

P

A

D

K

G

G

E

E

L

F

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

E

V

M

C

C

E

K

Y

R

L

M

E

Q

V

V

T

K

C

C

T

T

W

W

V

V

E

A

Q

S

D

D

W
x
F

D

D

G

A

I

L

I

I

P

P

G

S

L

L

M

K

A

A

R

K

N

K

Y

I

D

D

A

A

I

I

M

I

S

S

S
|
S

M

L

A
x
S

I

I

T

T

E

D

E

K

R
|
R

A

Q

E

Q

R

E

V

I

L

A

F

F

S

S

E

D

P

K

Y

L

Y

Y

T

A

P

D

S

S

A

R

W

L

I

I

T

A

R

K

D

G

R

S

D

P

I

I

D

Q

I

-

E

P

D

T

R

L

D

E

S

S

L

L

A

K

G

G

L

K

V

H

V

V

G

G

V

V

Q
x
L

R

Q

A

G

T
x
S

L
x
T

Q
|
Q

D

E

N

A

Y

Y

V

A

S

N

E

D

L

N

Y

W

-

R

G

T

D

K

L

G

V

V

E

D

I

V

R

V

R

A

Y

Y

T

A

S

N

A

Q

D

D

D

L

V

I

V

Y

T

S

D

D

M

L

R

T

A

A

G

G

R

R

L

L

D

D

L

A

T

A

F

L

M

Q

D
|
D

Y

E

P

V

V

A

A

A

E

S

N

E

T

G

M

F

G

L

I

K

D

Q

T

P

S

A

G

G

S

K

H

E

F

Y

K

A

R

F

I

A

S

G

G

P

F

S

I

V

K

K

E

D

P

K

E

K

H

Y

I

-

F

F

G

G

K

D

G

G

V

T

G

G

V

V

A

G

F

L

R

R

Q

K

R

D

D

D

E

T

A

E

L

L

A

K

E

A

R

A

F

F

N

D

E

K

A

A

L

L

A

T

A

E

L

L

K

R

E

Q

D

D

G

G

T

T

Y

Y

D

D

E

K

I

M

M

A

E

K

R

K

Y

Y

F

F

N

D

Y

F

D

N

I

V

binding lysine: Y14 (= Y37), F52 (≠ W75), S70 (= S93), S72 (≠ A95), R77 (= R100), L117 (≠ Q141), S120 (≠ T144), T121 (≠ L145), Q122 (= Q146), D161 (= D184)

1lahE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
34% identity, 89% coverage: 29:259/261 of query aligns to 6:235/238 of 1lahE

query
sites
1lahE

I

V

R

R

L

I

G

G

V

T

D

D

I

T

P

T

Y
|
Y

E

A

P

P

F

F

M

S

Y

S

R

K

Q

D

P

A

D

K

G

G

E

E

L

F

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

E

V

M

C

C

E

K

Y

R

L

M

E

Q

V

V

T

K

C

C

T

T

W

W

V

V

E

A

Q

S

D

D

W
x
F

D

D

G

A

I

L

I

I

P

P

G

S

L

L

M

K

A

A

R

K

N

K

Y

I

D

D

A

A

I

I

M

I

S

S

S
|
S

M

L

A
x
S

I

I

T

T

E

D

E

K

R
|
R

A

Q

E

Q

R

E

V

I

L

A

F

F

S

S

E

D

P

K

Y

L

Y

Y

T

A

P

D

S

S

A

R

W

L

I

I

T

A

R

K

D

G

R

S

D

P

I

I

D

Q

I

-

E

P

D

T

R

L

D

E

S

S

L

L

A

K

G

G

L

K

V

H

V

V

G

G

V

V

Q

L

R

Q

A

G

T
x
S

L

T

Q
|
Q

D

E

N

A

Y

Y

V

A

S

N

E

D

L

N

Y

W

-

R

G

T

D

K

L

G

V

V

E

D

I

V

R

V

R

A

Y

Y

T

A

S

N

A

Q

D

D

D

L

V

I

V

Y

T

S

D

D

M

L

R

T

A

A

G

G

R

R

L

L

D

D

L

A

T

A

F

L

M

Q

D
|
D

Y

E

P

V

V

A

A

A

E

S

N

E

T

G

M

F

G

L

I

K

D

Q

T

P

S

A

G

G

S

K

H

E

F

Y

K

A

R

F

I

A

S

G

G

P

F

S

I

V

K

K

E

D

P

K

E

K

H

Y

I

-

F

F

G

G

K

D

G

G

V

T

G

G

V

V

A

G

F

L

R

R

Q

K

R

D

D

D

E

T

A

E

L

L

A

K

E

A

R

A

F

F

N

D

E

K

A

A

L

L

A

T

A

E

L

L

K

R

E

Q

D

D

G

G

T

T

Y

Y

D

D

E

K

I

M

M

A

E

K

R

K

Y

Y

F

F

N

D

Y

F

D

N

I

V

binding L-ornithine: Y14 (= Y37), F52 (≠ W75), S70 (= S93), S72 (≠ A95), R77 (= R100), S120 (≠ T144), Q122 (= Q146), D161 (= D184)

1lagE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
34% identity, 89% coverage: 29:259/261 of query aligns to 6:235/238 of 1lagE

query
sites
1lagE

I

V

R

R

L

I

G

G

V

T

D

D

I

T

P

T

Y
|
Y

E

A

P

P

F

F

M

S

Y

S

R

K

Q

D

P

A

D

K

G

G

E

E

L

F

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

E

V

M

C

C

E

K

Y

R

L

M

E

Q

V

V

T

K

C

C

T

T

W

W

V

V

E

A

Q

S

D

D

W
x
F

D

D

G

A

I

L

I

I

P

P

G

S

L

L

M

K

A

A

R

K

N

K

Y

I

D

D

A

A

I

I

M

I

S
|
S

M
x
L

A
x
S

I

I

T

T

E

D

E

K

R
|
R

A

Q

E

Q

R

E

V

I

L

A

F

F

S

S

E

D

P

K

Y

L

Y

Y

T

A

P

D

S

S

A

R

W

L

I

I

T

A

R

K

D

G

R

S

D

P

I

I

D

Q

I

-

E

P

D

T

R

L

D

E

S

S

L

L

A

K

G

G

L

K

V

H

V

V

G

G

V

V

Q
x
L

R

Q

A

G

T
x
S

L

T

Q
|
Q

D

E

N

A

Y

Y

V

A

S

N

E

D

L

N

Y

W

-

R

G

T

D

K

L

G

V

V

E

D

I

V

R

V

R

A

Y

Y

T

A

S

N

A

Q

D

D

D

L

V

I

V

Y

T

S

D

D

M

L

R

T

A

A

G

G

R

R

L

L

D

D

L

A

T

A

F

L

M

Q

D
|
D

Y

E

P

V

V

A

A

A

E

S

N

E

T

G

M

F

G

L

I

K

D

Q

T

P

S

A

G

G

S

K

H

E

F

Y

K

A

R

F

I

A

S

G

G

P

F

S

I

V

K

K

E

D

P

K

E

K

H

Y

I

-

F

F

G

G

K

D

G

G

V

T

G

G

V

V

A

G

F

L

R

R

Q

K

R

D

D

D

E

T

A

E

L

L

A

K

E

A

R

A

F

F

N

D

E

K

A

A

L

L

A

T

A

E

L

L

K

R

E

Q

D

D

G

G

T

T

Y

Y

D

D

E

K

I

M

M

A

E

K

R

K

Y

Y

F

F

N

D

Y

F

D

N

I

V

binding histidine: Y14 (= Y37), F52 (≠ W75), S69 (= S92), S70 (= S93), L71 (≠ M94), S72 (≠ A95), R77 (= R100), L117 (≠ Q141), S120 (≠ T144), Q122 (= Q146), D161 (= D184)

1lafE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
34% identity, 89% coverage: 29:259/261 of query aligns to 6:235/238 of 1lafE

query
sites
1lafE

I

V

R

R

L

I

G

G

V

T

D
|
D

I

T

P

T

Y
|
Y

E

A

P

P

F

F

M

S

Y

S

R

K

Q

D

P

A

D

K

G

G

E

E

L

F

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

E

V

M

C

C

E

K

Y

R

L

M

E

Q

V

V

T

K

C

C

T

T

W

W

V

V

E

A

Q

S

D

D

W
x
F

D

D

G

A

I

L

I

I

P

P

G

S

L

L

M

K

A

A

R

K

N

K

Y

I

D

D

A

A

I

I

M

I

S
|
S

M

L

A
x
S

I

I

T

T

E

D

E

K

R
|
R

A

Q

E

Q

R

E

V

I

L

A

F

F

S

S

E

D

P

K

Y

L

Y

Y

T

A

P

D

S

S

A

R

W

L

I

I

T

A

R

K

D

G

R

S

D

P

I

I

D

Q

I

-

E

P

D

T

R

L

D

E

S

S

L

L

A

K

G

G

L

K

V

H

V

V

G

G

V

V

Q
x
L

R

Q

A

G

T
x
S

L
x
T

Q
|
Q

D

E

N

A

Y

Y

V

A

S

N

E

D

L

N

Y

W

-

R

G

T

D

K

L

G

V

V

E

D

I

V

R

V

R

A

Y

Y

T

A

S

N

A

Q

D

D

D

L

V

I

V

Y

T

S

D

D

M

L

R

T

A

A

G

G

R

R

L

L

D

D

L

A

T

A

F

L

M

Q

D
|
D

Y

E

P

V

V

A

A

A

E

S

N

E

T

G

M

F

G

L

I

K

D

Q

T

P

S

A

G

G

S

K

H

E

F

Y

K

A

R

F

I

A

S

G

G

P

F

S

I

V

K

K

E

D

P

K

E

K

H

Y

I

-

F

F

G

G

K

D

G

G

V

T

G

G

V

V

A

G

F

L

R

R

Q

K

R

D

D

D

E

T

A

E

L

L

A

K

E

A

R

A

F

F

N

D

E

K

A

A

L

L

A

T

A

E

L

L

K

R

E

Q

D

D

G

G

T

T

Y

Y

D

D

E

K

I

M

M

A

E

K

R

K

Y

Y

F

F

N

D

Y

F

D

N

I

V

binding arginine: D11 (= D34), Y14 (= Y37), F52 (≠ W75), S69 (= S92), S70 (= S93), S72 (≠ A95), R77 (= R100), L117 (≠ Q141), S120 (≠ T144), T121 (≠ L145), Q122 (= Q146), D161 (= D184)

5itoA Structure of the periplasmic binding protein m117n-noct from a. Tumefaciens in complex with octopine (see paper)
33% identity, 90% coverage: 25:258/261 of query aligns to 1:252/255 of 5itoA

query
sites
5itoA

D

D

Y

Y

S

K

E

S

I

I

R

T

L

I

G

A

V

T

D
x
E

I

G

P

S

Y
|
Y

E

A

P

P

F

Y

M

N

Y

F

R

K

Q

D

P

A

D

G

G

G

E

K

L

L

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

D

V

L

C

C

E

K

Y

R

L

M

E

N

V

I

T

E

C

C

T

K

W

F

V

V

E

E

Q

Q

D

A

W
|
W

D

D

G

G

I

I

P

P

G

S

L

L

M

T

A

A

R

G

N

R

Y

Y

D

D

A

A

I

I

M

M

S
x
A

M

M

A
x
G

I

I

T

Q

E

P

E

A

R
|
R

A

E

E

K

R

V

V

I

L

A

F

F

S

S

E

R

P

P

Y

Y

Y

L

T

L

T

T

P

P

S

N

A

T

W

F

I

L

T

T

R

A

D

D

R

S

-

P

-

L

-

K

-

T

-

Q

-

V

-

A

-

I

-

E

-

N

-

L

-

P

-

L

-

D

D

N

I

I

D

T

I

P

E

E

D

Q

R

K

D

A

S

E

L

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

A

E

G

G

L

V

V

K

V

F

G

G

V

V

Q
|
Q

R

A

A

G

T
|
T

L
x
S

Q
x
H

D

E

N

A

Y

F

V

M

S

K

E

Q

L

M

Y

M

G

P

D

S

L

-

V

V

E

Q

I

I

R

S

R

T

Y

Y

T

D

S

T

A

I

D

D

D

N

V

V

T

M

D

D

M

L

R

K

A

A

G

G

R

R

L

I

D

D

L

A

T

S

F

L

M

A

D
x
S

Y

V

-

S

-

F

-

L

-

K

P

P

V

L

A

T

E

D

N

K

T

P

M

D

G

N

I

K

D

D

T

L

S

K

G

-

S

M

H

F

F

G

K

P

R

R

I

M

S

T

G

G

F

-

I

-

K

-

E

-

P

-

E

-

H

G

I

L

F

F

G

G

K

K

G

G

V

V

G

G

V

V

A

G

F

I

R

R

Q

K

R

E

D

D

E

A

A

D

L

L

A

K

E

A

R

L

F

F

N

D

E

K

A

A

L

I

A

D

A

A

L

A

K

I

E

A

D

D

G

G

T

T

Y

V

D

Q

E

K

I

L

M

S

E

Q

R

Q

Y

W

F

F

N

G

Y

Y

D

D

binding octopine: E10 (≠ D34), Y13 (= Y37), W51 (= W75), A68 (≠ S92), A69 (≠ S93), G71 (≠ A95), R76 (= R100), Q139 (= Q141), T142 (= T144), S143 (≠ L145), H144 (≠ Q146), S181 (≠ D184)

5ovzA High resolution structure of the pbp noct in complex with nopaline (see paper)
33% identity, 90% coverage: 25:258/261 of query aligns to 1:252/259 of 5ovzA

query
sites
5ovzA

D

D

Y

Y

S

K

E

S

I

I

R

T

L

I

G

A

V

T

D
x
E

I

G

P

S

Y
|
Y

E

A

P

P

F

Y

M

N

Y

F

R

K

Q

D

P

A

D

G

G

G

E

K

L

L

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

D

V

L

C

C

E

K

Y

R

L

M

E

N

V

I

T

E

C

C

T

K

W

F

V

V

E

E

Q

Q

D

A

W
|
W

D

D

G

G

I

I

P

P

G

S

L

L

M

T

A

A

R

G

N

R

Y

Y

D

D

A

A

I

I

M

M

S
x
A

M

M

A
x
G

I

I

T

Q

E

P

E

A

R
|
R

A

E

E

K

R

V

V

I

L

A

F

F

S

S

E

R

P

P

Y

Y

Y

L

T

L

T

T

P

P

S
x
M

A

T

W

F

I

L

T

T

R

A

D

D

R

S

-

P

-

L

-

K

-

T

-

Q

-

V

-

A

-

I

-

E

-

N

-

L

-

P

-

L

-

D

D

N

I

I

D

T

I

P

E

E

D

Q

R

K

D

A

S

E

L

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

A

E

G

G

L

V

V

K

V

F

G

G

V

V

Q
|
Q

R

A

A

G

T
|
T

L
x
S

Q
x
H

D

E

N

A

Y

F

V

M

S

K

E

Q

L

M

Y

M

G

P

D

S

L

-

V

V

E

Q

I

I

R

S

R

T

Y

Y

T

D

S

T

A

I

D

D

D

N

V

V

T

M

D

D

M

L

R

K

A

A

G

G

R

R

L

I

D

D

L

A

T

S

F

L

M

A

D
x
S

Y

V

-

S

-

F

-

L

-

K

P

P

V

L

A

T

E

D

N

K

T

P

M

D

G

N

I

K

D

D

T

L

S

K

G

-

S

M

H

F

F

G

K

P

R

R

I

M

S

T

G

G

F

-

I

-

K

-

E

-

P

-

E

-

H

G

I

L

F

F

G

G

K

K

G

G

V
|
V

G

G

V

V

A

G

F

I

R

R

Q

K

R

E

D

D

E

A

A

D

L

L

A

K

E

A

R

L

F

F

N

D

E

K

A

A

L

I

A

D

A

A

L

A

K

I

E

A

D

D

G

G

T

T

Y

V

D

Q

E

K

I

L

M

S

E

Q

R

Q

Y

W

F

F

N

G

Y

Y

D

D

binding N-[(1S)-4-carbamimidamido-1-carboxybutyl]-D-glutamic acid: E10 (≠ D34), Y13 (= Y37), W51 (= W75), A68 (≠ S92), A69 (≠ S93), G71 (≠ A95), R76 (= R100), M91 (≠ S115), Q139 (= Q141), T142 (= T144), S143 (≠ L145), H144 (≠ Q146), S181 (≠ D184), V213 (= V219)

5otcA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with noroctopinic acid. (see paper)
32% identity, 89% coverage: 26:258/261 of query aligns to 1:251/256 of 5otcA

query
sites
5otcA

Y

Y

S

K

E

S

I

I

R

T

L

I

G

A

V

T

D
x
E

I

G

P

S

Y
|
Y

E

A

P

P

F

Y

M

N

Y

F

R

K

Q

D

P

A

D

G

G

G

E

K

L

L

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

D

V

L

C

C

E

K

Y

R

L

M

E

N

V

I

T

E

C

C

T

K

W

F

V

V

E

E

Q

Q

D

A

W
|
W

D

D

G

G

I

I

P

P

G

S

L

L

M

T

A

A

R

G

N

R

Y

Y

D

D

A

A

I

I

M

M

S

A

S
x
A

M

M

A
x
G

I

I

T

Q

E

P

E

A

R
|
R

A

E

E

K

R

V

V

I

L

A

F

F

S

S

E

R

P

P

Y

Y

Y

L

T

L

T

T

P

P

S

M

A

T

W

F

I

L

T

T

R

A

D

D

R

S

-

P

-

L

-

K

-

T

-

Q

-

V

-

A

-

I

-

E

-

N

-

L

-

P

-

L

-

D

D

N

I

I

D

T

I

P

E

E

D

Q

R

K

D

A

S

E

L

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

A

E

G

G

L

V

V

K

V

F

G

G

V

V

Q
|
Q

R

A

A

G

T
|
T

L
x
S

Q
x
H

D

E

N

A

Y

F

V

M

S

K

E

Q

L

M

Y

M

G

P

D

S

L

-

V

V

E

Q

I

I

R

S

R

T

Y

Y

T

D

S

T

A

I

D

D

D

N

V

V

T

M

D

D

M

L

R

K

A

A

G

G

R

R

L

I

D

D

L

A

T

S

F

L

M

A

D
x
S

Y

V

-

S

-

F

-

L

-

K

P

P

V

L

A

T

E

D

N

K

T

P

M

D

G

N

I

K

D

D

T

L

S

K

G

-

S

M

H

F

F

G

K

P

R

R

I

M

S

T

G

G

F

-

I

-

K

-

E

-

P

-

E

-

H

G

I

L

F

F

G

G

K

K

G

G

V

V

G

G

V

V

A

G

F

I

R

R

Q

K

R

E

D

D

E

A

A

D

L

L

A

K

E

A

R

L

F

F

N

D

E

K

A

A

L

I

A

D

A

A

L

A

K

I

E

A

D

D

G

G

T

T

Y

V

D

Q

E

K

I

L

M

S

E

Q

R

Q

Y

W

F

F

N

G

Y

Y

D

D

binding (2~{S})-5-azanyl-2-(2-hydroxy-2-oxoethylamino)pentanoic acid: E9 (≠ D34), Y12 (= Y37), W50 (= W75), A68 (≠ S93), G70 (≠ A95), R75 (= R100), Q138 (= Q141), T141 (= T144), S142 (≠ L145), H143 (≠ Q146), S180 (≠ D184)

5otaA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with octopinic acid (see paper)
32% identity, 89% coverage: 26:258/261 of query aligns to 1:251/254 of 5otaA

query
sites
5otaA

Y

Y

S

K

E

S

I

I

R

T

L

I

G

A

V

T

D
x
E

I

G

P

S

Y
|
Y

E

A

P

P

F

Y

M

N

Y

F

R

K

Q

D

P

A

D

G

G

G

E

K

L

L

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

D

V

L

C

C

E

K

Y

R

L

M

E

N

V

I

T

E

C

C

T

K

W

F

V

V

E

E

Q

Q

D

A

W
|
W

D

D

G

G

I

I

P

P

G

S

L

L

M

T

A

A

R

G

N

R

Y

Y

D

D

A

A

I

I

M

M

S

A

S
x
A

M

M

A
x
G

I

I

T

Q

E

P

E

A

R
|
R

A

E

E

K

R

V

V

I

L

A

F

F

S

S

E

R

P

P

Y

Y

Y

L

T

L

T

T

P

P

S
x
M

A

T

W

F

I

L

T

T

R

A

D

D

R

S

-

P

-

L

-

K

-

T

-

Q

-

V

-

A

-

I

-

E

-

N

-

L

-

P

-

L

-

D

D

N

I

I

D

T

I

P

E

E

D

Q

R

K

D

A

S

E

L

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

A

E

G

G

L

V

V

K

V

F

G

G

V

V

Q
|
Q

R

A

A

G

T
|
T

L
x
S

Q
x
H

D

E

N

A

Y

F

V

M

S

K

E

Q

L

M

Y

M

G

P

D

S

L

-

V

V

E

Q

I

I

R

S

R

T

Y

Y

T

D

S

T

A

I

D

D

D

N

V

V

T

M

D

D

M

L

R

K

A

A

G

G

R

R

L

I

D

D

L

A

T

S

F

L

M

A

D
x
S

Y

V

-

S

-

F

-

L

-

K

P

P

V

L

A

T

E

D

N

K

T

P

M

D

G

N

I

K

D

D

T

L

S

K

G

-

S

M

H

F

F

G

K

P

R

R

I

M

S

T

G

G

F

-

I

-

K

-

E

-

P

-

E

-

H

G

I

L

F

F

G

G

K

K

G

G

V

V

G

G

V

V

A

G

F

I

R

R

Q

K

R

E

D

D

E

A

A

D

L

L

A

K

E

A

R

L

F

F

N

D

E

K

A

A

L

I

A

D

A

A

L

A

K

I

E

A

D

D

G

G

T

T

Y

V

D

Q

E

K

I

L

M

S

E

Q

R

Q

Y

W

F

F

N

G

Y

Y

D

D

binding (2~{S})-5-azanyl-2-[[(2~{R})-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]pentanoic acid: E9 (≠ D34), Y12 (= Y37), W50 (= W75), A68 (≠ S93), G70 (≠ A95), R75 (= R100), M90 (≠ S115), Q138 (= Q141), T141 (= T144), S142 (≠ L145), H143 (≠ Q146), S180 (≠ D184)

5ot9A Structure of the periplasmic binding protein (pbp) noct from a.Tumefaciens c58 in complex with histopine. (see paper)
32% identity, 89% coverage: 26:258/261 of query aligns to 1:251/254 of 5ot9A

query
sites
5ot9A

Y

Y

S

K

E

S

I

I

R

T

L

I

G

A

V

T

D
x
E

I

G

P

S

Y
|
Y

E

A

P

P

F

Y

M

N

Y

F

R

K

Q

D

P

A

D

G

G

G

E

K

L

L

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

D

V

L

C

C

E

K

Y

R

L

M

E

N

V

I

T

E

C

C

T

K

W

F

V

V

E

E

Q

Q

D

A

W
|
W

D

D

G

G

I

I

P

P

G

S

L

L

M

T

A

A

R

G

N

R

Y

Y

D

D

A

A

I

I

M

M

S
x
A

M

M

A

G

I

I

T

Q

E

P

E

A

R
|
R

A

E

E

K

R

V

V

I

L

A

F

F

S

S

E

R

P

P

Y

Y

Y

L

T

L

T

T

P

P

S
x
M

A

T

W

F

I

L

T

T

R

A

D

D

R

S

-

P

-

L

-

K

-

T

-

Q

-

V

-

A

-

I

-

E

-

N

-

L

-

P

-

L

-

D

D

N

I

I

D

T

I

P

E

E

D

Q

R

K

D

A

S

E

L

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

A

E

G

G

L

V

V

K

V

F

G

G

V

V

Q
|
Q

R

A

A

G

T
|
T

L
x
S

Q
x
H

D

E

N

A

Y

F

V

M

S

K

E

Q

L

M

Y

M

G

P

D

S

L

-

V

V

E

Q

I

I

R

S

R

T

Y

Y

T

D

S

T

A

I

D

D

D

N

V

V

T

M

D

D

M

L

R

K

A

A

G

G

R

R

L

I

D

D

L

A

T

S

F

L

M

A

D
x
S

Y

V

-

S

-

F

-

L

-

K

P

P

V

L

A

T

E

D

N

K

T

P

M

D

G

N

I

K

D

D

T

L

S

K

G

-

S

M

H

F

F

G

K

P

R

R

I

M

S

T

G

G

F

-

I

-

K

-

E

-

P

-

E

-

H

G

I

L

F

F

G

G

K

K

G

G

V

V

G

G

V

V

A

G

F

I

R

R

Q

K

R

E

D

D

E

A

A

D

L

L

A

K

E

A

R

L

F

F

N

D

E

K

A

A

L

I

A

D

A

A

L

A

K

I

E

A

D

D

G

G

T

T

Y

V

D

Q

E

K

I

L

M

S

E

Q

R

Q

Y

W

F

F

N

G

Y

Y

D

D

binding Histopine: E9 (≠ D34), Y12 (= Y37), W50 (= W75), A67 (≠ S92), A68 (≠ S93), R75 (= R100), M90 (≠ S115), Q138 (= Q141), T141 (= T144), S142 (≠ L145), H143 (≠ Q146), S180 (≠ D184)

4powA Structure of the pbp noct in complex with pyronopaline (see paper)
32% identity, 89% coverage: 26:258/261 of query aligns to 1:251/254 of 4powA

query
sites
4powA

Y

Y

S

K

E

S

I

I

R

T

L

I

G

A

V

T

D
x
E

I

G

P

S

Y
|
Y

E

A

P

P

F

Y

M

N

Y

F

R

K

Q

D

P

A

D

G

G

G

E

K

L

L

T

I

G

G

F

F

E

D

I

I

E

D

L

L

G

G

N

N

A

D

V

L

C

C

E

K

Y

R

L

M

E

N

V

I

T

E

C

C

T

K

W

F

V

V

E

E

Q

Q

D

A

W
|
W

D

D

G

G

I

I

P

P

G

S

L

L

M

T

A

A

R

G

N

R

Y

Y

D

D

A

A

I

I

M

M

S
x
A

M

M

A
x
G

I

I

T

Q

E

P

E

A

R
|
R

A

E

E

K

R

V

V

I

L

A

F

F

S

S

E

R

P

P

Y

Y

Y

L

T

L

T

T

P

P

S
x
M

A

T

W

F

I

L

T

T

R

A

D

D

R

S

-

P

-

L

-

K

-

T

-

Q

-

V

-

A

-

I

-

E

-

N

-

L

-

P

-

L

-

D

D

N

I

I

D

T

I

P

E

E

D

Q

R

K

D

A

S

E

L

L

-

D

-

K

-

F

-

T

-

K

-

I

-

F

A

E

G

G

L

V

V

K

V

F

G

G

V

V

Q
|
Q

R

A

A

G

T
|
T

L
x
S

Q
x
H

D

E

N

A

Y

F

V

M

S

K

E

Q

L

M

Y

M

G

P

D

S

L

-

V

V

E

Q

I

I

R

S

R

T

Y

Y

T

D

S

T

A

I

D

D

D

N

V

V

T

M

D

D

M

L

R

K

A

A

G

G

R

R

L

I

D

D

L

A

T

S

F

L

M

A

D
x
S

Y

V

-

S

-

F

-

L

-

K

P

P

V

L

A

T

E

D

N

K

T

P

M

D

G

N

I

K

D

D

T

L

S

K

G

-

S

M

H

F

F

G

K

P

R

R

I

M

S

T

G

G

F

-

I

-

K

-

E

-

P

-

E

-

H

G

I

L

F

F

G

G

K

K

G

G

V

V

G

G

V

V

A

G

F

I

R

R

Q

K

R

E

D

D

E

A

A

D

L

L

A

K

E

A

R

L

F

F

N

D

E

K

A

A

L

I

A

D

A

A

L

A

K

I

E

A

D

D

G

G

T

T

Y

V

D

Q

E

K

I

L

M

S

E

Q

R

Q

Y

W

F

F

N

G

Y

Y

D

D

binding 1-[(1S)-4-carbamimidamido-1-carboxybutyl]-5-oxo-D-proline: E9 (≠ D34), Y12 (= Y37), W50 (= W75), A67 (≠ S92), A68 (≠ S93), G70 (≠ A95), R75 (= R100), M90 (≠ S115), Q138 (= Q141), T141 (= T144), S142 (≠ L145), H143 (≠ Q146), S180 (≠ D184)

3tqlA Structure of the amino acid abc transporter, periplasmic amino acid- binding protein from coxiella burnetii. (see paper)
32% identity, 87% coverage: 29:255/261 of query aligns to 4:225/225 of 3tqlA

query
sites
3tqlA

I

I

R

K

L

F

G

A

V

T

D
x
E

I

A

P

T

Y
|
Y

E

P

P

P

F

Y

M

V

Y

Y

R

M

Q

-

P

-

D

G

G

G

E

Q

L

V

T

E

G

G

F

F

E

G

I

A

E

D

L

I

G

V

N

K

A

A

V

V

C

C

E

K

Y

Q

L

M

E

Q

V

A

T

V

C

C

T

T

W

I

V

S

E

N

Q

Q

D

P

W
|
W

D

D

G

S

I

L

I

I

P

P

G

S

L

L

M

K

A

L

R

G

N

K

Y

F

D

D

A

A

I

L

M

F

S
x
G

M

M

A
x
N

I

I

T

T

E

T

E

A

R
|
R

A

Q

E

K

R

E

V

V

L

D

F

F

S

T

E

D

P

P

Y

Y

T

T

T

N

P

S

S

V

A
x
S

W

F

I

I

T

A

T

D

R

K

D

N

R

T

D

P

I

L

D

T

I

L

E

S

D

-

R

K

D

Q

S

G

L

L

A

K

G

G

L

K

V

I

G

G

V

V

Q

Q

R

G

A

G

T

T

L

T

Q

F

D

D

N

S

Y

Y

V

L

S

Q

E

D

L

S

Y

F

G

G

D

N

L

S

V

I

E

T

I

I

R

Q

R

R

Y

Y

T

P

S

S

A

E

D

E

D

D

V

A

V

L

T

M

D

D

M

L

R

T

A

S

G

G

R

R

L

V

D

D

L

A

T

V

F

V

M

G

D

D

Y

T

P

P

V

L

A

I

E

K

N

Q

T

W

M

L

G

K

I

-

D

Q

T

N

S

G

G

R

S

R

H

E

F

Y

K

V

R

L

I

I

S

G

G

K

F

P

I

V

K

N

E

D

P

P

E

N

H

Y

I

-

F

F

G

G

K

K

G

G

V

V

G

G

V

I

A

A

F

V

R

K

Q

K

R

G

D

N

E

Q

A

A

L

L

A

L

E

L

R

K

F

L

N

N

E

K

A

A

L

L

A

A

L

I

K

K

E

A

D

N

G

G

T

V

Y

Y

D

A

E

A

I

I

M

V

E

Q

R

K

Y

Y

F

F

binding arginine: E9 (≠ D34), Y12 (= Y37), W48 (= W75), G65 (≠ S92), G66 (≠ S93), N68 (≠ A95), R73 (= R100), S89 (≠ A116)

4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
32% identity, 87% coverage: 29:255/261 of query aligns to 6:225/226 of 4zv1A

query
sites
4zv1A

I

L

R

R

L

V

G

G

V

T

D
x
E

I

A

P

T

Y
x
F

E

P

P

P

F

F

M

G

Y

F

R

K

Q

D

P

E

D

N

G

G

E

K

L

L

T

V

G

G

F

F

E

D

I

I

E

D

L

L

G

A

N

K

A

A

V

I

C

A

E

K

Y

K

L

L

E

G

V

V

T

K

C

V

T

E

W

F

V

K

E

P

Q

M

D

D

W
x
F

D

D

G

G

I

I

P

P

G

A

L

L

M

Q

A

S

R

G

N

K

Y

I

D

D

A

V

I

V

M

I

S
x
A

S
x
G

M
|
M

A
x
T

I

I

T

T

E

E

R
|
R

A

K

E

K

R

Q

V

V

L

D

F

F

S

S

E

D

P

P

Y

Y

Y

F

T

E

T

A

P

G

S

Q

A

A

W

I

I

V

T

V

T

K

R

K

D

G

R

N

D

D

I

-

D

S

I

I

E

K

D

S

R

L

D

E

S

D

L

L

A

K

G

G

L

K

V

K

V

V

G

G

V

V

Q
|
Q

R

L

A

G

T
x
S

L
x
T

Q

S

D

E

N

Q

Y

H

V

V

S

K

E

K

L

V

Y

A

G

K

D

D

L

A

-

G

V

V

E

K

I

V

R

K

Y

F

T

D

S

N

A

F

D

S

D

E

V

A

V

F

T

Q

D

E

M

L

R

K

A

S

G

G

R

R

L

V

D

D

L

A

T

V

F

V

M

T

D
|
D

Y

N

P

A

V

V

A

A

-

L

-

A

-

Y

-

V

-

K

-

Q

E

N

N

P

T

N

M

A

G

G

I

V

D

K

T

I

S

V

G

G

S

E

H

T

F

F

K

-

R

-

I

-

S

S

G

G

F

-

I

-

K

-

E

E

P

P

E

-

H

-

I

-

F

-

G

-

K

-

G

-

V

Y

G

G

V

I

A

A

F

V

R

R

Q

K

R

G

D

N

E

S

A

E

L

L

A

L

E

E

R

K

F

I

N

N

E

K

A

A

L

L

A

E

L

M

K

K

E

K

D

D

G

G

T

T

Y

Y

D

D

E

K

I

I

M

Y

E

E

R

K

Y

W

F

F

binding arginine: E11 (≠ D34), F14 (≠ Y37), F52 (≠ W75), A69 (≠ S92), G70 (≠ S93), M71 (= M94), T72 (≠ A95), R77 (= R100), Q117 (= Q141), S120 (≠ T144), T121 (≠ L145), D161 (= D184)

4zv2A An ancestral arginine-binding protein bound to glutamine (see paper)
30% identity, 87% coverage: 29:255/261 of query aligns to 6:223/225 of 4zv2A

query
sites
4zv2A

I

L

R

R

L

V

G

G

V

T

D
x
E

I

A

P

T

Y
x
F

E

P

P

P

F

F

M

G

Y

F

R

K

Q

D

P

E

D

N

G

G

E

K

L

L

T

V

G

G

F

F

E

D

I

I

E

D

L

L

G

A

N

K

A

A

V

I

C

A

E

K

Y

K

L

L

E

G

V

V

T

K

C

V

T

E

W

F

V

K

E

P

Q

M

D

D

W
x
F

D

D

G

G

I

I

P

P

G

A

L

L

M

Q

A

S

R

G

N

K

Y

I

D

D

A

V

I

V

M

I

S

A

S
x
G

M
|
M

A
x
T

I

I

T

T

E

E

R
|
R

A

K

E

K

R

Q

V

V

L

D

F

F

S

S

E

D

P

P

Y

Y

Y

F

T

E

T

A

P

G

S

Q

A

A

W

I

I

V

T

V

T

K

R

K

D

G

R

N

D

D

I

-

D

S

I

I

E

K

D

S

R

L

D

E

S

D

L

L

A

K

G

G

L

K

V

K

V

V

G

G

V

V

Q

Q

R

L

A

G

T
x
S

L
x
T

Q

S

D

E

N

Q

Y

H

V

V

S

K

E

K

L

V

Y

A

G

A

D

G

L

-

V

V

E

K

I

V

R

K

Y

F

T

D

S

N

A

F

D

S

D

E

V

A

V

F

T

Q

D

E

M

L

R

K

A

S

G

G

R

R

L

V

D

D

L

A

T

V

F

V

M

T

D
|
D

Y

N

P

A

V

V

A

A

-

L

-

A

-

Y

-

V

-

K

-

Q

E

N

N

P

T

N

M

A

G

G

I

V

D

K

T

I

S

V

G

G

S

E

H

T

F

F

K

S

R

-

I

-

S

-

G

-

F

-

I

-

K

-

E

-

P

-

E

-

H

-

I

-

F

-

G

G

K

E

G

P

V

Y

G

G

V

I

A

A

F

V

R

R

Q

K

R

G

D

N

E

S

A

E

L

L

A

L

E

E

R

K

F

I

N

N

E

K

A

A

L

L

A

E

L

M

K

K

E

K

D

D

G

G

T

T

Y

Y

D

D

E

K

I

I

M

Y

E

E

R

K

Y

W

F

F

binding glutamine: E11 (≠ D34), F14 (≠ Y37), F52 (≠ W75), G70 (≠ S93), M71 (= M94), T72 (≠ A95), R77 (= R100), S120 (≠ T144), T121 (≠ L145), D159 (= D184)

3i6vA Crystal structure of a periplasmic his/glu/gln/arg/opine family- binding protein from silicibacter pomeroyi in complex with lysine
32% identity, 88% coverage: 29:258/261 of query aligns to 2:214/218 of 3i6vA

query
sites
3i6vA

I

V

R

R

L

M

G

G

V

T

D
x
E

I

G

P

A

Y
|
Y

E

P

P

P

F

Y

M

N

Y

F

R

I

Q

N

P

D

D

A

G

G

E

E

L

V

T

D

G

G

F

F

E

E

I

R

E

E

L

L

G

G

N

D

A

E

V

L

C

C

E

K

Y

R

L

A

E

G

V

L

T

T

C

C

T

E

W

W

V

V

E

K

Q

N

D

D

W
|
W

D

D

G

S

I

I

P

P

G

N

L

L

M

V

A

S

R

G

N

N

Y

Y

D

D

A

T

I

I

M

I

S

A

S
x
G

M
|
M

A
x
S

I

I

T

T

E

D

E

E

R
|
R

A

D

E

E

R

V

V

I

L

D

F

F

S

T

E

Q

P

N

Y

Y

Y

I

-

P

T

P

T

T

P

A

S

S

A

S

W

Y

I

V

T

A

T

T

R

S

D

-

R

-

D

-

I

-

D

-

I

-

E

-

D

D

R

G

D

A

S

D

L

L

A

S

G

G

L

-

V

I

V

V

G

A

V

A

Q
|
Q

R

T

A

A

T
|
T

L
x
I

Q
|
Q

D

A

N

G

Y

Y

V

I

S

A

E

E

L

S

Y

G

G

A

D

T

L

L

V

V

E

E

I

-

R

-

Y

F

T

A

S

T

A

P

D

E

V

T

V

I

T

A

D

A

M

V

R

R

A

N

G

G

R

E

L

A

D

D

L

A

T

V

F

F

M

A

D

D

-

R

-

D

-

Y

-

L

Y

V

P

P

V

I

A

-

E

-

N

-

T

-

M

-

G

-

I

V

D

A

T

E

S

S

G

G

S

G

H

E

F

L

K

M

R

F

I

V

S

G

G

D

F

D

I

V

K

P

E

-

P

-

E

-

H

-

I

-

F

L

G

G

K

G

G

G

V

V

G

G

V

M

A

G

F

L

R

R

Q

E

R

S

D

D

E

G

A

E

L

L

A

R

E

G

R

K

F

F

N

D

E

A

A

A

L

I

A

T

A

S

L

M

K

K

E

E

D

D

G

G

T

T

Y

L

D

N

E

T

I

M

M

I

E

K

R

K

Y

W

F

F

N

G

Y

E

D

D

binding lysine: E7 (≠ D34), Y10 (= Y37), W48 (= W75), G66 (≠ S93), M67 (= M94), S68 (≠ A95), R73 (= R100), Q107 (= Q141), T110 (= T144), I111 (≠ L145), Q112 (= Q146)

8hqrA Crystal structure of the arginine-/lysine-binding protein sar11_1210 from 'candidatus pelagibacter ubique' htcc1062 bound to arginine (see paper)
30% identity, 90% coverage: 28:261/261 of query aligns to 9:267/267 of 8hqrA

query
sites
8hqrA

E

K

I

I

R

K

L

I

G

G

V

T

D
x
E

I

G

P

A

Y
|
Y

E

P

P

P

F

W

M

N

Y

S

R

K

Q

D

P

A

D

S

G

G

E

A

L

L

T

I

G

G

F

F

E

E

I

V

E

E

L

L

G

A

N

E

A

E

V

L

C

C

E

K

Y

I

L

M

E

G

V

R

T

E

C

C

T

T

W

I

V

V

E

E

Q

Q

D

D

W
|
W

D

D

G

G

I

M

I

I

P

P

G

A

L

L

M

L

A

M

R

R

N

K

Y

F

D

D

A

A

I

I

M

M

S
x
A

S
x
G

M

M

A
x
S

I

I

T

T

E

A

E

E

R
|
R

A

Q

E

K

R

T

V

I

L

T

F

F

S

S

E

Q

P

G

Y

Y

Y

A

T

D

T
x
E

P

V

S

A

A

A

W

L

I

A

T

V

T

M

R

K

D

G

R

S

D

S

I

L

D

E

I

S

E

M

D

D

R

T

D

P

-

E

-

G

-

I

-

N

-

L

-

T

-

L

-

G

-

S

-

A

-

V

-

K

-

T

-

L

-

K

-

T

-

L

-

T

-

A

S

A

L

L

A

A

G

G

L

K

V

T

V

V

G

C

V

T

Q
|
Q

R

T

A

G

T
|
T

L
x
I

Q

H

D

Q

N

N

Y

F

V

L

S

E

E

S

L

-

Y

-

G

G

D

D

L

V

-

G

-

K

V

V

E

N

I

V

R

R

R

T

Y

Y

T

K

S

T

A

Q

D

D

D

E

V

V

V

N

T

L

D

D

M

L

R

T

A

S

G

G

R

R

L

C

D

D

-

V

-

A

-

L

-

A

L

V

T

A

F

F

M

T

D

D

Y

Y

P

A

V

-

A

-

E

-

N

-

T

-

M

-

G

-

I

-

D

D

T

K

S

S

G

G

S

K

H

P

F

V

K

V

R

L

I

V

S

G

G

P

F

T

I

F

K

S

E

G

P

G

E

A

H

-

I

-

F

F

G

G

K

N

G

G

V

V

G

G

V

V

A

G

F

I

R

R

Q

Q

-

G

-

D

-

A

-

I

-

G

-

T

R

R

D

D

E

A

A

K

L

L

A

L

E

K

R

D

F

F

N

N

E

K

A

A

L

I

A

N

A

T

L

A

K

R

E

K

D

Q

G

G

T

I

Y

I

D

S

E

K

I

L

M

A

E

I

R

K

Y

H

F

F

N

G

Y

F

D

D

I

A

K

S

L

M

binding arginine: E15 (≠ D34), Y18 (= Y37), W56 (= W75), A73 (≠ S92), G74 (≠ S93), S76 (≠ A95), R81 (= R100), E94 (≠ T113), Q143 (= Q141), T146 (= T144), I147 (≠ L145)

Query Sequence

>WP_086508344.1 NCBI__GCF_002151265.1:WP_086508344.1
MRALNMILAATLAAGLTAGTAQARDYSEIRLGVDIPYEPFMYRQPDGELTGFEIELGNAV
CEYLEVTCTWVEQDWDGIIPGLMARNYDAIMSSMAITEERAERVLFSEPYYTTPSAWITT
RDRDIDIEDRDSLAGLVVGVQRATLQDNYVSELYGDLVEIRRYTSADDVVTDMRAGRLDL
TFMDYPVAENTMGIDTSGSHFKRISGFIKEPEHIFGKGVGVAFRQRDEALAERFNEALAA
LKEDGTYDEIMERYFNYDIKL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory